Bogdan J Wlodarczyk

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. doi request reprint Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity
    Bogdan J Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Blvd, Houston, TX 77030, USA Electronic address
    Toxicol Appl Pharmacol 275:22-7. 2014
  2. doi request reprint Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate
    Bogdan Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Toxicol Lett 215:214-8. 2012
  3. pmc Antiepileptic drugs and pregnancy outcomes
    Bogdan J Wlodarczyk
    Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas 78723, USA
    Am J Med Genet A 158:2071-90. 2012
  4. doi request reprint Genetic basis of susceptibility to teratogen induced birth defects
    Bogdan J Wlodarczyk
    Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA
    Am J Med Genet C Semin Med Genet 157:215-26. 2011
  5. pmc Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Dev Biol 7:128. 2007
  6. pmc Transcriptional analyses of two mouse models of spina bifida
    Robert M Cabrera
    Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, USA
    Birth Defects Res A Clin Mol Teratol 94:782-9. 2012
  7. ncbi request reprint Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies
    Louisa S Tang
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030 3303, USA
    Am J Med Genet C Semin Med Genet 135:48-58. 2005
  8. ncbi request reprint Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos
    Bogdan J Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Neurotoxicology 27:547-57. 2006
  9. ncbi request reprint Cardiovascular abnormalities in Folr1 knockout mice and folate rescue
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 79:257-68. 2007
  10. doi request reprint Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model
    Denise S Hill
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Toxicol Appl Pharmacol 239:29-36. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity
    Bogdan J Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Blvd, Houston, TX 77030, USA Electronic address
    Toxicol Appl Pharmacol 275:22-7. 2014
    ..In this study, we investigated the potential interaction between 5,10-methylenetetrahydrofolate reductase (Mthfr) genotype and arsenic embryotoxicity using the Mthfr knockout mouse model...
  2. doi request reprint Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate
    Bogdan Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Toxicol Lett 215:214-8. 2012
    ..The current data suggest that both the Mthfr status and food folate level modulate in a significant manner excretion of arsenic in mice, following intraperitoneal administration of sodium arsenate...
  3. pmc Antiepileptic drugs and pregnancy outcomes
    Bogdan J Wlodarczyk
    Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas 78723, USA
    Am J Med Genet A 158:2071-90. 2012
    ..The purpose of this document is to review the most commonly used compounds in the treatment of WWE, and to provide information on the latest experimental and human epidemiological studies of the effects of AEDs in the exposed embryos...
  4. doi request reprint Genetic basis of susceptibility to teratogen induced birth defects
    Bogdan J Wlodarczyk
    Dell Pediatric Research Institute, 1400 Barbara Jordan Blvd, Austin, TX 78723, USA
    Am J Med Genet C Semin Med Genet 157:215-26. 2011
    ..2011 Wiley-Liss, Inc...
  5. pmc Differentially expressed genes in embryonic cardiac tissues of mice lacking Folr1 gene activity
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    BMC Dev Biol 7:128. 2007
    ..Defective function of the Folr1 (also known as Folbp1; homologue of human FRalpha) gene in mice results in inadequate transport, accumulation, or metabolism of folate during cardiovascular morphogenesis...
  6. pmc Transcriptional analyses of two mouse models of spina bifida
    Robert M Cabrera
    Department of Nutritional Sciences, Dell Pediatric Research Institute, The University of Texas at Austin, Austin, TX 78723, USA
    Birth Defects Res A Clin Mol Teratol 94:782-9. 2012
    ..Spina bifida is one of the most common of all human structural birth defects. Despite considerable effort over several decades, the causes and mechanisms underlying this malformation remain poorly characterized...
  7. ncbi request reprint Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies
    Louisa S Tang
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030 3303, USA
    Am J Med Genet C Semin Med Genet 135:48-58. 2005
    ..The results demonstrate a prominent role of Folbp1 in the regional regulation of apoptosis and cell proliferation that underlies the aberrant neural tube and craniofacial defects...
  8. ncbi request reprint Arsenic-induced gene expression changes in the neural tube of folate transport defective mouse embryos
    Bogdan J Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Neurotoxicology 27:547-57. 2006
    ..Additionally, we revealed new target genes which may be responsible for arsenic disrupted oxidative phosphorylation...
  9. ncbi request reprint Cardiovascular abnormalities in Folr1 knockout mice and folate rescue
    Huiping Zhu
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 79:257-68. 2007
    ..Folate-binding proteins or receptors serve to bind folic acid and 5-methyltetrahydrofolate, representing one of the two major mechanisms of cellular folate uptake...
  10. doi request reprint Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model
    Denise S Hill
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, 77030, USA
    Toxicol Appl Pharmacol 239:29-36. 2009
    ..Periconceptional hyperglycemia is a significant risk factor for neural tube defects (NTDs), the second most common structural birth defect. A suspected teratogen, arsenic (As) induces NTDs in laboratory animals...
  11. pmc Fuz regulates craniofacial development through tissue specific responses to signaling factors
    Zichao Zhang
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas, United States of America
    PLoS ONE 6:e24608. 2011
    ..These data demonstrate a new model for coordination of Hh and Wnt signaling and reveal a Fuz-dependent negative feedback loop controlling Wnt/β-catenin signaling...
  12. ncbi request reprint Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube
    Rebecca Lee Yean Wong
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, The Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 17:587-601. 2008
    ..The mutant Fkbp8 allele is a new experimental model which will be useful in dissecting the pathogenesis of spinal NTDs, and enhance our understanding of the etiology of human NTDs...
  13. pmc Teratogenic effects of antiepileptic drugs
    Denise S Hill
    Texas A and M Health Science Center, Houston, TX 77030, USA
    Expert Rev Neurother 10:943-59. 2010
    ..There is no evidence to suggest that additional folic acid supplementation ameliorates the increased risk of congenital malformations conferred by in utero AED exposure...
  14. pmc The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development
    Ryan S Gray
    Dept of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712, USA
    Nat Cell Biol 11:1225-32. 2009
    ..These results are significant because they provide new insights into the mechanisms by which developmental regulatory systems such as PCP signalling interface with fundamental cellular systems such as the vesicle trafficking machinery...
  15. ncbi request reprint Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients
    Bogdan J Wlodarczyk
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 77030, USA
    Toxicol Appl Pharmacol 213:55-63. 2006
    ..When the folate supplementation dose was increased to 200 mg/kg in the diet, the incidence of rescued splotch homozygotes reached 30%; however, this was accompanied by six-fold increased resorption rate...
  16. doi request reprint Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model
    Denise S Hill
    Interdisciplinary Faculty of Toxicology, Texas A and M University, College Station, Texas, USA
    Birth Defects Res B Dev Reprod Toxicol 83:40-7. 2008
    ..6/1,000 births worldwide, and 1/1,000 births in the United States. Of the many environmental agents suspected of being teratogenic, arsenic (As) is capable of inducing NTDs in laboratory animals...
  17. ncbi request reprint Developmental consequences of abnormal folate transport during murine heart morphogenesis
    Louisa S Tang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas, USA
    Birth Defects Res A Clin Mol Teratol 70:449-58. 2004
    ..In this study, we examined the role of folic acid on the phenotypic expression of heart defects in Folbp1 mice, mindful of the importance of neural crest cells to the formation of the conotruncus...