Research Topics
Genomes and Genes
| Monte S WillisSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Muscle ring finger 1 mediates cardiac atrophy in vivoMonte S Willis
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
Am J Physiol Heart Circ Physiol 296:H997-H1006. 2009..This study demonstrates, for the first time, that MuRF1 is essential for cardiac atrophy in vivo, both in the setting of therapeutic regression of cardiac hypertrophy and dexamethasone-induced atrophy...- Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivoMonte S Willis
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, 27599 7525, USA
Circ Res 105:80-8. 2009..This study demonstrates for the first time a role for MuRF1 in the regulation of cardiac energetics in vivo... - Appetite for destruction: E3 ubiquitin-ligase protection in cardiac diseaseMonte S Willis
University of North Carolina, Department of Pathology and Laboratory Medicine, Carolina Cardiovascular Biology Center, 2340B Medical Biomolecular Research Building, Chapel Hill, NC 27599 7525, USA
Future Cardiol 4:65-75. 2008..This review focuses on the UPS, its specific role in cardiac disease and opportunities for novel therapies... 
IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injuryNancy C Moss
Department of Surgery, University of North Carolina, Chapel Hill, North Carolina 27599 7065, USA
Am J Physiol Heart Circ Physiol 293:H2248-53. 2007..These results demonstrate that specific IKKbeta inhibition can provide both acute and delayed cardioprotection and offers a clinically accessible target for preventing cardiac injury following IR...- Build it up-Tear it down: protein quality control in the cardiac sarcomereMonte S Willis
Carolina Cardiovascular Biology Center, University of North Carolina, 8200 Medical Biomolecular Research Bldg, 103 Mason Farm Road, Chapel Hill, NC 27599 7126, USA
Cardiovasc Res 81:439-48. 2009..In this review, we highlight the dynamic interplay between sarcomere-specific chaperones and ubiquitin-dependent degradation of sarcomere proteins that is necessary in order to maintain structure and function of the cardiac sarcomere... - Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivoMonte S Willis
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
Circ Res 100:456-9. 2007..These studies describe for the first time distinct and nonoverlapping functional characteristics of MuRF1 and MuRF2 in response to cardiac stress in vivo... - Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteinsHui Hua Li
Carolina Cardiovascular Biology Center, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
J Clin Invest 117:3211-23. 2007.... - Back to your heart: ubiquitin proteasome system-regulated signal transductionAndrea L Portbury
McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599 7525, USA
J Mol Cell Cardiol 52:526-37. 2012..This article is part of a Special Section entitled "Post-translational Modification.".. - NF-κB inhibition protects against tumor-induced cardiac atrophy in vivoAshley Wysong
Duke University School of Medicine, Durham, North Carolina, USA
Am J Pathol 178:1059-68. 2011.... - Tearin' up my heart: proteolysis in the cardiac sarcomereAndrea L Portbury
McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7126, USA
J Biol Chem 286:9929-34. 2011..This minireview focuses on the individual as well as cooperative involvement of each of these three major pathways of proteolysis within the cardiac sarcomere... 
Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heartPamela Lockyer
McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
Mol Endocrinol 24:1111-9. 2010....- MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in miceThomas E Callis
Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, North Carolina, USA
J Clin Invest 119:2772-86. 2009..Together, our studies uncover what we believe are novel miRNA-dependent mechanisms that modulate cardiac hypertrophy and electrical conduction... - Cardiac muscle ring finger-1--friend or foe?Monte S Willis
McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599 7126, USA
Trends Cardiovasc Med 20:12-6. 2010.... - The bitter end: the ubiquitin-proteasome system and cardiac dysfunctionCam Patterson
Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
Circulation 115:1456-63. 2007..This review provides a general overview of these pathways and their known and postulated roles in human heart failure syndromes, with a focus on providing a clinically oriented understanding of these fundamental mechanisms... - BMPER regulates cardiomyocyte size and vessel density in vivoMonte S Willis
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA
Cardiovasc Pathol 22:228-40. 2013..Although previously described in the heart, the role of BMPER in cardiac development and function remain unknown... - Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heartMonte S Willis
120 Mason Farm Rd, Genetic Medicine Bldg, Room 5060, Chapel Hill, NC 27516 7264, USA
Circ Res 111:e111-22. 2012..BRG1 is required for vascular endothelial cell (VEC) development and embryonic survival, whereas BRM is dispensable... - Rise above: muscle ring-finger-1 (MURF1) regulation of cardiomyocyte size and energy metabolismCam Patterson
Division of Cardiology and McAllister Heart Institute, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
Trans Am Clin Climatol Assoc 122:70-81. 2011.... - Tear me down: role of calpain in the development of cardiac ventricular hypertrophyCam Patterson
McAllister Heart Institute, University of North Carolina at Chapel Hill, 27599 7525, USA
Circ Res 109:453-62. 2011..The context within which calpain inhibition might be developed for therapeutic intervention of cardiac hypertrophy is then discussed... - Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and diseaseMonte S Willis
Division of Cardiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
Circ Res 106:463-78. 2010..In summary, the crosstalk between the UPS and autophagy highlight the pivotal and diverse roles the UPS plays in maintaining protein quality control and regulating cardiovascular development and disease... - Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injuryWilliam E Stansfield
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7065, USA
Ann Thorac Surg 84:120-5. 2007..Its activation relies on the degradation of its inhibitory molecule, IkappaB, by the 20S proteasome. We hypothesized that proteasome inhibition would decrease the extent of infarction after temporary coronary occlusion... - You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record)Jonathan C Schisler
Carolina Cardiovascular Biology Center and Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina 27599 7126, USA
Cell Cycle 7:440-3. 2008..In context with other reports describing the regulation and role of FOXO transcription factors, we present a working model for the role of atrogin-1 in both physiologic and pathologic hypertrophy... - Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosisXinchun Pi
UNC McAllister Heart Institute, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
Arterioscler Thromb Vasc Biol 32:2214-22. 2012.... - All the little pieces. -Regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitin-like modifer and their potential relevance in the heart.-Makhosazane Zungu
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
Circ J 75:2513-21. 2011.... - Blood bank management of sickle cell patients at comprehensive sickle cell centersAraba Afenyi-Annan
Department of Pathology and Laboratory Medicine and the Cecil G Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina 27514 7600, USA
Transfusion 47:2089-97. 2007..The purpose of this study was to examine BB practices for SCD patients at NIH Comprehensive Sickle Cell Centers (CSCCs) and to determine whether consensus in BB management exists... - Merits of non-invasive rat models of left ventricular heart failureAlex P Carll
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 27599 USA
Cardiovasc Toxicol 11:91-112. 2011..Additional non-invasive techniques that may potentially enable the development of new HF models are also discussed... - Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heartEthan J Anderson
Department of Medicine, Pathology and Laboratory Medicine, 111 Mason Farm Road, 2340BMBRB, Chapel Hill, NC 27599 7525, USA
Clin Exp Pharmacol Physiol 39:179-93. 2012..e. induction of anti-oxidant systems) in cardiomyocytes. Thus, exploitation of the cardioprotective actions of the LPP may represent a novel therapeutic strategy for future treatment of heart disease... - Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomersNatee Jearawiriyapaisarn
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Cardiovasc Res 85:444-53. 2010.... - The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylationKristine M Wadosky
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
Am J Physiol Heart Circ Physiol 302:H515-26. 2012..Because PPAR activity is perturbed in a variety of forms of heart disease and specific proteins regulate this process (E3 ligases), this may be a fruitful area of investigation with respect to finding new therapeutic targets... - Dietary salt exacerbates isoproterenol-induced cardiomyopathy in ratsAlex P Carll
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA
Toxicol Pathol 39:925-37. 2011..Thus, combining ISO infusion with dietary salt loading in SHHFs holds promise for a new rat HF model that may help researchers to elucidate HF mechanisms and unearth effective treatments... - Into the heart: the emerging role of the ubiquitin-proteasome systemMonte S Willis
Carolina Cardiovascular Biology Center, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7126, USA
J Mol Cell Cardiol 41:567-79. 2006..g. ubiquitin, E1, E2, E3, proteasome) are themselves transcriptionally regulated in cardiac disease. Our understanding of the precise nature by which the UPS regulates key biological functions in cardiac disease has just begun... - Evaluation of digital images for identification and characterization of monoclonal immunoglobulins by immunofixationLaura M Bender
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
Clin Biochem 46:255-8. 2013..In this study, we compared the performance of five, experienced interpreters using digital images and physical gels to identify and characterize monoclonal gammopathies by immunofixation... - Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophyJessica M Ellis
Department of Nutrition, CB 7461, University of North Carolina at Chapel Hill, 135 Dauer Drive, MHRC 2301, Chapel Hill, NC 27599, USA
Mol Cell Biol 31:1252-62. 2011.... - Familial hypertrophic cardiomyopathy: basic concepts and future molecular diagnosticsJessica E Rodriguez
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Clin Biochem 42:755-65. 2009..In this review, we discuss FHC pathophysiology, the rationale for testing, and discuss the limitations and advantages of current and future diagnostics... - Effect of anemia on plasma concentrations of NT-proBNPMonte S Willis
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599-7525, United States
Clin Chim Acta 358:175-81. 2005..The impact of this finding on the clinical use and interpretation of the test needs to be examined...
Research Grants
- Myocyte specific regulation of metabolism and the response to biomechanical forceMonte S Willis; Fiscal Year: 2010..Elucidating these novel mechanisms as proposed in this study will help identify targets for the development of therapies for this common disease. ..