P E Wischmeyer

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint The glutamine story: where are we now?
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Crit Care 12:142-8. 2006
  2. ncbi request reprint Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression?
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 9:201-6. 2006
  3. ncbi request reprint Glutamine: role in gut protection in critical illness
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 9:607-12. 2006
  4. ncbi request reprint Glutamine: mode of action in critical illness
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 35:S541-4. 2007
  5. ncbi request reprint A survey of propofol abuse in academic anesthesia programs
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado, Denver, Colorado, USA
    Anesth Analg 105:1066-71, table of contents. 2007
  6. ncbi request reprint John M. Kinney International Award for General Nutrition. Glutamine, heat shock protein, and inflammation--opportunity from the midst of difficulty
    Paul Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nutrition 20:583-5. 2004
  7. ncbi request reprint Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    JPEN J Parenter Enteral Nutr 27:396-403. 2003
  8. doi request reprint Glutamine: role in critical illness and ongoing clinical trials
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Opin Gastroenterol 24:190-7. 2008
  9. ncbi request reprint Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado, Denver 80262, USA
    JPEN J Parenter Enteral Nutr 27:116-22. 2003
  10. ncbi request reprint Role of L-glutamine in critical illness: new insights
    David Kelly
    Valparaiso University, Valparaiso, Indiana and Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 6:217-22. 2003

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi request reprint The glutamine story: where are we now?
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Crit Care 12:142-8. 2006
    ....
  2. ncbi request reprint Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression?
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 9:201-6. 2006
    ..The purpose of this review is to examine recent data supporting the use of glutamine as a clinically relevant enhancer of heat shock protein expression...
  3. ncbi request reprint Glutamine: role in gut protection in critical illness
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 9:607-12. 2006
    ..Thus, the therapeutic potential for an agent to prevent gut barrier compromise and attenuate gut-derived inflammatory response is significant...
  4. ncbi request reprint Glutamine: mode of action in critical illness
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 35:S541-4. 2007
    ..Presently, randomized, multicenter, clinical trials utilizing glutamine as a pharmacologic and a nutritional agent are ongoing...
  5. ncbi request reprint A survey of propofol abuse in academic anesthesia programs
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado, Denver, Colorado, USA
    Anesth Analg 105:1066-71, table of contents. 2007
    ..Although propofol has not traditionally been considered a drug of abuse, subanesthetic doses may have an abuse potential. We used this survey to assess prevalence and outcome of propofol abuse in academic anesthesiology programs...
  6. ncbi request reprint John M. Kinney International Award for General Nutrition. Glutamine, heat shock protein, and inflammation--opportunity from the midst of difficulty
    Paul Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nutrition 20:583-5. 2004
  7. ncbi request reprint Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    JPEN J Parenter Enteral Nutr 27:396-403. 2003
    ..Thus, we hypothesized that GLN pretreatment given to the rat in vivo would protect the myocardium against I/R-induced dysfunction...
  8. doi request reprint Glutamine: role in critical illness and ongoing clinical trials
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Opin Gastroenterol 24:190-7. 2008
    ..This review will assess recent clinical and mechanistic data examining glutamine's ability to reduce morbidity and mortality in critical illness...
  9. ncbi request reprint Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia-reperfusion injury
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado, Denver 80262, USA
    JPEN J Parenter Enteral Nutr 27:116-22. 2003
    ..We tested the hypothesis that glutamine can enhance heat shock protein 72 (HSP 72) expression, attenuate intracellular oxidant generation, and protect cardiomyocytes against ischemia/reperfusion (I/R) injury...
  10. ncbi request reprint Role of L-glutamine in critical illness: new insights
    David Kelly
    Valparaiso University, Valparaiso, Indiana and Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Curr Opin Clin Nutr Metab Care 6:217-22. 2003
    ..It will try to present the concept of glutamine as a 'drug' or 'nutraceutical', given in addition to standard nutritional support...
  11. ncbi request reprint Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nutrition 19:1-6. 2003
    ..However, data on the effect of GLN on direct attenuation of cytokine release and HSP 72 expression in human peripheral blood polymorphonuclear cells (PBMCs) is lacking...
  12. ncbi request reprint Glutamine and heat shock protein expression
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nutrition 18:225-8. 2002
    ..g., cardiac, vascular, and transplantation) or in the critically ill...
  13. ncbi request reprint Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control
    P E Wischmeyer
    Department of Anesthesia and Critical Care and Clinical Pharmacology, The University of Chicago, Chicago, IL, USA
    Crit Care Med 29:2075-80. 2001
    ..Previous clinical studies in seriously ill patients suggest a beneficial effect of glutamine on infectious morbidity, but no trials have examined possible clinical benefits in severely burned patients...
  14. ncbi request reprint Glutamine induces heat shock protein and protects against endotoxin shock in the rat
    P E Wischmeyer
    Division of Clinical Pharmacology, The University of Chicago, Chicago, Illinois 60637, USA
    J Appl Physiol 90:2403-10. 2001
    ..Thus glutamine appears to be a clinically viable enhancer of HSP expression and may prove beneficial in the therapy of sepsis and sepsis-induced organ injury...
  15. ncbi request reprint Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia
    P E Wischmeyer
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois 60637, USA
    Shock 16:398-402. 2001
    ..Thus, one explanation for the clinical benefits observed from GLN-supplementation may be related to the attenuation of pro-inflammatory cytokines...
  16. ncbi request reprint Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression
    Zhi Yong Peng
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, 80262, USA
    JPEN J Parenter Enteral Nutr 30:373-8; discussion 379. 2006
    ..We hypothesize that GLN's attenuation of cellular metabolic dysfunction is dependent on presence of heat shock factor-1 (HSF-1)...
  17. ncbi request reprint Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 33:1206-13. 2005
    ..The aim of this study was to assess the ability of GLN to enhance pulmonary HSP expression, attenuate lung injury, and improve survival after sepsis in the rat...
  18. doi request reprint Glutamine in critical illness: the time has come, the time is now
    Lindsay Rae B Weitzel
    Department of Anesthesiology, Translational Pharmaconutrition TPN Research Laboratories, University of Colorado Denver, Research Complex 2, Box 8602, 12700 East 19th Avenue, Aurora, CO 80045, USA
    Crit Care Clin 26:515-25, ix-x. 2010
    ..A large and growing body of clinical data shows that in well-defined critically ill patient groups GLN can be a life-saving intervention...
  19. pmc Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Leprino Office Building LOB, 12401 East 17th Avenue, B113, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 373:445-9. 2008
    ..These are the first data describing a direct effect of GLN on Cul-1 deneddylation and provide a possible mechanistic explanation for GLN's anti-inflammatory effects...
  20. ncbi request reprint Glutamine attenuates endotoxin-induced lung metabolic dysfunction: potential role of enhanced heat shock protein 70
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Nutrition 21:214-23. 2005
    ..Our aim was to determine whether GLN could upregulate HSP-70 and attenuate metabolic dysfunction in lung tissue after sublethal endotoxemia...
  21. doi request reprint A survey of inhalational anaesthetic abuse in anaesthesia training programmes
    J E Wilson
    Department of Anaesthesia, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Anaesthesia 63:616-20. 2008
    ..The concern about substance abuse is not unique to American anaesthetists. Countries around the world deal with similar substance abuse issues...
  22. ncbi request reprint Glutamine's protection against cellular injury is dependent on heat shock factor-1
    Angela L Morrison
    Univ of Colorado Health Sciences Center, Dept of Anesthesiology, 4200 E 9th Ave, Denver, CO 80262, USA
    Am J Physiol Cell Physiol 290:C1625-32. 2006
    ..Furthermore, the mechanism of GLN-mediated protection against injury appears to involve an increase in nuclear HSF-1 content before stress and increased HSF-1 promoter binding and phosphorylation...
  23. doi request reprint Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients
    Robert MacLaren
    Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    JPEN J Parenter Enteral Nutr 32:412-9. 2008
    ..The purpose of this study is to evaluate erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric enteral nutrition (EN)...
  24. doi request reprint Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness
    Lindsay Rae B Weitzel
    Department of Anesthesiology, Anschutz Medical Campus, University of Colorado Denver, Denver, Colorado 80045, USA
    Curr Opin Anaesthesiol 22:177-83. 2009
    ..Further, targeted administration of these 'pharmaconutrients' may reverse or improve this dysfunction and improve clinical outcome...
  25. doi request reprint Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    JPEN J Parenter Enteral Nutr 32:371-6. 2008
    ..The authors hypothesized GLN-mediated enhancement of O-glycosylation and subsequent phosphorylation of key transcription factors in the HSP70 pathway would lead to increased HSP70 expression following experimental sepsis...
  26. ncbi request reprint Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression
    Kristen D Singleton
    Univ of Colorado Health Sciences Center, Dept of Anesthesiology, Denver, CO 80262, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1839-45. 2007
    ..These results confirm our hypothesis that HSP70 expression is required for GLN's effects on survival, tissue injury, and the inflammatory response after global inflammatory injury...
  27. ncbi request reprint Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression
    Zhi Yong Peng
    Department of Anesthesiology, University of Colorado Health Science Center, Denver, 80262, USA
    JPEN J Parenter Enteral Nutr 30:400-6; discussion 406-7. 2006
    ..This study tested the hypothesis that GLN-mediated activation of the HSP pathway is responsible for improved survival and attenuation of iNOS expression after an inflammatory cytokine-induced injury...
  28. ncbi request reprint GLUTAMINE PREVENTS ACTIVATION OF NF-kappaB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Shock 24:583-9. 2005
    ..GLN also showed an inhibition of increases in iNOS expression. The antiinflammatory effect of GLN was associated with attenuation of ARDS and mortality...
  29. ncbi request reprint Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Campus Box B113, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L956-61. 2006
    ..The specific absence of HSP70 gene expression also leads to increased mortality after septic insult...
  30. doi request reprint Performance-enhancing sports supplements: role in critical care
    Lindsay Rae B Weitzel
    Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA
    Crit Care Med 37:S400-9. 2009
    ..It is very possible that, under the supervision of a physician, many of these agents may prove beneficial in the prevention and treatment of post-intensive care unit weakness...
  31. pmc Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity
    Christine R Hamiel
    Department of Anesthesiology, University of Colorado Health Sciences Center, Aurora, 80045, USA
    Am J Physiol Cell Physiol 297:C1509-19. 2009
    ..This is an important mechanistic description of a pathway that appears responsible for GLN-mediated HSP70 expression...
  32. ncbi request reprint Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat
    K D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Eur Surg Res 35:486-91. 2003
    ..The aim of the present study was to evaluate the influence of the length of cecum ligated, independent of needle size, as a determinant of mortality...
  33. ncbi request reprint Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia
    Kristen D Singleton
    Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Shock 25:295-9. 2006
    ..Enhanced expression of HSP-70 may be an important mechanism leading to enhanced survival via GLN. These data indicate that oral GLN may useful in prevention of mortality from heatstroke in at risk populations...
  34. doi request reprint The future of critical care nutrition therapy
    Paul E Wischmeyer
    Department of Anesthesiology, University of Colorado at Denver School of Medicine, 12700 East 19th Avenue, Box 8602, RC2 P15 7120, Aurora, CO 80045, USA
    Crit Care Clin 26:433-41, vii. 2010
    ....
  35. ncbi request reprint Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition
    James Landzinski
    Department of Pharmacy, Georgetown University Hospital, Washington, DC, USA
    JPEN J Parenter Enteral Nutr 32:45-50. 2008
    ..This study evaluated gastric emptying in patients with limited GRV (tolerant group) vs volumes > or =150 mL (intolerant group) and whether prokinetic therapy improves gastric motility in intolerant patients...
  36. ncbi request reprint Can glutamine turn off the motor that drives systemic inflammation?
    Paul E Wischmeyer
    Crit Care Med 33:1175-8. 2005
  37. ncbi request reprint Parenteral glutamine increases serum heat shock protein 70 in critically ill patients
    Thomas R Ziegler
    Department of Medicine Center for Clinical and Molecular Nutrition, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Intensive Care Med 31:1079-86. 2005
    ..We examined whether Gln-supplemented parenteral nutrition (PN) increases serum HSP-70 levels in critically ill patients...
  38. ncbi request reprint Prevention of chemotherapy and radiation toxicity with glutamine
    Diane M F Savarese
    Division of Hematology Oncology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Cancer Treat Rev 29:501-13. 2003
    ..We reviewed the available data on the use of glutamine to decrease the incidence and severity of adverse effects due to chemotherapy and/or radiation in cancer patients...

Research Grants9

  1. Glutamine's role in cardioprotection from cardiac bypass
    Paul Wischmeyer; Fiscal Year: 2007
    ..Data will be collected on cardiac function (cardiac output), occurrence of arrhythmias, need for vasopressor therapy, length of post-operative ventilation, ICU stay; and survival trends. ..
  2. Effect of Glutamine on HSP-70 Expression in ICU patients
    Paul Wischmeyer; Fiscal Year: 2007
    ..We believe this study will demonstrate that GLN is the first clinically viable enhancer of HSP-70 expression. The potential for such an agent to reduce morbidity/mortality in surgical and critical illness is significant. ..
  3. Mechanism of Heat Shock Protein Induction by Glutamine
    Paul E Wischmeyer; Fiscal Year: 2010
    ....