MARC WOLD

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Essential functions of the 32 kDa subunit of yeast replication protein A
    Anne M Dickson
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242 2600, USA
    Nucleic Acids Res 37:2313-26. 2009
  2. pmc A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression
    Stuart J Haring
    Department of Biochemistry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Nucleic Acids Res 38:846-58. 2010
  3. ncbi request reprint Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
    M S Wold
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City 52242, USA
    Annu Rev Biochem 66:61-92. 1997
  4. ncbi request reprint Replication protein A interactions with DNA. III. Molecular basis of recognition of damaged DNA
    Y Lao
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, Iowa 52242 1109, USA
    Biochemistry 39:850-9. 2000
  5. pmc A novel assay for examining the molecular reactions at the eukaryotic replication fork: activities of replication protein A required during elongation
    A P Walther
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Nucleic Acids Res 27:656-64. 1999
  6. ncbi request reprint Functional domains of the 70-kilodalton subunit of human replication protein A
    X V Gomes
    Department of Biochemistry, University of Iowa School of Medicine, Iowa City 52242 1109, USA
    Biochemistry 35:10558-68. 1996

Collaborators

  • Stuart J Haring
  • Anne M Dickson
  • X V Gomes
  • Troy D Humphreys
  • Y Lao
  • Pavel Pestryakov
  • Olga Lavrik
  • Yulia Krasikova
  • A P Walther
  • J S Taylor
  • Y Ren
  • M P Bjerke

Detail Information

Publications6

  1. pmc Essential functions of the 32 kDa subunit of yeast replication protein A
    Anne M Dickson
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242 2600, USA
    Nucleic Acids Res 37:2313-26. 2009
    ..cerevisiae. We conclude that DNA-binding activity of RPA2 is dispensable in yeast and that the essential function of DBD D is intra- and/or inter-protein interactions...
  2. pmc A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression
    Stuart J Haring
    Department of Biochemistry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Nucleic Acids Res 38:846-58. 2010
    ..These studies suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell...
  3. ncbi request reprint Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism
    M S Wold
    Department of Biochemistry, University of Iowa College of Medicine, Iowa City 52242, USA
    Annu Rev Biochem 66:61-92. 1997
    ..Phosphorylation of RPA may play a role in coordinating DNA metabolism in the cell. RPA may also have a role in modulating gene expression...
  4. ncbi request reprint Replication protein A interactions with DNA. III. Molecular basis of recognition of damaged DNA
    Y Lao
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, Iowa 52242 1109, USA
    Biochemistry 39:850-9. 2000
    ..These findings suggest that RPA probably binds to both damaged and undamaged strands in the NER excision complex. RPA binding may be important for efficient excision of damaged DNA in NER...
  5. pmc A novel assay for examining the molecular reactions at the eukaryotic replication fork: activities of replication protein A required during elongation
    A P Walther
    Department of Biochemistry, University of Iowa College of Medicine, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Nucleic Acids Res 27:656-64. 1999
    ..We have used this system to show that both RPA-protein and RPA-DNA interactions are important for RPA's function in elongation...
  6. ncbi request reprint Functional domains of the 70-kilodalton subunit of human replication protein A
    X V Gomes
    Department of Biochemistry, University of Iowa School of Medicine, Iowa City 52242 1109, USA
    Biochemistry 35:10558-68. 1996
    ..For all mutant complexes examined, both phosphorylation of the 32-kDa subunit of RPA and the ability to support T antigen-dependent, origin-dependent DNA unwinding correlated with ssDNA binding activity...

Research Grants16

  1. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2009
    ..These studies will both elucidate the mechanism of the RPA regulatory switch and provide insights into RPA function in cellular DNA metabolism. ..
  2. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 1991
    ..In the future, these studies will be expanded to examine the roles of other DNA replication proteins. One future direction will be to establish non- viral model reactions for chromosomal DNA replication...
  3. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2007
    ..These studies will both elucidate the mechanism of the RPA regulatory switch and provide insights into RPA function in cellular DNA metabolism. ..
  4. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 2002
    ..These studies will lead to a better understanding of the molecular mechanism of DNA replication and cellular DNA metabolism. ..
  5. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 2000
    ..These studies will lead to a better understanding of the molecular mechanism of DNA replication and cellular DNA metabolism. ..
  6. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 1993
    ..In the future, these studies will be expanded to examine the roles of other DNA replication proteins. One future direction will be to establish non- viral model reactions for chromosomal DNA replication...
  7. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 1999
    ..These studies will lead to a better understanding of the molecular mechanism of DNA replication and cellular DNA metabolism. ..
  8. Functional Role of Cellular Proteins in DNA Replication
    MARC WOLD; Fiscal Year: 2006
    ..These studies will both elucidate the mechanism of the RPA regulatory switch and provide insights into RPA function in cellular DNA metabolism. ..
  9. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 2001
    ..These studies will lead to a better understanding of the molecular mechanism of DNA replication and cellular DNA metabolism. ..
  10. FUNCTIONAL ROLES OF CELLULAR PROTEINS IN DNA REPLICATION
    MARC WOLD; Fiscal Year: 1992
    ..In the future, these studies will be expanded to examine the roles of other DNA replication proteins. One future direction will be to establish non- viral model reactions for chromosomal DNA replication...