Research Topics
Genomes and Genes | Emily WillinghamSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Loratadine exerts estrogen-like effects and disrupts penile development in the mouseEmily Willingham
Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, San Francisco, California 94043, USA
J Urol 175:723-6. 2006..We examined the effect of in utero exposure to an over-the-counter loratadine syrup on urethral development, and expression of androgen and estrogen receptors...- Steroid receptors and mammalian penile development: an unexpected role for progesterone receptor?Emily Willingham
Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
J Urol 176:728-33. 2006..We investigated the role of steroid receptors in normal and abnormal genital tubercle development in males and females. We hypothesized that progesterone receptor expression might be involved in abnormal development in both sexes... - Ontogeny of androgen receptor and disruption of its mRNA expression by exogenous estrogens during morphogenesis of the genital tubercleKoray Agras
Institute for the Study and Treatment of Hypospadias, Department of Urology, UCSF Children s Medical Center, University of California San Francisco, San Francisco, CA, USA
J Urol 176:1883-8. 2006..The ontogeny of androgen receptor expression in male and female mouse genital tubercles, and the effects of in utero ethinyl estradiol exposure on androgen receptor mRNA expression in the hypospadias model were studied... - Endocrine disruptors and hypospadias: role of genistein and the fungicide vinclozolinMarcelo L B Vilela
Institute for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA
Urology 70:618-21. 2007..Because nonorganic diets can include residues of pesticides such as vinclozolin, we sought to assess the interaction of realistic daily exposures to genistein and vinclozolin and their effects on the incidence of hypospadias... - Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadiasBenchun Liu
Department of Urology, University of California, San Francisco, CA, USA
Pediatr Dev Pathol 10:446-54. 2007..Its potential involvement in other manifestations of developmental endocrine disruption is worth investigating... - Estrogen receptor-alpha and beta are differentially distributed, expressed and activated in the fetal genital tubercleKoray Agras
Institute for the Study and Treatment of Hypospadias, Department of Urology, UCSF Children s Medical Center, University of California San Francisco, San Francisco, CA, USA
J Urol 177:2386-92. 2007..We examined the ontogenic and sex specific expression of estrogen receptor-alpha and beta in mouse genital tubercles and assessed the effects of in utero estrogen exposure on these parameters... - Activating transcription factor 3 is estrogen-responsive in utero and upregulated during sexual differentiationBenchun Liu
Center for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco, Calif 94143, USA
Horm Res 65:217-22. 2006..We used a mouse model of steroid-dependent genital tubercle development to elucidate the ontogeny of ATF3 expression and the developmental response of ATF3 in vivo to estrogen exposure... - In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanismMichael H Hsieh
Department of Urology, University of California San Francisco, San Francisco, California, USA
J Urol 178:1637-42. 2007..We determined whether hypospadias would develop in male mice exposed to benzophenone-2 in utero and whether this outcome depended on estrogen receptor pathways... - Gene expression profiles in mouse urethral developmentJiang Li
Department of Urology, University of California, San Francisco, CA 94143 0738, USA
BJU Int 98:880-5. 2006.... 
Embryonic exposure to the fungicide vinclozolin causes virilization of females and alteration of progesterone receptor expression in vivo: an experimental study in miceJill Buckley
Institute for the Study and Treatment of Hypospadias, Department of Urology, School of Medicine, University of California, HSW 1434, San Francisco, CA 94143, USA
Environ Health 5:4. 2006..In the current work, we selected a relatively low dose of vinclozolin to examine its in utero effects on the development of the genital tubercle, both at the morphological and molecular levels...- Activating transcription factor 3 is up-regulated in patients with hypospadiasBenchun Liu
Center for the Study and Treatment of Hypospadias, Department of Urology, University of California, San Francisco 94143, USA
Pediatr Res 58:1280-3. 2005..Because the etiology of hypospadias may include exposure to estrogenic compounds, the responsiveness of ATF3 to estrogen is also discussed... - Candidate genes and their response to environmental agents in the etiology of hypospadiasEmily Willingham
Austin, TX 78746, USA
Nat Clin Pract Urol 4:270-9. 2007..In addition to steroid-hormone receptors, one gene of specific interest is activating transcription factor 3 (ATF3). We hypothesize a potential mechanism of action for ATF3 and other identified genes, including TGF-B... - Up-regulation of estrogen responsive genes in hypospadias: microarray analysisZhong Wang
Departments of Urology, Ninth People s Hospital, Shanghai Jiaotong University, Shanghai, People s Republic of China
J Urol 177:1939-46. 2007..We hypothesized that gene expression would differ between hypospadiac vs nonhypospadiac tissue and fraternal twin data would show patterns similar to those of group data on hypospadiac and nonhypospadiac tissue...