R W Williams

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi request reprint Genetic dissection of the olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size
    R W Williams
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis 38163, USA
    Behav Genet 31:61-77. 2001
  2. pmc A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice
    Zhengsheng Li
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e12181. 2010
  3. pmc Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
    PLoS Genet 4:e1000260. 2008
  4. pmc Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression
    Kenneth F Manly
    Department of Pathology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Genome Biol 6:R27. 2005
  5. pmc Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor
    Philippos Peidis
    Laboratory of Biochemistry, Department of Chemistry, The Aristotle University, 54124 Thessaloniki, Greece
    BMC Syst Biol 4:14. 2010
  6. pmc Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number
    G D Rosen
    Dyslexia Research Laboratory and Charles A, Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    BMC Neurosci 2:5. 2001
  7. pmc Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice
    Taha A Jan
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    BMC Neurosci 9:3. 2008
  8. pmc The genetic control of neocortex volume and covariation with neocortical gene expression in mice
    Shiv M Gaglani
    Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    BMC Neurosci 10:44. 2009
  9. pmc Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight
    Lu Lu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, PR China
    BMC Genomics 9:444. 2008
  10. pmc Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork
    Arnis Druka
    Scottish Crop Research Institute, Invergowrie, Dundee, UK
    BMC Genet 9:73. 2008

Research Grants

  1. INFORMATICS CENTER FOR MOUSE NEUROGENETICS
    Robert Williams; Fiscal Year: 2004
  2. INIA: Genotyping Core
    ROBERT WILLLIAMS; Fiscal Year: 2006
  3. INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS
    Robert W Williams; Fiscal Year: 2007
  4. INFORMATICS CENTER FOR MOUSE NEUROGENETICS
    Robert W Williams; Fiscal Year: 2007
  5. BIOMETRIC AND FUNCTIONAL STUDIES OF THE EYE AND RETINA O
    Robert Williams; Fiscal Year: 2002
  6. GENETIC AND EPIGENETIC CONTROL OF EYE GROWTH
    Robert Williams; Fiscal Year: 2003

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Genetic dissection of the olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size
    R W Williams
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis 38163, USA
    Behav Genet 31:61-77. 2001
    ..In contrast to the first two QTLs, B6 alleles at these two loci decrease bulb weight by 0.5-1.0 mg. Collectively, the four loci account for 20% of the phenotypic variance in bulb weight...
  2. pmc A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice
    Zhengsheng Li
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e12181. 2010
    ..This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits...
  3. pmc Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
    PLoS Genet 4:e1000260. 2008
    ..Our analysis revealed a highly complex gene expression regulatory interval in Qrr1, composed of multiple loci modulating the expression of functionally cognate sets of genes...
  4. pmc Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression
    Kenneth F Manly
    Department of Pathology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Genome Biol 6:R27. 2005
    ..This heritability varies greatly. We have tested heritability-weighted averages to define expression of a transcript and found that these allow detection of more QTLs than previously described methods...
  5. pmc Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor
    Philippos Peidis
    Laboratory of Biochemistry, Department of Chemistry, The Aristotle University, 54124 Thessaloniki, Greece
    BMC Syst Biol 4:14. 2010
    ..In the current studies, the online GeneNetwork system was employed to further probe P2P-R biological functions. Molecular studies were then performed to confirm the GeneNetwork evaluations...
  6. pmc Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron number
    G D Rosen
    Dyslexia Research Laboratory and Charles A, Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
    BMC Neurosci 2:5. 2001
    ..We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia...
  7. pmc Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice
    Taha A Jan
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    BMC Neurosci 9:3. 2008
    ..Cytochrome oxidase labeling was used to visualize barrels within the PMBSF...
  8. pmc The genetic control of neocortex volume and covariation with neocortical gene expression in mice
    Shiv M Gaglani
    Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    BMC Neurosci 10:44. 2009
    ..Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex...
  9. pmc Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight
    Lu Lu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, PR China
    BMC Genomics 9:444. 2008
    ..We also required verification of mRNA abundance by an independent method, and finally we required either differences in protein levels or confirmed DNA sequence differences...
  10. pmc Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork
    Arnis Druka
    Scottish Crop Research Institute, Invergowrie, Dundee, UK
    BMC Genet 9:73. 2008
    ....
  11. pmc A new set of BXD recombinant inbred lines from advanced intercross populations in mice
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    BMC Genet 5:7. 2004
    ..elegans, and Drosophila, mouse RI panels typically consist of fewer than 30 lines. This is a severe constraint on the power and precision of mapping efforts and greatly hampers analysis of epistatic interactions...
  12. ncbi request reprint The math of making mutant mice
    R W Williams
    Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Madison Avenue, Memphis, TN 38163, USA
    Genes Brain Behav 2:191-200. 2003
    ....
  13. ncbi request reprint Expression genetics and the phenotype revolution
    Robert W Williams
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Mamm Genome 17:496-502. 2006
    ..These models will also be essential to test new treatments in a robust systems context that accounts for genetic variation...
  14. pmc The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis
    R W Williams
    Center of Genomics and Bioinformatics University of Tennessee Health Science Center, College of Medicine, Memphis, TN 38163, USA
    Genome Biol 2:RESEARCH0046. 2001
    ..They have proved particularly effective in multidisciplinary genetic studies. Widespread use of RI strains has been hampered by their modest numbers and by the difficulty of combining results derived from different RI sets...
  15. ncbi request reprint Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects
    J L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Monroe Avenue, Memphis, Tennessee 38163, USA
    Genes Brain Behav 2:238-52. 2003
    ..Using WebQTL's extensive database of published BXD phenotypes, we also detected a strong and potentially biologically meaningful correlation between hippocampal volume and the acoustic startle response...
  16. ncbi request reprint Genetic control of the mouse cerebellum: identification of quantitative trait loci modulating size and architecture
    D C Airey
    Center for Neuroscience, Department of Anatomy, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 21:5099-109. 2001
    ..The QTLs we have discovered are among the first loci shown to modulate the size and architecture of the adult mouse cerebellum...
  17. ncbi request reprint Modulation of retinal cell populations and eye size in retinoic acid receptor knockout mice
    G Zhou
    Center for Neuroscience, University of Tennessee, Memphis, TN 38163, USA
    Mol Vis 7:253-60. 2001
    ..Rara is of particular interest because this gene is a candidate for Nnc1, a QTL that controls retinal ganglion cell proliferation...
  18. ncbi request reprint Complex trait analysis of the hippocampus: mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice
    L Lu
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 21:3503-14. 2001
    ..The Hipp gene loci modulate neuron number in the dentate gyrus, collectively shifting the population up or down by as much as 200,000 cells. Candidate genes for the Hipp loci include Rxrg and Fgfr3...
  19. pmc A promoter polymorphism in the Per3 gene is associated with alcohol and stress response
    X Wang
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Transl Psychiatry 2:e73. 2012
    ..Our data provide strong evidence that variation in the Per3 transcript is causally associated with and also responsive to stress and alcohol...
  20. ncbi request reprint Natural variation in neuron number in mice is linked to a major quantitative trait locus on Chr 11
    R W Williams
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 18:138-46. 1998
    ..Each receptor is expressed in the retina during development, and their ligands affect the proliferation or survival of retinal cells...
  21. ncbi request reprint Inferring gene transcriptional modulatory relations: a genetical genomics approach
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 14:1119-25. 2005
    ..SNPs that distinguish between the two progenitor strains were used to further winnow the list of candidate modulators. Bayesian network was then used to identify the genetic modulatory relations that best explain the microarray data...
  22. ncbi request reprint Eye1 and Eye2: gene loci that modulate eye size, lens weight, and retinal area in the mouse
    G Zhou
    Center for Neuroscience and the Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
    Invest Ophthalmol Vis Sci 40:817-25. 1999
    ..The genetic basis of variation in eye size in mice was explored, and genes that modulate eye weight, lens weight, and retinal area were mapped...
  23. ncbi request reprint Decreased retinal ganglion cell number and misdirected axon growth associated with fissure defects in Bst/+ mutant mice
    D S Rice
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163, USA
    Invest Ophthalmol Vis Sci 38:2112-24. 1997
    ..In this article, the authors present adult and developmental studies on the retinal phenotype in Bst/+ mice...
  24. pmc Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice
    Adrianus C M Boon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 83:10417-26. 2009
    ..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
  25. ncbi request reprint A quantitative genetic analysis of slow-wave sleep in influenza-infected CXB recombinant inbred mice
    L A Toth
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Behav Genet 29:339-48. 1999
    ..The analysis also suggests that dark phase and light phase responses are regulated by different genetic factors...
  26. ncbi request reprint Extrinsic modulation of retinal ganglion cell projections: analysis of the albino mutation in pigmentation mosaic mice
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee, 38105, USA
    Dev Biol 216:41-56. 1999
    ..These studies demonstrate that the albino mutation acts indirectly upon retinal ganglion cells, which in turn respond by making axonal guidance errors at the optic chiasm...
  27. pmc Detection, validation, and downstream analysis of allelic variation in gene expression
    Daniel C Ciobanu
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Genetics 184:119-28. 2010
    ..Using a systems genetics approach we show that two validated cis-modulated genes, Stk25 and Rasd2, are likely to control expression of downstream targets and affect disease susceptibility...
  28. ncbi request reprint Genetic control of interconnected neuronal populations in the mouse primary visual system
    Dave J Seecharan
    Institute for Neuroscience, Center of Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 23:11178-88. 2003
    ..33; p < 0.01). We conclude that numbers of these two functionally coupled neuron populations are modulated over a wide range by independent genetic and developmental mechanisms...
  29. ncbi request reprint Potential role of Atp5g3 in epigenetic regulation of alcohol preference or obesity from a mouse genomic perspective
    Y Huang
    Department of Orthopaedic Surgery and BME Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN, USA
    Genet Mol Res 12:3662-74. 2013
    ....
  30. ncbi request reprint A quantitative genetic analysis of locomotor activity in CXB recombinant inbred mice
    L A Toth
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Behav Genet 29:319-28. 1999
    ..Probabilities of linkage were not sufficient for declaration of an activity-related quantitative trait locus but were sufficient to warrant further analysis either with additional RI strains or with F2 panels...
  31. ncbi request reprint Genetic dissection of retinal development
    R W Williams
    Department of Anatomy and Neurobiology and the Center for Neuroscience, University of Tennessee, 855 Monroe Avenune, Memphis, TN 38163, USA
    Semin Cell Dev Biol 9:249-55. 1998
    ..Here we review this approach and give three specific examples of how genes with well-defined functions in retinal development are being mapped and characterized...
  32. ncbi request reprint A quantitative genetic analysis of slow-wave sleep and rapid-eye movement sleep in CXB recombinant inbred mice
    L A Toth
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Behav Genet 29:329-37. 1999
    ..Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels...
  33. pmc Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice
    David J Reiner
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA
    Chem Senses 33:693-707. 2008
    ..This study is an important first step in identifying genetic factors underlying tongue size, papillae size, and papillae number using QTL analysis...
  34. ncbi request reprint Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice
    Ruby Cook
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
    Brain Res Mol Brain Res 110:279-88. 2003
    ..Using genome wide PCR analysis, we found that a single major QTLs, Mptp1, located near the distal end of chromosome 1 between D1Mit113 and D1Mit293, accounts for the majority of the strain sensitivity to MPTP...
  35. ncbi request reprint Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships
    Lei Bao
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, TN 38163, USA
    Mamm Genome 17:575-83. 2006
    ..Our results show that the combination of gene eQTL mapping and phenotypic spectrum analysis may provide a valuable approach to uncovering gene regulatory relations underlying mammalian phenotypes...
  36. ncbi request reprint The Tennessee Mouse Genome Consortium: identification of ocular mutants
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Vis Neurosci 22:595-604. 2005
    ..Mice from each of these pedigrees of mutant mice are available for distribution to researchers for independent study...
  37. pmc Strain differences in stress responsivity are associated with divergent amygdala gene expression and glutamate-mediated neuronal excitability
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 30:5357-67. 2010
    ..Collectively, our data support a model in which genetic variation in glutamatergic neuroplasticity in corticolimbic circuitry underlies phenotypic variation in responsivity to stress...
  38. ncbi request reprint Genetic sources of individual differences in the cerebellum
    David C Airey
    Department of Anatomy and Neurobiology, University of Tennessee, Memphis, TN, USA
    Cerebellum 1:233-40. 2002
    ..Finally, we embed these methods in a hypothetical line of cerebellar research to illustrate the vast potential of combining complex trait analysis with a systems neuroscience perspective...
  39. ncbi request reprint GenomeMixer: a complex genetic cross simulator
    Alexander G Williams
    Center of Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee, 875 Monroe Avenue, Memphis, TN 38163, USA
    Bioinformatics 20:2491-2. 2004
    ....
  40. ncbi request reprint Mapping the Bst mutation on mouse chromosome 16: a model for human optic atrophy
    D S Rice
    University of Tennessee, Center for Neuroscience, Memphis 38163, USA
    Mamm Genome 6:546-8. 1995
  41. ncbi request reprint Identification of quantitative trait loci controlling activation of TRBV4 CD8+ T cells during murine gamma-herpesvirus-induced infectious mononucleosis
    C L Hardy
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Immunogenetics 53:395-400. 2001
    ..The first QTL is located on Chromosome (Chr) 17, near or proximal to H2. The second QTL is located on Chr 6 in a region spanning the Tcrb and Cd8a loci...
  42. ncbi request reprint Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits
    Hongqiang Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, 858 Madison Avenue Memphis, TN 38163, USA
    Hum Mol Genet 15:481-92. 2006
    ....
  43. ncbi request reprint An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes
    Lei Bao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Hum Mol Genet 16:1381-90. 2007
    ..This strategy integrates gene-phenotype relations from decades of experimental mutagenesis studies and new genomic resources to provide an approach to rapidly expand knowledge on genetic loci modulating phenotypes...
  44. ncbi request reprint Genetic and structural analysis of the basolateral amygdala complex in BXD recombinant inbred mice
    Khyobeni Mozhui
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Behav Genet 37:223-43. 2007
    ..Other candidates include Large, and Thra. Responses to drugs of abuse and locomotor activity were the most notable behavioral correlates of the BLAc traits...
  45. pmc PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits
    Lei Bao
    Department of Molecular Sciences, Memphis, TN 38163, USA
    Nucleic Acids Res 35:D51-4. 2007
    ..It is a resource for studying PolymiRTSs and their implications in phenotypic variations. PolymiRTS database can be accessed at http://compbio.utmem.edu/miRSNP/...
  46. pmc Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes
    K Mozhui
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Transl Psychiatry 1:e25. 2011
    ..By using the Molecular Genetics of Schizophrenia data set, we were able to test and confirm that markers in NRXN1 and GSK3B have epistatic interactions in human populations that can jointly modulate risk of schizophrenia...
  47. ncbi request reprint Structure of the cone photoreceptor mosaic in the retinal periphery of adult humans: analysis as a function of age, sex, and hemifield
    T D Kimble
    Center for Neuroscience and Department of Anatomy and Neurobiology, University of Tennessee at Memphis, 38163, USA
    Anat Embryol (Berl) 201:305-16. 2000
    ....
  48. pmc Gene expression in the mouse eye: an online resource for genetics using 103 strains of mice
    Eldon E Geisert
    Department of Ophthalmology and Center for Vision Research, Memphis, TN 38163, USA
    Mol Vis 15:1730-63. 2009
    ..We examined the causes of expression differences, and in their linkage to sequence variants, functional differences, and ocular pathophysiology...
  49. pmc Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
    Justin P Templeton
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis TN, 38163, USA
    BMC Neurosci 10:90. 2009
    ..Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains of mice...
  50. ncbi request reprint Increased brain size and glial cell number in CD81-null mice
    Eldon E Geisert
    Department of Anatomy and Neurobiology, and Neuroscience Institute, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, USA
    J Comp Neurol 453:22-32. 2002
    ..This work provides support for the role of CD81 in the regulation of astrocyte and microglial number, perhaps by regulating cell proliferation by a contact inhibition-dependent mechanism...
  51. pmc Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 3:e1977. 2008
    ..The critical problem with naïve mapping approaches in AIL populations is that the individual is not an exchangeable unit...
  52. ncbi request reprint The ldis1 lens mutation in RIIIS/J mice maps to chromosome 8 near cadherin 1
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA
    Mol Vis 10:577-87. 2004
    ..We also have fine-mapped the mutation, ldis1 (lens disrupter 1), and have evaluated positional candidate genes...
  53. pmc Genetic networks controlling retinal injury
    Felix R Vazquez-Chona
    Department of Ophthalmology, The Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Vis 11:958-70. 2005
    ..The present study defines genomic loci underlying coordinate changes in gene expression following retinal injury...
  54. ncbi request reprint Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    Elissa J Chesler
    University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Genet 37:233-42. 2005
    ..We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses...
  55. ncbi request reprint WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    Nat Neurosci 7:485-6. 2004
  56. ncbi request reprint How replicable are mRNA expression QTL?
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mamm Genome 17:643-56. 2006
    ..Finally, we note that while trans-acting QTL do not replicate well between data sets in general, at least one cluster of trans-acting QTL on distal Chr 1 is notably preserved between data sets...
  57. ncbi request reprint The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection
    Isao Miyairi
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 179:1814-24. 2007
    ..Data indicate that these p47 GTPases have cell-autonomous effects that result in vastly different inflammatory stimulations, leading to either recovery or death...
  58. pmc A simple method for combining genetic mapping data from multiple crosses and experimental designs
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 2:e1036. 2007
    ..Many phenotypes are now associated with enough mapping data that meta-analysis could help refine locations of known QTLs and detect many novel QTLs...
  59. ncbi request reprint Genetic correlates of gene expression in recombinant inbred strains: a relational model system to explore neurobehavioral phenotypes
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, USA
    Neuroinformatics 1:343-57. 2003
    ..By repeatedly studying the same panel of mice, early data can be re-examined in light of technological advances unforeseen at the time of their initial collection...
  60. ncbi request reprint P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA
    Robert E Scott
    Department of Pathology, University of Tennessee Health Science Center, Memphis Tennessee, USA
    J Cell Physiol 204:99-105. 2005
    ..This study represents the first description of a RNA target for mammalian Puf proteins and the first molecular confirmation of information obtained using the WebQTL database...
  61. ncbi request reprint An ENU-induced mutation in Rs1h causes disruption of retinal structure and function
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center and Tennessee Mouse Genome Consortium, Memphis, TN, USA
    Mol Vis 11:569-81. 2005
    ..Herein we present its retinal phenotype and genetic basis...
  62. ncbi request reprint Genetic control of retinal projections in inbred strains of albino mice
    D S Rice
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163, USA
    J Comp Neurol 354:459-69. 1995
    ..The consistent effect of null alleles at tyrosinase suggests a comparably tight linkage between the biochemical activity of this enzyme and the mechanisms that control decussation phenotype...
  63. ncbi request reprint Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice
    Cheng X Li
    Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA
    Somatosens Mot Res 22:141-50. 2005
    ....
  64. ncbi request reprint Brain gene expression: genomics and genetics
    Elissa J Chesler
    Department of Anatomy and Neurobiology, Center for Genomics and Bioinformatics, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Int Rev Neurobiol 60:59-95. 2004
  65. ncbi request reprint Hot topics in behavioral and neural genetics
    R W Williams
    Center of Genomics and Bioinformatics, University of Tennessee, Health Science Center Memphis, TN, USA
    Genes Brain Behav 1:117-30. 2002
  66. ncbi request reprint Asymmetric connections, duplicate layers, and a vertically inverted map in the primary visual system
    D Hogan
    Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee 38163, USA
    J Neurosci 19:RC38. 1999
    ..Despite a host of drastic abnormalities at all level of the visual system, from retina to cortex, this animal was behaviorally indistinguishable from normal dogs and did not have any detectable oculomotor abnormalities...
  67. ncbi request reprint Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
    ..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...
  68. doi request reprint Counting cells in sectioned material: a suite of techniques, tools, and tips
    Robert W Williams
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Curr Protoc Neurosci . 2003
    ....

Research Grants9

  1. INFORMATICS CENTER FOR MOUSE NEUROGENETICS
    Robert Williams; Fiscal Year: 2004
    ....
  2. INIA: Genotyping Core
    ROBERT WILLLIAMS; Fiscal Year: 2006
    ..Our goal is efficient service to INIA and NIAAA investigators. ..
  3. INIA: Robust Systems Genetics of Alcohol and Stress Effects on CNS
    Robert W Williams; Fiscal Year: 2007
    ....
  4. INFORMATICS CENTER FOR MOUSE NEUROGENETICS
    Robert W Williams; Fiscal Year: 2007
    ..abstract_text> ..
  5. BIOMETRIC AND FUNCTIONAL STUDIES OF THE EYE AND RETINA O
    Robert Williams; Fiscal Year: 2002
    ..All of these data are being integrated into a sophisticated and universally accessible database available on the World Wide Web at nervenet.org. ..
  6. GENETIC AND EPIGENETIC CONTROL OF EYE GROWTH
    Robert Williams; Fiscal Year: 2003
    ..Understanding how different QTLs affect different parts of the eye will ultimately contribute to a far better understanding of molecular and developmental mechanisms associated with eye growth in humans. ..