P M Wise

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies
    P M Wise
    Department of Physiology, University of Kentucky, College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    Brain Res Brain Res Rev 37:313-9. 2001
  2. ncbi request reprint The 'menopause' and the aging brain: causes and repercussions of hypoestrogenicity
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536, USA
    Biogerontology 2:113-5. 2001
  3. ncbi request reprint Estradiol: a protective factor in the adult brain
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536 0298, USA
    J Pediatr Endocrinol Metab 13:1425-9. 2000
  4. ncbi request reprint Neuroendocrine modulation of the "menopause": insights into the aging brain
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Physiol 277:E965-70. 1999
  5. ncbi request reprint Estradiol protects against ischemic brain injury in middle-aged rats
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Biol Reprod 63:982-5. 2000
  6. ncbi request reprint Estrogens: trophic and protective factors in the adult brain
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Front Neuroendocrinol 22:33-66. 2001
  7. ncbi request reprint Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 142:969-73. 2001
  8. ncbi request reprint Neuroprotective effects of estradiol in middle-aged female rats
    D B Dubal
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0298, USA
    Endocrinology 142:43-8. 2001
  9. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
  10. ncbi request reprint Neuroendocrine influences and repercussions of the menopause
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536 0298, USA
    Endocr Rev 20:243-8. 1999

Detail Information

Publications13

  1. ncbi request reprint Estradiol is a protective factor in the adult and aging brain: understanding of mechanisms derived from in vivo and in vitro studies
    P M Wise
    Department of Physiology, University of Kentucky, College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    Brain Res Brain Res Rev 37:313-9. 2001
    ..In summary, our findings demonstrate that estradiol exerts powerful protective effects both in vivo and in vitro and suggest that these actions are mediated by estrogen receptors...
  2. ncbi request reprint The 'menopause' and the aging brain: causes and repercussions of hypoestrogenicity
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536, USA
    Biogerontology 2:113-5. 2001
    ..Furthermore, the absence of estrogens leads to changes in many physiological systems. Thus, it is becoming clear that it is important to understand the broad impact of the prolonged hypoestrogenic state that characterizes the menopause...
  3. ncbi request reprint Estradiol: a protective factor in the adult brain
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536 0298, USA
    J Pediatr Endocrinol Metab 13:1425-9. 2000
    ..These data suggest that estrogen replacement therapy may provide important protection against age- and disease-related degenerative processes in the brain...
  4. ncbi request reprint Neuroendocrine modulation of the "menopause": insights into the aging brain
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Physiol 277:E965-70. 1999
    ....
  5. ncbi request reprint Estradiol protects against ischemic brain injury in middle-aged rats
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Biol Reprod 63:982-5. 2000
    ..These observations provide important insights into the potential protective actions of estrogen replacement therapy on age- and disease-related processes in the brain...
  6. ncbi request reprint Estrogens: trophic and protective factors in the adult brain
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Front Neuroendocrinol 22:33-66. 2001
    ..This area of research demands attention since estradiol may be an important therapeutic agent in the maintenance of normal neural function during aging and after injury...
  7. ncbi request reprint Minireview: neuroprotective effects of estrogen-new insights into mechanisms of action
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 142:969-73. 2001
    ..Clearly, it is critical for us understand the circumstances under which estradiol exerts protective actions and the cellular and molecular mechanisms that underlie these novel, nonreproductive actions...
  8. ncbi request reprint Neuroprotective effects of estradiol in middle-aged female rats
    D B Dubal
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0298, USA
    Endocrinology 142:43-8. 2001
    ....
  9. pmc Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury
    D B Dubal
    Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 98:1952-7. 2001
    ..Our discovery that ER alpha mediates protection of the brain carries far-reaching implications for the selective targeting of ERs in the treatment and prevention of neural dysfunction associated with normal aging or brain injury...
  10. ncbi request reprint Neuroendocrine influences and repercussions of the menopause
    P M Wise
    Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536 0298, USA
    Endocr Rev 20:243-8. 1999
    ..Furthermore, understanding how estrogen exerts trophic and protective actions should lead to its use as an important therapeutic agent in the maintenance of normal neural function during aging and after injury...
  11. pmc Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
    J Turchan
    Department of Neurology, University of Kentucky, Lexington, USA
    BMC Neurosci 2:3. 2001
    ..We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat...
  12. ncbi request reprint Acute effects of antisense antagonism of a single peptide neurotransmitter in the circadian clock
    K Scarbrough
    Department of Physiology, University of Kentucky College of Medicine, Lexington 40536, USA
    Am J Physiol 270:R283-8. 1996
    ..These results indicate that a single neuropeptide transmitter in the circadian clock may serve a distinct role in the control of specific circadian rhythms...
  13. ncbi request reprint Sex differences in the daily rhythm of vasoactive intestinal polypeptide but not arginine vasopressin messenger ribonucleic acid in the suprachiasmatic nuclei
    K Krajnak
    Department of Physiology, University of Kentucky, Lexington 40536 0084, USA
    Endocrinology 139:4189-96. 1998
    ....