Research Topics
| Brent WisseSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Physiology. An integrative view of obesityBrent E Wisse
Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
Science 318:928-9. 2007
Does hypothalamic inflammation cause obesity?Brent E Wisse
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA
Cell Metab 10:241-2. 2009..2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight...- Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signalsBrent E Wisse
Division of Metabolism, Harborview Medical Center, Seattle, WA 98104 2499, USA
Endocrinology 148:5230-7. 2007.... - Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasisBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, WA 98104 2499, USA
Am J Physiol Endocrinol Metab 287:E1107-13. 2004..05 vs. vehicle), an effect similar to that of ADX. These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin... - The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesityBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
J Am Soc Nephrol 15:2792-800. 2004..This review describes the role of proinflammatory cytokines and hormones released by adipose tissue in generating the chronic inflammatory profile associated with visceral obesity... - Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortinsBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
Peptides 27:265-73. 2006..These data suggest a potential role for central melanocortins in mediating the decrease of ambulation characteristic of the 'sickness' response... 
Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balanceBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
Brain Res 1144:101-6. 2007....- Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responsesJoshua P Thaler
Division of Metabolism, University of Washington, Seattle, Washington 98109, USA
Endocrinology 150:5362-72. 2009..We conclude that although hypothalamic aPKC signaling is not required for food intake inhibition by insulin or leptin, it plays a key role in inflammatory anorexia and fever induced by LPS... - MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 betaKayoko Ogimoto
Division of Metabolism, Endocrinology, and Nutrition, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, Washington 98104 2499, USA
Endocrinology 147:4445-53. 2006.... - Leptin deficiency causes insulin resistance induced by uncontrolled diabetesJonathan P German
Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 59:1626-34. 2010..This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements induced by uDM... - Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feedingShinsuke Oh-I
UW Medicine at South Lake Union, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
Am J Physiol Endocrinol Metab 299:E47-53. 2010..These observations add to growing evidence linking hypothalamic inflammation to obesity pathogenesis... - Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosisHarvey K Chiu
Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
Endocrinology 151:993-1001. 2010..Our results demonstrate that in mice, HL deficiency protects against diet-induced obesity and its hepatic sequelae. Inhibition of HL-activity may therefore have value in the prevention and/or treatment of obesity... - Hypothalamic inflammation and energy homeostasis: resolving the paradoxJoshua P Thaler
Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98108, USA
Front Neuroendocrinol 31:79-84. 2010..Rigorously evaluating the progression of the inflammatory signaling cascade within specific hypothalamic cell types is a key next step towards resolving the paradox surrounding the effect of inflammatory signaling on energy homeostasis... - Identification of body fat mass as a major determinant of metabolic rate in miceKarl J Kaiyala
Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, Washington, USA
Diabetes 59:1657-66. 2010.... - Improving insulin ordering safely: the development of an inpatient glycemic control programRachel Thompson
Division of General Internal Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
J Hosp Med 4:E30-5. 2009..003). Distinguishing characteristics of this Glycemic Control Program include the use of real-time data to identify patients with out-of-range glucoses and the employment of a single clinician to cover all non-critical care floors... - Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in miceGregory J Morton
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, USA
Am J Physiol Endocrinol Metab 300:E392-401. 2011..Thus, plasma leptin is a physiological regulator of spontaneous physical activity, but the nature of leptin's effect on activity is dependent on food availability... - Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8James E Blevins
VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009.... - Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acidsSun Ju Choi
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Diabetes, University of Washington, Seattle, WA 98109 4714, USA
Am J Physiol Endocrinol Metab 298:E1122-30. 2010..Therefore, hypothalamic neuronal inflammation in the setting of DIO may involve an indirect mechanism mediated by saturated fatty acids on nonneuronal cells... - Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemiaJonathan P German
Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, N334, PO Box 358055, Seattle, Washington 98195, USA
Endocrinology 152:394-404. 2011.... - Melanocortin signaling and anorexia in chronic disease statesBrent E Wisse
Division of Metabolism, Endocrinology and Nutrition, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
Ann N Y Acad Sci 994:275-81. 2003..The data presented in this paper summarize findings that implicate neuronal melanocortin signaling in inflammatory anorexia... - Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistanceFrancis Kim
Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
Arterioscler Thromb Vasc Biol 28:1982-8. 2008.... - Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient miceSun Ju Choi
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, Seattle, WA 98109, USA
Am J Physiol Endocrinol Metab 300:E1031-7. 2011..2 g vs. WT: -1.6 ± 0.1, P < 0.05) were increased in myostatin-deficient mice compared with WT controls. We conclude that increased EE, together with increased leptin sensitivity, contributes to low fat mass in mice lacking myostatin... - Current controversy related to glucocorticoid and insulin therapy in the intensive care unitLindy S Klaff
The Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
Endocr Pract 13:542-9. 2007..To review the controversy related to the widespread use of intensive insulin treatment (IIT) to maintain normoglycemia and of glucocorticoid replacement therapy in patients with sepsis in the intensive care unit (ICU)... - The skinny on neurotrophinsBrent E Wisse
Nat Neurosci 6:655-6. 2003
Research Grants
- Melanocortins, Energy Balance and Cancer AnorexiaBrent Wisse; Fiscal Year: 2006..Schwartz and the Harborview Medical Center Energy Metabolism Laboratory, and by joining a large community of productive researchers in the field of energy homeostasis across the University of Washington campus. ..
- Peripheral and Central Inflammatory Signals in the Sickness ResponseBrent Wisse; Fiscal Year: 2007..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..
- Peripheral and Central Inflammatory Signals in the Sickness ResponseBrent Wisse; Fiscal Year: 2009..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..
- Peripheral and Central Inflammatory Signals in the Sickness ResponseBrent E Wisse; Fiscal Year: 2010..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..
- Peripheral and Central Inflammatory Signals in the Sickness ResponseBrent E Wisse; Fiscal Year: 2010..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..