Research Topics
| James H WilligSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Publications
Nucleoside reverse-transcriptase inhibitor dosing errors in an outpatient HIV clinic in the electronic medical record eraJames H Willig
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, USA
Clin Infect Dis 45:658-61. 2007..Understanding the factors related to nucleoside reverse-transcriptase inhibitor dosing errors is an important step in the building of preventive tools...
Maraviroc observational study: the impact of expanded resistance testing and clinical considerations for antiretroviral regimen selection in treatment-experienced patientsJames H Willig
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
AIDS Res Hum Retroviruses 29:105-11. 2013....
Darunavir outcomes study: comparative effectiveness of virologic suppression, regimen durability, and discontinuation reasons for three-class experienced patients at 48 weeksJames H Willig
Division of Infectious Diseases, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
AIDS Res Hum Retroviruses 26:1279-85. 2010..New agents have transformed the treatment landscape for ARV-experienced patients, with effectiveness in routine clinical care mirroring efficacy in clinical trials...- Clinical inertia in the management of low-density lipoprotein abnormalities in an HIV clinicJames H Willig
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA
Clin Infect Dis 46:1315-8. 2008..Clinical inertia was observed in 44% of cases. Patients with higher baseline LDL levels were less likely to experience inertia, whereas women and those in the highest coronary heart disease risk category were more likely to be affected... - Increased regimen durability in the era of once-daily fixed-dose combination antiretroviral therapyJames H Willig
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
AIDS 22:1951-60. 2008..Modern regimens are thought to possess greater tolerability and convenience. We hypothesized this would translate into greater durability... - Durability of initial antiretroviral therapy in a resource-constrained setting and the potential need for zidovudine weight-based dosingJames H Willig
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL, USA
J Acquir Immune Defic Syndr 53:215-21. 2010..Whereas access to antiretroviral therapy (ART) for HIV-infected individuals in the developing world is increasing, data on factors impacting initial regimen durability are lacking... - The therapeutic implications of timely linkage and early retention in HIV careKimberly B Ulett
University of Alabama School of Medicine, Birmingham, Alabama, USA
AIDS Patient Care STDS 23:41-9. 2009..Missed clinic visits represent an important obstacle to the timely initiation of antiretroviral therapy. These data inform development of interventions to improve linkage and retention in HIV care, an emerging area of growing importance... - Antiretroviral prescribing patterns in treatment-naïve patients in the United StatesJames A McKinnell
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
AIDS Patient Care STDS 24:79-85. 2010..In contrast, regimen sequencing beyond the first regimen remained complex. These shifts in ART prescribing patterns may have implications for collaborative HIV care... - Short-term discontinuation of HAART regimens more common in vulnerable patient populationsLindsay S Robison
University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 24:1347-55. 2008..S. HIV/AIDS epidemic. More vigilant monitoring of patient populations at higher risk of toxicity and virologic failure may allow for improved HAART regimen durability... - Comparative efficacy versus effectiveness of initial antiretroviral therapy in clinical trials versus routine careJustin S Routman
Divisions of Infectious Diseases, Department of Medicine, University of Alabama School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2050, USA
Clin Infect Dis 50:574-84. 2010..Although well-chronicled in many conditions, the efficacy versus effectiveness of antiretroviral therapy (ART) remains understudied... - Temporal trends in presentation for outpatient HIV medical care 2000-2010: implications for short-term mortalityPaula S Seal
Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, CCB 142, 908 20th Street So, Birmingham, AL 35294 2050, USA
J Gen Intern Med 26:745-50. 2011..Many newly diagnosed patients present to outpatient care with advanced HIV infection. More timely HIV diagnosis and initiation of care has the potential to improve individual health outcomes and has public health implications... - Early virologic suppression with three-class experienced patients: 24-week effectiveness in the darunavir outcomes studyJames A McKinnell
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
AIDS 23:1539-46. 2009.... - Missed visits and mortality among patients establishing initial outpatient HIV treatmentMichael J Mugavero
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 908 20th St South, Birmingham, AL 35294 2050, USA
Clin Infect Dis 48:248-56. 2009.... - Patient reported outcomes in routine care: advancing data capture for HIV cohort researchMichael S Kozak
Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL 35294 2050, USA
Clin Infect Dis 54:141-7. 2012..Comparisons between data from PROs and Electronic Health Records (EHR) are lacking. We compare EHR and PRO for capture of depression and substance abuse and their relationship to adherence to antiretroviral therapy (ART)... - Multimorbidity patterns in HIV-infected patients: the role of obesity in chronic disease clusteringDavid J Kim
University of Alabama School of Medicine, Birmingham, AL 35294 2050, USA
J Acquir Immune Defic Syndr 61:600-5. 2012..Increases in multimorbidity and obesity have been noted in HIV-infected populations in the current treatment era. Patterns of multimorbid disease clustering and the impact of obesity on multimorbidity are understudied in this population... - Pain, mood, and substance abuse in HIV: implications for clinic visit utilization, antiretroviral therapy adherence, and virologic failureJessica S Merlin
Division of Infectious Diseases, Department of Medicine, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 61:164-70. 2012..Our objective was to investigate the relationship between pain, alone and in the context of mood disorders and substance abuse, on clinic utilization, antiretroviral therapy adherence, and virologic suppression... - Early retention in HIV care and viral load suppression: implications for a test and treat approach to HIV preventionMichael J Mugavero
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, USA
J Acquir Immune Defic Syndr 59:86-93. 2012..We evaluated factors associated with expeditious VL suppression and cumulative VL burden among patients establishing outpatient HIV care... - Underutilization of the AIDS Drug Assistance Program: associated factors and policy implicationsNoah C Godwin
University of Alabama School of Medicine, 908 20th St South, Birmingham, AL 35294, USA
Health Serv Res 46:982-95. 2011..The AIDS Drug Assistance Program (ADAP) provides antiretroviral medications to low-income individuals with HIV infection... - The role of toxicity-related regimen changes in the development of antiretroviral resistanceChrista R Nevin
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, USA
AIDS Res Hum Retroviruses 27:957-63. 2011..Understanding the role of ARV drug selection and other factors associated with the emergence of ARV resistance will help inform interventions to improve patient care and ensure long-term treatment success... - Racial disparities in HIV virologic failure: do missed visits matter?Michael J Mugavero
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 50:100-8. 2009..Racial/ethnic health care disparities are well described in people living with HIV/AIDS, although the processes underlying observed disparities are not well elucidated... - Uncompensated medical provider costs associated with prior authorization for prescription medications in an HIV clinicJames L Raper
Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, AL 35294 2050, USA
Clin Infect Dis 51:718-24. 2010..60 per PA. Although evidence supports that PA reduces third-party expenditures, it significantly delays medication accessibility for patients and imposes high costs that negatively impact operating margins for health care providers... - Clinical outcome of HIV-infected antiretroviral-naive patients with discordant immunologic and virologic responses to highly active antiretroviral therapyRuimin Tan
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Acquir Immune Defic Syndr 47:553-8. 2008..The prognostic significance of a response to highly active antiretroviral therapy (HAART) that is immunologically and virologically discordant is not well understood... - Viremia copy-years predicts mortality among treatment-naive HIV-infected patients initiating antiretroviral therapyMichael J Mugavero
Department of Medicine, Division of Infectious Diseases, University of Alabama, Birmingham, AL, USA
Clin Infect Dis 53:927-35. 2011..We evaluated the cumulative effect of exposure to HIV replication on mortality following initiation of combination antiretroviral therapy (ART)... - Mortality after cancer diagnosis in HIV-infected individuals treated with antiretroviral therapyChad J Achenbach
Division of Infectious Diseases, Center for Global Health, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
AIDS 25:691-700. 2011..To evaluate survival and predictors of mortality after cancer diagnosis among HIV-infected persons receiving combination antiretroviral therapy (cART)... - Underutilization of aspirin for primary prevention of cardiovascular disease among HIV-infected patientsGreer A Burkholder
Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Clin Infect Dis 55:1550-7. 2012..However, little is known about HIV provider practices regarding aspirin (ASA) for primary prevention of CVD... - Routine, self-administered, touch-screen, computer-based suicidal ideation assessment linked to automated response team notification in an HIV primary care settingSarah T Lawrence
Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA
Clin Infect Dis 50:1165-73. 2010..We sought to implement routine screening of suicidal ideation and associated conditions using computerized patient-reported outcome (PRO) assessments... - Comparative Effectiveness and Toxicity of Statins Among HIV-Infected PatientsSudershan Singh
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Clin Infect Dis 52:387-95. 2011..Little is known about the comparative effectiveness of statins among human immunodeficiency virus (HIV)-infected patients. This study compared the effectiveness and toxicity of statins among HIV-infected patients in clinical care... - Evaluation of the Single-Item Self-Rating Adherence Scale for Use in Routine Clinical Care of People Living with HIVB J Feldman
Department of Medicine, Harborview Medical Center, University of Washington, 325 9th Ave, Box 359931, Seattle, WA, 98104, USA
AIDS Behav 17:307-18. 2013..These results and the SRSI's low patient burden suggest its routine use could be helpful for assessing adherence in clinical care and should be more widespread, particularly where more complex instruments may be impractical... - Predictive accuracy of the Veterans Aging Cohort Study index for mortality with HIV infection: a North American cross cohort analysisAmy C Justice
Department of Internal Medicine, Yale University and the Veterans Affairs Healthcare System, West Haven, CT 06516, USA
J Acquir Immune Defic Syndr 62:149-63. 2013.... - HIV infection and obesity: where did all the wasting go?Tyler Tate
Department of Medicine, University of Alabama School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Antivir Ther 17:1281-9. 2012..As chronic diseases rates have increased in HIV+ populations, modifiable risk factors such as obesity have increased in importance. Our objective was to evaluate factors associated with weight change among patients receiving ART... - Short communication routine HIV testing in the emergency department: assessment of patient perceptionsD Scott Batey
Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, USA
AIDS Res Hum Retroviruses 28:352-6. 2012..These data are of particular benefit to decision makers considering the addition of routine HIV testing in EDs... - Failure to establish HIV care: characterizing the "no show" phenomenonMichael J Mugavero
Division of Infectious Diseases and International Health, Department of Medicine, University of Alabama at Birmingham, USA
Clin Infect Dis 45:127-30. 2007.... - New syphilis cases and concurrent STI screening in a southeastern U.S. HIV clinic: a call to actionCynthia W Baffi
Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
AIDS Patient Care STDS 24:23-9. 2010..These low rates are concerning as concurrent sexually transmitted infections (STIs) increase risk for HIV transmission. HIV care provider education with emphasis on STI testing in the setting of incident syphilis is key in prevention... - Effect of Persistency of First-Line HIV Antiretroviral Therapy on Clinical OutcomesJames H Willig
1 University of Alabama at Birmingham UAB, Birmingham, Alabama
AIDS Res Hum Retroviruses 29:698-703. 2013..Given these findings, the relationship between persistency and clinical outcomes merits further study... - Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine careRobert C Kalayjian
Metro Health Medical Center, Cleveland, Ohio, USA
AIDS 26:1907-15. 2012.... - Prevalence, incidence, and recurrence of oral lesions among HIV-infected patients on HAART in Alabama: a two-year longitudinal studyIrene M Tamí-Maury
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
South Med J 104:561-6. 2011..Our aim was to quantify prevalence, incidence, and recurrence of oral lesions (OL) among a population in the Southeast... - Late diagnosis, delayed presentation and late presentation in HIV: proposed definitions, methodological considerations and health implicationsMichael Kozak
Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Antivir Ther 18:17-23. 2013.... - Closing the Feedback Loop: An Interactive Voice Response System to Provide Follow-up and Feedback in Primary Care SettingsJames H Willig
University of Alabama at Birmingham, 1720 Second Ave South, Birmingham, AL, 35294, USA
J Med Syst 37:9905. 2013..With proper attention to design and development, modular follow-up and feedback systems can be integrated into existing EMR systems providing the benefits of IVRS follow-up to patients and providers across diverse practice settings...