C C Wilson

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes
    C C Wilson
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 75:4195-207. 2001
  2. ncbi Clinical phase 1 testing of the safety and immunogenicity of an epitope-based DNA vaccine in human immunodeficiency virus type 1-infected subjects receiving highly active antiretroviral therapy
    Cara C Wilson
    University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Clin Vaccine Immunol 15:986-94. 2008
  3. ncbi Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function
    Brent E Palmer
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:3337-47. 2004
  4. ncbi Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction
    Michelle D'Souza
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Immunol 179:1979-87. 2007
  5. ncbi Development of a DNA vaccine designed to induce cytotoxic T lymphocyte responses to multiple conserved epitopes in HIV-1
    Cara C Wilson
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 171:5611-23. 2003
  6. ncbi Diverse repertoire of HIV-1 p24-specific, IFN-gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy
    Eli Boritz
    Department of Immunology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Immunol 170:1106-16. 2003
  7. ncbi Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals
    Michelle A Barron
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Infect Dis 187:26-37. 2003
  8. ncbi CD4+ T cell targeting of human immunodeficiency virus type 1 (HIV-1) peptide sequences present in vivo during chronic, progressive HIV-1 disease
    Eli Boritz
    Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, USA
    Virology 361:34-44. 2007
  9. ncbi Human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levels
    Eli Boritz
    University of Colorado Health Sciences Center, Campus Box B-164, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Virol 78:12638-46. 2004
  10. ncbi Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development
    Michelle A Barron
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Immunol 26:251-64. 2006

Research Grants

  1. Interactions Between Recombinant Yeast and Blood DCs
    Cara Wilson; Fiscal Year: 2004

Collaborators

Detail Information

Publications23

  1. ncbi Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes
    C C Wilson
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 75:4195-207. 2001
    ..The epitopes described herein are potentially important components of HIV-1 therapeutic and prophylactic vaccines...
  2. ncbi Clinical phase 1 testing of the safety and immunogenicity of an epitope-based DNA vaccine in human immunodeficiency virus type 1-infected subjects receiving highly active antiretroviral therapy
    Cara C Wilson
    University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Clin Vaccine Immunol 15:986-94. 2008
    ....
  3. ncbi Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function
    Brent E Palmer
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:3337-47. 2004
    ....
  4. ncbi Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction
    Michelle D'Souza
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    J Immunol 179:1979-87. 2007
    ..0078). Thus, PD-1 expression on HIV-specific CD4(+) T cells is driven by persistent HIV replication, providing a potential target for enhancing the functional capacity of HIV-specific CD4(+) T cells...
  5. ncbi Development of a DNA vaccine designed to induce cytotoxic T lymphocyte responses to multiple conserved epitopes in HIV-1
    Cara C Wilson
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 171:5611-23. 2003
    ..These data indicate that the EP HIV-1090 DNA vaccine may be suitable for inducing relevant HIV-1-specific CTL responses in humans...
  6. ncbi Diverse repertoire of HIV-1 p24-specific, IFN-gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy
    Eli Boritz
    Department of Immunology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Immunol 170:1106-16. 2003
    ....
  7. ncbi Influence of plasma viremia on defects in number and immunophenotype of blood dendritic cell subsets in human immunodeficiency virus 1-infected individuals
    Michelle A Barron
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Infect Dis 187:26-37. 2003
    ..These findings further define the impact of HIV-1 replication on blood DC subsets in vivo...
  8. ncbi CD4+ T cell targeting of human immunodeficiency virus type 1 (HIV-1) peptide sequences present in vivo during chronic, progressive HIV-1 disease
    Eli Boritz
    Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, USA
    Virology 361:34-44. 2007
    ..However, with high-level in vivo HIV-1 replication, CD4+ T cells targeting autologous HIV-1 may be non-responsive or absent...
  9. ncbi Human immunodeficiency virus type 1 (HIV-1)-specific CD4+ T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levels
    Eli Boritz
    University of Colorado Health Sciences Center, Campus Box B-164, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Virol 78:12638-46. 2004
    ..Therefore, proliferation-competent, HIV-1-specific CD4+ T cells that might help control HIV-1 disease may persist during chronic, progressive HIV-1 disease except at very high levels of in vivo HIV-1 replication...
  10. ncbi Human dendritic cell interactions with whole recombinant yeast: implications for HIV-1 vaccine development
    Michelle A Barron
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Immunol 26:251-64. 2006
    ..These DC-targeting characteristics of yeast suggest that it may be an effective vaccine vector for induction of HIV-1-specific cellular immune responses...
  11. ncbi Increased survival from stage IV melanoma associated with fewer regulatory T Cells
    Joel M Baumgartner
    Department of Surgery, University of Colorado Denver, Denver, Colorado 80262, USA
    J Surg Res 154:13-20. 2009
    ..In this study, markers of immune escape including regulatory T cells (T(regs)), dendritic cells (DCs), and TGF-beta were evaluated in 14 Stage IV melanoma patients and correlated with survival...
  12. ncbi HIV-1-specific CD4+ T-cell responses are not associated with significant viral epitope variation in persons with persistent plasma viremia
    John R Koeppe
    Division of Infectious Diseases and Clinical Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Acquir Immune Defic Syndr 41:140-8. 2006
    ..To determine whether increased sequence variation occurs in regions of endogenous HIV-1 targeted by HIV-1-specific CD4 T cells. The presence of increased variation would be suggestive of immune evasion by HIV-1...
  13. ncbi Functional and phenotypic characterization of CD57+CD4+ T cells and their association with HIV-1-induced T cell dysfunction
    Brent E Palmer
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 175:8415-23. 2005
    ..A better understanding of the generation and persistence of CD57+ T cells in HIV-1 infection could provide important insights into the immunopathogenesis of this disease...
  14. ncbi Recombinant yeast as a vaccine vector for the induction of cytotoxic T-lymphocyte responses
    Andrew C Stubbs
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Curr Opin Mol Ther 4:35-40. 2002
    ....
  15. ncbi Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response
    Andrew P Fontenot
    Division of Clinical Immunology, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 115:2886-93. 2005
    ..Together, these findings indicate that the functional capability of antigen-specific CD4+ T cells is determined by the relative proportion of memory T cell subsets, which may reflect internal organ involvement...
  16. ncbi Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection
    Afework Kassu
    Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 185:3007-18. 2010
    ....
  17. ncbi Discordance between frequency of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-producing CD4(+) T cells and HIV-1-specific lymphoproliferation in HIV-1-infected subjects with active viral replication
    B E Palmer
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Virol 76:5925-36. 2002
    ....
  18. ncbi Plasmacytoid and myeloid dendritic cells with a partial activation phenotype accumulate in lymphoid tissue during asymptomatic chronic HIV-1 infection
    Stephanie M Dillon
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Acquir Immune Defic Syndr 48:1-12. 2008
    ..Activation and depletion of DCs in blood with accumulation in lymphoid tissue may contribute to HIV-associated chronic immune activation and T-cell dysfunction...
  19. ncbi Evidence for dendritic cell-dependent CD4(+) T helper-1 type responses to commensal bacteria in normal human intestinal lamina propria
    Rawleigh Howe
    Department of Medicine, University of Colorado Denver, Denver, Colorado 80045, USA
    Clin Immunol 131:317-32. 2009
    ..These results suggest that bacteria-reactive DCs and CD4(+) T cells in normal LP have substantial pro-inflammatory potential that is revealed upon disaggregation in vitro...
  20. ncbi Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity
    A C Stubbs
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Nat Med 7:625-9. 2001
    ..Recombinant yeast represent a novel vaccine strategy for the induction of broad-based cellular immune responses...
  21. ncbi Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes
    J A Mengshol
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Colorado Denver, Colorado, USA
    Gut 58:964-73. 2009
    ..Studies to date have produced inconsistent results regarding DC maturation and function: no large study has examined DCs before and after therapy...
  22. ncbi Human intestinal lamina propria CD1c+ dendritic cells display an activated phenotype at steady state and produce IL-23 in response to TLR7/8 stimulation
    Stephanie M Dillon
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 184:6612-21. 2010
    ..These findings highlight a potential mechanism by which viruses like HIV-1 may subvert homeostatic mechanisms and induce inflammation in the intestinal mucosa...
  23. ncbi Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTL
    Denise M McKinney
    Epimmune, San Diego, CA 92121, USA
    J Immunol 173:1941-50. 2004
    ..We believe the ability to predict CTL epitope immunogenicity and recognition patterns of variant epitopes can be useful for designing vaccines against multiple subtypes and circulating recombinant forms of HIV-1...

Research Grants2

  1. Interactions Between Recombinant Yeast and Blood DCs
    Cara Wilson; Fiscal Year: 2004
    ....