Monte S Willis

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint The role of ubiquitin ligases in cardiac disease
    Monte S Willis
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA Electronic address
    J Mol Cell Cardiol 71:43-53. 2014
  2. pmc Muscle ring finger 1 mediates cardiac atrophy in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Physiol Heart Circ Physiol 296:H997-H1006. 2009
  3. pmc Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease
    Monte S Willis
    University of North Carolina, Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, 2340B Medical Biomolecular Research Building, Chapel Hill, NC 27599 7525, USA
    Future Cardiol 4:65-75. 2008
  4. pmc Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, 27599 7525, USA
    Circ Res 105:80-8. 2009
  5. doi request reprint BMPER regulates cardiomyocyte size and vessel density in vivo
    Monte S Willis
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Cardiovasc Pathol 22:228-40. 2013
  6. ncbi request reprint IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury
    Nancy C Moss
    Department of Surgery, University of North Carolina, Chapel Hill, North Carolina 27599 7065, USA
    Am J Physiol Heart Circ Physiol 293:H2248-53. 2007
  7. ncbi request reprint Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Circ Res 100:456-9. 2007
  8. pmc Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    Hui Hua Li
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Clin Invest 117:3211-23. 2007
  9. pmc Build it up-Tear it down: protein quality control in the cardiac sarcomere
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, 8200 Medical Biomolecular Research Bldg, 103 Mason Farm Road, Chapel Hill, NC 27599 7126, USA
    Cardiovasc Res 81:439-48. 2009
  10. pmc Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo
    Monte S Willis
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Cell Biochem Funct 32:39-50. 2014

Collaborators

Detail Information

Publications41

  1. ncbi request reprint The role of ubiquitin ligases in cardiac disease
    Monte S Willis
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA Electronic address
    J Mol Cell Cardiol 71:43-53. 2014
    ..This article is part of a Special Issue entitled "Protein Quality Control, the Ubiquitin Proteasome System, and Autophagy". ..
  2. pmc Muscle ring finger 1 mediates cardiac atrophy in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Physiol Heart Circ Physiol 296:H997-H1006. 2009
    ..This study demonstrates, for the first time, that MuRF1 is essential for cardiac atrophy in vivo, both in the setting of therapeutic regression of cardiac hypertrophy and dexamethasone-induced atrophy...
  3. pmc Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease
    Monte S Willis
    University of North Carolina, Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, 2340B Medical Biomolecular Research Building, Chapel Hill, NC 27599 7525, USA
    Future Cardiol 4:65-75. 2008
    ..This review focuses on the UPS, its specific role in cardiac disease and opportunities for novel therapies...
  4. pmc Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, 27599 7525, USA
    Circ Res 105:80-8. 2009
    ..This study demonstrates for the first time a role for MuRF1 in the regulation of cardiac energetics in vivo...
  5. doi request reprint BMPER regulates cardiomyocyte size and vessel density in vivo
    Monte S Willis
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Cardiovasc Pathol 22:228-40. 2013
    ..Although previously described in the heart, the role of BMPER in cardiac development and function remain unknown...
  6. ncbi request reprint IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury
    Nancy C Moss
    Department of Surgery, University of North Carolina, Chapel Hill, North Carolina 27599 7065, USA
    Am J Physiol Heart Circ Physiol 293:H2248-53. 2007
    ..These results demonstrate that specific IKKbeta inhibition can provide both acute and delayed cardioprotection and offers a clinically accessible target for preventing cardiac injury following IR...
  7. ncbi request reprint Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Circ Res 100:456-9. 2007
    ..These studies describe for the first time distinct and nonoverlapping functional characteristics of MuRF1 and MuRF2 in response to cardiac stress in vivo...
  8. pmc Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins
    Hui Hua Li
    Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    J Clin Invest 117:3211-23. 2007
    ....
  9. pmc Build it up-Tear it down: protein quality control in the cardiac sarcomere
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, 8200 Medical Biomolecular Research Bldg, 103 Mason Farm Road, Chapel Hill, NC 27599 7126, USA
    Cardiovasc Res 81:439-48. 2009
    ..In this review, we highlight the dynamic interplay between sarcomere-specific chaperones and ubiquitin-dependent degradation of sarcomere proteins that is necessary in order to maintain structure and function of the cardiac sarcomere...
  10. pmc Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo
    Monte S Willis
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Cell Biochem Funct 32:39-50. 2014
    ..We recently reported that MuRF1, but not MuRF2, regulates pathologic cardiac hypertrophy in vivo. This was surprising given that MuRF1 and MuRF2 interact with each other and many of the same sarcomeric proteins experimentally...
  11. pmc Back to your heart: ubiquitin proteasome system-regulated signal transduction
    Andrea L Portbury
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    J Mol Cell Cardiol 52:526-37. 2012
    ..This article is part of a Special Section entitled "Post-translational Modification."..
  12. pmc NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo
    Ashley Wysong
    Duke University School of Medicine, Durham, North Carolina, USA
    Am J Pathol 178:1059-68. 2011
    ....
  13. pmc Tearin' up my heart: proteolysis in the cardiac sarcomere
    Andrea L Portbury
    McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7126, USA
    J Biol Chem 286:9929-34. 2011
    ..This minireview focuses on the individual as well as cooperative involvement of each of these three major pathways of proteolysis within the cardiac sarcomere...
  14. ncbi request reprint Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling
    Kristine M Wadosky
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Am J Physiol Endocrinol Metab 306:E723-39. 2014
    ....
  15. pmc Cardiac muscle ring finger-1--friend or foe?
    Monte S Willis
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Trends Cardiovasc Med 20:12-6. 2010
    ....
  16. ncbi request reprint Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart
    Pamela Lockyer
    McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    Mol Endocrinol 24:1111-9. 2010
    ....
  17. pmc MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
    Thomas E Callis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Clin Invest 119:2772-86. 2009
    ..Together, our studies uncover what we believe are novel miRNA-dependent mechanisms that modulate cardiac hypertrophy and electrical conduction...
  18. ncbi request reprint The bitter end: the ubiquitin-proteasome system and cardiac dysfunction
    Cam Patterson
    Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
    Circulation 115:1456-63. 2007
    ..This review provides a general overview of these pathways and their known and postulated roles in human heart failure syndromes, with a focus on providing a clinically oriented understanding of these fundamental mechanisms...
  19. pmc Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart
    Monte S Willis
    120 Mason Farm Rd, Genetic Medicine Bldg, Room 5060, Chapel Hill, NC 27516 7264, USA
    Circ Res 111:e111-22. 2012
    ..BRG1 is required for vascular endothelial cell (VEC) development and embryonic survival, whereas BRM is dispensable...
  20. pmc Tear me down: role of calpain in the development of cardiac ventricular hypertrophy
    Cam Patterson
    McAllister Heart Institute, University of North Carolina at Chapel Hill, 27599 7525, USA
    Circ Res 109:453-62. 2011
    ..The context within which calpain inhibition might be developed for therapeutic intervention of cardiac hypertrophy is then discussed...
  21. pmc Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease
    Monte S Willis
    Division of Cardiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
    Circ Res 106:463-78. 2010
    ..In summary, the crosstalk between the UPS and autophagy highlight the pivotal and diverse roles the UPS plays in maintaining protein quality control and regulating cardiovascular development and disease...
  22. ncbi request reprint Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury
    William E Stansfield
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
    Ann Thorac Surg 84:120-5. 2007
    ..Its activation relies on the degradation of its inhibitory molecule, IkappaB, by the 20S proteasome. We hypothesized that proteasome inhibition would decrease the extent of infarction after temporary coronary occlusion...
  23. ncbi request reprint You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record)
    Jonathan C Schisler
    Carolina Cardiovascular Biology Center and Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
    Cell Cycle 7:440-3. 2008
    ..In context with other reports describing the regulation and role of FOXO transcription factors, we present a working model for the role of atrogin-1 in both physiologic and pathologic hypertrophy...
  24. pmc Rise above: muscle ring-finger-1 (MURF1) regulation of cardiomyocyte size and energy metabolism
    Cam Patterson
    Division of Cardiology and McAllister Heart Institute, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
    Trans Am Clin Climatol Assoc 122:70-81. 2011
    ....
  25. pmc Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise
    Monte S Willis
    McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Cell Biochem Funct 31:724-35. 2013
    ..Copyright © 2013 John Wiley & Sons, Ltd. ..
  26. pmc Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis
    Xinchun Pi
    UNC McAllister Heart Institute, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
    Arterioscler Thromb Vasc Biol 32:2214-22. 2012
    ....
  27. ncbi request reprint All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-
    Makhosazane Zungu
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Circ J 75:2513-21. 2011
    ....
  28. doi request reprint Merits of non-invasive rat models of left ventricular heart failure
    Alex P Carll
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599 USA
    Cardiovasc Toxicol 11:91-112. 2011
    ..Additional non-invasive techniques that may potentially enable the development of new HF models are also discussed...
  29. ncbi request reprint Blood bank management of sickle cell patients at comprehensive sickle cell centers
    Araba Afenyi-Annan
    Department of Pathology and Laboratory Medicine and the Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27514 7600, USA
    Transfusion 47:2089-97. 2007
    ..The purpose of this study was to examine BB practices for SCD patients at NIH Comprehensive Sickle Cell Centers (CSCCs) and to determine whether consensus in BB management exists...
  30. ncbi request reprint Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin
    David S Paul
    McAllister Heart Institute, University of NC at Chapel Hill, 27599, USA Electronic address
    Biochim Biophys Acta 1841:880-7. 2014
    ..These data indicate that Acsl1-deficiency causes diastolic dysfunction and that mTOR activation is linked to the development of cardiac hypertrophy in Acsl1(H-/-) mice. ..
  31. ncbi request reprint MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
    Taylor A Mattox
    Department of Pharmacology, East Carolina University, Greenville, NC, USA
    J Bioenerg Biomembr 46:173-87. 2014
    ....
  32. pmc Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
    Ethan J Anderson
    Department of Medicine, Pathology and Laboratory Medicine, 111 Mason Farm Road, 2340BMBRB, Chapel Hill, NC 27599 7525, USA
    Clin Exp Pharmacol Physiol 39:179-93. 2012
    ..e. induction of anti-oxidant systems) in cardiomyocytes. Thus, exploitation of the cardioprotective actions of the LPP may represent a novel therapeutic strategy for future treatment of heart disease...
  33. pmc Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers
    Natee Jearawiriyapaisarn
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Cardiovasc Res 85:444-53. 2010
    ....
  34. doi request reprint SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease
    Ariana Bevilacqua
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Cardiovasc Pathol 23:85-91. 2014
    ....
  35. pmc The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation
    Kristine M Wadosky
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
    Am J Physiol Heart Circ Physiol 302:H515-26. 2012
    ..Because PPAR activity is perturbed in a variety of forms of heart disease and specific proteins regulate this process (E3 ligases), this may be a fruitful area of investigation with respect to finding new therapeutic targets...
  36. doi request reprint Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats
    Alex P Carll
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA
    Toxicol Pathol 39:925-37. 2011
    ..Thus, combining ISO infusion with dietary salt loading in SHHFs holds promise for a new rat HF model that may help researchers to elucidate HF mechanisms and unearth effective treatments...
  37. ncbi request reprint Into the heart: the emerging role of the ubiquitin-proteasome system
    Monte S Willis
    Carolina Cardiovascular Biology Center, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    J Mol Cell Cardiol 41:567-79. 2006
    ..g. ubiquitin, E1, E2, E3, proteasome) are themselves transcriptionally regulated in cardiac disease. Our understanding of the precise nature by which the UPS regulates key biological functions in cardiac disease has just begun...
  38. doi request reprint Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixation
    Laura M Bender
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Clin Biochem 46:255-8. 2013
    ..In this study, we compared the performance of five, experienced interpreters using digital images and physical gels to identify and characterize monoclonal gammopathies by immunofixation...
  39. doi request reprint Familial hypertrophic cardiomyopathy: basic concepts and future molecular diagnostics
    Jessica E Rodriguez
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Clin Biochem 42:755-65. 2009
    ..In this review, we discuss FHC pathophysiology, the rationale for testing, and discuss the limitations and advantages of current and future diagnostics...
  40. pmc Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy
    Jessica M Ellis
    Department of Nutrition, CB 7461, University of North Carolina at Chapel Hill, 135 Dauer Drive, MHRC 2301, Chapel Hill, NC 27599, USA
    Mol Cell Biol 31:1252-62. 2011
    ....
  41. ncbi request reprint Effect of anemia on plasma concentrations of NT-proBNP
    Monte S Willis
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599 7525, United States
    Clin Chim Acta 358:175-81. 2005
    ..Understanding the variables that influence the concentrations of NT-proBNP is required to refine its clinical use criteria. The effect of anemia on plasma concentrations of NT-proBNP was investigated...

Research Grants1

  1. Myocyte specific regulation of metabolism and the response to biomechanical force
    Monte S Willis; Fiscal Year: 2010
    ..Elucidating these novel mechanisms as proposed in this study will help identify targets for the development of therapies for this common disease. ..