Research Topics
| Catharine A WinstanleySummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disordersCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 30:669-82. 2005..These data suggest a significant role for 5-HT : DA interactions within the NAC in the control of impulsivity, and in the mechanism by which amphetamine decreases impulsive choice...
Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studiesCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
Clin Psychol Rev 26:379-95. 2006....- Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choiceCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
J Neurosci 24:4718-22. 2004..This is the first time that lesions to these two structures have produced opposite behavioral effects, indicating their distinct contributions to cognition... - Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse controlCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK
Eur J Neurosci 21:3107-16. 2005..These data bear a striking similarity to those observed after lesions of the orbitofrontal cortex and are suggestive of an important role for corticosubthalamic connections in complex cognitive behaviour... - Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choiceCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
Cereb Cortex 16:106-14. 2006..These data suggest a double dissociation between serotonergic and dopaminergic modulation of impulsive decision-making within distinct areas of frontal cortex... - Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behaviorCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 29:1331-43. 2004..However, not all measures of impulsivity appear to be uniformly affected by 5-HT depletion, or correlate with each other, supporting the suggestion that impulsivity is not a unitary construct... - 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletionCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 176:376-85. 2004..Mounting evidence suggests that 5-HT(2A) and 5-HT(2C) receptors have opposing effects on behaviour, and that the 5-HT(2C) receptor antagonist SB 242084 produces a pattern of behaviour similar to 5-HT depletion... - Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in ratsCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, UK
Psychopharmacology (Berl) 167:304-14. 2003..However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour... - Limbic corticostriatal systems and delayed reinforcementRudolf N Cardinal
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Ann N Y Acad Sci 1021:33-50. 2004.... - Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in ratsCatharine A Winstanley
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Psychopharmacology (Berl) 170:320-31. 2003..CONCLUSIONS: These data suggest that the ability of amphetamine to decrease impulsivity is not solely due to its effects on dopaminergic systems, but may also depend on serotonergic neurotransmission... - IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiatesScott J Russo
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Neurosci 10:93-9. 2007..These findings directly implicate the IRS2-Akt signaling pathway as a critical regulator of dopamine cell morphology and opiate reward... - DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunctionCatharine A Winstanley
Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Neurosci 27:10497-507. 2007..Identification of deltaFosB in the OFC as a mediator of tolerance to the effects of cocaine on cognition provides fundamentally new insight into the transcriptional modifications associated with addiction... - The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular levelCatharine A Winstanley
University of British Columbia, Department of Psychology, Vancouver BC, V6T 1Z4, Canada
Ann N Y Acad Sci 1121:639-55. 2007..Through integrating what is known of the interaction between addictive drugs and impulsivity at the neural, neurochemical, and molecular level, novel insight may be obtained into the multi-faceted regulation of the addicted state...