Stephen R Wisniewski

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D)
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Psychiatr Res 38:241-8. 2004
  2. pmc International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol
    Leanne M Williams
    BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
    Trials 12:4. 2011
  3. pmc Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: a computational model
    Tina Marie Assi
    University of Pittsburgh, Pittsburgh, PA, USA
    BMC Public Health 11:425. 2011
  4. pmc The Resources for Enhancing Alzheimer's Caregiver Health (REACH): project design and baseline characteristics
    Stephen R Wisniewski
    Department of Epidemiology, University of Pittsburgh, Pennsylvania 15261, USA
    Psychol Aging 18:375-84. 2003
  5. doi request reprint Global benefit-risk analysis of adjunctive aripiprazole in the treatment of patients with major depressive disorder
    Stephen R Wisniewski
    University of Pittsburgh, PA 15261, USA
    Pharmacoepidemiol Drug Saf 18:965-72. 2009
  6. ncbi request reprint Prevention of missing data in clinical research studies
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 59:997-1000. 2006
  7. ncbi request reprint Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Clin Trials 1:387-98. 2004
  8. ncbi request reprint Acceptability of second-step treatments to depressed outpatients: a STAR*D report
    Stephen R Wisniewski
    Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 164:753-60. 2007
  9. doi request reprint Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, 127 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Am J Psychiatry 166:599-607. 2009
  10. ncbi request reprint Comparison of quality of life measures in a depressed population
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Nerv Ment Dis 195:219-25. 2007

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D)
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Psychiatr Res 38:241-8. 2004
    ..While the information gathered was useful, it did delay the initiation of the formal trial. We view this cost as an investment in the development of overall study procedures that should lead to a stronger study...
  2. pmc International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol
    Leanne M Williams
    BRAINnet Foundation, 71 Stephenson Street, Suite 400, San Francisco, CA, 94105, USA
    Trials 12:4. 2011
    ..The aim of iSPOT-D is to identify pretreatment measures that predict or moderate MDD treatment response or remission to escitalopram, sertraline or venlafaxine; and develop a model that incorporates multiple predictors and moderators...
  3. pmc Impact of changing the measles vaccine vial size on Niger's vaccine supply chain: a computational model
    Tina Marie Assi
    University of Pittsburgh, Pittsburgh, PA, USA
    BMC Public Health 11:425. 2011
    ..The measles vaccine is particularly important in Niger, a country prone to measles outbreaks...
  4. pmc The Resources for Enhancing Alzheimer's Caregiver Health (REACH): project design and baseline characteristics
    Stephen R Wisniewski
    Department of Epidemiology, University of Pittsburgh, Pennsylvania 15261, USA
    Psychol Aging 18:375-84. 2003
    ..Caregivers reported high levels of depressive symptoms and moderate burden. Care recipients were older, with a mean age of 79, and were moderately to severely impaired with mean Mini-Mental State Exam scores of 13/30...
  5. doi request reprint Global benefit-risk analysis of adjunctive aripiprazole in the treatment of patients with major depressive disorder
    Stephen R Wisniewski
    University of Pittsburgh, PA 15261, USA
    Pharmacoepidemiol Drug Saf 18:965-72. 2009
    ..This study quantified the overall merit of adjunctive aripiprazole in major depressive disorder (MDD)...
  6. ncbi request reprint Prevention of missing data in clinical research studies
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 59:997-1000. 2006
    ..Despite efforts devoted to areas, no study is without missing data. Once the study is completed, it is essential to assess the pattern of missing data and apply the appropriate statistical analysis...
  7. ncbi request reprint Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Clin Trials 1:387-98. 2004
    ....
  8. ncbi request reprint Acceptability of second-step treatments to depressed outpatients: a STAR*D report
    Stephen R Wisniewski
    Department of Psychiatry, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, and Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 164:753-60. 2007
    ..This study sought to identify factors that affect patients' willingness to accept different second-step treatment approaches...
  9. doi request reprint Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report
    Stephen R Wisniewski
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, 127 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Am J Psychiatry 166:599-607. 2009
    ....
  10. ncbi request reprint Comparison of quality of life measures in a depressed population
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Nerv Ment Dis 195:219-25. 2007
    ....
  11. ncbi request reprint Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments: a STAR*D report
    Michael E Thase
    Department of Psychiatry, University of Pittsburgh Medical Center, 3811 OHara St, Pittsburgh, PA 15213 2593, and Massachusetts General Hospital, USA
    Am J Psychiatry 164:739-52. 2007
    ..Cognitive therapy was compared with medication augmentation and switch strategies...
  12. doi request reprint Income and attrition in the treatment of depression: a STAR*D report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9086, USA
    Depress Anxiety 26:622-33. 2009
    ..This report assessed whether attrition rates and predictors of attrition differed among depressed outpatients with different income levels...
  13. doi request reprint What predicts attrition in second step medication treatments for depression?: a STAR*D Report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9119, USA
    Int J Neuropsychopharmacol 12:459-73. 2009
    ..Focus on patients with attrition risk factors for medication augmentation or switch strategies may enhance retention and improve outcomes...
  14. pmc Major depression symptoms in primary care and psychiatric care settings: a cross-sectional analysis
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Ann Fam Med 5:126-34. 2007
    ....
  15. doi request reprint Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D report
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 165:342-51. 2008
    ..The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and 2 of the STAR*D study...
  16. ncbi request reprint Family history of completed suicide and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital Harvard Medical School, Boston, MA 01224, USA
    J Affect Disord 108:129-34. 2008
    ..It is unknown, however, whether patients with a family member who committed suicide differ from those without such a history...
  17. ncbi request reprint Clinical and sociodemographic characteristics associated with suicidal ideation in depressed outpatients
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Can J Psychiatry 58:113-22. 2013
    ..To identify clinical and sociodemographic characteristics associated with suicidal ideation (SI) among patients seeking care for depression in routine primary and psychiatric care settings...
  18. ncbi request reprint Does recovery from substance use disorder matter in patients with bipolar disorder?
    Roger D Weiss
    Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 66:730-5; quiz 808-9. 2005
    ..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
  19. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  20. ncbi request reprint Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D report
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas UT Southwestern Medical Center, Dallas 75390 9119, and the Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:185-95. 2006
    ..The aim of this study was to examine sociodemographic and clinical correlates of HRQOL in a large cohort of outpatients with MDD...
  21. doi request reprint Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trial
    Edward S Friedman
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 26:612-21. 2009
    ..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention...
  22. doi request reprint Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Arch Gen Psychiatry 65:870-80. 2008
    ..Little is known about selecting among second-step medications for major depressive disorder after intolerance or lack of remission with an initial selective serotonin reuptake inhibitor...
  23. ncbi request reprint Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    Am J Psychiatry 163:1905-17. 2006
    ..This report describes the participants and compares the acute and longer-term treatment outcomes associated with each of four successive steps in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  24. ncbi request reprint Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Rd, Suite 1300, Dallas, TX 75390 9119, USA
    Am J Psychiatry 163:28-40. 2006
    ....
  25. doi request reprint Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: an examination of citalopram in the STAR*D study
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, California, USA
    J Affect Disord 117:63-73. 2009
    ..The purpose of this study was to determine whether, and in whom, treatment of MDD is associated with increased or emergent SI...
  26. ncbi request reprint Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report
    Patrick J McGrath
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 69:1847-55. 2008
    ....
  27. doi request reprint Concurrent anxiety and substance use disorders among outpatients with major depression: clinical features and effect on treatment outcome
    Robert H Howland
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, United States
    Drug Alcohol Depend 99:248-60. 2009
    ....
  28. ncbi request reprint Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D
    William R Yates
    Department of Psychiatry, University of Oklahoma College of Medicine, Tulsa, OK 74135, USA
    Gen Hosp Psychiatry 26:421-9. 2004
    ..A significant percentage of patients with major depressive disorder (MDD) suffer from concurrent general medical conditions (GMCs)...
  29. ncbi request reprint Medication augmentation after the failure of SSRIs for depression
    Madhukar H Trivedi
    Mood Disorder Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    N Engl J Med 354:1243-52. 2006
    ..Although clinicians frequently add a second medication to an initial, ineffective antidepressant drug, no randomized controlled trial has compared the efficacy of this approach...
  30. ncbi request reprint Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
    Am J Psychiatry 161:2222-9. 2004
    ..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients...
  31. ncbi request reprint Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
    ..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
  32. ncbi request reprint Family history of depression and therapeutic outcome: findings from STAR*D
    Mustafa M Husain
    Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX 75390 8898, USA
    J Clin Psychiatry 70:185-95. 2009
    ....
  33. ncbi request reprint A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Bulfinch 351, 55 Fruit St, Boston, MA 02114, USA
    Am J Psychiatry 163:1161-72. 2006
    ....
  34. pmc Sex differences in depression symptoms in treatment-seeking adults: confirmatory analyses from the Sequenced Treatment Alternatives to Relieve Depression study
    Sheila M Marcus
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    Compr Psychiatry 49:238-46. 2008
    ..This article examines sex differences in terms of illness attributes in a cohort of 2541 outpatients from across the United States who enrolled in the Sequenced Treatment Alternatives to Relieve Depression study...
  35. ncbi request reprint A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report
    Andrew A Nierenberg
    Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
    Am J Psychiatry 163:1519-30; quiz 1665. 2006
    ..This study compared the effectiveness of lithium versus triiodothyronine (T(3)) augmentation as a third-step treatment for patients with major depressive disorder...
  36. ncbi request reprint Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Control Clin Trials 25:119-42. 2004
    ..Participants with an adequate symptomatic response may enter the 12-month naturalistic follow-up phase with brief monthly and more complete quarterly assessments...
  37. doi request reprint Increase in work productivity of depressed individuals with improvement in depressive symptom severity
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Psychiatry 170:633-41. 2013
    ..The authors sought to identify baseline clinical and sociodemographic characteristics associated with work productivity in depressed outpatients and to assess the effect of treatment on work productivity...
  38. pmc Primary versus specialty care outcomes for depressed outpatients managed with measurement-based care: results from STAR*D
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    J Gen Intern Med 23:551-60. 2008
    ..Whether the acute outcomes of major depressive disorder (MDD) treated in primary (PC) or specialty care (SC) settings are different is unknown...
  39. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  40. ncbi request reprint A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trial
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Gen Hosp Psychiatry 27:87-96. 2005
    ..The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (http://www.star-d.org) provides a unique opportunity to provide this comparison for patients with a major depressive disorder (MDD) requiring treatment...
  41. ncbi request reprint Effect of age at onset on the course of major depressive disorder
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, CA 92093, USA
    Am J Psychiatry 164:1539-46. 2007
    ..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study...
  42. ncbi request reprint Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study
    Roy H Perlis
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 66:159-66; quiz 147, 273-4. 2005
    ..Irritability with or without depression has been associated with risk for suicide, violence, and cardiovascular disease...
  43. ncbi request reprint Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D report
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9086, USA
    Am J Psychiatry 164:1189-97. 2007
    ..The purpose of this study was to identify the pretreatment predictors of attrition during acute treatment with citalopram in a large, "real world" clinical trial...
  44. pmc Baseline depression severity as a predictor of single and combination antidepressant treatment outcome: results from the CO-MED trial
    Edward S Friedman
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Eur Neuropsychopharmacol 22:183-99. 2012
    ..03). These data may help us to understand the impact of baseline features on antidepressant medication effectiveness and to inform the personalization of depression treatment across the spectrum of depressive severity...
  45. pmc Remission of maternal depression: relations to family functioning and youth internalizing and externalizing symptoms
    Cynthia Ewell Foster
    Department of Psychiatry, University of Michigan, Ann Arbor, MI 48105, USA
    J Clin Child Adolesc Psychol 37:714-24. 2008
    ..9% of the variance...
  46. ncbi request reprint Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study
    Andrew A Nierenberg
    Depression Clinical and Research Program, ACC 812, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 01224, USA
    J Psychiatr Res 41:214-21. 2007
    ....
  47. ncbi request reprint Health-related quality of life in depression: a STAR*D report
    Ella J Daly
    Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Ann Clin Psychiatry 22:43-55. 2010
    ..This report examined the psychological, physical, and social domains in a large sample of outpatients who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial...
  48. ncbi request reprint Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
    Andrew A Nierenberg
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1467-73. 2005
    ....
  49. doi request reprint Randomized comparison of selective serotonin reuptake inhibitor (escitalopram) monotherapy and antidepressant combination pharmacotherapy for major depressive disorder with melancholic features: a CO-MED report
    William V Bobo
    Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Affect Disord 133:467-76. 2011
    ..The clinical effects of antidepressant combinations vs. monotherapy as initial treatment for major depression with melancholic features (MDD-MF) are unknown...
  50. ncbi request reprint Insured and non-insured depressed outpatients: how do they compare?
    Ira M Lesser
    Department of Psychiatry, Harbor UCLA Medical Center, The Los Angeles Biomedical Research Institute, Los Angeles, CA, USA
    Ann Clin Psychiatry 19:73-82. 2007
    ....
  51. pmc Assessing anxious features in depressed outpatients
    Shawn M McClintock
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8898, USA
    Int J Methods Psychiatr Res 20:e69-82. 2011
    ..Both the HRSD(ANX) and IDS-C(ANX) subscales have acceptable psychometric properties and can be used to identify anxious features for clinical or research purposes...
  52. doi request reprint What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression
    Bradley N Gaynes
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Psychiatr Serv 60:1439-45. 2009
    ..STAR*D demonstrated that inclusion of more real-world patients in clinical trials is both feasible and informative. Policy implications of the findings, as well as the study's limitations, are discussed...
  53. doi request reprint Metabolic assessment of aripiprazole as adjunctive therapy in major depressive disorder: a pooled analysis of 2 studies
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    J Clin Psychopharmacol 29:362-7. 2009
    ..Also, there was no apparent change in the incidence of National Cholesterol Education Program-defined abnormal metabolic measures after treatment with aripiprazole...
  54. ncbi request reprint Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D
    Maurizio Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 34:1299-308. 2004
    ..Anxious depression, defined as Major Depressive Disorder (MDD) with high levels of anxiety symptoms, may represent a relatively common depressive subtype, with distinctive features...
  55. ncbi request reprint Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features
    A John Rush
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9086, USA
    J Affect Disord 87:43-55. 2005
    ..This study evaluated the clinical and sociodemographic features associated with various degrees of concurrent comorbidity in adult outpatients with nonpsychotic major depressive disorder (MDD)...
  56. ncbi request reprint Factors associated with concomitant psychotropic drug use in the treatment of major depression: a STAR*D Report
    Rchard C Shelton
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    CNS Spectr 14:487-98. 2009
    ..Concomitant psychotropic medication (CPM) treatment is common in persons with major depression (MDD). However, relationships with patient characteristics and response to treatment are unclear...
  57. pmc Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study
    Roy H Perlis
    Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
    Bipolar Disord 11:391-400. 2009
    ..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms...
  58. pmc Relationship between hyperglycemia and outcome in children with severe traumatic brain injury
    Rebecca L Smith
    Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Crit Care Med 13:85-91. 2012
    ..To determine the relationship between hyperglycemia and outcome in infants and children after severe traumatic brain injury...
  59. ncbi request reprint Pain in depression: STAR*D study findings
    Mustafa M Husain
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8898, USA
    J Psychosom Res 63:113-22. 2007
    ..Pain complaints commonly accompany major depressive disorder (MDD). However, whether patients with MDD and pain complaints differ from those without pain complaints is not well studied...
  60. ncbi request reprint Insomnia in patients with depression: a STAR*D report
    Prabha Sunderajan
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9119, USA
    CNS Spectr 15:394-404. 2010
    ..However, little is known about the prevalence and associated features of insomnia symptoms in representative treatment-seeking patients with depression...
  61. doi request reprint Diurnal mood variation in outpatients with major depressive disorder
    David W Morris
    Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Exchange Park Express, American General Tower, 6363 Forest Park Road, Suite 13 354, Dallas, TX 75390 9119, USA
    Depress Anxiety 26:851-63. 2009
    ..This report used data from the sequenced treatment alternatives to relieve depression study to determine whether DMV was associated with treatment outcome to citalopram...
  62. ncbi request reprint Maximizing the adequacy of medication treatment in controlled trials and clinical practice: STAR(*)D measurement-based care
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuropsychopharmacology 32:2479-89. 2007
    ..This approach signals a paradigm shift toward the use of measurement-based clinical decisions, both at the point of care and following each visit, to deliver optimal pharmacotherapy for depression...
  63. ncbi request reprint What clinical and symptom features and comorbid disorders characterize outpatients with anxious major depressive disorder: a replication and extension
    Maurizio Fava
    Massachusetts General Hospital, Boston, Harvard Medical School, MA 02114, USA
    Can J Psychiatry 51:823-35. 2006
    ..This study was designed to replicate and extend our initial findings in a subsequent, larger cohort of outpatient STAR*D participants with nonpsychotic major depressive disorder (MDD)...
  64. pmc Disturbed sleep and inflammatory cytokines in depressed and nondepressed pregnant women: an exploratory analysis of pregnancy outcomes
    Michele L Okun
    Sleep Medicine Institute and Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Psychosom Med 75:670-81. 2013
    ....
  65. ncbi request reprint REVAMP - Research Evaluating the Value of Augmenting Medication with Psychotherapy: rationale and design
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Psychopharmacol Bull 41:5-33. 2008
    ....
  66. ncbi request reprint Brief report: paroxetine in younger and adult individuals at high risk for suicide
    Mark S Bauer
    Department of Psychiatry, Brown University, USA
    Psychopharmacol Bull 39:31-7. 2006
    ..In fact, the younger group showed a trend for decreased suicidality (P = .13). Thus, increased suicidality risk with paroxetine exposure does not extend to this other high-risk mood disordered population, even among younger individuals...
  67. pmc Early adverse events and attrition in selective serotonin reuptake inhibitor treatment: a suicide assessment methodology study report
    Diane Warden
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    J Clin Psychopharmacol 30:259-66. 2010
    ..Neither global ratings nor specific adverse effects at week 2 were related to patient attrition during SSRI treatment. Other factors seem to contribute to patient decisions about continuing with treatment...
  68. doi request reprint Concise Health Risk Tracking scale: a brief self-report and clinician rating of suicidal risk
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9086, USA
    J Clin Psychiatry 72:757-64. 2011
    ..This report evaluates the psychometric properties of a brief self- and clinician-rated measure of factors related to the risk of suicide attempt or completion...
  69. doi request reprint The relationship between adverse events during selective serotonin reuptake inhibitor treatment for major depressive disorder and nonremission in the suicide assessment methodology study
    Ella J Daly
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Psychopharmacol 31:31-8. 2011
    ....
  70. ncbi request reprint Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:512-20. 2004
    ..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
  71. pmc Identifying risk for attrition during treatment for depression
    Diane Warden
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Psychother Psychosom 78:372-9. 2009
    ..Understanding patients' ambivalence about treatment persistence may be useful in tailoring retention interventions for individual patients with major depressive disorder...
  72. ncbi request reprint Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program
    Christopher D Schneck
    Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
    Am J Psychiatry 161:1902-8. 2004
    ..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status...
  73. ncbi request reprint Diurnal mood variation in outpatients with major depressive disorder: implications for DSM-V from an analysis of the Sequenced Treatment Alternatives to Relieve Depression Study data
    David W Morris
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9119, USA
    J Clin Psychiatry 68:1339-47. 2007
    ....
  74. doi request reprint Treatment outcomes for older depressed patients with earlier versus late onset of first depressive episode: a Sequenced Treatment Alternatives to Relieve Depression (STAR*D) report
    F Andrew Kozel
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Am J Geriatr Psychiatry 16:58-64. 2008
    ..In this study of older depressed outpatients, the authors evaluated whether the age at onset of the first major depressive episode (MDE) was related to clinical outcomes...
  75. ncbi request reprint Ethnicity/race and outcome in the treatment of depression: results from STAR*D
    Ira M Lesser
    Department of Psychiatry, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, 1000 W Carson Street, Torrance, CA 90509, USA
    Med Care 45:1043-51. 2007
    ....
  76. ncbi request reprint TREAD: TReatment with Exercise Augmentation for Depression: study rationale and design
    Madhukar H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Clin Trials 3:291-305. 2006
    ..However, no randomized controlled trials have evaluated exercise as an augmentation strategy for patients with carefully diagnosed MDD who remain symptomatic following an adequate acute phase trial of antidepressant therapy...
  77. ncbi request reprint Care satisfaction, hope, and life functioning among adults with bipolar disorder: data from the first 1000 participants in the Systematic Treatment Enhancement Program
    Chad D Morris
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
    Compr Psychiatry 46:98-104. 2005
    ..This prospective study examined the longitudinal relationships between patients' satisfaction with care, levels of hope, and life functioning in the first 1000 patients to enter STEP-BD...
  78. ncbi request reprint Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Gary S Sachs
    Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1028-42. 2003
    ....
  79. pmc Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  80. ncbi request reprint Introduction to the special section on Resources for Enhancing Alzheimer's Caregiver Health (REACH)
    Richard Schulz
    Department of Psychiatry, University Center for Social and Urban Research, University of Pittsburgh, 121 University Place, Pennsylvania 15260, USA
    Psychol Aging 18:357-60. 2003
    ..The authors describe the design of the study, summarize the interventions implemented at each site, and provide an overview of the 4 articles in this special section...
  81. ncbi request reprint Bone mineral density and prevalent vertebral fractures in men and women
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Osteoporos Int 15:32-7. 2004
    ..Measures of bone mass that partially correct for gender differences in bone size may yield universal estimates of fracture risk. Prospective studies are needed to confirm this observation...
  82. ncbi request reprint Assessment of the macrophage marker quinolinic acid in cerebrospinal fluid after pediatric traumatic brain injury: insight into the timing and severity of injury in child abuse
    Rachel Pardes Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Neurotrauma 21:1123-30. 2004
    ..Higher initial and peak QUIN concentrations after iTBI may be due to severity of injury, young age, and/or delay in seeking medical care, which allows for increased secondary injury...
  83. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated...
  84. ncbi request reprint Physical activity and risk of revision total knee arthroplasty in individuals with knee osteoarthritis: a matched case-control study
    Dina L Jones
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Rheumatol 31:1384-90. 2004
    ..To determine if physical activity was a risk factor for revision arthroplasty after primary total knee arthroplasty (TKA) due to osteoarthritis (OA) within the previous 15 years...
  85. ncbi request reprint Development of an efficient SAS macro to perform permutation tests for two independent samples
    G K Balasubramani
    Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Comput Methods Programs Biomed 79:179-87. 2005
    ....
  86. ncbi request reprint Serum S100B concentrations are increased after closed head injury in children: a preliminary study
    Rachel Pardes Berger
    Department of Pediatrics, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 19:1405-9. 2002
    ..The increase is transient, lasting less than 12 h after injury, except in children with severe injury. Future research will focus on the possibility of using serum S100B as a screening test for inflicted CHI...
  87. ncbi request reprint How patients feel about prolonged mechanical ventilation 1 year later
    Aaron B Mendelsohn
    Department of Epidemiology, University of Pittsburg, Pittsburg, PA, USA
    Crit Care Med 30:1439-45. 2002
    ....
  88. pmc Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with knee osteoarthritis: a randomized clinical trial
    G Kelley Fitzgerald
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15101, USA
    Phys Ther 91:452-69. 2011
    ..It has previously been proposed that adding agility and perturbation training to exercise programs for people with knee OA may improve treatment effects for pain and function...
  89. ncbi request reprint Quality improvement methods as applied to a multicenter effectiveness trial--STAR*D
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX, USA
    Contemp Clin Trials 26:95-112. 2005
    ..This paper describes the background, rationale, development, and potential utility of implementing a quality improvement system to improve the performance and efficiency of the trial...
  90. ncbi request reprint Clinical and demographic factors associated with DSM-IV melancholic depression
    Ahsan Y Khan
    University of Kansas School of Medicine Wichita, Department of Psychiatry, Wichita, KS, USA
    Ann Clin Psychiatry 18:91-8. 2006
    ..The purpose of this paper is to use demographic and clinical data from a large diverse group of outpatients diagnosed with non-psychotic major depression to investigate the validity of the DSM-IV concept of melancholic depression...
  91. ncbi request reprint Diabetes and postcataract extraction endophthalmitis
    Bernard H Doft
    Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Ophthalmol 13:147-51. 2002
    ..A new clinical trial is needed to determine if in fact there is a difference in response to treatment among diabetic and nondiabetic patients who present with better than LP vision...
  92. ncbi request reprint Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort
    Lori L Davis
    VA Medical Center, Tuscaloosa, AL 35404, USA
    Compr Psychiatry 46:81-9. 2005
    ..In conclusion, gender, marital status, age of onset of major depression, functional impairment, and suicide risk factors differ in depressed patients with concurrent SUD symptoms compared to those without SUD comorbidity...
  93. ncbi request reprint Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    Xian Zhang Hu
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:783-92. 2007
    ....
  94. ncbi request reprint The STAR*D Project results: a comprehensive review of findings
    Diane Warden
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9086, USA
    Curr Psychiatry Rep 9:449-59. 2007
    ..These results highlight the prevalence of treatment-resistant depression and suggest potential benefit for using more vigorous treatments in the earlier steps...
  95. pmc Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  96. pmc The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort
    Magnus Lekman
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 63:1103-10. 2008
    ..The present study aimed at studying the associated FKBP5 markers in the ethnically diverse Sequenced Treatment Alternatives to Relieve Depression (STAR*D) sample of non-hospitalized patients treated with citalopram...
  97. ncbi request reprint Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury
    Donald W Marion
    Brain Trauma Research Center, Department of Neurological Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Suite B400, Pittsburgh, PA 15213, USA
    Crit Care Med 30:2619-25. 2002
    ..To determine the potential adverse effects of brief periods of hyperventilation commonly used for acute neurologic deterioration...
  98. ncbi request reprint Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort
    Lori L Davis
    Department of Veterans Affairs VA Medical Center, Tuscaloosa, Ala 35404, USA
    J Clin Psychiatry 68:1931-8. 2007
    ....
  99. pmc Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 64:419-26. 2007
    ..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
  100. ncbi request reprint Does the duration of index episode affect the treatment outcome of major depressive disorder? A STAR*D report
    William S Gilmer
    Asher Center for the Study and Treatment of Depressive Disorders, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    J Clin Psychiatry 69:1246-56. 2008
    ....
  101. ncbi request reprint Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort
    Lori L Davis
    VA Medical Center, Tuscaloosa, AL 35404, USA
    Am J Addict 15:278-85. 2006
    ..048 to <0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities (p = 0.006 and 0.002, respectively)...