Matthew W Wilson

..His symptoms resolved and his disease has not recurred. Use of infliximab may be useful in the treatment of recalcitrant idiopathic orbital pseudotumor...

..To compare the expression of multidrug-resistant proteins in retinoblastoma tumors among eyes treated with primary enucleation...

..To report the incidence of new tumor formation in hereditary retinoblastoma patients treated with primary systemic chemotherapy...

..Our objective for this study was to examine the impact of the modern management of intraocular retinoblastoma on the patient and the family...

..To report the use of a combination of low-dose cyclophosphamide and interferon alfa 2a (IFNalpha2a) for the treatment of orbital juvenile capillary hemangioma...

..To evaluate vincristine and carboplatin with intensive focal treatments in the management of intraocular retinoblastoma...

..To evaluate the efficacy of chemoreduction using vincristine and carboplatin in preventing or delaying external-beam radiotherapy (EBRT) or enucleation in patients with intraocular retinoblastoma...

..To determine the impact of chemotherapy or external beam radiotherapy (EBRT) on pediatric anophthalmic sockets...

..The risk for death in patients with retinoblastoma is increased in those who present with metastatic disease, and the role of intensive chemotherapy and autologous hematopoietic stem cell rescue in these patients remains unclear...

..New, effective chemotherapeutic agents are needed for intraocular retinoblastoma...

..We retrospectively assessed the incidence of ototoxicity and its risk factors in children with retinoblastoma who were treated with carboplatin...

..To identify the type and frequency of ocular and orbital complications observed following treatment for primary rhabdomyosarcoma of the paranasal sinuses or the orbit...

..The purpose of this study was to report our experience using episcleral plaque brachytherapy (EPBRT) to treat retinoblastoma and to demonstrate its applicability in multimodality treatment...

..Early diagnosis of trilateral retinoblastoma may facilitate the use of less intensive therapeutic approaches and result in excellent outcomes in these patients...

..To compare the expression of pregnane xenobiotic receptor and certain multi-drug resistance proteins in retinoblastoma...

..Our long-term goal is to determine if changes in the drug of choice and/or delivery procedures will decrease vascular toxicity and lead to better eye-targeted treatment strategies...

..Accurate diagnosis requires careful clinical and pathologic examinations...

..The impact of chemotherapy, focal therapies, radiation and co-existing ocular morbidities on histology of eyes with retinoblastoma enucleated following chemoreduction is not well known...

..To characterize the clinical and imaging features of orbital leukemic tumors in 27 patients seen and treated at St. Jude Children's Research Hospital...

..To correlate the clinical and histopathological findings of eyes primarily enucleated for advanced intraocular retinoblastoma...

..To use functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to investigate visual system development in children being treated for retinoblastoma...

..Alveolar rhabdomyosarcoma from distant sites rarely metastasizes to the extraocular muscles. However, our case shows that alveolar rhabdomyosarcoma may metastasize to the orbit and involve a single muscle...

..To compare the difference in volume between enucleated and contralateral, uninvolved orbits in patients with unilateral retinoblastoma treated with primary enucleation who received either hydroxyapatite or solid silicone implants...

..Carboplatin is the most effective drug in retinoblastoma but systemic clearance is variable in young patients. While most regimens use a flat dose, individualized targeting may provide a more adjusted systemic exposure...

..CONCLUSIONS: Because fungal orbital cellulitis can be fatal even if detected early in patients who are immunocompromised, ophthalmologists and otolaryngologists should be alert to the disease's subtle clinical manifestations...

..However, patients with this disease have a poor prognosis...

..CONCLUSIONS: Retained intraorbital metallic foreign bodies are well-tolerated and typically have minimal adverse visual prognosis. They should be managed conservatively in the absence of specific indications for removal...

..Intracranial chordoma should be considered in the differential diagnosis of children with orbital lesions. Immunohistochemistry is helpful in differentiating chordomas from other primitive round-cell or spindle-cell tumors...

..Repeat surgical resection with removal of the lateral orbital rim was performed. Histopathology was consistent with recurrent chondromyxoid fibroma...

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..When surgery is indicated, the potential complications can be vision-or life-threatening. Here we report the results of cataract extraction with intraocular lens placement in young children with retinoblastoma...

..To our knowledge, this case represents the first description of occult orbital metastases in a patient with neuroblastoma detected after administration of an antitumor vaccine...

..To report the long-term complications and rate of local recurrence in a cohort of patients with histopathologically confirmed conjunctival melanoma (CM) treated with adjuvant topical mitomycin C (MMC)...

..She died within 2 days of admission. CONCLUSION: We believe that this is the first description of a patient with retinoblastoma and Waardenburg syndrome and of an ovarian metastasis from retinoblastoma...

..We developed a nonhuman primate (NHP) model of SSIOAC and reported our clinical observations. For validation, we compared ophthalmic artery (OA) diameters between NHPs and children (<6 years)...

..The current dilemmas in the diagnosis and management of conjunctival melanoma are reviewed in this paper. Available evidence for the role of sentinel lymph node biopsy as it applies to conjunctival melanoma is examined...

..Clinical studies, surgical exploration, and pathology revealed a hemorrhagic cyst lined with respiratory epithelium surrounding her previously placed silicone implant...

..Recent developments in understanding genetic and molecular features of these tumors are discussed with emphasis on clinical application...

..To correlate the histologic and magnetic resonance imaging results of the optic nerve in eyes primarily enucleated for retinoblastoma...

..A diagnostic approach using fine needle aspiration is described...

..A thorough examination and proper workup are necessary to rule out serious conditions but may fail to determine a cause. These idiopathic cases typically resolve without treatment...

..Each of the children was having life stresses in addition to his medical treatment that may have accounted for his behavior...

..Careful review of the clinical manifestations, histopathological review of all previous biopsy specimens, and repeat biopsy aided in the correct diagnosis and management of disease in these 3 patients...

..To report real-time ophthalmoscopic findings during superselective intraophthalmic artery chemotherapy (SSIOAC) in a nonhuman primate model...

..Features useful in discriminating among these entities are emphasized...

..RESULTS: Histologic examination revealed fungal elements without evidence of tumor. CONCLUSION: Although rare, fungi should be included in the differential diagnosis of pigmented lesions of the conjunctiva...

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..We believe that microdiathermy applied to the base of the cyst removes residual epithelial tissue that accounted for the recurrences documented in previous reports...

..The purpose of this study was to document the ocular preservation rate after 36 Gy external beam radiation therapy (EBRT) for retinoblastoma...

..The authors studied a series of patients with Langerhans cell histiocytosis in an attempt to better define the incidence and significance of orbital involvement within the vast spectrum of the disease...

..Jude Children's Research Hospital, and the University of Tennessee Hamilton Eye Institute...

..To review our institution's experience in the treatment of craniopharyngioma and assess the merits of initial therapy with limited surgery and irradiation...

..RESULTS: By clinical examination, retinoblastoma was diagnosed in the right eye. CONCLUSION: Chromosomal abnormalities on the long arm of chromosome 13 predispose to retinoblastoma formation and characteristic facial features...

..CONCLUSIONS: Treatment therapies for choroidal melanoma warrant further study. Currently, enucleation remains as effective as the eye- and vision-sparing approaches...

..Injuries may range from minor lacerations to complex orbital fractures; visual loss may be severe. We believe that the age of the vehicles' operators and their failure to wear protective helmets contribute to the severity of injuries...

..These experiments suggest that chimeric ribozyme targeted against PCNA may have a therapeutic or preventative role in humans...

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..This study evaluated the outcome of retinoblastoma patients, when employing a telemedicine-based twinning program in Jordan...