MARK E WINEY

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p
    Sue L Jaspersen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 159:945-56. 2002
  2. pmc New Tetrahymena basal body protein components identify basal body domain structure
    Chandra L Kilburn
    Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Cell Biol 178:905-12. 2007
  3. pmc The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p
    Andrea R Castillo
    MCD Biology, UCB 347, University of Colorado, Boulder CO 80309, USA
    J Cell Biol 156:453-65. 2002
  4. pmc The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication
    A R Schutz
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, 80309 0347, USA
    J Cell Biol 136:969-82. 1997
  5. ncbi request reprint Centrosomes and checkpoints: the MPS1 family of kinases
    Mark Winey
    MCD Biology, 347 UCB, University of Colorado Boulder, Boulder, Colorado, CO 80309 0347, USA
    Oncogene 21:6161-9. 2002
  6. ncbi request reprint The spindle cycle in budding yeast
    M Winey
    MCD Biology, CB 347, University of Colorado, Boulder, Colorado 80309, USA
    Nat Cell Biol 3:E23-7. 2001
  7. pmc Three-dimensional ultrastructure of Saccharomyces cerevisiae meiotic spindles
    Mark Winey
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80309 0347, USA
    Mol Biol Cell 16:1178-88. 2005
  8. pmc Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation
    Eric P Holinger
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    J Biol Chem 284:12949-55. 2009
  9. pmc Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
    Harold A Fisk
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Proc Natl Acad Sci U S A 100:14875-80. 2003
  10. ncbi request reprint A field guide to the Mps1 family of protein kinases
    Harold A Fisk
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    Cell Cycle 3:439-42. 2004

Research Grants

  1. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2006
  2. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2007
  3. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2007
  4. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2006
  5. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2007
  6. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2009
  7. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2009
  8. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2010
  9. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2009
  10. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2009

Collaborators

  • HAROLD FISK
  • Sue L Jaspersen
  • T H Giddings
  • Chad G Pearson
  • D N Mastronarde
  • K Bloom
  • Heather B McDonald
  • Janet B Meehl
  • Christopher P Mattison
  • Michele H Jones
  • Brady P Culver
  • Garry Morgan
  • Eric P Holinger
  • John R Yates
  • William M Old
  • Chandra L Kilburn
  • Brenda J Huneycutt
  • Alexander J Stemm-Wolf
  • Corine K Lau
  • Andrea R Castillo
  • Susan McBratney
  • Catherine Wong
  • Edwin P Romijn
  • Estelle Steiner
  • Natalie G Ahn
  • Katheryn A Resing
  • Robb Marchione
  • Kevan Shokat
  • Erin A White
  • Chao Zhang
  • A R Schutz
  • Amy Schutz-Geschwender
  • E Steiner

Detail Information

Publications25

  1. pmc Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p
    Sue L Jaspersen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 159:945-56. 2002
    ....
  2. pmc New Tetrahymena basal body protein components identify basal body domain structure
    Chandra L Kilburn
    Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Cell Biol 178:905-12. 2007
    ..Thus, we present a high resolution localization map of basal body structure highlighting important new components for future functional studies...
  3. pmc The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p
    Andrea R Castillo
    MCD Biology, UCB 347, University of Colorado, Boulder CO 80309, USA
    J Cell Biol 156:453-65. 2002
    ..Finally, Spc42p assembly is abnormal in a mps1-1 mutant strain. We conclude that Mps1p regulates assembly of the integral SPB component Spc42p during SPB duplication...
  4. pmc The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication
    A R Schutz
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, 80309 0347, USA
    J Cell Biol 136:969-82. 1997
    ..These data demonstrate a requirement for CDC37 in SPB duplication and suggest a role for this gene in G1 control. CDC37 may provide a chaperone function that promotes the activity of protein kinases...
  5. ncbi request reprint Centrosomes and checkpoints: the MPS1 family of kinases
    Mark Winey
    MCD Biology, 347 UCB, University of Colorado Boulder, Boulder, Colorado, CO 80309 0347, USA
    Oncogene 21:6161-9. 2002
  6. ncbi request reprint The spindle cycle in budding yeast
    M Winey
    MCD Biology, CB 347, University of Colorado, Boulder, Colorado 80309, USA
    Nat Cell Biol 3:E23-7. 2001
    ..Recent work has revealed that many general aspects of mitosis are conserved, making budding yeast an excellent model for the study of mitosis...
  7. pmc Three-dimensional ultrastructure of Saccharomyces cerevisiae meiotic spindles
    Mark Winey
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80309 0347, USA
    Mol Biol Cell 16:1178-88. 2005
    ..This analysis offers a structural basis for considering meiotic segregation in yeast and for the analysis of mutants defective in this process...
  8. pmc Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation
    Eric P Holinger
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    J Biol Chem 284:12949-55. 2009
    ....
  9. pmc Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression
    Harold A Fisk
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Proc Natl Acad Sci U S A 100:14875-80. 2003
    ....
  10. ncbi request reprint A field guide to the Mps1 family of protein kinases
    Harold A Fisk
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309 0347, USA
    Cell Cycle 3:439-42. 2004
    ..More recently it has been demonstrated that human Mps1 is also required for centrosome duplication, normal mitotic progression, and cytokinesis...
  11. ncbi request reprint Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis
    Michele H Jones
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80309 0347, USA
    Curr Biol 15:160-5. 2005
    ..Taken together, our experiments are consistent with an important role for Mps1 at the kinetochore in mitotic spindle assembly and function...
  12. ncbi request reprint The budding yeast spindle pole body: structure, duplication, and function
    Sue L Jaspersen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Annu Rev Cell Dev Biol 20:1-28. 2004
    ..In addition, we discuss how studies of the yeast SPB have aided investigation of other MTOCs, most notably the centrosome of animal cells...
  13. pmc Basal body assembly in ciliates: the power of numbers
    Chad G Pearson
    Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, 347 UCB, Porter Biosciences, Boulder, CO 80309 0347, USA
    Traffic 10:461-71. 2009
    ..Recent advances in the ciliate genetic and molecular toolkit have placed these model organisms in a favorable position to study the molecular mechanisms of centriole and basal body assembly...
  14. pmc Basal body components exhibit differential protein dynamics during nascent basal body assembly
    Chad G Pearson
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Mol Biol Cell 20:904-14. 2009
    ..The bimodal dynamics found for centrin and Sas6a reveal unique protein assembly mechanisms at basal bodies that may reflect novel functions for these important basal body and centriolar proteins...
  15. pmc Basal body stability and ciliogenesis requires the conserved component Poc1
    Chad G Pearson
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 187:905-20. 2009
    ..A second dynamic population assembles throughout the cell cycle. Our experiments identify novel roles for Poc1 in centriole stability and ciliogenesis...
  16. ncbi request reprint Centrioles want to move out and make cilia
    Chad G Pearson
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Dev Cell 13:319-21. 2007
    ..Several recent studies have begun to uncover the links between centriole duplication and their transformation to basal bodies...
  17. ncbi request reprint Mps1 activation loop autophosphorylation enhances kinase activity
    Christopher P Mattison
    Molecular Cellular, and Developmental Biology, University of Colorado, Colorado 80309, USA
    J Biol Chem 282:30553-61. 2007
    ..Our data strongly support the conclusion that site-specific Mps1 autophosphorylation within the activation loop is required for full activity in vitro and function in vivo...
  18. pmc A novel allele of Saccharomyces cerevisiae NDC1 reveals a potential role for the spindle pole body component Ndc1p in nuclear pore assembly
    Corine K Lau
    MCD Biology, University of Colorado Boulder, Boulder, Colorado 80309 0347, USA
    Eukaryot Cell 3:447-58. 2004
    ..We postulate that Ndc1p is crucial for the biogenesis of both the SPBs and the NPCs at the step of insertion into the nuclear envelope...
  19. ncbi request reprint Centrosome duplication: is asymmetry the clue?
    Michele H Jones
    MCD Biology, University of Colorado Boulder, 347 UCB, Boulder, Colorado 80309 0347, USA
    Curr Biol 16:R808-10. 2006
    ..The structure of the yeast Sfi1-centrin complex, and its asymmetric position within the yeast centrosome, suggest a model for the initiation of centrosome duplication and provides a target for licensing this event...
  20. ncbi request reprint The centrosome cycle
    Christopher P Mattison
    MCD Biology, University of Colorado Boulder, 80309 0347, USA
    Results Probl Cell Differ 42:111-46. 2006
    ..Defects in centrosome duplication or function are linked to human diseases including cancer. Here we provide a multifaceted look at centrosomes with a detailed summary of the centrosome cycle...
  21. doi request reprint High pressure freezing, electron microscopy, and immuno-electron microscopy of Tetrahymena thermophila basal bodies
    Janet B Meehl
    Department of MCD Biology, University of Colorado, Boulder, CO, USA
    Methods Mol Biol 586:227-41. 2009
    ..In combination with identification and manipulation of a rapidly expanding list of basal body-associated gene products, these methods are being used to increase our understanding of basal body composition, assembly, and function...
  22. pmc The two SAS-6 homologs in Tetrahymena thermophila have distinct functions in basal body assembly
    Brady P Culver
    Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA
    Mol Biol Cell 20:1865-77. 2009
    ..Our data suggest a model where TtSAS6a and TtSAS6b have diverged such that TtSAS6a acts as a structural component of basal bodies, whereas TtSAS6b influences the location of new basal body assembly...
  23. pmc Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway
    Susan McBratney
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
    Genetics 162:567-78. 2002
    ..Our data indicate that Mps2p may be targeted for degradation by the ER quality control pathway...
  24. pmc Basal body duplication and maintenance require one member of the Tetrahymena thermophila centrin gene family
    Alexander J Stemm-Wolf
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA
    Mol Biol Cell 16:3606-19. 2005
    ..This study provides evidence that in addition to its previously known function in the duplication of basal bodies, centrin is also important for the integrity of these organelles...
  25. ncbi request reprint Centrosomes and tumour suppressors
    Harold A Fisk
    Molecular, Cellular and Developmental Biology, UCB347, University of Colorado, Boulder, CO 80309 0347, USA
    Curr Opin Cell Biol 14:700-5. 2002
    ..Surprisingly, some well-known tumour suppressors have recently been found at centrosomes, where they influence centrosome duplication and function, suggesting that control of centrosome function is central to genetic stability...

Research Grants31

  1. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2006
    ..Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. ..
  2. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2007
    ..Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. ..
  3. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2007
    ..By understanding the role phosphorylation plays at centrosomes, we will gain important insights into how centrosome assembly is coordinated with the cell cycle, and how the fidelity of mitosis is maintained. ..
  4. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2006
    ..Overall, we will explore further how Mps1p kinase acts in centrosome duplication and in spindle function. ..
  5. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2007
    ..Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. ..
  6. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2009
    ..Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. ..
  7. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2009
    ..By understanding the role phosphorylation plays at centrosomes, we will gain important insights into how centrosome assembly is coordinated with the cell cycle, and how the fidelity of mitosis is maintained. ..
  8. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2010
    ..By understanding the role phosphorylation plays at centrosomes, we will gain important insights into how centrosome assembly is coordinated with the cell cycle, and how the fidelity of mitosis is maintained. ..
  9. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2009
    ..By understanding the role phosphorylation plays at centrosomes, we will gain important insights into how centrosome assembly is coordinated with the cell cycle, and how the fidelity of mitosis is maintained. ..
  10. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2009
    ..Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. ..
  11. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2005
    ..Overall, we will explore further how Mps1p kinase acts in centrosome duplication and in spindle function. ..
  12. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2004
    ..Overall, we will explore further how Mps1p kinase acts in centrosome duplication and in spindle function. ..
  13. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2004
    ....
  14. MPS1 KINASE AND YEAST SPINDLE POLE CYCLE
    Mark Winey; Fiscal Year: 1999
    ..The results should indicate if the MPS1 kinase encodes a conserved function in either of its known roles. ..
  15. SPINDLE POLES AND NUCLEAR PORES--YEAST NDC1 AND MPS2
    Mark Winey; Fiscal Year: 2000
    ..The proposed project is aimed at understanding the function of a set of unusual membrane proteins at the SPB and the NPC, and at identifying other proteins with which the interact at these organelles. ..
  16. MPS1 KINASE AND YEAST SPINDLE POLE CYCLE
    Mark Winey; Fiscal Year: 2000
    ..The results should indicate if the MPS1 kinase encodes a conserved function in either of its known roles. ..
  17. MPS1 KINASE AND YEAST SPINDLE POLE CYCLE
    Mark Winey; Fiscal Year: 2001
    ..The results should indicate if the MPS1 kinase encodes a conserved function in either of its known roles. ..
  18. SPINDLE POLES AND NUCLEAR PORES--YEAST NDC1 AND MPS2
    Mark Winey; Fiscal Year: 2001
    ..The proposed project is aimed at understanding the function of a set of unusual membrane proteins at the SPB and the NPC, and at identifying other proteins with which the interact at these organelles. ..
  19. SPINDLE POLES AND NUCLEAR PORES--YEAST NDC1 AND MPS2
    Mark Winey; Fiscal Year: 2002
    ..The proposed project is aimed at understanding the function of a set of unusual membrane proteins at the SPB and the NPC, and at identifying other proteins with which the interact at these organelles. ..
  20. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2002
    ..Overall, we will explore further how Mps1p kinase acts in centrosome duplication and in spindle function. ..
  21. Role of MPSI Kinase and Yeast Spindle Pole Cycle
    Mark Winey; Fiscal Year: 2003
    ..Overall, we will explore further how Mps1p kinase acts in centrosome duplication and in spindle function. ..
  22. SPINDLE POLES AND NUCLEAR PORES--YEAST NDC1 AND MPS2
    Mark Winey; Fiscal Year: 2003
    ..The proposed project is aimed at understanding the function of a set of unusual membrane proteins at the SPB and the NPC, and at identifying other proteins with which the interact at these organelles. ..
  23. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2010
    ..Overall, our approaches using Tetrahymena will identify new basal body and centriole components and define mechanisms for their roles in basal body and centriole assembly. ..