Research Topics
Genomes and GenesSpecies | P J WittkoppSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergencePatricia J Wittkopp
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Rev Genet 13:59-69. 2012....
Variable gene expression in eukaryotes: a network perspectivePatricia J Wittkopp
Department of Ecology and Evolutionary Biology, Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
J Exp Biol 210:1567-75. 2007..Here I review the basic structure of eukaryotic regulatory networks and discuss selected case studies that provide insight into how these networks are altered to create expression differences within and between species...- Evolutionary genetics: how flies get nakedPatricia J Wittkopp
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
Curr Biol 17:R881-3. 2007..Researchers studying evolution of 'naked' (hairless) larval cuticle in Drosophila sechellia have discovered surprising complexity in the pattern of cis-regulatory differences that differentiate this species from its 'hairy' ancestors... 
Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogasterPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Genetics 178:1831-5. 2008..The frequency of such independent interactions on a genomic scale is yet to be determined...- Regulatory changes underlying expression differences within and between Drosophila speciesPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nat Genet 40:346-50. 2008..Specifically, cis-regulatory changes seem to accumulate preferentially over time... - Development and evolution of insect pigmentation: genetic mechanisms and the potential consequences of pleiotropyPatricia J Wittkopp
830 North University Avenue, Department of Ecology and Evolutionary Biology, Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
Semin Cell Dev Biol 20:65-71. 2009..This review discusses recent work on the development and evolution of insect pigmentation, with a focus on pleiotropy and its effects on color pattern diversification... - Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in DrosophilaPatricia J Wittkopp
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Science 326:540-4. 2009..These alleles appear to predate speciation, which suggests that standing genetic variation present in the common ancestor gave rise to both intraspecific polymorphism and interspecific divergence... - Variable transcription factor binding: a mechanism of evolutionary changePatricia J Wittkopp
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Biol 8:e1000342. 2010..This primer discusses a study from Bradley et al. in which changes in transcription factor binding between two Drosophila species are revealed by chromatin immunoprecipitation and high-throughput sequencing... - Local adaptation for body color in Drosophila americanaP J Wittkopp
Department of Ecology and Evolutionary Biology, Ann Arbor, MI, USA
Heredity (Edinb) 106:592-602. 2011..americana. We found no significant effect of pigmentation on desiccation resistance in this experiment, suggesting that pigmentation and desiccation resistance are not unequivocally linked in all Drosophila species... - Using pyrosequencing to measure allele-specific mRNA abundance and infer the effects of cis- and trans-regulatory differencesPatricia J Wittkopp
University of Michigan, Ann Arbor, MI, USA
Methods Mol Biol 772:297-317. 2011..I also describe how such data can be used to infer the relative contribution of cis- and trans-acting changes to expression differences between genotypes... - Evolution of cis-regulatory sequence and function in DipteraP J Wittkopp
Department of Ecology and Evolutionary Biology, University of Michigan, 1061 Natural Science Building, 830 North University Ave, Ann Arbor, MI 48109 1048, USA
Heredity (Edinb) 97:139-47. 2006..Biochemical characterization and in vivo assays of cis-regulatory sequences on a genomic-scale will relieve this barrier... - Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprintingPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Genetics 173:1817-21. 2006..Offspring from reciprocal crosses exhibit differences in total expression without differences in allelic expression, indicating that other types of maternal and/or paternal effects alter expression... - Evolutionary changes in cis and trans gene regulationPatricia J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 430:85-8. 2004..These data indicate that interspecific expression differences are not caused by select trans-regulatory changes with widespread effects, but rather by many cis-acting changes spread throughout the genome... - The function and regulation of Ultrabithorax in the legs of Drosophila melanogasterGregory K Davis
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
Dev Biol 308:621-31. 2007..While the enhancer could reside within the small regions we have not surveyed, it is also possible that the enhancer is structurally complex and/or acts only within its native genomic context... - A gene necessary for normal male courtship, yellow, acts downstream of fruitless in the Drosophila melanogaster larval brainMark David Drapeau
Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California 92697, USA
J Neurobiol 55:53-72. 2003..Overall, these data suggest that y is a downstream member of the fru branch of the D. melanogaster sex determination hierarchy, where it plays a currently unknown role in the development of adult male wing extension during courtship... - Evolution in black and white: genetic control of pigment patterns in DrosophilaPatricia J Wittkopp
Molecular Biology and Genetics, 227 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
Trends Genet 19:495-504. 2003 - Genomic sources of regulatory variation in cis and in transP J Wittkopp
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Cell Mol Life Sci 62:1779-83. 2005..I argue that the molecular function of the protein encoded by each gene and how the gene is wired into the genomic regulatory network may influence its propensity for cis and trans regulatory changes... - Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in DrosophilaNicolas Gompel
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA
Nature 433:481-7. 2005.... - Compensatory cis-trans evolution and the dysregulation of gene expression in interspecific hybrids of DrosophilaChristian R Landry
Department of Organismic and Evolutionary Biology, The Biological Laboratories, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
Genetics 171:1813-22. 2005..Using a mathematical model for the regulation of gene expression, we explored the conditions under which cis-trans compensatory evolution can lead to misexpression in interspecific hybrids... - Immunohistochemical colocalization of Yellow and male-specific Fruitless in Drosophila melanogaster neuroblastsAnna Radovic
Department of Developmental and Cell Biology, University of California, Irvine, CA, USA
Biochem Biophys Res Commun 293:1262-4. 2002..We hypothesize that yellow is downstream of fruitless in a male courtship behavior developmental genetic pathway... - Drosophila pigmentation evolution: divergent genotypes underlying convergent phenotypesPatricia J Wittkopp
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 100:1808-13. 2003..These findings bear upon understanding classic models of melanism and mimicry... - Evolution of yellow gene regulation and pigmentation in DrosophilaPatricia J Wittkopp
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA
Curr Biol 12:1547-56. 2002..Here, we compare the regulation of the yellow gene, which is required for melanization, among distantly related Drosophila species with different pigment patterns and determine the phenotypic effects of divergent Yellow expression... - Annotating ebony on the flyMichael H Kohn
Mol Ecol 16:2831-3. 2007..In addition, the study raises issues to consider when extrapolating from selection at the molecular level to selection at the phenotypic level... - Reciprocal functions of the Drosophila yellow and ebony proteins in the development and evolution of pigment patternsPatricia J Wittkopp
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
Development 129:1849-58. 2002..These findings provide a developmental and genetic framework for understanding the evolution of melanin patterns...
Research Grants
- Evolutionary Genetics: Contribution of Tan to Drosophila Pigmentation DivergencePatricia J Wittkopp; Fiscal Year: 2010..This project will identify specific genetic changes underlying divergence in a complex trait as well as reveal how these genetic changes alter development to produce alternative phenotypes. ..