Research Topics
Species | Daniel H WolfSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challengeDaniel H Wolf
Department of Psychiatry, University of Pennsylvania, 10th Floor Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
Psychopharmacology (Berl) 218:503-12. 2011..Pharmacological modulation of emotion-processing deficits and related neural abnormalities may provide useful phenotypes for pathophysiological investigation...
Association of enhanced limbic response to threat with decreased cortical facial recognition memory response in schizophreniaTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Psychiatry 167:418-26. 2010..The authors used an affective face recognition paradigm to examine possible interactions between cognitive and affective neural systems in schizophrenia...
Ventrolateral prefrontal cortex and the effects of task demand context on facial affect appraisal in schizophreniaDavid I Leitman
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Soc Cogn Affect Neurosci 6:66-73. 2011..In schizophrenia, reduced modulation of OFC/VLPFC by context coupled with reduced behavioural efficiency suggests impaired ventral prefrontal control mechanisms that optimize affective appraisal...
Not pitch perfect: sensory contributions to affective communication impairment in schizophreniaDavid I Leitman
Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
Biol Psychiatry 70:611-8. 2011..The neural correlates of this dysfunction are unclear. Prior study has suggested that schizophrenia vocal affect perception deficits stem from an inability to use acoustic cues, notably pitch, in decoding emotion...
Abnormal superior temporal connectivity during fear perception in schizophreniaDavid I Leitman
Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Schizophr Bull 34:673-8. 2008..Such abnormal integration may disrupt the evaluation of threat within fronto-cortical regions...
Frontolimbic responses to emotional face memory: the neural correlates of first impressionsTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hum Brain Mapp 30:3748-58. 2009..The results indicate that a network of frontolimbic regions may provide emotional bias signals during facial recognition...
Opposing amygdala and ventral striatum connectivity during emotion identificationTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Brain Cogn 76:353-63. 2011..These results indicate that activity in the amygdala and ventral striatum may be inversely related, and that both regions may provide opposing affective bias signals during emotion identification...
Being right is its own reward: load and performance related ventral striatum activation to correct responses during a working memory task in youthTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 61:723-9. 2012..These findings provide evidence for scalable intrinsic reinforcement signals during standard cognitive tasks, and suggest a novel link between motivation and cognition during adolescent development...
An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity dataTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
Neuroimage 64:240-56. 2013..These results demonstrate that the effect of motion on rsfc-MRI can be substantially attenuated through improved preprocessing procedures, but not completely removed...
Limbic activation associated with misidentification of fearful faces and flat affect in schizophreniaRaquel E Gur
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 64:1356-66. 2007..Deficits in emotion processing are prominent in schizophrenia, and flat affect is resistant to treatment and portends poor outcome. Investigation of the underlying neural circuitry can elucidate affective dysfunction...
Striatal intrinsic reinforcement signals during recognition memory: relationship to response bias and dysregulation in schizophreniaDaniel H Wolf
Department of Psychiatry, University of Pennsylvania Philadelphia, PA, USA
Front Behav Neurosci 5:81. 2011..These findings highlight the importance of accounting for intrinsic motivation and reward when studying cognitive tasks, and add to growing evidence of reward circuit dysfunction in schizophrenia that may impact cognition and function...
Impact of in-scanner head motion on multiple measures of functional connectivity: relevance for studies of neurodevelopment in youthTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 60:623-32. 2012..The results demonstrate the pervasive influence of motion on multiple types functional connectivity analysis, and underline the importance of accounting for motion in studies of neurodevelopment...
"It's Not What You Say, But How You Say it": A Reciprocal Temporo-frontal Network for Affective ProsodyDavid I Leitman
Department of Psychiatry Neuropsychiatry Program, Brain Behavior Laboratory, University of Pennsylvania School of Medicine Philadelphia, PA, USA
Front Hum Neurosci 4:19. 2010..Auditory regions may thus integrate acoustic information with amygdala input to form emotion-specific representations, which are evaluated within inferior frontal regions...
Alterations of fronto-temporal connectivity during word encoding in schizophreniaDaniel H Wolf
University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
Psychiatry Res 154:221-32. 2007..The results suggest that reduced temporal-DLPFC connectivity in schizophrenia could underlie encoding deficits, and increased temporal-VLPFC connectivity may represent an ineffective compensatory effort...
Regulation of neuronal PLCgamma by chronic morphineDaniel H Wolf
Interdepartmental Neuroscience Program, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven, CT 06508, USA
Brain Res 1156:9-20. 2007..As chronic morphine treatment has been shown to increase ERK activity within the VTA, the current results suggest that increased PLCgamma1 activity may be an upstream mediator of this effect...
Anhedonia in schizophreniaDaniel H Wolf
Department of Psychiatry, Neuropsychiatry Program, University of Pennsylvania, 10 Gates Building, 3400 Spruce Street, Philadelphia PA 19104, USA
Curr Psychiatry Rep 8:322-8. 2006....
A meta-analysis of the risk of acute extrapyramidal symptoms with intramuscular antipsychotics for the treatment of agitationTheodore D Satterthwaite
Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market St, 2nd Floor, Philadelphia, PA 19104, USA
J Clin Psychiatry 69:1869-79. 2008..We examined the evidence for a decreased risk of extrapyramidal symptoms (EPS) with intramuscular second-generation antipsychotics (SGAs) versus intramuscular haloperidol alone or in combination with an anticholinergic agent...
