BETTINA R WINCKLER

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Scientiae forum / models and speculations pathways for axonal targeting of membrane proteins
    Bettina Winckler
    Department of Neuroscience, University of Virginia Medical School, Lane Road Extension MR4, Charlottesville, VA 22908 1392, USA
    Biol Cell 96:669-74. 2004
  2. pmc Endocytosis and endosomes at the crossroads of regulating trafficking of axon outgrowth-modifying receptors
    Bettina Winckler
    Department of Neuroscience, University of Virginia Medical School, MR4 6115, 409 Lane Road Ext, Charlottesville, VA 22936, USA
    Traffic 12:1099-108. 2011
  3. ncbi request reprint BDNF instructs the kinase LKB1 to grow an axon
    Bettina Winckler
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Cell 129:459-60. 2007
  4. ncbi request reprint Cordon-bleu: a new taste in actin nucleation
    Bettina Winckler
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22093, USA
    Cell 131:236-8. 2007
  5. pmc Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting
    Chan Choo C Yap
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, Virginia 22936, USA
    J Neurosci 30:6646-57. 2010
  6. ncbi request reprint Inhibition of sphingolipid synthesis affects kinetics but not fidelity of L1/NgCAM transport along direct but not transcytotic axonal pathways
    Michael C Chang
    Department of Neuroscience, University of Virginia, 409 Lane Road, MR4 6112, Charlottesville, VA 22908, USA
    Mol Cell Neurosci 31:525-38. 2006
  7. doi request reprint Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses
    Zofia M Lasiecka
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Int Rev Cell Mol Biol 272:303-89. 2009
  8. pmc Trafficking guidance receptors
    Bettina Winckler
    University of Virginia, Department of Neuroscience, Charlottesville, Virgina 22908, USA
    Cold Spring Harb Perspect Biol 2:a001826. 2010
  9. pmc The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM
    Chan Choo Yap
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Cell Biol 180:827-42. 2008
  10. ncbi request reprint Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule
    Tatiana Boiko
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:590-603. 2007

Research Grants

  1. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2007
  2. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2009
  3. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2010

Collaborators

  • DOROTHY SCHAFER
  • Ira Mellman
  • Chan Choo Yap
  • Zofia M Lasiecka
  • Tatiana Boiko
  • Dolora Wisco
  • Michael C Chang
  • Chan Choo C Yap
  • Max Vakulenko
  • Caren Norden
  • Helge Ewers
  • Steven Caplan
  • Judith Klumperman
  • Eric Anderson
  • Pekka Kujala
  • Johanna T Cannon
  • Rita L Nokes
  • Harald Hirling
  • HEIKE FOLSCH

Detail Information

Publications12

  1. ncbi request reprint Scientiae forum / models and speculations pathways for axonal targeting of membrane proteins
    Bettina Winckler
    Department of Neuroscience, University of Virginia Medical School, Lane Road Extension MR4, Charlottesville, VA 22908 1392, USA
    Biol Cell 96:669-74. 2004
    ..A protein might in fact be sorted multiple times at different places to achieve axonal localization...
  2. pmc Endocytosis and endosomes at the crossroads of regulating trafficking of axon outgrowth-modifying receptors
    Bettina Winckler
    Department of Neuroscience, University of Virginia Medical School, MR4 6115, 409 Lane Road Ext, Charlottesville, VA 22936, USA
    Traffic 12:1099-108. 2011
    ..We will first summarize the pathways underlying the axonal transport of these proteins and then discuss the potential roles of EHD4/Pincher in mediating their endocytosis...
  3. ncbi request reprint BDNF instructs the kinase LKB1 to grow an axon
    Bettina Winckler
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Cell 129:459-60. 2007
    ..Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1...
  4. ncbi request reprint Cordon-bleu: a new taste in actin nucleation
    Bettina Winckler
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22093, USA
    Cell 131:236-8. 2007
    ..In this issue, Ahuja et al. (2007) identify and characterize a new actin nucleator called cordon-bleu (Cobl) that may drive morphogenesis of the central nervous system during development...
  5. pmc Alterations of EHD1/EHD4 protein levels interfere with L1/NgCAM endocytosis in neurons and disrupt axonal targeting
    Chan Choo C Yap
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, Virginia 22936, USA
    J Neurosci 30:6646-57. 2010
    ..Our data suggest that EHD1 plays roles in both endosomal recycling and a specialized endocytosis pathway in neurons used by NgCAM. We propose that EHD1 and EHD4 act as hetero-oligomeric complexes in this pathway...
  6. ncbi request reprint Inhibition of sphingolipid synthesis affects kinetics but not fidelity of L1/NgCAM transport along direct but not transcytotic axonal pathways
    Michael C Chang
    Department of Neuroscience, University of Virginia, 409 Lane Road, MR4 6112, Charlottesville, VA 22908, USA
    Mol Cell Neurosci 31:525-38. 2006
    ..Therefore, the formation and/or transport of a subset of axonally-targeted vesicles are coupled to sphingolipid synthesis. Our results yield a mechanism for the axon outgrowth defect observed in FB1...
  7. doi request reprint Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses
    Zofia M Lasiecka
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    Int Rev Cell Mol Biol 272:303-89. 2009
    ....
  8. pmc Trafficking guidance receptors
    Bettina Winckler
    University of Virginia, Department of Neuroscience, Charlottesville, Virgina 22908, USA
    Cold Spring Harb Perspect Biol 2:a001826. 2010
    ..It is likely that the localization of all guidance receptors is regulated by a combination of sorting, retrieval, recycling and retention, similar to the ones we discuss here for L1...
  9. pmc The somatodendritic endosomal regulator NEEP21 facilitates axonal targeting of L1/NgCAM
    Chan Choo Yap
    Department of Neuroscience, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Cell Biol 180:827-42. 2008
    ..We propose that small endosomal carriers derived from somatodendritic recycling endosomes can serve to redistribute a distinct set of membrane proteins from dendrites to axons...
  10. ncbi request reprint Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule
    Tatiana Boiko
    Department of Neuroscience, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 27:590-603. 2007
    ..Our results suggest that NF and L1/NgCAM accumulate in the axon by an ankyrin-independent pathway, but retention at the IS requires ankyrin binding...
  11. pmc Myelin under construction -- teamwork required
    Tatiana Boiko
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 172:799-801. 2006
    ..show that neuronal signaling regulates cell surface expression of the myelin proteolipid protein in cultured oligodendrocytes in unexpected ways that may also contribute to myelination in situ...
  12. doi request reprint Pathway selection to the axon depends on multiple targeting signals in NgCAM
    Chan Choo Yap
    University of Virginia Medical School, Department of Neuroscience, Charlottesville, VA 22908, USA
    J Cell Sci 121:1514-25. 2008
    ..Additionally, we show that the axonal cytoplasmic signal promotes apical targeting in MDCK cells. Transcytosis of NgCAM to the axon thus requires the sequential regulated execution of multiple targeting signals...

Research Grants8

  1. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2007
    ..The overall goal of our work is to specify the mechanisms producing the polarized architecture of neurons. ..
  2. Targeting Pathways of Axonal Cell Adhesion Molecules
    Bettina Winckler; Fiscal Year: 2009
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..
  3. Targeting Pathways of Axonal Cell Adhesion Molecules
    BETTINA R WINCKLER; Fiscal Year: 2010
    ..Since L1 expression is upregulated after neuronal injury and after stroke, understanding L1 trafficking to axons has implications for regenerative processes after injury. ..