Brent Wisse

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals
    Brent E Wisse
    Division of Metabolism, Harborview Medical Center, Seattle, WA 98104 2499, USA
    Endocrinology 148:5230-7. 2007
  2. ncbi Physiology. An integrative view of obesity
    Brent E Wisse
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
    Science 318:928-9. 2007
  3. doi Does hypothalamic inflammation cause obesity?
    Brent E Wisse
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA
    Cell Metab 10:241-2. 2009
  4. ncbi Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, WA 98104 2499, USA
    Am J Physiol Endocrinol Metab 287:E1107-13. 2004
  5. ncbi The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
    J Am Soc Nephrol 15:2792-800. 2004
  6. ncbi Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Peptides 27:265-73. 2006
  7. pmc Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Brain Res 1144:101-6. 2007
  8. pmc Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses
    Joshua P Thaler
    Division of Metabolism, University of Washington, Seattle, Washington 98109, USA
    Endocrinology 150:5362-72. 2009
  9. ncbi MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta
    Kayoko Ogimoto
    Division of Metabolism, Endocrinology, and Nutrition, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, Washington 98104 2499, USA
    Endocrinology 147:4445-53. 2006
  10. pmc Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    Jonathan P German
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1626-34. 2010

Collaborators

Detail Information

Publications24

  1. ncbi Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals
    Brent E Wisse
    Division of Metabolism, Harborview Medical Center, Seattle, WA 98104 2499, USA
    Endocrinology 148:5230-7. 2007
    ....
  2. ncbi Physiology. An integrative view of obesity
    Brent E Wisse
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, WA 98104, USA
    Science 318:928-9. 2007
  3. doi Does hypothalamic inflammation cause obesity?
    Brent E Wisse
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA
    Cell Metab 10:241-2. 2009
    ..2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight...
  4. ncbi Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, WA 98104 2499, USA
    Am J Physiol Endocrinol Metab 287:E1107-13. 2004
    ..05 vs. vehicle), an effect similar to that of ADX. These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin...
  5. ncbi The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
    J Am Soc Nephrol 15:2792-800. 2004
    ..This review describes the role of proinflammatory cytokines and hormones released by adipose tissue in generating the chronic inflammatory profile associated with visceral obesity...
  6. ncbi Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Peptides 27:265-73. 2006
    ..These data suggest a potential role for central melanocortins in mediating the decrease of ambulation characteristic of the 'sickness' response...
  7. pmc Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Brain Res 1144:101-6. 2007
    ....
  8. pmc Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses
    Joshua P Thaler
    Division of Metabolism, University of Washington, Seattle, Washington 98109, USA
    Endocrinology 150:5362-72. 2009
    ..We conclude that although hypothalamic aPKC signaling is not required for food intake inhibition by insulin or leptin, it plays a key role in inflammatory anorexia and fever induced by LPS...
  9. ncbi MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta
    Kayoko Ogimoto
    Division of Metabolism, Endocrinology, and Nutrition, Harborview Medical Center, 325 Ninth Avenue, Box 359757, Seattle, Washington 98104 2499, USA
    Endocrinology 147:4445-53. 2006
    ....
  10. pmc Leptin deficiency causes insulin resistance induced by uncontrolled diabetes
    Jonathan P German
    Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 59:1626-34. 2010
    ..This study investigated the role of leptin deficiency in the genesis of severe insulin resistance and related metabolic and neuroendocrine derangements induced by uDM...
  11. pmc Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding
    Shinsuke Oh-I
    UW Medicine at South Lake Union, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 299:E47-53. 2010
    ..These observations add to growing evidence linking hypothalamic inflammation to obesity pathogenesis...
  12. pmc Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis
    Harvey K Chiu
    Department of Pediatrics, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA
    Endocrinology 151:993-1001. 2010
    ..Our results demonstrate that in mice, HL deficiency protects against diet-induced obesity and its hepatic sequelae. Inhibition of HL-activity may therefore have value in the prevention and/or treatment of obesity...
  13. doi Hypothalamic inflammation and energy homeostasis: resolving the paradox
    Joshua P Thaler
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98108, USA
    Front Neuroendocrinol 31:79-84. 2010
    ..Rigorously evaluating the progression of the inflammatory signaling cascade within specific hypothalamic cell types is a key next step towards resolving the paradox surrounding the effect of inflammatory signaling on energy homeostasis...
  14. pmc Identification of body fat mass as a major determinant of metabolic rate in mice
    Karl J Kaiyala
    Department of Dental Public Health Sciences, School of Dentistry, University of Washington, Seattle, Washington, USA
    Diabetes 59:1657-66. 2010
    ....
  15. doi Improving insulin ordering safely: the development of an inpatient glycemic control program
    Rachel Thompson
    Division of General Internal Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    J Hosp Med 4:E30-5. 2009
    ..003). Distinguishing characteristics of this Glycemic Control Program include the use of real-time data to identify patients with out-of-range glucoses and the employment of a single clinician to cover all non-critical care floors...
  16. pmc Identification of a physiological role for leptin in the regulation of ambulatory activity and wheel running in mice
    Gregory J Morton
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, USA
    Am J Physiol Endocrinol Metab 300:E392-401. 2011
    ..Thus, plasma leptin is a physiological regulator of spontaneous physical activity, but the nature of leptin's effect on activity is dependent on food availability...
  17. doi Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
    James E Blevins
    VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009
    ....
  18. pmc Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids
    Sun Ju Choi
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine and Diabetes, University of Washington, Seattle, WA 98109 4714, USA
    Am J Physiol Endocrinol Metab 298:E1122-30. 2010
    ..Therefore, hypothalamic neuronal inflammation in the setting of DIO may involve an indirect mechanism mediated by saturated fatty acids on nonneuronal cells...
  19. pmc Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia
    Jonathan P German
    Department of Medicine, University of Washington at South Lake Union, 815 Mercer Street, N334, PO Box 358055, Seattle, Washington 98195, USA
    Endocrinology 152:394-404. 2011
    ....
  20. ncbi Melanocortin signaling and anorexia in chronic disease states
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Ann N Y Acad Sci 994:275-81. 2003
    ..The data presented in this paper summarize findings that implicate neuronal melanocortin signaling in inflammatory anorexia...
  21. pmc Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
    Francis Kim
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98104, USA
    Arterioscler Thromb Vasc Biol 28:1982-8. 2008
    ....
  22. pmc Increased energy expenditure and leptin sensitivity account for low fat mass in myostatin-deficient mice
    Sun Ju Choi
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Diabetes and Obesity Center of Excellence, Seattle, WA 98109, USA
    Am J Physiol Endocrinol Metab 300:E1031-7. 2011
    ..2 g vs. WT: -1.6 ± 0.1, P < 0.05) were increased in myostatin-deficient mice compared with WT controls. We conclude that increased EE, together with increased leptin sensitivity, contributes to low fat mass in mice lacking myostatin...
  23. ncbi Current controversy related to glucocorticoid and insulin therapy in the intensive care unit
    Lindy S Klaff
    The Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
    Endocr Pract 13:542-9. 2007
    ..To review the controversy related to the widespread use of intensive insulin treatment (IIT) to maintain normoglycemia and of glucocorticoid replacement therapy in patients with sepsis in the intensive care unit (ICU)...
  24. ncbi The skinny on neurotrophins
    Brent E Wisse
    Nat Neurosci 6:655-6. 2003

Research Grants6

  1. Melanocortins, Energy Balance and Cancer Anorexia
    Brent Wisse; Fiscal Year: 2006
    ..Schwartz and the Harborview Medical Center Energy Metabolism Laboratory, and by joining a large community of productive researchers in the field of energy homeostasis across the University of Washington campus. ..
  2. Peripheral and Central Inflammatory Signals in the Sickness Response
    Brent Wisse; Fiscal Year: 2007
    ..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..
  3. Peripheral and Central Inflammatory Signals in the Sickness Response
    Brent Wisse; Fiscal Year: 2009
    ..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..
  4. Peripheral and Central Inflammatory Signals in the Sickness Response
    Brent E Wisse; Fiscal Year: 2010
    ..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..
  5. Peripheral and Central Inflammatory Signals in the Sickness Response
    Brent E Wisse; Fiscal Year: 2010
    ..These aims make an important contribution to understanding the mechanism whereby inflammation affects energy balance and may identify potential therapies for disorders ranging from obesity to chronic wasting illnesses. ..