Robert Wolfe

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury
    Dennis C Gore
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 1172, USA
    Ann Surg 241:334-42. 2005
  2. doi request reprint The recommended dietary allowance of protein: a misunderstood concept
    Robert R Wolfe
    Center for Translational Research in Aging and Longevity, Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 806, Little Rock, AR 72205, USA
    JAMA 299:2891-3. 2008
  3. doi request reprint Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial
    Yvette C Luiking
    Center for Translational Research in Aging and Longevity, Donald W, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W, Markham St, Slot 806, Little Rock AR 72205, USA
    Nutr J 13:9. 2014
  4. doi request reprint The role of dietary protein in optimizing muscle mass, function and health outcomes in older individuals
    Robert R Wolfe
    Center for Translational Research in Aging and Longevity, Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 806, Little Rock, AR 72205, USA
    Br J Nutr 108:S88-93. 2012
  5. pmc Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals
    Robert H Coker
    Center for Translational Research in Aging and Longevity, Little Rock, AR, USA
    Nutr J 11:105. 2012
  6. ncbi request reprint Protein Summit: consensus areas and future research
    Robert R Wolfe
    University of Arkansas for Medical Sciences, The Department of Geriatrics, the Center for Translational Research in Aging and Longevity, Little Rock, AR, USA
    Am J Clin Nutr 87:1582S-1583S. 2008
  7. doi request reprint Optimal protein intake in the elderly
    Robert R Wolfe
    University of Arkansas for Medical Sciences, Department of Geriatrics, Center for Translational Research in Aging and Longevity, 4301W Markham Street, Slot 806, Little Rock, AR 72205, USA
    Clin Nutr 27:675-84. 2008
  8. ncbi request reprint Total aminoacyl-transfer RNA pool is greater in liver than muscle in rabbits
    Robert R Wolfe
    Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 137:2333-8. 2007
  9. ncbi request reprint Functional impact of 10 days of bed rest in healthy older adults
    Patrick Kortebein
    University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Gerontol A Biol Sci Med Sci 63:1076-81. 2008
  10. doi request reprint Cachexia: a new definition
    William J Evans
    Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
    Clin Nutr 27:793-9. 2008

Research Grants

  1. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert R Wolfe; Fiscal Year: 2010
  2. EXERCISE, LIPOLYSIS AND FAT OXIDATION
    Robert Wolfe; Fiscal Year: 1993
  3. EFFECT OF EXERCISE ON PROTEIN METABOLISM IN HUMANS
    Robert Wolfe; Fiscal Year: 1993
  4. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert Wolfe; Fiscal Year: 2002
  5. EXERCISE EFFECTS ON PROTEIN METABOLISM
    Robert Wolfe; Fiscal Year: 2002
  6. EXERCISE, LIPOLYSIS AND FAT OXIDATION
    Robert Wolfe; Fiscal Year: 2002
  7. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert R Wolfe; Fiscal Year: 2010
  8. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert Wolfe; Fiscal Year: 2007
  9. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
  10. MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLY
    Robert Wolfe; Fiscal Year: 2002

Collaborators

Detail Information

Publications72

  1. pmc Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury
    Dennis C Gore
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 1172, USA
    Ann Surg 241:334-42. 2005
    ..The purpose of this study was to determine the effect of metformin on glucose kinetics and muscle protein metabolism in severely burned patients and assess any potential benefit of metformin in this clinical setting...
  2. doi request reprint The recommended dietary allowance of protein: a misunderstood concept
    Robert R Wolfe
    Center for Translational Research in Aging and Longevity, Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 806, Little Rock, AR 72205, USA
    JAMA 299:2891-3. 2008
  3. doi request reprint Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial
    Yvette C Luiking
    Center for Translational Research in Aging and Longevity, Donald W, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W, Markham St, Slot 806, Little Rock AR 72205, USA
    Nutr J 13:9. 2014
    ..Moreover, the combined effect with resistance exercise was studied by using a unilateral resistance exercise protocol...
  4. doi request reprint The role of dietary protein in optimizing muscle mass, function and health outcomes in older individuals
    Robert R Wolfe
    Center for Translational Research in Aging and Longevity, Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 806, Little Rock, AR 72205, USA
    Br J Nutr 108:S88-93. 2012
    ....
  5. pmc Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals
    Robert H Coker
    Center for Translational Research in Aging and Longevity, Little Rock, AR, USA
    Nutr J 11:105. 2012
    ..We have previously demonstrated the effectiveness of whey protein and essential amino acids towards the preservation of lean tissue, even under the conditions of strict bedrest in the elderly...
  6. ncbi request reprint Protein Summit: consensus areas and future research
    Robert R Wolfe
    University of Arkansas for Medical Sciences, The Department of Geriatrics, the Center for Translational Research in Aging and Longevity, Little Rock, AR, USA
    Am J Clin Nutr 87:1582S-1583S. 2008
  7. doi request reprint Optimal protein intake in the elderly
    Robert R Wolfe
    University of Arkansas for Medical Sciences, Department of Geriatrics, Center for Translational Research in Aging and Longevity, 4301W Markham Street, Slot 806, Little Rock, AR 72205, USA
    Clin Nutr 27:675-84. 2008
    ..It appears that an intake of 1.5 g protein/kg/day, or about 15-20% of total caloric intake, is a reasonable target for elderly individuals wishing to optimize protein intake in terms of health and function...
  8. ncbi request reprint Total aminoacyl-transfer RNA pool is greater in liver than muscle in rabbits
    Robert R Wolfe
    Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 137:2333-8. 2007
    ..05). The greater availability and charging efficiency of tRNA in liver as compared with muscle may influence the extent to which amino acid precursor availability regulates protein synthesis in these 2 tissues...
  9. ncbi request reprint Functional impact of 10 days of bed rest in healthy older adults
    Patrick Kortebein
    University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Gerontol A Biol Sci Med Sci 63:1076-81. 2008
    ..This study reports on the effect of 10 days of bed rest on multiple functional parameters in healthy older adults...
  10. doi request reprint Cachexia: a new definition
    William J Evans
    Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
    Clin Nutr 27:793-9. 2008
    ..While this definition has not been tested in epidemiological or intervention studies, a consensus operational definition provides an opportunity for increased research...
  11. ncbi request reprint Restoration of hormonal action and muscle protein
    Arny A Ferrando
    Center for Translational Research on Aging and Longevity, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Crit Care Med 35:S630-4. 2007
    ..To restore hormonal influence, clinicians should consider reestablishing anabolic stimuli and reducing catabolic stimuli...
  12. doi request reprint EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
    Arny A Ferrando
    University of Arkansas for Medical Sciences, USA
    Clin Nutr 29:18-23. 2010
    ..In the present study, we examined the effects of increasing protein intake by essential amino acid (EAA) supplementation in older individuals subjected to 10 d bed rest on LBM and muscle function...
  13. pmc Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children
    Ricki Y Fram
    Metabolism Unit and Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 38:1475-83. 2010
    ..To institute intensive insulin therapy protocol in an acute pediatric burn unit and study the mechanisms underlying its benefits...
  14. ncbi request reprint Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance
    Melanie G Cree
    University of Arkansas Medical Sciences, Donald W Reynolds Center on Aging, Nutrition, Metabolism and Exercise Lab, Little Rock, AR, USA
    Crit Care Med 35:S476-83. 2007
    ..Review current evidence on the role of fat in post-trauma insulin resistance, in reference to new studies with peroxisome proliferating activating receptor-alpha agonists...
  15. ncbi request reprint Postburn trauma insulin resistance and fat metabolism
    Melanie G Cree
    Donald W Reynolds Institute on Aging, 4301 W Markham St, Slot 806, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 294:E1-9. 2008
    ..The resultant increases in intracellular TG or related lipid products may in turn contribute to alterations in insulin signaling...
  16. ncbi request reprint Aerobic exercise training increases skeletal muscle protein turnover in healthy adults at rest
    Matthew A Pikosky
    Department Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Nutr 136:379-83. 2006
    ..072 +/- 0.012%/h, P < 0.05); FBR tended to increase (0.105+/- 0.014 vs. 0.143+/- 0.018%/h; P=0.06) after training. Findings show that aerobic training for 4 wk increases skeletal muscle protein turnover in previously unfit subjects...
  17. ncbi request reprint Optimal nutrition, exercise, and hormonal therapy promote muscle anabolism in the elderly
    Robert R Wolfe
    University of Texas Medical Branch and Shriners Burns Hospital, Galveston, TX, USA
    J Am Coll Surg 202:176-80. 2006
  18. ncbi request reprint Skeletal muscle protein metabolism and resistance exercise
    Robert R Wolfe
    Department of Surgery, The University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, Galveston, TX, USA
    J Nutr 136:525S-528S. 2006
    ....
  19. ncbi request reprint Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS
    Dayong Sun
    Metabolism Unit, Shriners Burn Hospital, University of Texas Medical Branch, Galveston, TX 77550
    J Lipid Res 47:431-9. 2006
    ..Applying this protocol to biological muscle samples proves it to be a very sensitive, accurate, and precise analytical tool...
  20. ncbi request reprint Bed rest and myopathies
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Shrine Hospital for Children, Galveston, Texas 77550, USA
    Curr Opin Clin Nutr Metab Care 9:410-5. 2006
    ..Changes in protein metabolism with bed rest alone and during physiological stress are discussed. Nutritional and hormonal interventions that ameliorate the loss of skeletal muscle are highlighted...
  21. ncbi request reprint Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations
    Christos S Katsanos
    Department of Surgery, Shriners Hospitals for Children Galveston, and University of Texas Medical Branch, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 289:E1064-70. 2005
    ..We conclude that the protein NB in non-steady-state blood phenylalanine concentrations can be determined from the arteriovenous phenylalanine NB by accounting for changes in free phenylalanine within its volume of distribution...
  22. ncbi request reprint Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise
    Douglas R Bolster
    Dept of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Am J Physiol Endocrinol Metab 289:E678-83. 2005
    ..Future studies directed at mechanisms by which level of protein intake influences skeletal muscle turnover are needed...
  23. ncbi request reprint Milk ingestion stimulates net muscle protein synthesis following resistance exercise
    Tabatha A Elliot
    Metabolism Unit, Shriners Hospitals for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Med Sci Sports Exerc 38:667-74. 2006
    ..This study was designed to determine the response of net muscle protein balance following resistance exercise to ingestion of nutrients as components of milk...
  24. ncbi request reprint Quantification of protein metabolism in vivo for skin, wound, and muscle in severe burn patients
    Dennis C Gore
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 1172, USA
    JPEN J Parenter Enteral Nutr 30:331-8. 2006
    ..The purpose of this study is to assess a technique by which in vivo protein kinetics of muscle, wound, and normal skin can be quantified in burn-injured patients...
  25. ncbi request reprint Stimulation of net muscle protein synthesis by whey protein ingestion before and after exercise
    Kevin D Tipton
    The Univ of Birmingham, School of Sport and Exercise Sciences, Edgbaston, Birmington B15 2TT, UK
    Am J Physiol Endocrinol Metab 292:E71-6. 2007
    ..Thus the response of net muscle protein balance to timing of intact protein ingestion does not respond as does that of the combination of free amino acids and carbohydrate...
  26. ncbi request reprint Quantification of amino acid transport through interstitial fluid: assessment of four-compartment modeling for muscle protein kinetics
    Dennis C Gore
    Dept of Surgery, Univ of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    Am J Physiol Endocrinol Metab 292:E319-23. 2007
    ..Therefore, any effective therapy to correct illness-induced muscle catabolism should be directed at altering the rates of breakdown and synthesis of muscle protein and are not likely related to tissue edema...
  27. ncbi request reprint The underappreciated role of muscle in health and disease
    Robert R Wolfe
    University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, TX 77550, USA
    Am J Clin Nutr 84:475-82. 2006
    ....
  28. ncbi request reprint Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 91:4836-41. 2006
    ..We recently demonstrated that 28-d bed rest in healthy volunteers results in a moderate loss of lean leg mass and strength...
  29. pmc Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate
    Melanie G Cree
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555, USA
    Ann Surg 245:214-21. 2007
    ..To determine some of the mechanisms involved in insulin resistance immediately following burn trauma, and to determine the efficacy of PPAR-alpha agonism for alleviating insulin resistance in this population...
  30. ncbi request reprint Acute responses of muscle protein metabolism to reduced blood flow reflect metabolic priorities for homeostasis
    Xiao Jun Zhang
    Metabolism Unit, Shriners Hospital for Children, The University of Texas Medical Branch, Galveston, Texas, USA
    Am J Physiol Endocrinol Metab 294:E551-7. 2008
    ..These findings cannot be extrapolated to more chronic conditions without experimental validation...
  31. ncbi request reprint Role of dietary protein in the sarcopenia of aging
    Douglas Paddon-Jones
    Department of Physical Therapy, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 87:1562S-1566S. 2008
    ..However, renal function decreases with age, and high protein intake is contraindicated in individuals with renal disease. Assessment of renal function is recommended for older individuals before they adopt a higher-protein diet...
  32. ncbi request reprint Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion
    Kevin D Tipton
    Metabolism Unit, Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 284:E76-89. 2003
    ..Results for other amino acids were similar. The acute anabolic response of muscle to EAA intake and exercise is additive to the response at rest and thus reflects the 24-h response...
  33. ncbi request reprint Amino acid control of muscle protein turnover in renal disease
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    J Ren Nutr 15:34-8. 2005
    ..Despite the substantial evidence of ICAA regulation, its physiologic significance is not evident. However, the regulation of ICAAs represents a method by which skeletal muscle ensures its capacity for anabolism...
  34. ncbi request reprint Regulation of muscle protein by amino acids
    Robert R Wolfe
    University of Texas Medical Branch and Shriners Burns Hospital, Department of Surgery, Galveston 77550, USA
    J Nutr 132:3219S-24S. 2002
    ..Finally, acute anabolic responses in net MPS correspond quantitatively to differences in 24-h net muscle balances...
  35. ncbi request reprint Protein and amino acids for athletes
    Kevin D Tipton
    Department of Surgery, University of Texas Medical Branch, Shriner s Hospital for Children, 815 Market Street, Galveston, TX 77550, USA
    J Sports Sci 22:65-79. 2004
    ....
  36. ncbi request reprint Extremity hyperinsulinemia stimulates muscle protein synthesis in severely injured patients
    Dennis C Gore
    The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1172, USA
    Am J Physiol Endocrinol Metab 286:E529-34. 2004
    ..In conclusion, this study demonstrates that insulin directly stimulates muscle protein synthesis in severely injured patients...
  37. ncbi request reprint Latency, duration and dose response relationships of amino acid effects on human muscle protein synthesis
    Michael J Rennie
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Scotland, United Kingdom
    J Nutr 132:3225S-7S. 2002
    ..The maximal capacity for storage of amino acids as muscle protein probably sets an upper value on the extent to which amino acids can be stored after a single meal...
  38. pmc Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study
    Julien Bohe
    Division of Metabolism, Department of Surgery, University of Texas Medical Branch, Shriners Burns Hospital, Galveston, TX 77550, USA
    J Physiol 552:315-24. 2003
    ..We propose that the stimulation of protein synthesis depends on the sensing of the concentration of extracellular, rather than intramuscular EAAs...
  39. ncbi request reprint Gene expression profiles and protein balance in skeletal muscle of burned children after beta-adrenergic blockade
    David N Herndon
    Department of Surgery, The University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 285:E783-9. 2003
    ..The upregulation of genes involved in muscle metabolism correlates well with the increase in net protein balance across the leg...
  40. ncbi request reprint Differential anabolic effects of testosterone and amino acid feeding in older men
    Arny A Ferrando
    Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 88:358-62. 2003
    ..Taken together, however, these diverse stimulatory effects can increase lean body mass and muscle strength over time...
  41. pmc Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned
    Steven E Wolf
    Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, 815 Market, Galveston, TX 77550, USA
    Ann Surg 237:801-10; discussion 810-1. 2003
    ..To determine the effects of the anabolic agent oxandrolone on muscle protein and gene expression in severely burned children...
  42. ncbi request reprint Effects of early excision and aggressive enteral feeding on hypermetabolism, catabolism, and sepsis after severe burn
    David W Hart
    Department of Surgery, The University of Texas Medical Branch, Galveston, USA
    J Trauma 54:755-61; discussion 761-4. 2003
    ..We hypothesized that early burn excision and aggressive enteral feeding diminish hypermetabolism...
  43. ncbi request reprint Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B
    Hisamine Kobayashi
    Department of Surgery, Shriners Burns Hospital, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 284:E488-98. 2003
    ....
  44. ncbi request reprint Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch and Metabolism Unit, Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 284:E946-53. 2003
    ..180 min) in the C + AA group. Thus, although differences in protein metabolism were evident, EAA ingestion improved muscle protein anabolism during acute hypercortisolemia and may help minimize muscle loss following debilitating injury...
  45. ncbi request reprint Measurement of protein metabolism in epidermis and dermis
    Xiao Jun Zhang
    Shriners Hospitals for Children, Departments of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 284:E1191-201. 2003
    ..We conclude that, in the skin, efficient reutilization of amino acids from proteolysis for synthesis enables the maintenance of protein mass in the postabsorptive state...
  46. ncbi request reprint Measurement of muscle protein fractional synthesis and breakdown rates from a pulse tracer injection
    Xiao Jun Zhang
    Metabolism Unit, Shriners Hospitals for Children, and Departments of Surgery and Anesthesiology, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 283:E753-64. 2002
    ..This method can be completed in 1 h with one muscle biopsy and has technical advantages over currently used methods...
  47. ncbi request reprint The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation
    Douglas Paddon-Jones
    Metabolism Unit, 815 Market Street, Galveston, Texas
    J Clin Endocrinol Metab 90:1453-9. 2005
    ..04%.h(-1)) and post-BR (EXP, 0.111 +/- 0.015, and CON, 0.05 +/- 0.002%.h(-1)). Unlike a typical clinical meal, AA/CHO supplementation stimulated net muscle protein synthesis despite acute hypercortisolemia and prolonged inactivity...
  48. ncbi request reprint Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
    Arny A Ferrando
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 282:E601-7. 2002
    ..We conclude that physiological and near-physiological increases of testosterone in older men will increase muscle protein anabolism and muscle strength...
  49. ncbi request reprint Regulation of skeletal muscle protein metabolism in catabolic states
    Robert R Wolfe
    The University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, Texas, USA
    Curr Opin Clin Nutr Metab Care 8:61-5. 2005
    ..Studies focused on molecular mechanisms of muscle catabolism are not reviewed...
  50. ncbi request reprint Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion
    Douglas Paddon-Jones
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Am J Physiol Endocrinol Metab 288:E761-7. 2005
    ..2 +/- 8.5 nmol x min(-1) x 100 ml leg volume(-1). These data indicate that CAA supplementation produces a greater anabolic effect than ingestion of intact protein but does not interfere with the normal metabolic response to a meal...
  51. ncbi request reprint Leucine supplementation has an anabolic effect on proteins in rabbit skin wound and muscle
    Xiao Jun Zhang
    Metabolism Unit, Shriners Hospital for Children, Galveston, TX 77550, USA
    J Nutr 134:3313-8. 2004
    ..h)] or muscle [-2.7 +/- 0.7 micromol/(100 g . h)]. We conclude that leucine supplementation had an anabolic effect on proteins in skin wounds and muscle, provided that adequate additional amino acids were also available...
  52. ncbi request reprint Anabolic action of insulin on skin wound protein is augmented by exogenous amino acids
    Xiao Jun Zhang
    Metabolism Unit, Shriners Burns Hospital for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 282:E1308-15. 2002
    ..We conclude that there is an interactive effect of insulin and sufficient amino acid supply on protein metabolism in skin wound, meaning that their combined anabolic effect is greater than the sum of their individual effects...
  53. ncbi request reprint Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patients
    Gianni Biolo
    Shriners Burns Hospital, 815 Market Street, Galveston, TX 77550, USA
    J Clin Endocrinol Metab 87:3378-84. 2002
    ..In contrast, transmembrane transport in the inward direction is impaired relatively to the increased delivery of circulating amino acid to skeletal muscle secondary to accelerated blood flow...
  54. ncbi request reprint Relative influence of glucose and insulin on peripheral amino acid metabolism in severely burned patients
    Dennis C Gore
    JPEN J Parenter Enteral Nutr 26:271-7. 2002
    ..Protein catabolism and glucose intolerance are prominent in critically injured patients. The objective of this study was to assess if glucose or insulin availability influences the extent of protein catabolism in hypermetabolic patients...
  55. ncbi request reprint Effect of an amino acid, protein, and carbohydrate mixture on net muscle protein balance after resistance exercise
    Elisabet Borsheim
    Metabolism Unit in the Department of Surgery at the Shriners Hospitals for Children Galveston, University of Texas Medical Branch, 77550, USA
    Int J Sport Nutr Exerc Metab 14:255-71. 2004
    ..Further, compared to previously reported findings, the addition of protein to an AA+ CHO mixture seems to extend the anabolic effect...
  56. pmc Propranolol decreases splanchnic triacylglycerol storage in burn patients receiving a high-carbohydrate diet
    Beatrice Morio
    University of Texas Medical Branch, Department of Surgery, Shriners Burns Hospital, Metabolism Unit, Galveston, Texas 77550, USA
    Ann Surg 236:218-25. 2002
    ....
  57. doi request reprint Incomplete financial disclosures
    Robert R Wolfe
    JAMA 300:1763. 2008
  58. ncbi request reprint Alterations in protein metabolism during space flight and inactivity
    Arny A Ferrando
    Department of Surgery, University of Texas Medical Branch, and the Metabolism Unit, Shriners Hospital for Children, Galveston, Texas 77550, USA
    Nutrition 18:837-41. 2002
    ....
  59. ncbi request reprint Independent and combined effects of amino acids and glucose after resistance exercise
    Sharon L Miller
    Dairy Management, Inc, Rosemont, IL, USA
    Med Sci Sports Exerc 35:449-55. 2003
    ..This study was designed to assess the independent and combined effects of a dose of amino acids (approximately 6 g) and/or carbohydrate (approximately 35 g) consumed at 1 and 2 h after resistance exercise on muscle protein metabolism...
  60. ncbi request reprint Amino acid supplementation for reversing bed rest and steroid myopathies
    Douglas Paddon-Jones
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX, USA
    J Nutr 135:1809S-1812S. 2005
    ..It may be necessary to concomitantly reduce the catabolic influence of cortisol or provide another anabolic stimulus...
  61. ncbi request reprint Determination of phenylalanine isotope ratio enrichment by liquid chromatography/time- of-flight mass spectrometry
    Zhanpin Wu
    Analytical Instrument Division, JEOL USA, Inc, 11 Dearborn Road, Peabody, MA 01960, USA
    Eur J Mass Spectrom (Chichester, Eng) 10:619-23. 2004
    ..9999. The coefficient of variation for the isotope ratio measurement was below 2%. The method is simple, rapid, and accurate and presents an attractive alternative to traditional GC/MS applications...
  62. ncbi request reprint Fractional synthesis rates of DNA and protein in rabbit skin are not correlated
    Xiao Jun Zhang
    Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
    J Nutr 134:2401-6. 2004
    ..This new approach enables investigations of metabolic disorders of skin diseases and regulation of skin wound healing by distinguishing the 2 principal components of skin metabolism, which are cell division and protein synthesis...
  63. ncbi request reprint Intramuscular and liver triglycerides are increased in the elderly
    Melanie G Cree
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 89:3864-71. 2004
    ..Increases of IMCL and LFAT occur in elderly individuals and may be related to insulin resistance...
  64. pmc Insulin resistance of muscle protein metabolism in aging
    Blake B Rasmussen
    Department of Kinesiology, University of Southern California, Los Angeles, California, USA
    FASEB J 20:768-9. 2006
    ..89; P=0.0001) and blood flow (R=0.90; P<0.0001). In conclusion, skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia...
  65. ncbi request reprint A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    Christos S Katsanos
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 291:E381-7. 2006
    ..We conclude that increasing the proportion of leucine in a mixture of EAA can reverse an attenuated response of muscle protein synthesis in elderly but does not result in further stimulation of muscle protein synthesis in young subjects...
  66. ncbi request reprint Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound
    Xiao Jun Zhang
    Metabolism Unit, University of Texas Medical Branch, Galveston, TX, USA
    Surgery 139:633-9. 2006
    ..Whereas Sulfamylon is effective in treatment of burn wound infection, controversy exists regarding its effect on the healing process...
  67. ncbi request reprint Compartmental distribution of amino acids during hemodialysis-induced hypoaminoacidemia
    Elisabet Børsheim
    Metabolism Unit, Department of Surgery, Shriners Hospitals for Children Galveston, and University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 290:E643-52. 2006
    ..In conclusion, intracellular concentrations of amino acids are regulated to maintain relatively constant values, even when plasma and interstitial concentrations fall as a consequence of hemodialysis...
  68. ncbi request reprint Fatiguing exercise reduces DNA binding activity of NF-kappaB in skeletal muscle nuclei
    William J Durham
    Pulmonary and Critical Care Medicine Section, Baylor College of Medicine, Houston, Texas 77030, USA
    J Appl Physiol (1985) 97:1740-5. 2004
    ..These data provide no support for our original hypothesis. Instead, acute fatiguing exercise appears to decrease NF-kappaB activity in muscle under a variety of conditions...
  69. ncbi request reprint Effect of carbohydrate intake on net muscle protein synthesis during recovery from resistance exercise
    Elisabet Børsheim
    Department of Surgery, Shriners Hospitals for Children Galveston, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Appl Physiol 96:674-8. 2004
    ..We conclude that ingestion of carbohydrates improved net leg protein balance after resistance exercise. However, the effect was minor and delayed compared with the previously reported effect of ingestion of amino acids...
  70. ncbi request reprint Aging does not impair the anabolic response to a protein-rich meal
    T Brock Symons
    Division of Rehabilitation Sciences, The University of Texas Medical Branch, Galveston, TX 77555 1144, USA
    Am J Clin Nutr 86:451-6. 2007
    ..However, the ability of an actual protein-rich food to stimulate anabolism in the young and the elderly has not been explored...
  71. pmc Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy
    E L Dillon
    Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1060, USA
    Clin Nutr 26:736-43. 2007
    ..Our considerable data showing the strong anabolic potential of amino acids (AA) led us to test whether AA can acutely stimulate muscle protein synthesis in cancer patients (CA) undergoing intense chemotherapy...
  72. pmc Human mitochondrial oxidative capacity is acutely impaired after burn trauma
    Melanie G Cree
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Surg 196:234-9. 2008
    ..Mitochondrial proteins and genes are damaged after burn injury in animals and are assessed in human burn patients in this study...

Research Grants58

  1. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert R Wolfe; Fiscal Year: 2010
    ..The results from these studies will have direct application in the nutritional care of severely burned or injured patients. ..
  2. EXERCISE, LIPOLYSIS AND FAT OXIDATION
    Robert Wolfe; Fiscal Year: 1993
    ..These will be the first quantitative studies of factors controlling lipid metabolism in exercising men and women...
  3. EFFECT OF EXERCISE ON PROTEIN METABOLISM IN HUMANS
    Robert Wolfe; Fiscal Year: 1993
    ..These results will provide the fundamental knowledge necessary to formulate an optimal nutrition approach to the promotion of net protein synthesis following exercise...
  4. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert Wolfe; Fiscal Year: 2002
    ..This information will provide a physiological basis for the development of a practical approach to controlling increased triglyceride synthesis in insulin resistant states. ..
  5. EXERCISE EFFECTS ON PROTEIN METABOLISM
    Robert Wolfe; Fiscal Year: 2002
    ..The results of this study will also contribute to our understanding of the mechanism whereby nutritional intake affects muscle protein metabolism. ..
  6. EXERCISE, LIPOLYSIS AND FAT OXIDATION
    Robert Wolfe; Fiscal Year: 2002
    ..abstract_text> ..
  7. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert R Wolfe; Fiscal Year: 2010
    ..The results from these studies will have direct application in the nutritional care of severely burned or injured patients. ..
  8. SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert Wolfe; Fiscal Year: 2007
    ..abstract_text> ..
  9. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
    ..abstract_text> ..
  10. MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLY
    Robert Wolfe; Fiscal Year: 2002
    ..These studies will provide the metabolic basis for the formulation of a nutritional supplement that should optimally stimulate net muscle protein synthesis. ..
  11. THE ROLE OF SUBSTRATE CYCLING IN ENERGY METABOLISM
    Robert Wolfe; Fiscal Year: 1993
    ..e., glycerol kinase or PEPCK), and in part by stimulation of pyruvate kinase...