Affiliation: University of Florida
- Design issues in a prospective randomized double-blinded trial of prophylaxis with fluconazole versus voriconazole after allogeneic hematopoietic cell transplantationJohn R Wingard
Department of Medicine, Blood and Marrow Transplant Program, Division of Hematology Oncology, University of Florida Shands Cancer Center, Gainesville, FL 32610, USA
Clin Infect Dis 39:S176-80. 2004..About 15% of patients become infected, with a case fatality rate of approximately 65%. To date, no effective prophylactic strategies have been developed...
- Pharmacoeconomic analysis of caspofungin versus liposomal amphotericin B as empirical antifungal therapy for neutropenic feverJohn R Wingard
Division of Hematology and Oncology, College of Medicine, University of Florida Shands Cancer Center, Gainesville, Florida 32610 0277, USA
Am J Health Syst Pharm 64:637-43. 2007..An analysis was conducted that evaluated and compared the cost differences between caspofungin and liposomal amphotericin B when the medications were used as empirical antifungal therapy for persistent fever during neutropenia...
- Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosisJ R Wingard
University of Florida College of Medicine, Department of Medicine, Division of Hematology Oncology, Gainesville, FL 32610 0277, USA
Clin Infect Dis 29:1402-7. 1999..46; P=.002). These data indicate that elevated creatinine levels during amphotericin B treatment are associated with a substantial risk for hemodialysis and a higher mortality rate, but the risks vary in different patient groups...
- Strategies for minimizing complications of neutropenia: prophylactic myeloid growth factors or antibioticsJohn R Wingard
Division of Hematology Oncology, University of Florida College of Medicine, P O Box 103633, 1376 Mowry Road, Gainesville, FL 32610 3633, USA
Crit Rev Oncol Hematol 72:144-54. 2009..Each type of prophylaxis has advantages and disadvantages. Additional studies are needed to optimize how these are employed in clinical practice...
- Prophylaxis, empirical therapy, or pre-emptive therapy of fungal infections in immunocompromised patients: which is better for whom?Helen L Leather
Department of Pharmacy, College of Medicine, University of Florida, Gainesville, Florida, USA
Curr Opin Infect Dis 15:369-75. 2002..Validations of the various techniques show promise and are reviewed in this paper...
- Changes in causes of death over time after treatment for invasive aspergillosisJohn R Wingard
Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 3633, USA
Cancer 112:2309-12. 2008..Assessment of response to invasive aspergillosis (IA) therapy has been challenging in treatment trials...
- Influenza: preparedness for an inevitable "Emergency" for oncology and BMT unitsJohn R Wingard
Division of Hematology Oncology, University of Florida College of Medicine, Gainesville, FL 32610 3633, USA
J Natl Compr Canc Netw 6:215-22. 2008..Ongoing engagement by the entire team to evaluate the effectiveness of its actions and modify its plan as necessary will ensure success...
- New approaches to invasive fungal infections in acute leukemia and hematopoietic stem cell transplant patientsJohn R Wingard
Blood and Marrow Transplant Program, Division of Hematology Oncology, University of Florida Shands Cancer Center, 1376 Mowry Road, Room 145, Gainesville, FL 32610 3633, USA
Best Pract Res Clin Haematol 20:99-107. 2007..Combining the new diagnostic tools with new drugs, novel strategies are being evaluated to change our approaches to these deadly infections...
- Preparing for the unthinkable: emergency preparedness for the hematopoietic cell transplant programJohn R Wingard
University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
Biol Blood Marrow Transplant 12:1229-38. 2006..This report provides the framework for a HCT-specific emergency preparedness plan that can be used by individual centers to develop customized guidelines on preparing for, responding to, and recovering from an emergency...
- Caspofungin versus amphotericin B for candidemia: a pharmacoeconomic analysisJohn R Wingard
University of Florida College of Medicine, Gainesville, 32610, USA
Clin Ther 27:960-9. 2005..7% and 62.8% of patients, respectively) and exhibited a generally better safety profile, particularly with respect to impaired renal function (IRF) (P = 0.02)...
- The changing face of invasive fungal infections in hematopoietic cell transplant recipientsJohn R Wingard
Department of Medicine, University of Florida Shands Cancer Center, Division of Hematology Oncology, Gainesville, Florida 32610 0277, USA
Curr Opin Oncol 17:89-92. 2005....
- A new era of antifungal therapyJohn R Wingard
Blood and Marrow Transplant Program, Division of Hematology Oncology, University of Florida Shands Cancer Center, Gainesville, USA
Biol Blood Marrow Transplant 10:73-90. 2004..It is hoped that these new therapies and new diagnostics will usher in a new era of antifungal therapy...
- Antifungal chemoprophylaxis after blood and marrow transplantationJohn R Wingard
Division of Hematology Oncology, University of Florida College of Medicine, Gainesville, FL 32610, USA
Clin Infect Dis 34:1386-90. 2002..Fluconazole prophylaxis is highly effective for the control of invasive yeast infections and associated with few breakthrough infections. The development of antimould prophylaxis in this patient population is a high priority...
- Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantationJohn R Wingard
University of Florida, Gainesville, FL, USA
Blood 116:5111-8. 2010..This trial was registered at www.clinicaltrials.gov as NCT00075803...
- Empirical antifungal therapy in treating febrile neutropenic patientsJohn R Wingard
Department of Medicine, Blood and Marrow Transplant Program, University of Florida Shands Cancer Center, Gainesville, Florisa 32610 0277, USA
Clin Infect Dis 39:S38-43. 2004..Newer diagnostic tools are needed to target those most in need of antifungal therapy...
- A randomized, double-blind comparative trial evaluating the safety of liposomal amphotericin B versus amphotericin B lipid complex in the empirical treatment of febrile neutropenia. L Amph/ABLC Collaborative Study GroupJ R Wingard
Division of Hematology, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
Clin Infect Dis 31:1155-63. 2000..9% and 12.3% vs. 32.1%; P=.004). After day 1, infusional reactions were less frequent with ABLC, but chills/rigors were still higher (21.0% and 24.3% vs. 50.7%; P<.001). Therapeutic success was similar in all 3 groups...
- Empiric antifungal therapy for the neutropenic patientJ R Wingard
Bone Marrow Transplant Program, University of Florida College of Medicine, USA
Oncology (Williston Park) 15:351-63; discussion 363-4, 367-9. 2001..Finally, the future of diagnostic and therapeutic strategies for protecting the immunocompromised patient will be considered...
- Opportunistic infections after blood and marrow transplantationJ R Wingard
Bone Marrow Transplant Program, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Transpl Infect Dis 1:3-20. 1999..Such shifts and new syndromes pose continuing new challenges to the transplant clinician...
- Late onset of invasive aspergillus infection in bone marrow transplant patients at a university hospitalW B Grow
University of Florida College of Medicine, Shands Hospital, Gainesville, FL 32610-0277, USA
Bone Marrow Transplant 29:15-9. 2002..These data have important implications in an era of alternate donor transplants and more intense immunosuppression. Established strategies implementing newer, less toxic antifungal agents as prophylaxis in high-risk patients are needed...
- Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood graftsClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
Blood 118:282-8. 2011..The trials are registered at www.clinicaltrials.gov under NCT00864227 (BMT CTN 0604) and NCT00849147 (BMT CTN 0603)...
- Granulocytic sarcoma (chloroma) of the breast: a diagnostic dilemma and review of the literatureBarbara Shea
Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
Breast J 10:48-53. 2004..It appears that early initiation of systemic acute myelogenous leukemia (AML)-type chemotherapy is beneficial and may delay or avert the development of AML in bone marrow and blood...
- Engraftment syndrome in breast cancer patients after stem cell transplantation is associated with poor long-term survivalS A Khan
Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville 32610 0277, USA
Biol Blood Marrow Transplant 7:433-8. 2001..Thus, patients with ES should be considered for close follow-up and further therapy posttransplantation...
- Subcutaneous phaeohyphomycosis in transplant recipients: review of the literature and demonstration of in vitro synergy between antifungal agentsC J Clancy
Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
Med Mycol 38:169-75. 2000..Results of in vitro testing of the isolate for susceptibility to a combination of amphotericin B, flucytosine and itraconazole confirmed the potential role of combination antifungal therapy in the setting of refractory infection...
- Strongyloides stercoralis hyperinfection in hematopoietic stem cell transplantationB Wirk
Bone Marrow Transplant Program, Division of Hematology Oncology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Transpl Infect Dis 11:143-8. 2009....
- Flow cytometric minimal residual disease monitoring in patients with multiple myeloma undergoing autologous stem cell transplantation: a retrospective studyHong Liu
Department of Medicine, University of Florida, Gainesville, FL, USA
Leuk Lymphoma 49:306-14. 2008..11 months, P = 0.004). In conclusion, the detection of a significant population of APC by FCM prior to ASCT significantly correlates with poorer PFS in MM patients...
- GM-CSF versus G-CSF: engraftment characteristics, resource utilization, and cost following autologous PBSC transplantationM S Zumberg
University of Florida College of Medicine, Department of Medicine and the Bone Marrow Transplant Program, Shands Hospital at the University of Florida, Gainesville, USA
Cytotherapy 4:531-8. 2002..Resource utilization for fever treatment and evaluation may be greater with GM-CSF. Determination of which agent is more cost-effective depends on institutional acquisition costs...
- Resource use and cost of treatment with voriconazole or conventional amphotericin B for invasive aspergillosisJ R Wingard
University of Florida, Gainesville, Florida, USA
Transpl Infect Dis 9:182-8. 2007..Voriconazole, a broad-spectrum triazole, has demonstrated significantly improved survival compared with conventional amphotericin B (CAB) as initial therapy for invasive aspergillosis (IA)...
- A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantationD J Winston
Department of Medicine, UCLA Center for the Health Sciences, Los Angeles, CA 90095, USA
Bone Marrow Transplant 28:187-96. 2001..These results should be considered when designing cost-effective strategies for the use of intravenous immunoglobulin in allogeneic marrow transplants receiving other current regimens for prophylaxis of GVHD and infection...
- Infections following hematopoietic stem cell transplantationH L Leather
Department of Pharmacy, Shands at the University of Florida, College of Pharmacy, Gainesville, Florida, USA
Infect Dis Clin North Am 15:483-520. 2001..As we increase our understanding of the HSCT process, and use the immune system rather than relying on high-dose chemotherapy, the authors are likely to reduce toxicities and improve patient outcomes...
- Gastroparesis following bone marrow transplantationD A Eagle
University of Florida College of Medicine, Gainesville, FL 32610-0277, USA
Bone Marrow Transplant 28:59-62. 2001..Patients usually respond to prokinetic drugs at the time of scintigraphy. GVHD and CMV infection do not appear to be major contributing factors...
- Evolution, incidence, and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patientsB A Collin
Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Clin Infect Dis 33:947-53. 2001..aeruginosa and the Enterobacter, Serratia, Citrobacter group. There was no mortality attributable to gram-positive organisms such as Staphylococcus aureus and viridans streptococci...
- Monitoring vital signs in a bone marrow transplant unit: are they needed in the middle of the night?S Sharda
University of Florida College of Medicine, Department of Pediatrics, Gainesville, FL, USA
Bone Marrow Transplant 27:1197-200. 2001..0002). There was also a trend for CNS events (P = 0.057) to be associated with MON intervention. Larger, prospective studies need to be done to accurately identify day time risk factors that can predict the need for night time monitoring...
- Reduced-intensity conditioning using fludarabine with either antithymocyte globulin and BU, or low-dose TBI allowing allogeneic hematopoietic SCTC Cable
Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA
Bone Marrow Transplant 45:31-7. 2010..Yet, rapid attainment of full donor chimerism after flu/TBI is associated with greater survival than after flu/ATG/BU. Further, larger prospective randomized studies are required to define the advantage of one regimen over the other...
- Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and RituximabS Skoda-Smith
Department of Pediatrics, University of Florida College of Medicine, Gainesville 32610-0296, USA
Bone Marrow Transplant 27:329-32. 2001..The administration of Rituximab in the early post-transplant course may provide additional anti-tumor activity without affecting the new stem cell compartment...
- Poor mobilization of peripheral blood stem cells is a risk factor for worse outcome in lymphoma patients undergoing autologous stem cell transplantationL N Gordan
Department of Medicine, Division of Hematology-Oncology, College of Medicine, University of Florida, P.O. Box 100277, Gainesville, FL 32610, USA
Leuk Lymphoma 44:815-20. 2003....
- Conditioning therapy with intravenous busulfan and cyclophosphamide (IV BuCy2) for hematologic malignancies prior to allogeneic stem cell transplantation: a phase II studyBorje S Andersson
Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, Houston 77005, USA
Biol Blood Marrow Transplant 8:145-54. 2002..In conclusion, the IV Bu in this regimen was very well tolerated and demonstrated excellent antitumor efficacy, most likely because of dose assurance with predictable pharmacokinetics...
- A prospective randomized trial of prophylactic platelet transfusion and bleeding incidence in hematopoietic stem cell transplant recipients: 10,000/L versus 20,000/microL triggerMarc S Zumberg
University of Florida College of Medicine, Department of Medicine, Gainesville 32610, USA
Biol Blood Marrow Transplant 8:569-76. 2002..In conclusion, a platelet transfusion trigger of 10K was found to be safe; however, a decrease in platelet use was not achieved because of safety measures incorporated into our study design...
- Use of bronchoalveolar lavage to detect galactomannan for diagnosis of pulmonary aspergillosis among nonimmunocompromised hostsM Hong Nguyen
Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
J Clin Microbiol 45:2787-92. 2007..Given the likelihood of false-positive results, a BAL GM test should not be ordered routinely in this population...
- Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipientsCornelius J Clancy
Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
J Clin Microbiol 45:1759-65. 2007..9% and 62.5%, respectively (cutoff, > or = 1.0). In conclusion, BAL GM testing facilitated more-rapid diagnoses of IPA and the institution of antifungal therapy among non-lung solid-organ transplant recipients and helped to rule out IPA...
- Late effects of cancer and hematopoietic stem-cell transplantation on spouses or partners compared with survivors and survivor-matched controlsMichelle M Bishop
Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0277, USA
J Clin Oncol 25:1403-11. 2007..The purpose of this study was to examine the health-related quality of life and post-traumatic growth (PTG) of spouses/partners compared with survivors and controls and to identify factors associated with those outcomes...
- Spatial distribution of blood vessels and CD34+ hematopoietic stem and progenitor cells within the marrow cavities of human cancellous boneChristopher J Watchman
Department of Radiation Oncology, University of Arizona, Tucson, Arizona, USA
J Nucl Med 48:645-54. 2007..The objective of the present study was to directly measure the spatial concentration of these cells, as well as marrow vasculature structures, within images of human disease-free bone marrow...
- Access to stem cell transplantation: do women fare as well as men?Paulette Mehta
Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA
Am J Hematol 72:99-102. 2003..While boys with ALL appear to receive SCT at a higher rate, this difference is likely attributable to biological rather than social reasons...
- Umbilical cord blood produces small megakaryocytes after transplantationMark Ignatz
Department of Pediatrics, University of Florida, Gainesville, Florida, USA
Biol Blood Marrow Transplant 13:145-50. 2007..For the first time, we demonstrate that the attainment of adult size in CB-derived megakaryocytes is delayed after human CB transplantation...
- Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapyWilliam W Hope
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:455-66. 2007..Little is known about the pathogenesis of invasive pulmonary aspergillosis and the relationship between the kinetics of diagnostic markers and the outcome of antifungal therapy...
- Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjunctsBrahm H Segal
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Clin Infect Dis 44:402-9. 2007..Finally, we discuss the implications of newer antifungal agents and diagnostic adjuncts in the design of future clinical trials to evaluate prophylaxis and early prevention strategies...
- The role of the donor in the repair of the marrow vascular niche following hematopoietic stem cell transplantWilliam B Slayton
University of Florida Program in Stem Cell Biology and Regenerative Medicine, Department of Pediatrics, University of Florida Health Science Center, Gainesville, Florida 32610, USA
Stem Cells 25:2945-55. 2007..Donor support for the repair of the marrow vascular niche may be a critical first step of hematopoietic engraftment...
- Sites and kinetics of donor thrombopoiesis following transplantation of whole bone marrow and progenitor subsetsXiao Miao Li
Department of Pediatrics, University of Florida, Gainesville, USA
Exp Hematol 35:1567-79. 2007..The spleen is a site of hematopoiesis in a healthy mouse, and hematopoietic activity increases in response to stress. We hypothesized that the spleen is a major site of early post-transplant thrombopoiesis...
- Increased risk of lethal graft-versus-host disease-like syndrome after transplantation into NOD/SCID mice of human mobilized peripheral blood stem cells, as compared to bone marrow or cord bloodNorbert Claude Gorin
Johns Hopkins University School of Medicine, Department of Oncology, Baltimore, MD 21231, USA
J Hematother Stem Cell Res 11:277-92. 2002..Quantitative criteria for optimal T cell content of allogeneic donor hematopoietic grafts from different sources are discussed...
- An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/beta2-microglobulin(null) miceFumihiko Ishikawa
Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29401-5799, USA
Exp Hematol 30:488-94. 2002..5 +/- 0.42% at 2 months after secondary transplantation. CONCLUSION: Our assay may provide a quantitative method for analysis of human hematopoietic stem cells...
- A double-blind, randomized, controlled trial of amphotericin B colloidal dispersion versus amphotericin B for treatment of invasive aspergillosis in immunocompromised patientsRaleigh Bowden
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Clin Infect Dis 35:359-66. 2002..However, infusion-related chills and fever occurred more frequently in patients receiving ABCD than in those receiving AmB...
- Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiationXiao Miao Li
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
Exp Hematol 36:1143-1156. 2008..Bone marrow sinusoids remain predominantly host-derived following bone marrow transplantation. Systematic analysis was conducted at the cellular level to investigate how the host sinusoidal structures survived after lethal irradiation...
- Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survivalMary Eapen
Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Biol Blood Marrow Transplant 13:1461-8. 2007..The higher rate of cGVHD after PBSC transplants and, consequently, more frequent late adverse events warrant extended follow up of PBSC recipients...
- Transplanted human cord blood cells generate amylase-producing pancreatic acinar cells in engrafted miceHitoshi Minamiguchi
Department of Veterans Affairs Medical Center and Department of Medicine, Medical University of South Carolina, Charleston, SC, USA
Pancreas 36:e30-5. 2008..Based on this developmental proximity between liver and pancreatic acinar cells, we examined whether human cord blood (CB) cells can generate pancreatic cells in vivo using a murine xenograft model...
- Voriconazole versus amphotericin B for primary therapy of invasive aspergillosisRaoul Herbrecht
Département d Hématologie et d Oncologie, Hopital de Hautepierre, Strasbourg, France
N Engl J Med 347:408-15. 2002..Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis...
- Racial and ethnic composition of volunteer cord blood donors: comparison with volunteer unrelated marrow donorsKaren K Ballen
American Red Cross Cord Blood Program, University of Massachusetts Memorial Health Care, Worcester, MA, USA
Transfusion 42:1279-84. 2002..Umbilical cord blood is an alternative peripheral blood progenitor cell source for patients who need transplantation. A presumed advantage of cord blood is the ability to increase minority recruitment...
- An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null miceHitoshi Minamiguchi
Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, South Carolina 29401-5799, USA
Biol Blood Marrow Transplant 11:487-94. 2005..Accordingly, conditioned newborn NOD- Rag1 null Prf1 null mice provide a desirable model for an assay of long-term transplantable human HSCs...
- Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of AmericaThomas J Walsh
Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
Clin Infect Dis 46:327-60. 2008
- Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo signReginald E Greene
Massachusetts General Hospital, Boston, MA 02114, USA
Clin Infect Dis 44:373-9. 2007....
- Busulfan, cyclophosphamide, and etoposide as conditioning for autologous stem cell transplantation in multiple myelomaChristopher R Cogle
University of Florida, Division of Hematology/Oncology, Gainesville, Florida 32610, USA
Am J Hematol 73:169-75. 2003....
- Factors associated with parameters of engraftment potential of umbilical cord bloodThomas J George
University of Florida, College of Medicine, Gainesville, Florida, USA
Transfusion 46:1803-12. 2006..A total of 1033 UCB samples with neonatal and paternal characteristics that might influence hematopoietic content were examined...
- Hepatotoxicity associated with antifungal therapy after bone marrow transplantationJohn R Wingard
Clin Infect Dis 41:308-10. 2005
- Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategiesMichael Boeckh
University of Washington, Seattle, WA 81009, USA
Biol Blood Marrow Transplant 9:543-58. 2003....
- Study of renal safety in amphotericin B lipid complex-treated patientsBarbara D Alexander
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Infect Dis 40:S414-21. 2005..These data provide evidence that ABLC may be used safely to treat patients who are at increased risk for renal impairment...
- Intravenous busulfan in pretransplant chemotherapy: bioavailability and patient benefitBorje S Andersson
Biol Blood Marrow Transplant 9:722-4. 2003
- Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantationMichael A Andrykowski
Department of Behavioral Science, University of Kentucky College of Medicine, Lexington, KY 40536 0086, USA
J Clin Oncol 23:599-608. 2005..To examine health-related quality of life (HRQOL) and growth, and spiritual well-being in adult survivors of hematopoietic stem-cell transplantation (HSCT) for a malignant disease...
- Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host diseaseVijay Reddy
Division of Hematology Oncology, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA
Blood 103:4330-5. 2004..Low numbers of circulating DCs significantly increase the risk for relapse and acute GVHD and predict death after allogeneic SCT...
- The design of clinical trials that evaluate antifungal prophylaxis and combination therapy: introduction and overviewJohn H Rex
AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom
Clin Infect Dis 39:S165-9. 2004..This supplement presents 12 articles by leading clinicians who are currently active in trials in this area and presents a current view of the unmet needs and challenges...
- Dose modification protocol using intravenous busulfan (Busulfex) and cyclophosphamide followed by autologous or allogeneic peripheral blood stem cell transplantation in patients with hematologic malignanciesCasey B Williams
Blood and Marrow Transplant Program of the Kansas City Cancer Centers, Cancer Institute at Saint Luke s Hospital, Kansas City, Missouri, USA
Biol Blood Marrow Transplant 10:614-23. 2004..On the basis of the dosing guidelines and schedule outlined in this study, our data suggest that administration of IV Bu 3.2 mg/kg IV every 24 hours for 4 doses in combination with Cy may result in excessive toxicity...
- A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapyFrancis J Giles
M D Anderson Cancer Center, Department of Leukemia, The University of Texas, 1515 Holcombe Boulevard, Box 428, Houston, TX 77030, USA
Leuk Res 28:559-65. 2004..A major impact of Iseganan on reducing stomatitis, UOM, or its clinical sequelae in patients receiving stomatotoxic therapy was not detected on this study...
- Bone marrow transdifferentiation in brain after transplantation: a retrospective studyChristopher R Cogle
Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL 32610, USA
Lancet 363:1432-7. 2004..Transplantable human haemopoietic cells could serve as a therapeutic source for long-term regenerative neuropoiesis...
- A phase III, randomized, double-blind, placebo-controlled, multinational trial of iseganan for the prevention of oral mucositis in patients receiving stomatotoxic chemotherapy (PROMPT-CT trial)Francis J Giles
Department of Leukemia, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 428, Houston, TX 77030, USA
Leuk Lymphoma 44:1165-72. 2003..6 and 2.0 (P = 0.0131). Iseganan was well tolerated; no systemic absorption was detected. Iseganan is safe and may be effective in reducing UOM and its clinical sequelae...
- Increased levels of tumor necrosis factor alpha are associated with an increased risk of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantationVijay Reddy
University of Florida College of Medicine, Gainesville, FL 32610, USA
Biol Blood Marrow Transplant 11:698-705. 2005..017). In conclusion, a high posttransplantation TNF level is significantly associated with the risk for developing CMV infection. Early detection of high levels of TNF may be used to identify patients at high risk for developing CMV-Ag...
- Developmental differences in megakaryocyte maturation are determined by the microenvironmentWilliam B Slayton
University of Florida Department of Pediatrics, Gainesville, Florida 32610, USA
Stem Cells 23:1400-8. 2005..These differences may contribute to the delay in platelet engraftment that frequently complicates cord blood transplants...
- Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients?Helen L Leather
Shands Healthcare at the University of Florida, 32610 0316, USA
Curr Opin Infect Dis 19:371-9. 2006..The recent literature is reviewed and the relative arguments for and against combination antifungal therapy are outlined with summative recommendations to assist practitioners in decision-making...
- New strategies of antifungal therapy in hematopoietic stem cell transplant recipients and patients with hematological malignanciesHelen L Leather
Shands at the University of Florida, Gainesville, FL 32610 0316, USA
Blood Rev 20:267-87. 2006....
- Pharmacokinetic evaluation of the drug interaction between intravenous itraconazole and intravenous tacrolimus or intravenous cyclosporin A in allogeneic hematopoietic stem cell transplant recipientsHelen Leather
Shands at the University of Florida, Gainesville, Florida 32610 0316, USA
Biol Blood Marrow Transplant 12:325-34. 2006....
- Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant ResJ Douglas Rizzo
Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Biol Blood Marrow Transplant 12:138-51. 2006....
- Interleukin 12 is associated with reduced relapse without increased incidence of graft-versus-host disease after allogeneic hematopoietic stem cell transplantationVijay Reddy
Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
Biol Blood Marrow Transplant 11:1014-21. 2005..Patients with high pretransplantation IL-12 levels have an increased likelihood of higher posttransplantation IL-12 levels, possibly because of a host-graft interaction, and this may predispose to better clinical outcomes...
- National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group reportAlexandra H Filipovich
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
Biol Blood Marrow Transplant 11:945-56. 2005..It is currently recommended that systemic therapy be considered for patients who meet criteria for chronic GVHD of moderate to severe global severity...
- Treatment of zygomycosis with posaconazole in a patient with acute myeloid leukemiaHelen L Leather
University of Florida, Gainesville, 32610, USA
Clin Adv Hematol Oncol 3:773-7. 2005
- Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcomeThomas F Patterson
Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Clin Infect Dis 41:1448-52. 2005..In that trial, treatment with voriconazole or amphotericin B deoxycholate could be followed with other licensed antifungal therapies (OLAT). Here, we report the impact of OLAT on the outcome of patients with invasive aspergillosis...
- Typhlitis with concurrent appendicitis in a patient with chronic lymphocytic leukemiaChristopher R Cogle
University of Florida Shands Cancer Center, Gainesville, FL 32610, USA
Clin Adv Hematol Oncol 1:284-6; discussion 286. 2003
- Physicians' attitudes about quality-of-life issues in hematopoietic stem cell transplantationStephanie J Lee
Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Blood 104:2194-200. 2004....
- Clinical research in the lay press: irresponsible journalism raises a huge dose of doubtElias J Anaissie
Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Clin Infect Dis 43:1031-9. 2006
- Learning from our failures: the antifungal treatment conundrumJohn R Wingard
Clin Infect Dis 46:1434-5. 2008
- QUALITY OF LIFE AND RELATIONSHIPS AFTER BMTJohn Wingard; Fiscal Year: 2001..This information is essential to subsequent planning and implementation of relevant, well-aimed interventions to minimize psychosocial disruption and enhance growth in future BMT recipients and their loved ones. ..
- Core Clinical Center for BMT Clinical Research NetworkJohn Wingard; Fiscal Year: 2007..End of abstract.) ..