John J Wixted

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor
    John J Wixted
    Department of Orthopedic Surgery and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 221:31-9. 2009
  2. pmc Secreted frizzled related protein 1 is a target to improve fracture healing
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 220:174-81. 2009
  3. pmc The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cancer Ther 9:3210-20. 2010
  4. doi request reprint Use of the trauma pelvic orthotic device (T-POD) for provisional stabilisation of anterior-posterior compression type pelvic fractures: a cadaveric study
    Nicola A Deangelis
    Orthopedic Surgery Sports Medicine, UMass Memorial Medical Center, 281 Lincoln Street, Worcester, MA 01605, USA
    Injury 39:903-6. 2008
  5. pmc Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
  6. pmc Biomechanical investigation of a novel ratcheting arthrodesis nail
    Jeremy J McCormick
    Department of Orthopaedic Surgery, University of Massachusetts, Medical Center, Worcester, Massachusetts 01655, USA
    J Orthop Surg Res 5:74. 2010
  7. doi request reprint Three-part head-splitting proximal humerus fracture through a unicameral bone cyst
    John A Younghein
    Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Orthopedics 35:e988-90. 2012
  8. doi request reprint Arachidonic acid, eicosanoids, and fracture repair
    John J Wixted
    Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Orthop Trauma 24:539-42. 2010
  9. doi request reprint Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study
    Jason A Silva
    Department of Orthopedics, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Injury 41:S85-9. 2010
  10. ncbi request reprint Computer-aided surgery: assessing the accuracy of a navigation system
    Douglass R Weiss
    Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Memorial Medical School, Worcester, Massachusetts 01655, USA
    Orthopedics 31:247. 2008

Collaborators

Detail Information

Publications13

  1. pmc Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor
    John J Wixted
    Department of Orthopedic Surgery and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 221:31-9. 2009
    ....
  2. pmc Secreted frizzled related protein 1 is a target to improve fracture healing
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 220:174-81. 2009
    ..Thus, developing an antagonist to specifically inhibit sFRP1 represents a safe target for stimulating fracture repair and bone formation in metabolic bone disorders, osteoporosis and aging...
  3. pmc The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cancer Ther 9:3210-20. 2010
    ..Vorinostat treatment reduces tumor growth in bone and accompanying osteolytic disease as a result of decreased tumor burden in bone. However, vorinostat can promote osteopenia throughout the skeleton independent of tumor cell activity...
  4. doi request reprint Use of the trauma pelvic orthotic device (T-POD) for provisional stabilisation of anterior-posterior compression type pelvic fractures: a cadaveric study
    Nicola A Deangelis
    Orthopedic Surgery Sports Medicine, UMass Memorial Medical Center, 281 Lincoln Street, Worcester, MA 01605, USA
    Injury 39:903-6. 2008
    ..To demonstrate that a commercially available pelvic binder the trauma pelvic orthotic device (T-POD) is an effective way to provisionally stabilise anterior-posterior compression type pelvic injuries...
  5. pmc Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 68:7795-802. 2008
    ..Thus, our studies define a novel role of Runx2 in up-regulating the vicious cycle of metastatic bone disease, in addition to Runx2 regulation of genes related to progression of tumor metastasis...
  6. pmc Biomechanical investigation of a novel ratcheting arthrodesis nail
    Jeremy J McCormick
    Department of Orthopaedic Surgery, University of Massachusetts, Medical Center, Worcester, Massachusetts 01655, USA
    J Orthop Surg Res 5:74. 2010
    ..abstract:..
  7. doi request reprint Three-part head-splitting proximal humerus fracture through a unicameral bone cyst
    John A Younghein
    Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Orthopedics 35:e988-90. 2012
    ..The current case demonstrates the complexity of decision making resulting from a rare injury in a young, healthy patient and shows that open reduction and internal fixation can provide acceptable reconstruction in such situations...
  8. doi request reprint Arachidonic acid, eicosanoids, and fracture repair
    John J Wixted
    Department of Orthopedic Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Orthop Trauma 24:539-42. 2010
    ..This article reviews recent investigations into the potential role of leukotrienes as negative regulators of fracture healing and potential pharmacologic use of medications that block this effect...
  9. doi request reprint Biomechanical effects of harvesting bone graft with the Reamer/Irrigator/Aspirator on the adult femur: a cadaver study
    Jason A Silva
    Department of Orthopedics, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Injury 41:S85-9. 2010
    ..Test the biomechanical properties of femurs that have undergone reaming with the Reamer Irrigator Aspirator (RIA) device with an aim to prove no difference in torsional strength between matched pairs...
  10. ncbi request reprint Computer-aided surgery: assessing the accuracy of a navigation system
    Douglass R Weiss
    Department of Orthopedics and Physical Rehabilitation, University of Massachusetts Memorial Medical School, Worcester, Massachusetts 01655, USA
    Orthopedics 31:247. 2008
    ..20 mm. These systems have the potential to be accurate, but are software dependent and rely on rigid instrumentation to take full advantage of the benefits afforded by virtual multiplanar instrument tracking...
  11. doi request reprint Ankle fractures in the elderly: initial and long-term outcomes
    Sarah A Anderson
    University of Massachusetts Medical Center, Department of Orthopaedic Surgery, Worcester, MA 01655, USA
    Foot Ankle Int 29:1184-8. 2008
    ..The purpose of this study was to evaluate short- and long-term outcomes after surgical treatment of isolated malleolar fractures in both the elderly and non-elderly population...
  12. doi request reprint The effect of an orthopedic trauma room on after-hours surgery at a level one trauma center
    John J Wixted
    Department of Orthopedics, UMass Memorial Medical Center, Worcester, Massachusetts 01605, USA
    J Orthop Trauma 22:234-6. 2008
    ..The frequency of after-hours surgery and the impact of patients who present with acute orthopedic injuries are reviewed...
  13. doi request reprint An improved murine femur fracture device for bone healing studies
    Joseph E Marturano
    Department of Biomedical Engineering, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 41:1222-8. 2008
    ..Maintaining kinetic energy parameters within suggested ranges may also aid in ensuring accuracy and reproducibility...