Affiliation: University of Colorado Denver
Martino V, Sabljic T, Deschamps P, Green R, Akula M, Peacock E, et al
. Conditional deletion of AP-2? in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma. Dis Model Mech. 2016;9:849-61 pubmed publisher
Green R, Feng W, Phang T, Fish J, Li H, Spritz R, et al
. Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015;8:31-43 pubmed publisher
..Overall, our findings suggest that CL/P can result from small gene-expression changes that alter the shape of the facial prominences and uncouple their coordinated morphogenesis, which is necessary for normal fusion. ..
Schmidt L, Taiyab A, Melvin V, Jones K, Williams T. Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull. Dis Model Mech. 2018;11: pubmed publisher
..These results have implications for evolution of the different methods of ossification as well as for therapeutic intervention in craniosynostosis. ..
Hooper J, Feng W, Li H, Leach S, Phang T, Siska C, et al
. Systems biology of facial development: contributions of ectoderm and mesenchyme. Dev Biol. 2017;426:97-114 pubmed publisher
Van Otterloo E, Li H, Jones K, Williams T. AP-2Î± and AP-2Î² cooperatively orchestrate homeobox gene expression during branchial arch patterning. Development. 2018;145: pubmed publisher