MYLES S WOLF

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
    Julia J Scialla
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 83:1159-68. 2013
  2. pmc Update on fibroblast growth factor 23 in chronic kidney disease
    Myles Wolf
    Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 82:737-47. 2012
  3. doi request reprint Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Bone Miner Res 28:1793-803. 2013
  4. pmc Mineral metabolites and CKD progression in African Americans
    Julia J Scialla
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Nephrol 24:125-35. 2013
  5. pmc Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio
    Steve Mangos
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 27:4314-22. 2012
  6. ncbi request reprint Fibroblast growth factor 23 and the future of phosphorus management
    Myles Wolf
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Curr Opin Nephrol Hypertens 18:463-8. 2009
  7. pmc Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, 1120 NW 14th Street, CRB 819, Miami, FL 33136, USA
    J Am Soc Nephrol 22:956-66. 2011
  8. doi request reprint Forging forward with 10 burning questions on FGF23 in kidney disease
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, CRB, C 221, Room 819, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1427-35. 2010
  9. pmc Fibroblast growth factor 23 in patients undergoing peritoneal dialysis
    Tamara Isakova
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin J Am Soc Nephrol 6:2688-95. 2011
  10. doi request reprint FGF23 or PTH: which comes first in CKD ?
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 78:947-9. 2010

Detail Information

Publications39

  1. pmc Fibroblast growth factor 23 is not associated with and does not induce arterial calcification
    Julia J Scialla
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 83:1159-68. 2013
    ..Thus, in contrast to serum phosphate, FGF23 is not associated with arterial calcification and does not promote calcification experimentally. Hence, phosphate and FGF23 promote cardiovascular disease through distinct mechanisms...
  2. pmc Update on fibroblast growth factor 23 in chronic kidney disease
    Myles Wolf
    Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 82:737-47. 2012
    ..The report concludes with a critical review of the effects of different therapeutic strategies targeting FGF23 reduction and how these might be leveraged in a future randomized trial aimed at improving outcomes in CKD...
  3. doi request reprint Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Bone Miner Res 28:1793-803. 2013
    ....
  4. pmc Mineral metabolites and CKD progression in African Americans
    Julia J Scialla
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Nephrol 24:125-35. 2013
    ..In conclusion, abnormalities of mineral metabolism worsen with progressive CKD and associate with higher risk for ESRD among African Americans with hypertensive nephrosclerosis...
  5. pmc Expression of fgf23 and αklotho in developing embryonic tissues and adult kidney of the zebrafish, Danio rerio
    Steve Mangos
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 27:4314-22. 2012
    ..These data indicate conservation of the FGF23-αklotho system across species and suggest a likely role for αklotho in the proximal and distal tubules...
  6. ncbi request reprint Fibroblast growth factor 23 and the future of phosphorus management
    Myles Wolf
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Curr Opin Nephrol Hypertens 18:463-8. 2009
    ..To present emerging data on the role of fibroblast growth factor 23 (FGF23) in mineral metabolism and adverse outcomes in chronic kidney disease (CKD)...
  7. pmc Elevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami, Miller School of Medicine, 1120 NW 14th Street, CRB 819, Miami, FL 33136, USA
    J Am Soc Nephrol 22:956-66. 2011
    ..We conclude that a high (or elevated) FGF23 is an independent risk factor for death and allograft loss in kidney transplant recipients...
  8. doi request reprint Forging forward with 10 burning questions on FGF23 in kidney disease
    Myles Wolf
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, CRB, C 221, Room 819, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1427-35. 2010
    ..Ten burning questions must be addressed to galvanize FGF23 research further in CKD...
  9. pmc Fibroblast growth factor 23 in patients undergoing peritoneal dialysis
    Tamara Isakova
    Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Clin J Am Soc Nephrol 6:2688-95. 2011
    ..Fibroblast growth factor 23 (FGF23) is an independent risk factor for mortality in patients with ESRD. Before FGF23 testing can be integrated into clinical practice of ESRD, further understanding of its determinants is needed...
  10. doi request reprint FGF23 or PTH: which comes first in CKD ?
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 78:947-9. 2010
    ..However, almost 6000 papers later, fundamental pathophysiological concepts remain unclear, particularly regarding the early pathogenesis of disordered mineral metabolism...
  11. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  12. doi request reprint Vitamin D deficiency and anemia in early chronic kidney disease
    Neha M Patel
    Division of Nephrology and Hypertension, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Kidney Int 77:715-20. 2010
    ..Our study shows that 25D and 1,25D deficiency are independently associated with decreased hemoglobin levels and anemia in chronic kidney disease. Whether this association is causal requires further study...
  13. pmc Chronic kidney disease, hypovitaminosis D, and mortality in the United States
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Department of Medicine, Los Angeles Biomedical Research Institute, Torrance, California 90502, USA
    Kidney Int 76:977-83. 2009
    ..Randomized, controlled trials are needed to conclusively determine whether vitamin D supplementation reduces mortality...
  14. pmc Racial differences in postprandial mineral ion handling in health and in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 25:3970-7. 2010
    ..The aim of this study was to examine racial differences in postprandial urinary mineral ion excretion in health and in CKD...
  15. doi request reprint N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  16. pmc Low socioeconomic status associates with higher serum phosphate irrespective of race
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Am Soc Nephrol 21:1953-60. 2010
    ....
  17. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  18. pmc Pilot study of dietary phosphorus restriction and phosphorus binders to target fibroblast growth factor 23 in patients with chronic kidney disease
    Tamara Isakova
    Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Nephrol Dial Transplant 26:584-91. 2011
    ..Reducing dietary phosphorus intake lowers FGF23 secretion in healthly individuals, but there is little data on its effects in patients with pre-dialysis CKD...
  19. doi request reprint Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design
    Lynda A Szczech
    Renal Division, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Nephrol Dial Transplant 25:2368-75. 2010
    ..Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to permit larger infusions compared to currently available IV standards such as Venofer(R) (iron sucrose)...
  20. ncbi request reprint Insulin resistance but not inflammation is associated with gestational hypertension
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 40:886-91. 2002
    ..Furthermore, important mechanistic differences exist in the pathogenesis of gestational hypertension comparing nulliparous and multiparous women...
  21. ncbi request reprint Postpartum diabetes screening in women with a history of gestational diabetes
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Obstet Gynecol 106:1297-303. 2005
    ..We sought to examine postpartum glycemic testing in women diagnosed with GDM...
  22. ncbi request reprint Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
    David Martins
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
    Arch Intern Med 167:1159-65. 2007
    ..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D...
  23. ncbi request reprint Predicting gestational diabetes: choosing the optimal early serum marker
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 196:410.e1-6; discussion 410.e6-7. 2007
    ..To select an optimal early (<20 weeks) marker, we prospectively compared 3 serum markers examined simultaneously in a single cohort...
  24. doi request reprint A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease
    Tamara Isakova
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 76:705-16. 2009
    ....
  25. ncbi request reprint Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Semin Dial 18:302-6. 2005
    ..Several of these nontraditional actions are reviewed with an emphasis on those that might impact hemodialysis outcomes...
  26. ncbi request reprint Differential risk of hypertensive disorders of pregnancy among Hispanic women
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1330-8. 2004
    ..The initial presentation of hypertension during pregnancy in Hispanic women most likely represents early preeclampsia...
  27. ncbi request reprint First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  28. ncbi request reprint Recent advances in the rapidly evolving field of fibroblast growth factor 23 in chronic kidney disease
    Anna L Zisman
    Section of Nephrology, Department of Medicine, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
    Curr Opin Nephrol Hypertens 19:335-42. 2010
    ..In recent years, there has been an increasing awareness of the central regulatory role of fibroblast growth factor 23 (FGF23) in mineral metabolism and its particular prominence in patients with chronic kidney disease (CKD)...
  29. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  30. ncbi request reprint Vitamin D in patients with kidney disease: cautiously optimistic
    Ravi Thadhani
    Center for D receptor Activation Research and Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 14:22-6. 2007
    ..If consistent with the recent observations, these studies may provide nephrologists with an intervention to alter the otherwise poor outcomes in patients with kidney disease...
  31. pmc Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD
    Tamara Isakova
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Soc Nephrol 19:615-23. 2008
    ....
  32. doi request reprint Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury
    David E Leaf
    Department of Medicine, Columbia University, New York, NY, USA
    Nephrol Dial Transplant 25:1335-7. 2010
    ..Here, we document, for the first time, elevated levels of FGF-23 in a patient with rhabdomyolysis-induced AKI...
  33. pmc Impact of activated vitamin D and race on survival among hemodialysis patients
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 19:1379-88. 2008
    ..Further studies should determine whether treatment differences based on biologic differences contribute to disparities in other conditions...
  34. ncbi request reprint Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital and the Renal Division, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02114, USA
    Am J Obstet Gynecol 193:16-22. 2005
    ..Additional studies are needed to verify these findings and to further examine ethnic differences in angiogenesis factors and their potential impact on the incidence of preeclampsia...
  35. pmc Vitamin D in patients with renal failure: a summary of observational mortality studies and steps moving forward
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Steroid Biochem Mol Biol 103:487-90. 2007
    ..Potential steps moving forward in light of these observational studies are subsequently discussed...
  36. ncbi request reprint Early pregnancy insulin resistance and subsequent gestational diabetes mellitus
    Karen V Smirnakis
    GRB 1003, Renal Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Diabetes Care 28:1207-8. 2005
  37. ncbi request reprint Clinical problem-solving. Needle in a haystack
    Krishna R Polu
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 354:68-73. 2006
  38. ncbi request reprint First-trimester C-reactive protein and subsequent gestational diabetes
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:819-24. 2003
    ..We tested the hypothesis that increased inflammation, measured early in pregnancy, is associated with the subsequent development of gestational diabetes mellitus (GDM), a precursor of type 2 diabetes...
  39. pmc Klotho variants and chronic hemodialysis mortality
    David J Friedman
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 24:1847-55. 2009
    ..Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk...

Research Grants9

  1. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2003
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. ..
  2. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2004
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. ..
  3. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2005
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. ..
  4. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2006
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. ..
  5. Cardiovascular Disease Following Hypertensive Pregnancy
    Myles Wolf; Fiscal Year: 2007
    ..They believe the results will provide critical insight into mechanisms of CVD in women and potentially suggest means to alter their CVD risk. ..
  6. Role of FGF-23 in Mineral Metabolism Across the Spectum of Chronic Kidney Disease
    Myles Wolf; Fiscal Year: 2009
    ....
  7. FGF23 and Cardiovascular Disease in CKD
    Myles Wolf; Fiscal Year: 2009
    ..The results could suggest a major paradigm shift for clinical practice with public health implications: phosphate reduction strategies for far more people far earlier in their course of CKD. ..
  8. Role of FGF-23 in Mineral Metabolism Across the Spectum of Chronic Kidney Disease
    MYLES S WOLF; Fiscal Year: 2010
    ....
  9. FGF23 and Cardiovascular Disease in CKD
    MYLES S WOLF; Fiscal Year: 2010
    ..The results could suggest a major paradigm shift for clinical practice with public health implications: phosphate reduction strategies for far more people far earlier in their course of CKD. ..