B Winther

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. doi request reprint Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705, Fifth Avenue, DeSoto Street, Pittsburgh, PA 15213, USA
    Eur Arch Otorhinolaryngol 266:199-205. 2009
  2. doi request reprint Decreased rhinovirus shedding after intranasal oxymetazoline application in adults with induced colds compared with intranasal saline
    Birgit Winther
    Department of Otolaryngology, University of Virginia Health System, Charlottesville, 22908 0713, USA
    Am J Rhinol Allergy 24:374-7. 2010
  3. pmc Acute cough: a diagnostic and therapeutic challenge
    Peter V Dicpinigaitis
    Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Cough 5:11. 2009
  4. doi request reprint Rhinovirus contamination of surfaces in homes of adults with natural colds: transfer of virus to fingertips during normal daily activities
    B Winther
    Department of Otolaryngology, University of Virginia Health System, Charlottesville, Virginia 22908 0713, USA
    J Med Virol 83:906-9. 2011
  5. doi request reprint Rhinovirus infections in the upper airway
    Birgit Winther
    University of Virginia Health System, Department of Otolaryngology, Head and Neck Surgery, P O Box 800713, Charlottesville, VA 22908, USA
    Proc Am Thorac Soc 8:79-89. 2011
  6. doi request reprint Location of bacterial biofilm in the mucus overlying the adenoid by light microscopy
    Birgit Winther
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Arch Otolaryngol Head Neck Surg 135:1239-45. 2009
  7. ncbi request reprint Middle ear pressure in preschool age children: influence of respiratory illness, season, and picornavirus or bacteria in the nasopharynx
    Birgit Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Acta Otolaryngol 127:796-800. 2007
  8. ncbi request reprint Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity
    Birgit Winther
    Department of Otolaryngology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    J Med Virol 79:1606-10. 2007
  9. ncbi request reprint Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season
    Birgit Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    J Med Virol 78:644-50. 2006
  10. ncbi request reprint Radiopaque contrast dye in nasopharynx reaches the middle ear during swallowing and/or yawning
    B Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville 22908, USA
    Acta Otolaryngol 125:625-8. 2005

Collaborators

Detail Information

Publications28

  1. doi request reprint Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705, Fifth Avenue, DeSoto Street, Pittsburgh, PA 15213, USA
    Eur Arch Otorhinolaryngol 266:199-205. 2009
    ..Cytokine polymorphisms may be one of an expectedly large number of genetic factors contributing to the known heritability of OM...
  2. doi request reprint Decreased rhinovirus shedding after intranasal oxymetazoline application in adults with induced colds compared with intranasal saline
    Birgit Winther
    Department of Otolaryngology, University of Virginia Health System, Charlottesville, 22908 0713, USA
    Am J Rhinol Allergy 24:374-7. 2010
    ..ICAM-1 is the major receptor used by rhinovirus to gain entry to human cells. The objective of this study was to assess the effect of OMZ on geometric mean titer of rhinovirus in nasal lavage fluid after rhinovirus inoculation...
  3. pmc Acute cough: a diagnostic and therapeutic challenge
    Peter V Dicpinigaitis
    Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
    Cough 5:11. 2009
    ..The current strategies for acute cough management need to be reassessed, with a focus on developing new, reliable products and formulations with proven efficacy and safety...
  4. doi request reprint Rhinovirus contamination of surfaces in homes of adults with natural colds: transfer of virus to fingertips during normal daily activities
    B Winther
    Department of Otolaryngology, University of Virginia Health System, Charlottesville, Virginia 22908 0713, USA
    J Med Virol 83:906-9. 2011
    ..Infectious rhinovirus found on surfaces in homes of people with colds can be transferred to fingertips, but infectivity of virus in mucus declines by 24 hr after deposition...
  5. doi request reprint Rhinovirus infections in the upper airway
    Birgit Winther
    University of Virginia Health System, Department of Otolaryngology, Head and Neck Surgery, P O Box 800713, Charlottesville, VA 22908, USA
    Proc Am Thorac Soc 8:79-89. 2011
    ..Most research has been done in young healthy adults with self-limiting experimental and natural rhinovirus infections, and this may set the stage for understanding rhinovirus infections in the ear, sinus, and lower airways...
  6. doi request reprint Location of bacterial biofilm in the mucus overlying the adenoid by light microscopy
    Birgit Winther
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Arch Otolaryngol Head Neck Surg 135:1239-45. 2009
    ..To determine the location of bacteria and biofilm in adenoid tissue and in mucus overlying the adenoid...
  7. ncbi request reprint Middle ear pressure in preschool age children: influence of respiratory illness, season, and picornavirus or bacteria in the nasopharynx
    Birgit Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Acta Otolaryngol 127:796-800. 2007
    ..Middle ear pressure was affected by respiratory illness and season; picornavirus (without illness) or pathogenic bacteria in the nasopharynx had no or minor effect...
  8. ncbi request reprint Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity
    Birgit Winther
    Department of Otolaryngology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    J Med Virol 79:1606-10. 2007
    ..Adults with colds commonly contaminate environmental surfaces with rhinovirus; virus on surfaces can be transferred to a fingertip during normal daily activities...
  9. ncbi request reprint Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season
    Birgit Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    J Med Virol 78:644-50. 2006
    ..51/child-month), episodic, and usually associated with brief illness; one fifth of infections were asymptomatic. The infection rate was highest in fall; infections in winter occurred at the same rate as in spring and summer...
  10. ncbi request reprint Radiopaque contrast dye in nasopharynx reaches the middle ear during swallowing and/or yawning
    B Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia Health System, Charlottesville 22908, USA
    Acta Otolaryngol 125:625-8. 2005
    ..Contrast dye in the nasopharynx reaches the middle ear during swallowing and yawning in normal adults. This suggests that displacement of bacteria in nasopharyngeal secretion to the middle ear may occur frequently during sleep...
  11. ncbi request reprint Cross-linked fibrin in the nasal fluid of patients with the common cold
    Birgit Winther
    University of Virginia Health System, Department of Otolaryngology, Head and Neck Surgery, Charlottesville, VA, 22908, USA
    Clin Infect Dis 34:708-10. 2002
    ..8+/-0.4 microgram/mL to a peak of 2.4+/-0.7 microgram/mL (P=.0008) on day 4 after inoculation of the virus, but the fibrin concentration remained at baseline levels in the 4 uninfected control subjects...
  12. ncbi request reprint Viral respiratory infection in schoolchildren: effects on middle ear pressure
    Birgit Winther
    University of Virginia Health System, Charlottesville, Virginia 22906, USA
    Pediatrics 109:826-32. 2002
    ..To evaluate the effect of uncomplicated viral respiratory infections (colds) on middle ear pressure in healthy school-aged children...
  13. doi request reprint Daily tympanometry as a functional measure of middle ear status and Eustachian tube function
    William J Doyle
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Auris Nasus Larynx 36:20-5. 2009
    ....
  14. ncbi request reprint Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season
    Birgit Winther
    Department of Otolaryngology, University of Virginia Health System, Charlottesville, Virginia, USA
    Pediatrics 119:1069-75. 2007
    ..We determined the incidence of otitis-media complications in young children when referenced to cold-like illnesses and to concurrent virus recovery from the nasopharynx...
  15. ncbi request reprint Nasopharyngeal reservoir of bacterial otitis media and sinusitis pathogens in adults during wellness and viral respiratory illness
    David H Chi
    Department of Otolaryngology Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22906 0713, USA
    Am J Rhinol 17:209-14. 2003
    ..The carriage rate of pathogenic bacteria in the nasopharynx (NP) was determined using three separate techniques for obtaining samples...
  16. pmc The incidence, prevalence and burden of OM in unselected children aged 1-8 years followed by weekly otoscopy through the "common cold" season
    Ellen M Mandel
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Pediatr Otorhinolaryngol 72:491-9. 2008
    ..Often overlooked in past studies are the contributions of cold-like illnesses (CLIs) and sampling interval to those estimates...
  17. ncbi request reprint Bacterial pathogens of otitis media and sinusitis: detection in the nasopharynx with selective agar media
    S Dudley
    Department of Clinical Microbiology, University of Virginia Health System, Charlottesville, 22908, USA
    J Lab Clin Med 138:338-42. 2001
    ..0004). Selective agars were more accurate than standard agars for detecting otitis pathogens in the nasopharynx, where they are a common part of normal flora in healthy children...
  18. doi request reprint Impact of oseltamivir treatment on the incidence and course of acute otitis media in children with influenza
    Birgit Winther
    Department of Otolaryngology, Head and Neck Surgery, University of Virginia, PO Box 800713, Charlottesville, VA 22908 0713, USA
    Int J Pediatr Otorhinolaryngol 74:684-8. 2010
    ..Acute otitis media (AOM) is the most common complication of pediatric influenza, and imposes a substantial health care burden. We examined the influence of oseltamivir treatment on the incidence and course of AOM in children with influenza...
  19. ncbi request reprint Weekly point prevalence of Streptococcus pneumoniae, Hemophilus influenzae and Moraxella catarrhalis in the upper airways of normal young children: effect of respiratory illness and season
    J Owen Hendley
    Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA
    APMIS 113:213-20. 2005
    ..82, p=0.01). Detection of bacteria varied with the amount of secretion in the sample. This variation accounts for the apparent differences in bacterial carriage during illness vs. wellness and during different seasons...
  20. ncbi request reprint Symptom profile of common colds in school-aged children
    Diane E Pappas
    Division of General Pediatrics, Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    Pediatr Infect Dis J 27:8-11. 2008
    ..Subjective symptoms include nasal congestion, feverishness, headache, and sore throat. School-aged children may provide a more accurate picture of the symptom profile during colds because they can self-report...
  21. ncbi request reprint Combined antiviral-antimediator treatment for the common cold
    Jack M Gwaltney
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Infect Dis 186:147-54. 2002
    ..IFN-alpha2b added to the effectiveness of chlorpheniramine and ibuprofen and was well tolerated...
  22. doi request reprint Rate of concurrent otitis media in upper respiratory tract infections with specific viruses
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Otolaryngol Head Neck Surg 135:17-21. 2009
    ..New OM episodes are usually coincident with a viral upper respiratory tract infection (vURTI), but there are conflicting data regarding the association between specific viruses and OM...
  23. ncbi request reprint Expression of ICAM-1 in nasal epithelium and levels of soluble ICAM-1 in nasal lavage fluid during human experimental rhinovirus infection
    Birgit Winther
    University of Virginia Health System, Department of Internal Medicine, Box 800473, Charlottesville, VA 22908, USA
    Arch Otolaryngol Head Neck Surg 128:131-6. 2002
    ..Up-regulation of ICAM-1 receptor expression on nasal epithelial cells occurred within 24 hours after inoculation in experimental rhinovirus infections (prior to onset of symptoms) and declined promptly by day 5...
  24. ncbi request reprint Temporal relationships for cold-like illnesses and otitis media in sibling pairs
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 26:778-81. 2007
    ..Interference with intrafamily CLI transmission may present a strategy for OM prophylaxis in high risk children. This study estimated factors relevant to strategy efficiency...
  25. ncbi request reprint A high prevalence of new onset otitis media during parent diagnosed common colds
    Birgit Winther
    Department of Otolaryngology, University of Virginia Health System, United States
    Int J Pediatr Otorhinolaryngol 70:1725-30. 2006
    ..A prospective format was used to determine the coincidence of otitis media and parent diagnosed cold/flu episodes in young children followed over a typical cold/flu season...
  26. ncbi request reprint Computed tomography imaging of the maxillary and ethmoid sinuses in children with short-duration purulent rhinorrhea
    R H Schwartz
    Department of Pediatrics, Inova Fairfax Hospital for Children, Virginia, USA
    Otolaryngol Head Neck Surg 124:160-3. 2001
    ..There are no comparable data for children. The purpose of this study was to document the sinus CT findings in children with short-duration purulent rhinorrhea...
  27. doi request reprint Daily tympanometry for high-resolution measurement of the time between onset of cold-like illness and middle ear effusion
    William J Doyle
    Department of Otolaryngology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Laryngoscope 118:1066-71. 2008
    ..Tympanometry is a simple method to assess middle ear pressure (MEP) and the presence of middle ear effusion (MEE), a marker of otitis media (OM)...
  28. doi request reprint Upper respiratory virus detection without parent-reported illness in children is virus-specific
    Cuneyt M Alper
    Department of Otolaryngology, Children s Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, 3705 Fifth Avenue DeSoto Street, Pittsburgh, PA 15213, United States
    J Clin Virol 43:120-2. 2008
    ..Viral upper respiratory tract infection (vURI) may or may not present with a cold/flu-like illness (CFLI)...