Saul Winegrad

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Effect of MyBP-C binding to actin on contractility in heart muscle
    Irina Kulikovskaya
    Department of Physiology, School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA
    J Gen Physiol 122:761-74. 2003
  2. ncbi request reprint Cardiac myosin binding protein C
    S Winegrad
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Circ Res 84:1117-26. 1999
  3. ncbi request reprint Self-protection by cardiac myocytes against hypoxia and hyperoxia
    S Winegrad
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Circ Res 85:690-8. 1999
  4. pmc Multiple forms of cardiac myosin-binding protein C exist and can regulate thick filament stability
    Irina Kulikovskaya
    Department of Physiology, University of Philadelphia School of Medicine, Philadelphia, PA 19104, USA
    J Gen Physiol 129:419-28. 2007
  5. ncbi request reprint Cardiac myosin binding protein C: modulator of contractility
    Saul Winegrad
    Department of Physiology, University of Pennsylvania, Philadelphia, PA, USA
    Adv Exp Med Biol 565:269-81; discussion 281-2, 405-15. 2005
  6. ncbi request reprint Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility
    Saul Winegrad
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19072, USA
    Adv Exp Med Biol 538:31-40; discussion 40-1. 2003
  7. pmc Changes in cardiac contractility related to calcium-mediated changes in phosphorylation of myosin-binding protein C
    G McClellan
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 81:1083-92. 2001
  8. ncbi request reprint Effect of extraction of myosin binding protein C on contractility of rat heart
    I Kulikovskaya
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Am J Physiol Heart Circ Physiol 285:H857-65. 2003
  9. ncbi request reprint Effect of cardiac myosin-binding protein C on stability of the thick filament
    G McClellan
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    J Mol Cell Cardiol 37:823-35. 2004
  10. pmc Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle
    A Weisberg
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085, USA
    Proc Natl Acad Sci U S A 93:8999-9003. 1996

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Effect of MyBP-C binding to actin on contractility in heart muscle
    Irina Kulikovskaya
    Department of Physiology, School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA
    J Gen Physiol 122:761-74. 2003
    ..These results suggest that cardiac contractility can be regulated by shifting the binding of the NH2 terminus of MyBP-C between actin and myosin. This mechanism may have an effect on diastolic filling of the heart...
  2. ncbi request reprint Cardiac myosin binding protein C
    S Winegrad
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Circ Res 84:1117-26. 1999
    ....
  3. ncbi request reprint Self-protection by cardiac myocytes against hypoxia and hyperoxia
    S Winegrad
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Circ Res 85:690-8. 1999
    ..By acting as oxygen sensors, cardiac myocytes modulate vascular tone according to the needs of the myocytes and reduce potential problems of hypoxia and extensive formation of reactive oxygen species...
  4. pmc Multiple forms of cardiac myosin-binding protein C exist and can regulate thick filament stability
    Irina Kulikovskaya
    Department of Physiology, University of Philadelphia School of Medicine, Philadelphia, PA 19104, USA
    J Gen Physiol 129:419-28. 2007
    ..We hypothesize that modulation of filament stability can be coupled at the molecular level with the strength of contraction by the sensitivity of each to the concentration of calcium ions...
  5. ncbi request reprint Cardiac myosin binding protein C: modulator of contractility
    Saul Winegrad
    Department of Physiology, University of Pennsylvania, Philadelphia, PA, USA
    Adv Exp Med Biol 565:269-81; discussion 281-2, 405-15. 2005
  6. ncbi request reprint Myosin-binding protein C (MyBP-C) in cardiac muscle and contractility
    Saul Winegrad
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19072, USA
    Adv Exp Med Biol 538:31-40; discussion 40-1. 2003
    ..The normal interactions may be necessary to allow transitions in binding and filament structure that are associated with phosphorylation of the MyBP-C motif...
  7. pmc Changes in cardiac contractility related to calcium-mediated changes in phosphorylation of myosin-binding protein C
    G McClellan
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biophys J 81:1083-92. 2001
    ..These results suggest that Ca-dependent phosphorylation of MyBP-C modulates contractility by changing thick filament structure...
  8. ncbi request reprint Effect of extraction of myosin binding protein C on contractility of rat heart
    I Kulikovskaya
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Am J Physiol Heart Circ Physiol 285:H857-65. 2003
    ..Extraction of MyBP-C appears to produce a change in the orientation of myosin heads that is associated with a decreased ability of the contractile system to develop force...
  9. ncbi request reprint Effect of cardiac myosin-binding protein C on stability of the thick filament
    G McClellan
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6085, USA
    J Mol Cell Cardiol 37:823-35. 2004
    ..MyBP-C appears to stabilize the structure of the thick filament and modulate the way in which myosin heads extend to the thin filament...
  10. pmc Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle
    A Weisberg
    Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia 19104 6085, USA
    Proc Natl Acad Sci U S A 93:8999-9003. 1996
    ..These changes could alter rate constants for attachment to and detachment from the thin filament and thereby modify force production in activated cardiac muscle...
  11. pmc Multiple structures of thick filaments in resting cardiac muscle and their influence on cross-bridge interactions
    R Levine
    MCP-Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Biophys J 81:1070-82. 2001
    ..This mechanism may modulate the number of cross-bridges generating force during activation...
  12. ncbi request reprint Myosin-binding protein C phosphorylation, myofibril structure, and contractile function during low-flow ischemia
    Robert S Decker
    Feinberg Cardiovascular Research Institute, Tarry 12 733, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611 3008, USA
    Circulation 111:906-12. 2005
    ..The objective of this study is to identify whether changes in the phosphorylation state of myosin-binding protein C (MyBP-C) are a potential cause of dysfunction...
  13. ncbi request reprint Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes
    Lutz Pohlmann
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Circ Res 101:928-38. 2007
    ..Our findings indicate that cMyBP-C functions as a restraint on myosin-actin interaction at low Ca2+ and short SL to allow complete relaxation during diastole...

Research Grants7

  1. C PROTEIN AND CROSS BRIDGE FUNCTION IN HEART MUSCLE
    Saul Winegrad; Fiscal Year: 2000
    ....
  2. C PROTEIN AND CROSS BRIDGE FUNCTION IN HEART MUSCLE
    Saul Winegrad; Fiscal Year: 2004
    ..Abnormalities in its structure and function are responsible for one of the more common forms of Familial Hypertrophic Cardiomyopathy. ..