Emily Willingham

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Loratadine exerts estrogen-like effects and disrupts penile development in the mouse
    Emily Willingham
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, San Francisco, California 94043, USA
    J Urol 175:723-6. 2006
  2. ncbi request reprint Steroid receptors and mammalian penile development: an unexpected role for progesterone receptor?
    Emily Willingham
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
    J Urol 176:728-33. 2006
  3. ncbi request reprint Ontogeny of androgen receptor and disruption of its mRNA expression by exogenous estrogens during morphogenesis of the genital tubercle
    Koray Agras
    Institute for the Study and Treatment of Hypospadias, Department of Urology, UCSF Children s Medical Center, University of California San Francisco, San Francisco, CA, USA
    J Urol 176:1883-8. 2006
  4. ncbi request reprint Endocrine disruptors and hypospadias: role of genistein and the fungicide vinclozolin
    Marcelo L B Vilela
    Institute for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA
    Urology 70:618-21. 2007
  5. ncbi request reprint Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias
    Benchun Liu
    Department of Urology, University of California, San Francisco, CA, USA
    Pediatr Dev Pathol 10:446-54. 2007
  6. ncbi request reprint Estrogen receptor-alpha and beta are differentially distributed, expressed and activated in the fetal genital tubercle
    Koray Agras
    Institute for the Study and Treatment of Hypospadias, Department of Urology, UCSF Children s Medical Center, University of California San Francisco, San Francisco, CA, USA
    J Urol 177:2386-92. 2007
  7. ncbi request reprint Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiation
    Benchun Liu
    Center for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco, Calif 94143, USA
    Horm Res 65:217-22. 2006
  8. ncbi request reprint In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism
    Michael H Hsieh
    Department of Urology, University of California San Francisco, San Francisco, California, USA
    J Urol 178:1637-42. 2007
  9. ncbi request reprint Gene expression profiles in mouse urethral development
    Jiang Li
    Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    BJU Int 98:880-5. 2006
  10. pmc Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in mice
    Jill Buckley
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, HSW 1434, San Francisco, CA 94143, USA
    Environ Health 5:4. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Loratadine exerts estrogen-like effects and disrupts penile development in the mouse
    Emily Willingham
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, San Francisco, California 94043, USA
    J Urol 175:723-6. 2006
    ..We examined the effect of in utero exposure to an over-the-counter loratadine syrup on urethral development, and expression of androgen and estrogen receptors...
  2. ncbi request reprint Steroid receptors and mammalian penile development: an unexpected role for progesterone receptor?
    Emily Willingham
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
    J Urol 176:728-33. 2006
    ..We investigated the role of steroid receptors in normal and abnormal genital tubercle development in males and females. We hypothesized that progesterone receptor expression might be involved in abnormal development in both sexes...
  3. ncbi request reprint Ontogeny of androgen receptor and disruption of its mRNA expression by exogenous estrogens during morphogenesis of the genital tubercle
    Koray Agras
    Institute for the Study and Treatment of Hypospadias, Department of Urology, UCSF Children s Medical Center, University of California San Francisco, San Francisco, CA, USA
    J Urol 176:1883-8. 2006
    ..The ontogeny of androgen receptor expression in male and female mouse genital tubercles, and the effects of in utero ethinyl estradiol exposure on androgen receptor mRNA expression in the hypospadias model were studied...
  4. ncbi request reprint Endocrine disruptors and hypospadias: role of genistein and the fungicide vinclozolin
    Marcelo L B Vilela
    Institute for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA
    Urology 70:618-21. 2007
    ..Because nonorganic diets can include residues of pesticides such as vinclozolin, we sought to assess the interaction of realistic daily exposures to genistein and vinclozolin and their effects on the incidence of hypospadias...
  5. ncbi request reprint Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias
    Benchun Liu
    Department of Urology, University of California, San Francisco, CA, USA
    Pediatr Dev Pathol 10:446-54. 2007
    ..Its potential involvement in other manifestations of developmental endocrine disruption is worth investigating...
  6. ncbi request reprint Estrogen receptor-alpha and beta are differentially distributed, expressed and activated in the fetal genital tubercle
    Koray Agras
    Institute for the Study and Treatment of Hypospadias, Department of Urology, UCSF Children s Medical Center, University of California San Francisco, San Francisco, CA, USA
    J Urol 177:2386-92. 2007
    ..We examined the ontogenic and sex specific expression of estrogen receptor-alpha and beta in mouse genital tubercles and assessed the effects of in utero estrogen exposure on these parameters...
  7. ncbi request reprint Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiation
    Benchun Liu
    Center for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco, Calif 94143, USA
    Horm Res 65:217-22. 2006
    ..We used a mouse model of steroid-dependent genital tubercle development to elucidate the ontogeny of ATF3 expression and the developmental response of ATF3 in vivo to estrogen exposure...
  8. ncbi request reprint In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism
    Michael H Hsieh
    Department of Urology, University of California San Francisco, San Francisco, California, USA
    J Urol 178:1637-42. 2007
    ..We determined whether hypospadias would develop in male mice exposed to benzophenone-2 in utero and whether this outcome depended on estrogen receptor pathways...
  9. ncbi request reprint Gene expression profiles in mouse urethral development
    Jiang Li
    Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    BJU Int 98:880-5. 2006
    ....
  10. pmc Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in mice
    Jill Buckley
    Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, HSW 1434, San Francisco, CA 94143, USA
    Environ Health 5:4. 2006
    ..In the current work, we selected a relatively low dose of vinclozolin to examine its in utero effects on the development of the genital tubercle, both at the morphological and molecular levels...
  11. ncbi request reprint Activating transcription factor 3 is up-regulated in patients with hypospadias
    Benchun Liu
    Center for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco 94143, USA
    Pediatr Res 58:1280-3. 2005
    ..Because the etiology of hypospadias may include exposure to estrogenic compounds, the responsiveness of ATF3 to estrogen is also discussed...
  12. ncbi request reprint Candidate genes and their response to environmental agents in the etiology of hypospadias
    Emily Willingham
    Austin, TX 78746, USA
    Nat Clin Pract Urol 4:270-9. 2007
    ..In addition to steroid-hormone receptors, one gene of specific interest is activating transcription factor 3 (ATF3). We hypothesize a potential mechanism of action for ATF3 and other identified genes, including TGF-B...
  13. ncbi request reprint Up-regulation of estrogen responsive genes in hypospadias: microarray analysis
    Zhong Wang
    Departments of Urology, Ninth People s Hospital, Shanghai Jiaotong University, Shanghai, People s Republic of China
    J Urol 177:1939-46. 2007
    ..We hypothesized that gene expression would differ between hypospadiac vs nonhypospadiac tissue and fraternal twin data would show patterns similar to those of group data on hypospadiac and nonhypospadiac tissue...