Christopher H Woelk

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery
    Christopher H Woelk
    Department of Medicine, University of California, San Diego, La Jolla, USA
    AIDS 24:217-22. 2010
  2. ncbi Evolution of the interferon alpha gene family in eutherian mammals
    Christopher H Woelk
    Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA
    Gene 397:38-50. 2007
  3. ncbi Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages
    Christopher H Woelk
    Department of Pathology, University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS Res Hum Retroviruses 20:1210-22. 2004
  4. ncbi GARD: a genetic algorithm for recombination detection
    Sergei L Kosakovsky Pond
    Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA
    Bioinformatics 22:3096-8. 2006
  5. ncbi A public health model for the molecular surveillance of HIV transmission in San Diego, California
    Davey M Smith
    University of California San Diego, La Jolla, CA 92093 0679, USA
    AIDS 23:225-32. 2009
  6. ncbi Automated phylogenetic detection of recombination using a genetic algorithm
    Sergei L Kosakovsky Pond
    Department of Pathology, University of California San Diego, USA
    Mol Biol Evol 23:1891-901. 2006
  7. ncbi Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance
    Lin Liu
    University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS 22:835-9. 2008
  8. ncbi Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4+ T cells
    Nadejda Beliakova-Bethell
    aDepartment of Medicine, University of California San Diego, La Jolla bVeterans Affairs San Diego Healthcare System, San Diego cDepartment of Pathology, University of California San Diego, La Jolla, California, USA
    AIDS 27:29-37. 2013
  9. ncbi The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders
    Christopher H Woelk
    Department of Medicine, University of California San Diego, La Jolla, California, USA
    Int Rev Neurobiol 101:41-63. 2011
  10. ncbi Codon volatility does not reflect selective pressure on the HIV-1 genome
    Satish K Pillai
    University of California, San Diego, Stein Clinical Research Building, Room 325, 9500 Gilman Drive 0679, La Jolla 92093, USA
    Virology 336:137-43. 2005

Research Grants

  1. Gene expression biomarkers of immune recovery in HIV infected patients
    Christopher H Woelk; Fiscal Year: 2010
  2. Gene expression biomarkers of immune recovery in HIV infected patients
    Christopher H Woelk; Fiscal Year: 2011

Collaborators

Detail Information

Publications16

  1. ncbi Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery
    Christopher H Woelk
    Department of Medicine, University of California, San Diego, La Jolla, USA
    AIDS 24:217-22. 2010
    ..To identify a pre-HAART gene expression signature in peripheral blood mononuclear cells (PBMCs) predictive of CD4 T-cell recovery during HAART in HIV-infected individuals...
  2. ncbi Evolution of the interferon alpha gene family in eutherian mammals
    Christopher H Woelk
    Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA
    Gene 397:38-50. 2007
    ..Gene conversion, similar to duplication, provides a mechanism by which the protein product of a specific IFNA gene can be increased...
  3. ncbi Interferon gene expression following HIV type 1 infection of monocyte-derived macrophages
    Christopher H Woelk
    Department of Pathology, University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS Res Hum Retroviruses 20:1210-22. 2004
    ..The nuclear factor in activated T cells (NFAT) and members of the interferon family of transcription factors appeared to be responsible for the upregulation of this set of interferon-stimulated genes following HIV-1 exposure...
  4. ncbi GARD: a genetic algorithm for recombination detection
    Sergei L Kosakovsky Pond
    Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA
    Bioinformatics 22:3096-8. 2006
    ..The evolution of recombinant sequences can not be properly explained by a single phylogenetic tree, but several phylogenies may be used to correctly model the evolution of non-recombinant fragments...
  5. ncbi A public health model for the molecular surveillance of HIV transmission in San Diego, California
    Davey M Smith
    University of California San Diego, La Jolla, CA 92093 0679, USA
    AIDS 23:225-32. 2009
    ..Here, we investigate how molecular epidemiology can be used to identify highly related HIV networks within a population and how voluntary contact tracing of sexual partners can be used to selectively target these networks...
  6. ncbi Automated phylogenetic detection of recombination using a genetic algorithm
    Sergei L Kosakovsky Pond
    Department of Pathology, University of California San Diego, USA
    Mol Biol Evol 23:1891-901. 2006
    ..Finally, we demonstrate that prescreening alignments with our method allows one to analyze recombinant sequences for positive selection...
  7. ncbi Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance
    Lin Liu
    University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS 22:835-9. 2008
    ..We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance...
  8. ncbi Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4+ T cells
    Nadejda Beliakova-Bethell
    aDepartment of Medicine, University of California San Diego, La Jolla bVeterans Affairs San Diego Healthcare System, San Diego cDepartment of Pathology, University of California San Diego, La Jolla, California, USA
    AIDS 27:29-37. 2013
    ..To assess the off-target effects of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA) in human primary CD4 T cells...
  9. ncbi The utility of gene expression in blood cells for diagnosing neuropsychiatric disorders
    Christopher H Woelk
    Department of Medicine, University of California San Diego, La Jolla, California, USA
    Int Rev Neurobiol 101:41-63. 2011
    ....
  10. ncbi Codon volatility does not reflect selective pressure on the HIV-1 genome
    Satish K Pillai
    University of California, San Diego, Stein Clinical Research Building, Room 325, 9500 Gilman Drive 0679, La Jolla 92093, USA
    Virology 336:137-43. 2005
    ..Volatility failed to correlate with the results of any of the comparative methods demonstrating that it is not a reliable indicator of selection pressure...
  11. ncbi Factors regulated by interferon gamma and hypoxia-inducible factor 1A contribute to responses that protect mice from Coccidioides immitis infection
    Christopher H Woelk
    Veterans Affairs San Diego Healthcare System, Mail Code 9111 F, San Diego, California, 92161, USA
    BMC Microbiol 12:218. 2012
    ..abstract:..
  12. ncbi A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia
    Josué Pérez-Santiago
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    J Psychiatr Res 46:1464-74. 2012
    ..In conclusion, this combined analysis has resulted in a statistically robust identification of genes whose dysregulation may contribute to the mechanism of schizophrenia...
  13. ncbi Antiretroviral drug resistance and risk behavior among recently HIV-infected men who have sex with men
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 7353, USA
    J Acquir Immune Defic Syndr 47:639-43. 2008
    ..Examine associations among behaviors including substance use during sexual encounters, and transmitted HIV drug resistance in recently HIV-infected men who have sex with men (MSM)...
  14. ncbi Comparative study of adaptive molecular evolution in different human immunodeficiency virus groups and subtypes
    Marc Choisy
    CEPM, UMR CNRS-IRD 9926, Montpellier, France
    J Virol 78:1962-70. 2004
    ..We found a significant tendency for positively selected sites to fall outside T-helper epitopes and for positively selected sites to be strongly associated with N glycosylation sites...
  15. ncbi Genetic constraints and the adaptive evolution of rabies virus in nature
    Edward C Holmes
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    Virology 292:247-57. 2002
    ..Assuming that the average rate of synonymous change does not vary among species, we estimated that the current genetic diversity in lyssavirus genotype 1 may have arisen only during the last 500 years...
  16. ncbi Increased positive selection pressure in persistent (SSPE) versus acute measles virus infections
    Christopher H Woelk
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Gen Virol 83:1419-30. 2002
    ..Finally, using H gene data, we estimated the rate of molecular evolution for SSPE strains as 3.4 x 10(-4) substitutions/site/year, which is similar to previous estimates obtained for acute strains...

Research Grants2

  1. Gene expression biomarkers of immune recovery in HIV infected patients
    Christopher H Woelk; Fiscal Year: 2010
    ..This proposal will also identify which drugs an HIV-infected patient should be treated with in order to maximize the extent of their immune recovery. ..
  2. Gene expression biomarkers of immune recovery in HIV infected patients
    Christopher H Woelk; Fiscal Year: 2011
    ..This proposal will also identify which drugs an HIV-infected patient should be treated with in order to maximize the extent of their immune recovery. ..