Research Topics
Species | H WitschiSummaryAffiliation: University of California Country: USA Publications
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Publications
Tobacco smoke as a mouse lung carcinogenH Witschi
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, USA
Exp Lung Res 24:385-94. 1998..This suggested that gas-phase constituents play an important role in tobacco smoke carcinogenesis. The strain A/J lung tumor model is thus suitable to study questions associated with tobacco smoke toxicity and carcinogenicity...- Tobacco smoke-induced lung cancer in animals--a challenge to toxicology (?)Hanspeter Witschi
Center for Health and the Environment, University of California, Davis, Davis, California, USA
Int J Toxicol 26:339-44. 2007..The challenge will be to make such data broadly acceptable and accepted in lieu of having to do more and more long term studies involving larger and larger number of animals... - Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smokeHanspeter Witschi
Center for Health and the Environment CHE, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Cancer Lett 241:64-8. 2006..It was concluded that tobacco smoke exposure not simply accelerates the development of lesions that eventually would have developed spontaneously, but induced de novo formation of lung tumors in A/J mice... - The complexities of an apparently simple lung tumor model: The A/J mouseHanspeter Witschi
Center for Health and the Environment, University of California, Davis, USA
Exp Toxicol Pathol 57:171-81. 2005..From all available evidence it must be concluded that the complex mixture of tobacco smoke, a known human carcinogen, is a rather weak rodent carcinogen... - Chemoprevention of tobacco smoke-induced lung cancer: what animal studies tell usHanspeter Witschi
Center for Health and the Environment, University of California, Davis, Davis, CA, USA
Chest 125:128S. 2004 - The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed miceHanspeter Witschi
Center for Health and the Environment, University of California, Davis, California, USA
Inhal Toxicol 16:195-201. 2004..It was concluded that myoinositol has less chemopreventive activity against the full complex mixture of tobacco smoke than it has against selected constituents such as NNK or benzo[a]pyrene... - Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteineHanspeter Witschi
Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
Toxicol Sci 84:81-7. 2005..5% beta-carotene or 0.4% N-acetylcysteine afforded some chemoprevention. It was tentatively concluded that 1,3-butadiene might be an important contributor to lung tumorigenesis in this mouse model of tobacco smoke carcinogenesis... - The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposureHanspeter Witschi
Center for Health and the Environment, University of California, Davis, California 95616, USA
Inhal Toxicol 17:119-22. 2005..It is concluded that the dietary intake of dexamethasone against full tobacco smoke might show improved chemopreventive activity when combined with other agents... - A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknessesHanspeter Witschi
Center for Health and Environment, University of California, Davis, CA 95616, USA
Exp Lung Res 31:3-18. 2005..Although the assay allowed one to detect substantial chemopreventive activity of a mixture of myo-inositol and dexamethasone, it was less successful in showing efficacy for several other agents... - A mouse lung tumor model of tobacco smoke carcinogenesisHanspeter Witschi
Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
Toxicol Sci 68:322-30. 2002..The lung tumor model might be suitable for future evaluation of chemopreventive agents or modified tobacco products... - Development of tobacco smoke-induced lung tumors in mice fed Bowman-Birk protease inhibitor concentrate (BBIC)Hanspeter Witschi
Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
Cancer Lett 183:141-6. 2002..It was found that in the animals treated with MCA, BBIC decreased lung tumor multiplicities, whereas in the smoke exposed mice, BBIC did not modulate lung tumor development... - Chemoprevention of tobacco smoke-induced lung tumors by inhalation of an epigallocatechin gallate (EGCG) aerosol: a pilot studyHanspeter Witschi
Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
Inhal Toxicol 16:763-70. 2004..It is concluded that water-soluble chemopreventive agents that need to be ingested in comparatively high doses are not the most suitable candidates for administration by inhalation... - The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J miceH Witschi
Institute of Toxicology and Environmental Health, Division of Statistics, College of Letters and Sciences, University of California, Davis 95616 8615, USA
Carcinogenesis 19:1789-94. 1998..It was concluded that successful chemoprevention of tobacco smoke-induced lung tumorigenesis might require administration of several chemopreventive agents rather than just a single one... - Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agentsHanspeter Witschi
Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
Carcinogenesis 23:289-94. 2002..It was concluded that expression of cyclin D1/2 might be a potentially useful marker in the identification of chemopreventive agents for tobacco smoke and could be of some help in the evaluation of their effects... - Ozone carcinogenesis revisitedH Witschi
Institute of Toxicology and Environmental Health, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA
Toxicol Sci 52:162-7. 1999..It was concluded that ozone is not a lung carcinogen in strain A/J mice at those exposure levels. Moreover, this mouse strain appears to be particularly resistant towards chronic ozone toxicity... - Successful and not so successful chemoprevention of tobacco smoke-induced lung tumorsH Witschi
ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
Exp Lung Res 26:743-55. 2000..The observations made with myo-inositol-dexamethasone suggest that people who have recently quit smoking might benefit the most from active chemoprevention... - Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposureH Witschi
Institute of Toxicology and Environmental Health and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
Carcinogenesis 21:977-82. 2000..On the other hand, agents otherwise shown to prevent lung tumor formation following administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or benzo[a]pyrene were ineffective against tobacco smoke... - Fritz Haber: December 9, 1868-January 29, 1934H Witschi
ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis 95616, USA
Toxicology 149:3-15. 2000..And yet he was one of the truly great modern scientists. not only because of his science, but also because of the role he played in science politics and policies... - Lung tumor development in mice exposed to tobacco smoke and fed beta-carotene dietsUte C Obermueller-Jevic
Center for Comparative Respiratory Biology and Medicine, Department of Medicine, School of Medicine, University of California, Davis, California 95616, USA
Toxicol Sci 69:23-9. 2002.... - Quantitation and localization of pulmonary manganese superoxide dismutase and tumor necrosis factor alpha following exposure to ozone and nitrogen dioxideB L Weller
Center for Comparative Respiratory Biology and Medicine, California Regional Primate Research Center, Institute of Toxicology and Environmental Health, University of California, Davis 95616, USA
Toxicol Sci 54:452-61. 2000..We conclude that MnSOD is elevated in areas of focal injury as well as the more distal protected areas of the lungs, while TNFalpha correlates strongly with both the temporal and spatial aspects of greatest cellular injury in the lungs... - Lung tumor response in strain a mice exposed to tobacco smoke: some dose-effect relationshipsHanspeter Witschi
Center for Health and the Environment, University of California, Davis, California 95616, USA
Inhal Toxicol 16:27-32. 2004..The shape of the dose-response curve and a comparison with previous data suggest that cigarette smoke is only a comparatively weak mouse lung carcinogen... - Lung tumors in A/J mice exposed to environmental tobacco smoke: estimated potency and implied human riskKenneth T Bogen
Health and Ecology Assessment Division L 396, Lawrence Livermore National Laboratory, University of California, 7000 E Ave, Livermore, CA 94550, USA
Carcinogenesis 23:511-9. 2002..The results obtained add to evidence that A/J mouse lung tumors induced by ETS provide a relevant biological model of ETS-induced human lung tumors... - John Morrison Barnes, 1913-1975Hanspeter Witschi
CHE, University of California, One Shields Avenue, Davis, California 95616-8615, USA
Toxicol Sci 68:267-9. 2002 - Induction of lung cancer by passive smoking in an animal model systemHanspeter Witschi
CHE and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA
Methods Mol Med 74:441-55. 2003 - Short-term exposure to aged and diluted sidestream cigarette smoke enhances ozone-induced lung injury in B6C3F1 miceMang Yu
Center for Comparative Respiratory Biology and Medicine, Institute of Toxicology and Environmental Health, and California Regional Primate Research Center, University of California, One Shields Avenue, Davis, California 95616, USA
Toxicol Sci 65:99-106. 2002..We conclude that ADSS exposure enhances the sensitivity of animals to ozone-induced lung injury... - MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of ratsCai-Yun Zhong
Center for Health and the Environment, University of California, Davis, CA 95616, USA
Carcinogenesis 26:2187-95. 2005..These findings suggest the important role of MAPK/AP-1 pathway in TS-induced pathogenesis, thus providing new insights into the molecular mechanisms of TS-associated lung diseases including lung cancers... - Acute tobacco smoke-induced airways inflammation in spontaneously hypertensive ratsBei Yu
Center for Health and the Environment, University of California, Davis, California 95616, USA
Inhal Toxicol 20:623-33. 2008..The spontaneously hypertensive rat may be a more relevant animal model of acute tobacco smoke-induced airway inflammation than other laboratory rats... - The role of interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutantsMang Yu
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, California 95616, USA
Toxicol Sci 68:488-97. 2002..Data from this study further suggest that IL-6 antibody treatment modalities may be a means to attenuate pulmonary inflammation and injury... - Chemoprevention of lung cancerHanspeter Witschi
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA
Methods Mol Med 75:739-54. 2003 - Gestation stage-specific oxidative deoxyribonucleic acid damage from sidestream smoke in pregnant rats and their fetusesAnna Maciag
Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
Arch Environ Health 58:238-44. 2003..These gestational stage- and tissue-specific increases of 1.2- to 1.4-fold are similar to the putative relative increases in risk of human cancers related to ETS...
Research Grants
- Chemoprevention in Mice after Tobacco Smoke ExposureHanspeter Witschi; Fiscal Year: 2004..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..