H Witschi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Tobacco smoke as a mouse lung carcinogen
    H Witschi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, USA
    Exp Lung Res 24:385-94. 1998
  2. ncbi request reprint Tobacco smoke-induced lung cancer in animals--a challenge to toxicology (?)
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, Davis, California, USA
    Int J Toxicol 26:339-44. 2007
  3. ncbi request reprint Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke
    Hanspeter Witschi
    Center for Health and the Environment CHE, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Cancer Lett 241:64-8. 2006
  4. ncbi request reprint The complexities of an apparently simple lung tumor model: The A/J mouse
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, USA
    Exp Toxicol Pathol 57:171-81. 2005
  5. ncbi request reprint Chemoprevention of tobacco smoke-induced lung cancer: what animal studies tell us
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, Davis, CA, USA
    Chest 125:128S. 2004
  6. ncbi request reprint The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California, USA
    Inhal Toxicol 16:195-201. 2004
  7. ncbi request reprint Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 84:81-7. 2005
  8. ncbi request reprint The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 17:119-22. 2005
  9. ncbi request reprint A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses
    Hanspeter Witschi
    Center for Health and Environment, University of California, Davis, CA 95616, USA
    Exp Lung Res 31:3-18. 2005
  10. ncbi request reprint A mouse lung tumor model of tobacco smoke carcinogenesis
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 68:322-30. 2002

Research Grants

  1. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004

Detail Information

Publications30

  1. ncbi request reprint Tobacco smoke as a mouse lung carcinogen
    H Witschi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, USA
    Exp Lung Res 24:385-94. 1998
    ..This suggested that gas-phase constituents play an important role in tobacco smoke carcinogenesis. The strain A/J lung tumor model is thus suitable to study questions associated with tobacco smoke toxicity and carcinogenicity...
  2. ncbi request reprint Tobacco smoke-induced lung cancer in animals--a challenge to toxicology (?)
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, Davis, California, USA
    Int J Toxicol 26:339-44. 2007
    ..The challenge will be to make such data broadly acceptable and accepted in lieu of having to do more and more long term studies involving larger and larger number of animals...
  3. ncbi request reprint Lung tumors in 2 year old strain A/J mice exposed for 6 months to tobacco smoke
    Hanspeter Witschi
    Center for Health and the Environment CHE, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Cancer Lett 241:64-8. 2006
    ..It was concluded that tobacco smoke exposure not simply accelerates the development of lesions that eventually would have developed spontaneously, but induced de novo formation of lung tumors in A/J mice...
  4. ncbi request reprint The complexities of an apparently simple lung tumor model: The A/J mouse
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, USA
    Exp Toxicol Pathol 57:171-81. 2005
    ..From all available evidence it must be concluded that the complex mixture of tobacco smoke, a known human carcinogen, is a rather weak rodent carcinogen...
  5. ncbi request reprint Chemoprevention of tobacco smoke-induced lung cancer: what animal studies tell us
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, Davis, CA, USA
    Chest 125:128S. 2004
  6. ncbi request reprint The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California, USA
    Inhal Toxicol 16:195-201. 2004
    ..It was concluded that myoinositol has less chemopreventive activity against the full complex mixture of tobacco smoke than it has against selected constituents such as NNK or benzo[a]pyrene...
  7. ncbi request reprint Carcinogenic activity of cigarette smoke gas phase and its modulation by beta-carotene and N-acetylcysteine
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 84:81-7. 2005
    ..5% beta-carotene or 0.4% N-acetylcysteine afforded some chemoprevention. It was tentatively concluded that 1,3-butadiene might be an important contributor to lung tumorigenesis in this mouse model of tobacco smoke carcinogenesis...
  8. ncbi request reprint The chemopreventive effects of orally administered dexamethasone in Strain A/J mice following cessation of smoke exposure
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 17:119-22. 2005
    ..It is concluded that the dietary intake of dexamethasone against full tobacco smoke might show improved chemopreventive activity when combined with other agents...
  9. ncbi request reprint A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses
    Hanspeter Witschi
    Center for Health and Environment, University of California, Davis, CA 95616, USA
    Exp Lung Res 31:3-18. 2005
    ..Although the assay allowed one to detect substantial chemopreventive activity of a mixture of myo-inositol and dexamethasone, it was less successful in showing efficacy for several other agents...
  10. ncbi request reprint A mouse lung tumor model of tobacco smoke carcinogenesis
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 68:322-30. 2002
    ..The lung tumor model might be suitable for future evaluation of chemopreventive agents or modified tobacco products...
  11. ncbi request reprint Development of tobacco smoke-induced lung tumors in mice fed Bowman-Birk protease inhibitor concentrate (BBIC)
    Hanspeter Witschi
    Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Cancer Lett 183:141-6. 2002
    ..It was found that in the animals treated with MCA, BBIC decreased lung tumor multiplicities, whereas in the smoke exposed mice, BBIC did not modulate lung tumor development...
  12. ncbi request reprint Chemoprevention of tobacco smoke-induced lung tumors by inhalation of an epigallocatechin gallate (EGCG) aerosol: a pilot study
    Hanspeter Witschi
    Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Inhal Toxicol 16:763-70. 2004
    ..It is concluded that water-soluble chemopreventive agents that need to be ingested in comparatively high doses are not the most suitable candidates for administration by inhalation...
  13. ncbi request reprint The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice
    H Witschi
    Institute of Toxicology and Environmental Health, Division of Statistics, College of Letters and Sciences, University of California, Davis 95616 8615, USA
    Carcinogenesis 19:1789-94. 1998
    ..It was concluded that successful chemoprevention of tobacco smoke-induced lung tumorigenesis might require administration of several chemopreventive agents rather than just a single one...
  14. ncbi request reprint Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents
    Hanspeter Witschi
    Center for Health and the Environment and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Carcinogenesis 23:289-94. 2002
    ..It was concluded that expression of cyclin D1/2 might be a potentially useful marker in the identification of chemopreventive agents for tobacco smoke and could be of some help in the evaluation of their effects...
  15. ncbi request reprint Ozone carcinogenesis revisited
    H Witschi
    Institute of Toxicology and Environmental Health, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA
    Toxicol Sci 52:162-7. 1999
    ..It was concluded that ozone is not a lung carcinogen in strain A/J mice at those exposure levels. Moreover, this mouse strain appears to be particularly resistant towards chronic ozone toxicity...
  16. ncbi request reprint Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors
    H Witschi
    ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Exp Lung Res 26:743-55. 2000
    ..The observations made with myo-inositol-dexamethasone suggest that people who have recently quit smoking might benefit the most from active chemoprevention...
  17. ncbi request reprint Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure
    H Witschi
    Institute of Toxicology and Environmental Health and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Carcinogenesis 21:977-82. 2000
    ..On the other hand, agents otherwise shown to prevent lung tumor formation following administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or benzo[a]pyrene were ineffective against tobacco smoke...
  18. ncbi request reprint Fritz Haber: December 9, 1868-January 29, 1934
    H Witschi
    ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis 95616, USA
    Toxicology 149:3-15. 2000
    ..And yet he was one of the truly great modern scientists. not only because of his science, but also because of the role he played in science politics and policies...
  19. ncbi request reprint Lung tumor development in mice exposed to tobacco smoke and fed beta-carotene diets
    Ute C Obermueller-Jevic
    Center for Comparative Respiratory Biology and Medicine, Department of Medicine, School of Medicine, University of California, Davis, California 95616, USA
    Toxicol Sci 69:23-9. 2002
    ....
  20. ncbi request reprint Quantitation and localization of pulmonary manganese superoxide dismutase and tumor necrosis factor alpha following exposure to ozone and nitrogen dioxide
    B L Weller
    Center for Comparative Respiratory Biology and Medicine, California Regional Primate Research Center, Institute of Toxicology and Environmental Health, University of California, Davis 95616, USA
    Toxicol Sci 54:452-61. 2000
    ..We conclude that MnSOD is elevated in areas of focal injury as well as the more distal protected areas of the lungs, while TNFalpha correlates strongly with both the temporal and spatial aspects of greatest cellular injury in the lungs...
  21. ncbi request reprint Lung tumor response in strain a mice exposed to tobacco smoke: some dose-effect relationships
    Hanspeter Witschi
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 16:27-32. 2004
    ..The shape of the dose-response curve and a comparison with previous data suggest that cigarette smoke is only a comparatively weak mouse lung carcinogen...
  22. ncbi request reprint Lung tumors in A/J mice exposed to environmental tobacco smoke: estimated potency and implied human risk
    Kenneth T Bogen
    Health and Ecology Assessment Division L 396, Lawrence Livermore National Laboratory, University of California, 7000 E Ave, Livermore, CA 94550, USA
    Carcinogenesis 23:511-9. 2002
    ..The results obtained add to evidence that A/J mouse lung tumors induced by ETS provide a relevant biological model of ETS-induced human lung tumors...
  23. ncbi request reprint John Morrison Barnes, 1913-1975
    Hanspeter Witschi
    CHE, University of California, One Shields Avenue, Davis, California 95616 8615, USA
    Toxicol Sci 68:267-9. 2002
  24. ncbi request reprint Induction of lung cancer by passive smoking in an animal model system
    Hanspeter Witschi
    CHE and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    Methods Mol Med 74:441-55. 2003
  25. ncbi request reprint Short-term exposure to aged and diluted sidestream cigarette smoke enhances ozone-induced lung injury in B6C3F1 mice
    Mang Yu
    Center for Comparative Respiratory Biology and Medicine, Institute of Toxicology and Environmental Health, and California Regional Primate Research Center, University of California, One Shields Avenue, Davis, California 95616, USA
    Toxicol Sci 65:99-106. 2002
    ..We conclude that ADSS exposure enhances the sensitivity of animals to ozone-induced lung injury...
  26. ncbi request reprint MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats
    Cai Yun Zhong
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Carcinogenesis 26:2187-95. 2005
    ..These findings suggest the important role of MAPK/AP-1 pathway in TS-induced pathogenesis, thus providing new insights into the molecular mechanisms of TS-associated lung diseases including lung cancers...
  27. ncbi request reprint Acute tobacco smoke-induced airways inflammation in spontaneously hypertensive rats
    Bei Yu
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 20:623-33. 2008
    ..The spontaneously hypertensive rat may be a more relevant animal model of acute tobacco smoke-induced airway inflammation than other laboratory rats...
  28. ncbi request reprint The role of interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants
    Mang Yu
    Center for Comparative Respiratory Biology and Medicine, University of California, Davis, California 95616, USA
    Toxicol Sci 68:488-97. 2002
    ..Data from this study further suggest that IL-6 antibody treatment modalities may be a means to attenuate pulmonary inflammation and injury...
  29. ncbi request reprint Chemoprevention of lung cancer
    Hanspeter Witschi
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA
    Methods Mol Med 75:739-54. 2003
  30. ncbi request reprint Gestation stage-specific oxidative deoxyribonucleic acid damage from sidestream smoke in pregnant rats and their fetuses
    Anna Maciag
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    Arch Environ Health 58:238-44. 2003
    ..These gestational stage- and tissue-specific increases of 1.2- to 1.4-fold are similar to the putative relative increases in risk of human cancers related to ETS...

Research Grants3

  1. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..