Research Topics
Species | MYLES S WOLFSummaryAffiliation: University of Miami Country: USA Publications
Research Grants
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Detail Information
Publications
Mineral metabolites and CKD progression in African AmericansJulia J Scialla
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
J Am Soc Nephrol 24:125-35. 2013..In conclusion, abnormalities of mineral metabolism worsen with progressive CKD and associate with higher risk for ESRD among African Americans with hypertensive nephrosclerosis...- Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerioSteve Mangos
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
Nephrol Dial Transplant 27:4314-22. 2012..These data indicate conservation of the FGF23-αklotho system across species and suggest a likely role for αklotho in the proximal and distal tubules... 
Fibroblast growth factor 23 and the future of phosphorus managementMyles Wolf
Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
Curr Opin Nephrol Hypertens 18:463-8. 2009..To present emerging data on the role of fibroblast growth factor 23 (FGF23) in mineral metabolism and adverse outcomes in chronic kidney disease (CKD)...- Forging forward with 10 burning questions on FGF23 in kidney diseaseMyles Wolf
Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, CRB, C 221, Room 819, Miami, FL 33136, USA
J Am Soc Nephrol 21:1427-35. 2010..Ten burning questions must be addressed to galvanize FGF23 research further in CKD... - Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortalityMyles Wolf
Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, 1120 NW 14th Street, CRB 819, Miami, FL 33136, USA
J Am Soc Nephrol 22:956-66. 2011..We conclude that a high (or elevated) FGF23 is an independent risk factor for death and allograft loss in kidney transplant recipients... - Fibroblast growth factor 23 in patients undergoing peritoneal dialysisTamara Isakova
Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Clin J Am Soc Nephrol 6:2688-95. 2011..Fibroblast growth factor 23 (FGF23) is an independent risk factor for mortality in patients with ESRD. Before FGF23 testing can be integrated into clinical practice of ESRD, further understanding of its determinants is needed... - FGF23 or PTH: which comes first in CKD ?Tamara Isakova
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
Kidney Int 78:947-9. 2010..However, almost 6000 papers later, fundamental pathophysiological concepts remain unclear, particularly regarding the early pathogenesis of disordered mineral metabolism... - Fibroblast growth factor 23 and mortality among patients undergoing hemodialysisORLANDO M GUTIERREZ
Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
N Engl J Med 359:584-92. 2008..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown... - Vitamin D deficiency and anemia in early chronic kidney diseaseNeha M Patel
Division of Nephrology and Hypertension, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
Kidney Int 77:715-20. 2010..Our study shows that 25D and 1,25D deficiency are independently associated with decreased hemoglobin levels and anemia in chronic kidney disease. Whether this association is causal requires further study... - Racial differences in postprandial mineral ion handling in health and in chronic kidney diseaseORLANDO M GUTIERREZ
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
Nephrol Dial Transplant 25:3970-7. 2010..The aim of this study was to examine racial differences in postprandial urinary mineral ion excretion in health and in CKD... - Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney diseaseTamara Isakova
Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
Nephrol Dial Transplant 26:584-91. 2011..Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD... - Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney diseaseORLANDO M GUTIERREZ
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Circulation 119:2545-52. 2009..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD... - Low socioeconomic status associates with higher serum phosphate irrespective of raceORLANDO M GUTIERREZ
Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
J Am Soc Nephrol 21:1953-60. 2010.... - N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurementsORLANDO M GUTIERREZ
Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Clin Chem 54:1339-48. 2008..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time... - Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study designLynda A Szczech
Renal Division, Department of Medicine, Duke University Medical Center, Durham, NC, USA
Nephrol Dial Transplant 25:2368-75. 2010..Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to permit larger infusions compared to currently available IV standards such as Venofer(R) (iron sucrose)... 
Insulin resistance but not inflammation is associated with gestational hypertensionMyles Wolf
Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
Hypertension 40:886-91. 2002..Furthermore, important mechanistic differences exist in the pathogenesis of gestational hypertension comparing nulliparous and multiparous women...- Postpartum diabetes screening in women with a history of gestational diabetesKaren V Smirnakis
Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Obstet Gynecol 106:1297-303. 2005..Efforts to improve postpartum DM screening in this high-risk group are warranted... - Predicting gestational diabetes: choosing the optimal early serum markerKaren V Smirnakis
Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Obstet Gynecol 196:410.e1-6; discussion 410.e6-7. 2007..To select an optimal early (<20 weeks) marker, we prospectively compared 3 serum markers examined simultaneously in a single cohort... - Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination SurveyDavid Martins
Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
Arch Intern Med 167:1159-65. 2007..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D... - Chronic kidney disease, hypovitaminosis D, and mortality in the United StatesRajnish Mehrotra
Division of Nephrology and Hypertension, Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
Kidney Int 76:977-83. 2009..Randomized, controlled trials are needed to conclusively determine whether vitamin D supplementation reduces mortality... - Differential risk of hypertensive disorders of pregnancy among Hispanic womenMyles Wolf
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 15:1330-8. 2004..The initial presentation of hypertension during pregnancy in Hispanic women most likely represents early preeclampsia... - First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsiaRavi Thadhani
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 89:770-5. 2004..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE... - Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnanciesMyles Wolf
Renal Unit, Department of Medicine, Massachusetts General Hospital and the Renal Division, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02114, USA
Am J Obstet Gynecol 193:16-22. 2005..Additional studies are needed to verify these findings and to further examine ethnic differences in angiogenesis factors and their potential impact on the incidence of preeclampsia... - Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal diseaseMyles Wolf
Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Semin Dial 18:302-6. 2005..Several of these nontraditional actions are reviewed with an emphasis on those that might impact hemodialysis outcomes... - Recent advances in the rapidly evolving field of fibroblast growth factor 23 in chronic kidney diseaseAnna L Zisman
Section of Nephrology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
Curr Opin Nephrol Hypertens 19:335-42. 2010..In recent years, there has been an increasing awareness of the central regulatory role of fibroblast growth factor 23 (FGF23) in mineral metabolism and its particular prominence in patients with chronic kidney disease (CKD)... - Common genetic determinants of vitamin D insufficiency: a genome-wide association studyThomas J Wang
Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Lancet 376:180-8. 2010..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency... - Impact of activated vitamin D and race on survival among hemodialysis patientsMyles Wolf
Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 19:1379-88. 2008..Further studies should determine whether treatment differences based on biologic differences contribute to disparities in other conditions... - Vitamin D in patients with kidney disease: cautiously optimisticRavi Thadhani
Center for D receptor Activation Research and Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Adv Chronic Kidney Dis 14:22-6. 2007..If consistent with the recent observations, these studies may provide nephrologists with an intervention to alter the otherwise poor outcomes in patients with kidney disease... - Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injuryDavid E Leaf
Department of Medicine, Columbia University, New York, NY, USA
Nephrol Dial Transplant 25:1335-7. 2010..Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI... - A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney diseaseTamara Isakova
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 76:705-16. 2009.... - Postprandial mineral metabolism and secondary hyperparathyroidism in early CKDTamara Isakova
Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Soc Nephrol 19:615-23. 2008.... - Vitamin D in patients with renal failure: a summary of observational mortality studies and steps moving forwardMyles Wolf
Renal Unit, Department of Medicine, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
J Steroid Biochem Mol Biol 103:487-90. 2007..Potential steps moving forward in light of these observational studies are subsequently discussed... - Clinical problem-solving. Needle in a haystackKrishna R Polu
Renal Division, Department of Medicine, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 354:68-73. 2006 - Early pregnancy insulin resistance and subsequent gestational diabetes mellitusKaren V Smirnakis
GRB 1003, Renal Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Diabetes Care 28:1207-8. 2005 - First-trimester C-reactive protein and subsequent gestational diabetesMyles Wolf
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Diabetes Care 26:819-24. 2003..We tested the hypothesis that increased inflammation, measured early in pregnancy, is associated with the subsequent development of gestational diabetes mellitus (GDM), a precursor of type 2 diabetes... - Klotho variants and chronic hemodialysis mortalityDavid J Friedman
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
J Bone Miner Res 24:1847-55. 2009..Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk...
Research Grants
- Cardiovascular Disease Following Hypertensive PregnancyMyles Wolf; Fiscal Year: 2007..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. ..
- Role of FGF-23 in Mineral Metabolism Across the Spectum of Chronic Kidney DiseaseMYLES S WOLF; Fiscal Year: 2010....
- FGF23 and Cardiovascular Disease in CKDMYLES S WOLF; Fiscal Year: 2010..The results could suggest a major paradigm shift for clinical practice with public health implications: phosphate reduction strategies for far more people far earlier in their course of CKD. ..