Catharine A Winstanley

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Cereb Cortex 16:106-14. 2006
  2. pmc Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
    Clin Psychol Rev 26:379-95. 2006
  3. ncbi Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:4718-22. 2004
  4. ncbi Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse control
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK
    Eur J Neurosci 21:3107-16. 2005
  5. ncbi Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:669-82. 2005
  6. ncbi Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1331-43. 2004
  7. ncbi 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 176:376-85. 2004
  8. ncbi Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 167:304-14. 2003
  9. ncbi Limbic corticostriatal systems and delayed reinforcement
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1021:33-50. 2004
  10. ncbi Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 170:320-31. 2003

Collaborators

Detail Information

Publications14

  1. ncbi Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, CB2 3EB, UK
    Cereb Cortex 16:106-14. 2006
    ..These data suggest a double dissociation between serotonergic and dopaminergic modulation of impulsive decision-making within distinct areas of frontal cortex...
  2. pmc Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, UK
    Clin Psychol Rev 26:379-95. 2006
    ....
  3. ncbi Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:4718-22. 2004
    ..This is the first time that lesions to these two structures have produced opposite behavioral effects, indicating their distinct contributions to cognition...
  4. ncbi Lesions to the subthalamic nucleus decrease impulsive choice but impair autoshaping in rats: the importance of the basal ganglia in Pavlovian conditioning and impulse control
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK
    Eur J Neurosci 21:3107-16. 2005
    ..These data bear a striking similarity to those observed after lesions of the orbitofrontal cortex and are suggestive of an important role for corticosubthalamic connections in complex cognitive behaviour...
  5. ncbi Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:669-82. 2005
    ..These data suggest a significant role for 5-HT : DA interactions within the NAC in the control of impulsivity, and in the mechanism by which amphetamine decreases impulsive choice...
  6. ncbi Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 29:1331-43. 2004
    ..However, not all measures of impulsivity appear to be uniformly affected by 5-HT depletion, or correlate with each other, supporting the suggestion that impulsivity is not a unitary construct...
  7. ncbi 5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 176:376-85. 2004
    ..Mounting evidence suggests that 5-HT(2A) and 5-HT(2C) receptors have opposing effects on behaviour, and that the 5-HT(2C) receptor antagonist SB 242084 produces a pattern of behaviour similar to 5-HT depletion...
  8. ncbi Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, UK
    Psychopharmacology (Berl) 167:304-14. 2003
    ..However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour...
  9. ncbi Limbic corticostriatal systems and delayed reinforcement
    Rudolf N Cardinal
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Ann N Y Acad Sci 1021:33-50. 2004
    ....
  10. ncbi Global 5-HT depletion attenuates the ability of amphetamine to decrease impulsive choice on a delay-discounting task in rats
    Catharine A Winstanley
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 170:320-31. 2003
    ..Although most behavioural effects of amphetamine are attributed to the dopaminergic system, some recent evidence suggests a role for serotonin in this paradoxical "calming" effect...
  11. pmc Pathological choice: the neuroscience of gambling and gambling addiction
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom, Laboratory for Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 HP Nijmegen, The Netherlands, Department of Psychology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada, and State Key Laboratory of Cognitive Neuroscience and Learning, and IDG McGovern Institute for Brain Research, Beijing Normal University, Beijing, China 100875
    J Neurosci 33:17617-23. 2013
    ....
  12. ncbi IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
    Scott J Russo
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 10:93-9. 2007
    ..These findings directly implicate the IRS2-Akt signaling pathway as a critical regulator of dopamine cell morphology and opiate reward...
  13. ncbi DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction
    Catharine A Winstanley
    Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:10497-507. 2007
    ..Identification of deltaFosB in the OFC as a mediator of tolerance to the effects of cocaine on cognition provides fundamentally new insight into the transcriptional modifications associated with addiction...
  14. ncbi The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level
    Catharine A Winstanley
    University of British Columbia, Department of Psychology, Vancouver BC, V6T 1Z4, Canada
    Ann N Y Acad Sci 1121:639-55. 2007
    ..Through integrating what is known of the interaction between addictive drugs and impulsivity at the neural, neurochemical, and molecular level, novel insight may be obtained into the multi-faceted regulation of the addicted state...