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lymphocytic choriomeningitis virus
Matthew A Williams
University of Utah
Williams M. Instant recall: a key role for effector-phenotype CD8⁺ memory T cells in immune protection. Immunity. 2013;38:1090-1
Snook J, Kim C, Williams M. TCR signal strength controls the differentiation of CD4+ effector and memory T cells. Sci Immunol. 2018;3:
..We conclude that strong TCR signals during early T cell activation favor terminal T
1 differentiation over long-term T
1 and T follicular helper cell memory responses. ..
Williams M, Ravkov E, Bevan M. Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity. 2008;28:533-45
..These results support a model in which CD4+ T cell memory differentiation and longevity depend on the strength of the TCR signal during the primary response. ..
Meek S, Williams M. IFN-Gamma-Dependent and Independent Mechanisms of CD4âº Memory T Cell-Mediated Protection from Listeria Infection. Pathogens. 2018;7:
..Overall, we conclude that protection mediated by CD4âº memory T cells from heterologous
challenge is most directly dependent on TNF, whereas IFNÎ³ only plays a minor role. ..
Stephanie M Meek
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