Carolee Winstein

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Hemispheric specialization in the co-ordination of arm and trunk movements during pointing in patients with unilateral brain damage
    Danilo Y Esparza
    Neurological Science Research Centre, Universite de Montreal, Montreal, Quebec, Canada
    Exp Brain Res 148:488-97. 2003
  2. doi request reprint Contextual interference effect: elaborative processing or forgetting-reconstruction? A post hoc analysis of transcranial magnetic stimulation-induced effects on motor learning
    Chien Ho Janice Lin
    Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    J Mot Behav 40:578-86. 2008
  3. ncbi request reprint The mirror neuron system: a neural substrate for methods in stroke rehabilitation
    Kathleen A Garrison
    Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy, Brain and Creativity Institute, University of Southern California, Los Angeles, CA 90089 9006, USA
    Neurorehabil Neural Repair 24:404-12. 2010
  4. pmc A transformative subfield in rehabilitation science at the nexus of new technologies, aging, and disability
    Carolee J Winstein
    Division Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California Los Angeles, CA, USA Department of Neurology, Keck School of Medicine, University of Southern California Los Angeles, CA, USA
    Front Psychol 3:340. 2012
  5. pmc Planning and adjustments for the control of reach extent in a virtual environment
    Jill Campbell Stewart
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP 155, Los Angeles, CA 90089 9006, USA
    J Neuroeng Rehabil 10:27. 2013
  6. pmc Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE): a randomized controlled trial protocol
    Carolee J Winstein
    Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry University of Southern California, Los Angeles, CA, USA
    BMC Neurol 13:5. 2013
  7. pmc Intervention to enhance skilled arm and hand movements after stroke: A feasibility study using a new virtual reality system
    Jill Campbell Stewart
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, Los Angeles, CA, USA
    J Neuroeng Rehabil 4:21. 2007
  8. pmc Socially assistive robotics for post-stroke rehabilitation
    Maja J Matarić
    Computer Science Department, University of Southern California, Los Angeles, CA, USA
    J Neuroeng Rehabil 4:5. 2007
  9. pmc Pediatric endurance and limb strengthening for children with cerebral palsy (PEDALS)--a randomized controlled trial protocol for a stationary cycling intervention
    Eileen G Fowler
    Department of Orthopedics, UCLA Orthopaedic Hospital Center for Cerebral Palsy, Los Angeles, CA, USA
    BMC Pediatr 7:14. 2007
  10. pmc The immediate and long-term effects of exercise and patient education on physical, functional, and quality-of-life outcome measures after single-level lumbar microdiscectomy: a randomized controlled trial protocol
    David M Selkowitz
    Department of Physical Therapy Education, Western University of Health Sciences, 309 E Second St, Pomona, CA 91766, USA
    BMC Musculoskelet Disord 7:70. 2006

Research Grants

  1. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2002
  2. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2003
  3. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2004
  4. CI Therapy and Novel Virtual Environments
    Carolee Winstein; Fiscal Year: 2005
  5. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2004

Detail Information

Publications40

  1. ncbi request reprint Hemispheric specialization in the co-ordination of arm and trunk movements during pointing in patients with unilateral brain damage
    Danilo Y Esparza
    Neurological Science Research Centre, Universite de Montreal, Montreal, Quebec, Canada
    Exp Brain Res 148:488-97. 2003
    ....
  2. doi request reprint Contextual interference effect: elaborative processing or forgetting-reconstruction? A post hoc analysis of transcranial magnetic stimulation-induced effects on motor learning
    Chien Ho Janice Lin
    Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    J Mot Behav 40:578-86. 2008
    ..Unlike the prediction of the forgetting-reconstruction hypothesis, adding perturbation during Blocked Practice did not significantly enhance motor learning...
  3. ncbi request reprint The mirror neuron system: a neural substrate for methods in stroke rehabilitation
    Kathleen A Garrison
    Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy, Brain and Creativity Institute, University of Southern California, Los Angeles, CA 90089 9006, USA
    Neurorehabil Neural Repair 24:404-12. 2010
    ..Here the authors review research into each condition of practice, and discuss the relevance of the mirror neuron system to stroke recovery...
  4. pmc A transformative subfield in rehabilitation science at the nexus of new technologies, aging, and disability
    Carolee J Winstein
    Division Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California Los Angeles, CA, USA Department of Neurology, Keck School of Medicine, University of Southern California Los Angeles, CA, USA
    Front Psychol 3:340. 2012
    ..We conclude with a set of recommendations for the design of interactive media systems to both increase acceptability and stimulate research...
  5. pmc Planning and adjustments for the control of reach extent in a virtual environment
    Jill Campbell Stewart
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, 1540 Alcazar Street, CHP 155, Los Angeles, CA 90089 9006, USA
    J Neuroeng Rehabil 10:27. 2013
    ..The purpose of this study was to directly compare the use of planning and adjustments to control extent for unconstrained reach actions performed in an immersive VE to those performed in an analogous real-world environment (RWE)...
  6. pmc Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE): a randomized controlled trial protocol
    Carolee J Winstein
    Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry University of Southern California, Los Angeles, CA, USA
    BMC Neurol 13:5. 2013
    ..Two secondary objectives are to compare ASAP to a true (active monitoring only) usual and customary (UCC) therapy group and to compare DEUCC and UCC...
  7. pmc Intervention to enhance skilled arm and hand movements after stroke: A feasibility study using a new virtual reality system
    Jill Campbell Stewart
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, Los Angeles, CA, USA
    J Neuroeng Rehabil 4:21. 2007
    ..We describe four VR tasks that were developed and tested to improve arm and hand movement skills for individuals with hemiparesis...
  8. pmc Socially assistive robotics for post-stroke rehabilitation
    Maja J Matarić
    Computer Science Department, University of Southern California, Los Angeles, CA, USA
    J Neuroeng Rehabil 4:5. 2007
    ..We demonstrate the approach with an implemented and tested post-stroke recovery robot and discuss its potential for effectiveness...
  9. pmc Pediatric endurance and limb strengthening for children with cerebral palsy (PEDALS)--a randomized controlled trial protocol for a stationary cycling intervention
    Eileen G Fowler
    Department of Orthopedics, UCLA Orthopaedic Hospital Center for Cerebral Palsy, Los Angeles, CA, USA
    BMC Pediatr 7:14. 2007
    ..However, few studies have examined the potential benefits of cardiorespiratory fitness exercises in this patient population...
  10. pmc The immediate and long-term effects of exercise and patient education on physical, functional, and quality-of-life outcome measures after single-level lumbar microdiscectomy: a randomized controlled trial protocol
    David M Selkowitz
    Department of Physical Therapy Education, Western University of Health Sciences, 309 E Second St, Pomona, CA 91766, USA
    BMC Musculoskelet Disord 7:70. 2006
    ....
  11. ncbi request reprint Does the cholinesterase inhibitor, donepezil, benefit both declarative and non-declarative processes in mild to moderate Alzheimer's disease?
    Carolee J Winstein
    University of Southern California, Los Angeles, CA 90089 9006, USA
    Curr Alzheimer Res 4:273-6. 2007
    ..When the data were examined for coincidental changes in the two outcome measures together they are suggestive of a benefit from donepezil treatment for non-declarative and declarative processes...
  12. ncbi request reprint Methods for a multisite randomized trial to investigate the effect of constraint-induced movement therapy in improving upper extremity function among adults recovering from a cerebrovascular stroke
    Carolee J Winstein
    Department of Biokinesiology and Physical Therapy, University of Southern California, 1540 E Alcazar Street, CHP 155, Los Angeles, CA 90089 9006, USA
    Neurorehabil Neural Repair 17:137-52. 2003
    ..Secondary outcomes concern function, behavior, and compliance. This is the first multisite, single-blind RCT of a formal training intervention for upper extremity rehabilitation in subacute stroke in the United States...
  13. ncbi request reprint A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomes
    Carolee J Winstein
    Dept of Biokinesiology and Physical Therapy, University of Southern California, Health Sciences Campus, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089 9006, USA
    Arch Phys Med Rehabil 85:620-8. 2004
    ..To evaluate the immediate and long-term effects of 2 upper-extremity rehabilitation approaches for stroke compared with standard care in participants stratified by stroke severity...
  14. ncbi request reprint The best we can be is yet to come
    Carolee J Winstein
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, Los Angeles, CA 90033, USA
    Phys Ther 89:1236-49. 2009
    ..She was elected a Catherine Worthingham Fellow in 2003...
  15. pmc Neural correlate of the contextual interference effect in motor learning: a kinematic analysis
    Chien Ho Janice Lin
    School of Dentistry, University of Southern California, Los Angeles, CA, USA
    J Mot Behav 41:232-42. 2009
    ..The authors' data suggest that increased corticomotor activity during high CI practice may reflect preferential processing of the temporal parameter of the task...
  16. ncbi request reprint Hemisphere specific impairments in reach-to-grasp control after stroke: effects of object size
    Jarugool Tretriluxana
    Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, Department of Neurology, Keck School of Medicine, Los Angeles, CA 90033, USA
    Neurorehabil Neural Repair 23:679-91. 2009
    ..Based on a bilateral model, the authors hypothesized that after unilateral stroke there would be hemisphere-specific deficits revealed by the ipsilesional limb...
  17. ncbi request reprint Manual asymmetries in grasp pre-shaping and transport-grasp coordination
    Jarugool Tretriluxana
    Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 East Alcazar Street CHP155, Los Angeles, CA 90033, USA
    Exp Brain Res 188:305-15. 2008
    ..Our findings compliment the specialization previously observed for pointing movements of the dominant and non-dominant hemispheric/limb system and the coordinated control of complex movements and visuo-spatial components, respectively...
  18. ncbi request reprint Socially assistive robotics for stroke and mild TBI rehabilitation
    Maja Mataric
    Department of Computer Science, University of Southern California, Los Angeles, USA
    Stud Health Technol Inform 145:249-62. 2009
    ....
  19. ncbi request reprint Effects of task-specific locomotor and strength training in adults who were ambulatory after stroke: results of the STEPS randomized clinical trial
    Katherine J Sullivan
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089, USA
    Phys Ther 87:1580-602. 2007
    ..A phase II, single-blinded, randomized clinical trial was conducted to determine the effects of combined task-specific and lower-extremity (LE) strength training to improve walking ability after stroke...
  20. ncbi request reprint An intensive, progressive exercise program reduces disability and improves functional performance in patients after single-level lumbar microdiskectomy
    Kornelia Kulig
    Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 E Alcazar St, CHP 155, Los Angeles, CA 90089 9006, USA
    Phys Ther 89:1145-57. 2009
    ..Restoration of physical function following lumbar microdiskectomy may be influenced by the postoperative care provided...
  21. pmc A functional threshold for long-term use of hand and arm function can be determined: predictions from a computational model and supporting data from the Extremity Constraint-Induced Therapy Evaluation (EXCITE) Trial
    Nicolas Schweighofer
    Division of Biokinesiology and Physical Therapy at the School of Dentistry, and Department of Computer Science, University of Southern California, Los Angeles, CA 90089, USA
    Phys Ther 89:1327-36. 2009
    ..A previous neurocomputational model predicted that if the dose of therapy is sufficient to bring performance above a certain threshold, training can be stopped...
  22. ncbi request reprint Effect of task practice order on motor skill learning in adults with Parkinson disease: a pilot study
    Chien Ho Janice Lin
    School of Dentistry, University of Southern California, Los Angeles, CA 90089, USA
    Phys Ther 87:1120-31. 2007
    ..Random practice of motor tasks has been shown to enhance motor learning. The purpose of this study was to investigate the effects of task practice order (random, blocked) on motor learning in adults with Parkinson disease (PD)...
  23. ncbi request reprint Virtual reality applications for addressing the needs of those aging with disability
    Albert Rizzo
    University of Southern California, Institute for Creative Technologies, Playa Vista, CA 90064, USA
    Stud Health Technol Inform 163:510-6. 2011
    ..This is the theme of the research to be presented at this MMVR workshop...
  24. pmc Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study
    Yun Dong
    Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 1769, USA
    Neurorehabil Neural Repair 21:412-28. 2007
    ..Previous studies report that motor recovery after partial destruction of the primary motor cortex (M1) may be associated with adaptive functional reorganization within spared M1...
  25. doi request reprint Neural correlates of the contextual interference effect in motor learning: a transcranial magnetic stimulation investigation
    Chien Ho Janice Lin
    Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California, Los Angeles, CA, USA
    J Mot Behav 42:223-32. 2010
    ..Results contribute to knowledge of the critical and specific role that M1 plays in generating a learning advantage following high-interference practice conditions...
  26. ncbi request reprint Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke
    Yun Dong
    Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA
    Stroke 37:1552-5. 2006
    ..Functional brain imaging after stroke offers insight into motor network adaptations. This exploratory study examined whether motor cortical activation captured during arm-focused therapy can predict paretic hand functional gains...
  27. ncbi request reprint A systematic review of voluntary arm recovery in hemiparetic stroke: critical predictors for meaningful outcomes using the international classification of functioning, disability, and health
    Shu Ya Chen
    Division of Biokinesiology and Physical Therapy, School of Dentistry, University of Southern California, Los Angeles, California, USA
    J Neurol Phys Ther 33:2-13. 2009
    ....
  28. ncbi request reprint Bimanual training after stroke: are two hands better than one?
    Dorian K Rose
    Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA
    Top Stroke Rehabil 11:20-30. 2004
    ..Based on our review, we suggest a set of prerequisite task features and patient characteristics for consideration in the application of bimanual training protocols for poststroke rehabilitation...
  29. doi request reprint Task-oriented rehabilitation robotics
    Nicolas Schweighofer
    Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089 9006, USA
    Am J Phys Med Rehabil 91:S270-9. 2012
    ....
  30. ncbi request reprint Neural substrates of motor memory consolidation depend on practice structure
    Shailesh S Kantak
    Motor Behavior and Neurorehabilitation Laboratory, Division of Biokinesiology and Physical Therapy at the Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, California, USA
    Nat Neurosci 13:923-5. 2010
    ..We conclude that neural substrates of motor-memory consolidation are modulated by practice structure...
  31. ncbi request reprint Impact of explicit information on implicit motor-sequence learning following middle cerebral artery stroke
    Lara A Boyd
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, 3056 Robinson, Mail Stop 2002, 3901 Rainbow Blvd, Kansas City, KS 66160 7601, USA
    Phys Ther 83:976-89. 2003
    ..The purpose of this work was to systematically investigate the impact of explicit information (EI) on implicit motor-sequence learning using the ipsilesional arm in people with damage in the middle cerebral artery (MCA) distribution...
  32. pmc Providing explicit information disrupts implicit motor learning after basal ganglia stroke
    Lara A Boyd
    Department of Physical Therapy and Rehabilitation Sciences, Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Learn Mem 11:388-96. 2004
    ..This may be due to the increased demand placed on working memory by explicit information. Thus, basal ganglia integrity may be a crucial factor in determining the efficacy of explicit information for implicit motor-sequence learning...
  33. ncbi request reprint Cerebellar stroke impairs temporal but not spatial accuracy during implicit motor learning
    Lara A Boyd
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, 3056 Robinson, Mail Stop 2002, 3901 Rainbow Boulevard, Kansas City 66160 7601, USA
    Neurorehabil Neural Repair 18:134-43. 2004
    ..The purpose of this study was to determine if specific components (spatial or temporal) of an implicit motor-tracking task were affected by cerebellar stroke...
  34. ncbi request reprint The EXCITE trial: attributes of the Wolf Motor Function Test in patients with subacute stroke
    Steven L Wolf
    Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA 30345, USA
    Neurorehabil Neural Repair 19:194-205. 2005
    ..The WMFT discriminates higher from lower functioning participants tested across research sites. Comparable findings using the FMA support the criterion validity of the WMFT...
  35. ncbi request reprint Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial
    Steven L Wolf
    Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    JAMA 296:2095-104. 2006
    ....
  36. ncbi request reprint Reliability of intracortical and corticomotor excitability estimates obtained from the upper extremities in chronic stroke
    Lisa Koski
    Division of Geriatrics, Faculty of Medicine, Department of Neurology and Neurosurgery, McGill University, Canada
    Neurosci Res 58:19-31. 2007
    ..Due to high intrasubject variability, the use of some excitability parameters as indicators of functional neuroplasticity in response to treatment may be limited to interventions with large effect sizes...
  37. ncbi request reprint Learning implicitly: effects of task and severity after stroke
    Lara A Boyd
    School of Rehabilitation Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Neurorehabil Neural Repair 21:444-54. 2007
  38. pmc Retention of upper limb function in stroke survivors who have received constraint-induced movement therapy: the EXCITE randomised trial
    Steven L Wolf
    Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lancet Neurol 7:33-40. 2008
    ..The EXCITE trial has previously shown the efficacy of this intervention for patients 3-9 months poststroke who were followed-up for the next 12 months. We assessed the retention of improvements 24 months after the intervention...
  39. ncbi request reprint Determining the optimal challenge point for motor skill learning in adults with moderately severe Parkinson's disease
    Somporn Onla-or
    Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
    Neurorehabil Neural Repair 22:385-95. 2008
    ..To test the predictions of the Challenge Point Framework (CPF) for motor learning in individuals with Parkinson's disease (PD) by manipulating nominal task difficulty and conditions of practice...
  40. ncbi request reprint The Excite Trial: relationship of intensity of constraint induced movement therapy to improvement in the wolf motor function test
    Steven L Wolf
    Department of Rehabilitation Medicine, Division of Physical Therapy, Emory University School of Medicine, Atlanta, GA 30322, USA
    Restor Neurol Neurosci 25:549-62. 2007
    ..To examine the relationship between change scores on the log mean Wolf Motor Function Test (lmWMFT) and the intensity of supervised Constraint Induced Movement Therapy (CIMT) in participants with subacute and chronic stroke...

Research Grants5

  1. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2002
    ..abstract_text> ..
  2. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2003
    ..abstract_text> ..
  3. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2004
    ..abstract_text> ..
  4. CI Therapy and Novel Virtual Environments
    Carolee Winstein; Fiscal Year: 2005
    ..Phase II will establish a broader application in the clinical environment, incorporate patient perspectives, and longer-term outcomes. ..
  5. Brain and Behavior Correlates of Arm Rehabilitation
    Carolee Winstein; Fiscal Year: 2004
    ..abstract_text> ..