DOMINIK F WODARZ

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Towards predictive computational models of oncolytic virus therapy: basis for experimental validation and model selection
    Dominik Wodarz
    Department of Ecology and Evolution, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4271. 2009
  2. pmc Effect of cellular quiescence on the success of targeted CML therapy
    Natalia L Komarova
    Department of Mathematics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 2:e990. 2007
  3. pmc Combination of two but not three current targeted drugs can improve therapy of chronic myeloid leukemia
    Natalia L Komarova
    Department of Mathematics, University of California Irvine, Irvine, California, USA
    PLoS ONE 4:e4423. 2009
  4. ncbi request reprint Dynamics of cellular responses to radiation
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America Department of Mathematics, Rowland Hall, University of California, Irvine, California, United States of America
    PLoS Comput Biol 10:e1003513. 2014
  5. pmc Dependence of the firearm-related homicide rate on gun availability: a mathematical analysis
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California, USA
    PLoS ONE 8:e71606. 2013
  6. pmc Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Biol Direct 8:14. 2013
  7. doi request reprint Computational modeling approaches to studying the dynamics of oncolytic viruses
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92617, USA
    Math Biosci Eng 10:939-57. 2013
  8. pmc Increased burst size in multiply infected cells can alter basic virus dynamics
    Kara W Cummings
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, 92617, Irvine, CA, USA
    Biol Direct 7:16. 2012
  9. pmc Complex spatial dynamics of oncolytic viruses in vitro: mathematical and experimental approaches
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America
    PLoS Comput Biol 8:e1002547. 2012
  10. ncbi request reprint Apparent competition and recovery from infection
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, Steinhaus Hall, University of California, Irvine, CA 92697, USA
    J Theor Biol 227:403-12. 2004

Research Grants

Detail Information

Publications36

  1. pmc Towards predictive computational models of oncolytic virus therapy: basis for experimental validation and model selection
    Dominik Wodarz
    Department of Ecology and Evolution, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 4:e4271. 2009
    ..It can further serve as the basis for future, more complex models that take into account other clinically relevant factors such as immune responses...
  2. pmc Effect of cellular quiescence on the success of targeted CML therapy
    Natalia L Komarova
    Department of Mathematics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 2:e990. 2007
    ..Using mathematical models, we investigate the effect of cellular quiescence on the outcome of therapy with targeted small molecule inhibitors...
  3. pmc Combination of two but not three current targeted drugs can improve therapy of chronic myeloid leukemia
    Natalia L Komarova
    Department of Mathematics, University of California Irvine, Irvine, California, USA
    PLoS ONE 4:e4423. 2009
    ..We conclude that among the targeted drugs currently available for the treatment of CML, only the two most effective ones should be used in combination for the prevention of drug resistance...
  4. ncbi request reprint Dynamics of cellular responses to radiation
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America Department of Mathematics, Rowland Hall, University of California, Irvine, California, United States of America
    PLoS Comput Biol 10:e1003513. 2014
    ..Experimental tests to address our model predictions are proposed. ..
  5. pmc Dependence of the firearm-related homicide rate on gun availability: a mathematical analysis
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California, USA
    PLoS ONE 8:e71606. 2013
    ..However, the model clearly defines what needs to be measured, and provides a basis for a scientific discussion about assumptions and data. ..
  6. pmc Methylation kinetics and CpG-island methylator phenotype status in colorectal cancer cell lines
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Biol Direct 8:14. 2013
    ..Tumor cells with relatively high levels of CpG island methylation are considered CpG island methylator phenotypes (CIMP). The mechanisms that are responsible for regulating the activity of de novo methylation are not well understood...
  7. doi request reprint Computational modeling approaches to studying the dynamics of oncolytic viruses
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92617, USA
    Math Biosci Eng 10:939-57. 2013
    ..Problems of model robustness are discussed and so are some clinically important insight derived from the models. ..
  8. pmc Increased burst size in multiply infected cells can alter basic virus dynamics
    Kara W Cummings
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, 92617, Irvine, CA, USA
    Biol Direct 7:16. 2012
    ..e. viral replication is limited by cellular rather than viral factors. In this case, basic virus dynamics properties are not altered by coinfection...
  9. pmc Complex spatial dynamics of oncolytic viruses in vitro: mathematical and experimental approaches
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California, United States of America
    PLoS Comput Biol 8:e1002547. 2012
    ..This analysis provides a first step towards understanding spatial oncolytic virus dynamics, upon which more detailed investigations and further complexity can be built...
  10. ncbi request reprint Apparent competition and recovery from infection
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, Steinhaus Hall, University of California, Irvine, CA 92697, USA
    J Theor Biol 227:403-12. 2004
    ..The models presented are related to the concept of apparent competition, and our results are discussed in relation to both theoretical and empirical studies...
  11. pmc Immunity and protection by live attenuated HIV/SIV vaccines
    Dominik Wodarz
    Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine CA 92697, USA
    Virology 378:299-305. 2008
    ..According to these arguments, an inverse correlation between the level of attenuation and the level of protection is expected, and this has indeed been observed in experimental data...
  12. pmc Use of oncolytic viruses for the eradication of drug-resistant cancer cells
    Dominik Wodarz
    Department of Ecology and Evolution, University of California, Irvine, 321 Steinhaus Hall, Irvine, CA 92697, USA
    J R Soc Interface 6:179-86. 2009
    ..This is derived from a population dynamic principle known as apparent competition. Therefore, a sequential combination of oncolytic virus and targeted therapies can overcome major weaknesses of either approach alone...
  13. doi request reprint Multiple HIV-1 infection of cells and the evolutionary dynamics of cytotoxic T lymphocyte escape mutants
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology and Department of Mathematics, 321 Steinhaus Hall, University of California, Irvine, California 92697, USA
    Evolution 63:2326-39. 2009
    ..It is hypothesized that an intermediate strength of the CTL response, and thus the suboptimal virus suppression observed in HIV-1 infection, might be adaptive to minimize the impact of existing CTL escape mutants on overall virus load...
  14. pmc Heterogeneity in chronic myeloid leukaemia dynamics during imatinib treatment: role of immune responses
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, CA 92607, USA
    Proc Biol Sci 277:1875-80. 2010
    ..Boosting immunity during drug therapy could enhance the response to treatment in patients...
  15. doi request reprint Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanisms
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Exp Biol Med (Maywood) 236:926-37. 2011
    ..Here, we review this topic and discuss how immune control of the infection and the ability of the virus to escape immune control is affected by co-infection...
  16. pmc Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infection
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
    J R Soc Interface 8:289-300. 2011
    ....
  17. pmc Human immunodeficiency virus evolution towards reduced replicative fitness in vivo and the development of AIDS
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
    Proc Biol Sci 274:2481-90. 2007
    ....
  18. pmc Immune responses and the emergence of drug-resistant virus strains in vivo
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Proc Biol Sci 271:1101-9. 2004
    ..Drug resistance is much more likely to be a problem in HIV than in acute and self-limiting infections...
  19. ncbi request reprint Dynamical interactions between multiple cancers
    Dominik Wodarz
    Department of Ecology and Evolution, University of California, Irvine, California 92697, USA
    Cell Cycle 4:764-71. 2005
    ..We further discuss the inefficiency of metastatic cells to grow successfully, and suggest an explanation for the occurrence of multiple metastases with an unknown primary cancer...
  20. ncbi request reprint Does programmed CTL proliferation optimize virus control?
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Trends Immunol 26:305-10. 2005
    ..The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance...
  21. ncbi request reprint Effect of the CTL proliferation program on virus dynamics
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Int Immunol 17:1269-76. 2005
    ..We discuss these results in the context of data from murine virus infections and explore implications for virus dynamics in CD4 helper-deficient hosts...
  22. ncbi request reprint Emergence and prevention of resistance against small molecule inhibitors
    Dominik Wodarz
    Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Semin Cancer Biol 15:506-14. 2005
    ....
  23. ncbi request reprint Ecological and evolutionary principles in immunology
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Ecol Lett 9:694-705. 2006
    ....
  24. ncbi request reprint Effect of stem cell turnover rates on protection against cancer and aging
    Dominik Wodarz
    Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    J Theor Biol 245:449-58. 2007
    ..g. if DNA is hit by damaging agents), I find that a high cellular turnover rate protects against aging, while it promotes the development of cancer. Implications for optimal tissue design are discussed...
  25. ncbi request reprint Can loss of apoptosis protect against cancer?
    Dominik Wodarz
    Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Trends Genet 23:232-7. 2007
    ....
  26. pmc Dynamics of killer T cell inflation in viral infections
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    J R Soc Interface 4:533-43. 2007
    ..This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age...
  27. ncbi request reprint Stem cell regulation and the development of blast crisis in chronic myeloid leukemia: Implications for the outcome of Imatinib treatment and discontinuation
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Med Hypotheses 70:128-36. 2008
    ..Further, the model defines conditions when Imatinib treatment might lead to the eradication of CML, which is relevant in the context of recent data that show absence of relapse as long as two years after treatment cessation...
  28. ncbi request reprint Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus?
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Math Biosci 209:14-29. 2007
    ....
  29. ncbi request reprint On the relative fitness of early and late stage Simian immunodeficiency virus isolates
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Theor Popul Biol 72:426-35. 2007
    ..One possibility is that the ability of multiple virus particles to infect the same cell (coinfection) might be a pre-requisite for the emergence of the cytopathic strain SIVMne170 as the disease progresses...
  30. ncbi request reprint Checkpoint genes, ageing, and the development of cancer
    Dominik Wodarz
    Department of Ecology and Evolution, Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Oncogene 23:7799-809. 2004
    ..The models help to identify differences in the experimental protocols which could explain the seemingly contradictory observations...
  31. pmc ODE models for oncolytic virus dynamics
    Natalia L Komarova
    Department of Mathematics, 340 Rowland Hall, University of California, Irvine, CA 92697, USA
    J Theor Biol 263:530-43. 2010
    ..Our methodology can be used to study the dynamics of many biological systems, and thus has implications beyond the study of virus therapy of cancers...
  32. pmc Drug resistance in cancer: principles of emergence and prevention
    Natalia L Komarova
    Department of Mathematics, 103 MSTB, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:9714-9. 2005
    ....
  33. ncbi request reprint Stochastic modeling of cellular colonies with quiescence: an application to drug resistance in cancer
    Natalia L Komarova
    Department of Mathematics, University of California, Irvine, CA 92697, USA
    Theor Popul Biol 72:523-38. 2007
    ..Finally, we study the influence of quiescence on the treatment phase. Starting from a given composition of mutants, the chances of treatment success are not influenced by the presence of quiescence...
  34. doi request reprint Combination therapies against chronic myeloid leukemia: short-term versus long-term strategies
    Natalia L Komarova
    Departments of Mathematics and Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Cancer Res 69:4904-10. 2009
    ....

Research Grants5

  1. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2005
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..
  2. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2006
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..
  3. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2007
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..
  4. Mathematical Models of Programmed CTL Proliferation
    Dominik Wodarz; Fiscal Year: 2009
    ..These are the role of effector molecules (such as perform and IFN-g) for CTL dynamics, and the role of CD4 T cell help. The modeling work will be complemented by experiments with VSV and LCMV infected mice. ..