M S Wolfe

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    M S Wolfe
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 398:513-7. 1999
  2. ncbi FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex
    W Xia
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Neurobiol Dis 7:673-81. 2000
  3. pmc Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
    W Xia
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9299-304. 2000
  4. ncbi The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
    W T Kimberly
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 275:3173-8. 2000
  5. ncbi A portrait of Alzheimer secretases--new features and familiar faces
    W P Esler
    Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 293:1449-54. 2001
  6. ncbi gamma-Secretase inhibitors as molecular probes of presenilin function
    M S Wolfe
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Mol Neurosci 17:199-204. 2001
  7. pmc Discovery of notch-sparing gamma-secretase inhibitors
    C E Augelli-Szafran
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Alzheimer Res 7:207-9. 2010
  8. pmc Gamma -secretase inhibitors repress thymocyte development
    B K Hadland
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:7487-91. 2001
  9. ncbi Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
    O Berezovska
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Charlestown, California, USA
    J Neurochem 75:583-93. 2000
  10. ncbi A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    B De Strooper
    Neuronal Cell Biology and Gene Transfer Laboratory, Flanders Institute for Biotechnology VIB4, Center for Human Genetics, KU Leuven, Belgium
    Nature 398:518-22. 1999

Collaborators

  • W Xia
  • D J Selkoe
  • J Zhang
  • Y Gu
  • T Yang
  • Alison Goate
  • R Kopan
  • GERALDINE WEINMASTER
  • C E Augelli-Szafran
  • C Jack
  • O Berezovska
  • W T Kimberly
  • R L Bernardos
  • B K Hadland
  • W P Esler
  • B T Hyman
  • D Lu
  • H X Wei
  • E H Schroeter
  • W Ye
  • P Osenkowski
  • B De Strooper
  • P A Raymond
  • S I Lentz
  • C L Moore
  • G D Longmore
  • D Su
  • N R Manley
  • P McLean
  • T Rahmati
  • C Hicks
  • J C Aster
  • J S Mumm
  • P Cupers
  • P Saftig
  • W J Ray
  • W Annaert
  • V Schrijvers
  • K Craessaerts

Detail Information

Publications12

  1. ncbi Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
    M S Wolfe
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 398:513-7. 1999
    ....
  2. ncbi FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex
    W Xia
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Neurobiol Dis 7:673-81. 2000
    ..Taken together, these findings suggest that PS1 participates physically in a complex with APP during the gamma-secretase cleavage event...
  3. pmc Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation
    W Xia
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9299-304. 2000
    ..Thus, PSs are complexed with the gamma-secretase substrates C83 and C99 in the subcellular locations where Abeta is generated, indicating that PSs are directly involved in the pathogenically critical intramembranous proteolysis of APP...
  4. ncbi The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation
    W T Kimberly
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 275:3173-8. 2000
    ..We conclude that presenilins, and their TM aspartates in particular, are attractive targets for lowering Abeta therapeutically to prevent Alzheimer's disease...
  5. ncbi A portrait of Alzheimer secretases--new features and familiar faces
    W P Esler
    Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 293:1449-54. 2001
    ..Identification of the alpha-, beta-, and gamma-secretases provides potential targets for designing new drugs to treat AD...
  6. ncbi gamma-Secretase inhibitors as molecular probes of presenilin function
    M S Wolfe
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Mol Neurosci 17:199-204. 2001
    ..Heterodimeric presenilin appears to be the catalytic portion of a multi-protein gamma-secretase complex...
  7. pmc Discovery of notch-sparing gamma-secretase inhibitors
    C E Augelli-Szafran
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Alzheimer Res 7:207-9. 2010
    ..These compounds are of low molecular weight and are under evaluation for drug-like properties. The discovery and development of these compounds will be discussed...
  8. pmc Gamma -secretase inhibitors repress thymocyte development
    B K Hadland
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:7487-91. 2001
    ....
  9. ncbi Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
    O Berezovska
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Charlestown, California, USA
    J Neurochem 75:583-93. 2000
    ..The latter is an important finding from the perspective of therapeutic treatment of Alzheimer's disease by targeting gamma-secretase processing of APP to reduce Abeta production...
  10. ncbi A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    B De Strooper
    Neuronal Cell Biology and Gene Transfer Laboratory, Flanders Institute for Biotechnology VIB4, Center for Human Genetics, KU Leuven, Belgium
    Nature 398:518-22. 1999
    ..Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling...
  11. ncbi Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons
    C Jack
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Brain Res Mol Brain Res 87:166-74. 2001
    ..These results support the hypothesis that PS1 deficiency blocks neuronal Notch1 processing and signaling...
  12. ncbi Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina
    R L Bernardos
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109 0616, USA
    Dev Biol 278:381-95. 2005
    ..In contrast to neurons, Müller glia failed to differentiate suggesting an instructive role for Notch-Delta signaling in gliogenesis...