Kevin W Williams

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
    Kevin W Williams
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Neurosci 15:1350-5. 2012
  2. pmc The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:13147-56. 2011
  3. pmc Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    Michael M Scott
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:2413-21. 2011
  4. pmc Estradiol modulates Kiss1 neuronal response to ghrelin
    Renata Frazao
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas
    Am J Physiol Endocrinol Metab 306:E606-14. 2014
  5. pmc Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:2472-9. 2010
  6. pmc Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons
    Jong Woo Sohn
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 152:612-9. 2013
  7. pmc Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 71:488-97. 2011
  8. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
  9. pmc 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    Yong Xu
    Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 13:1457-9. 2010
  10. pmc Leptin signaling in Kiss1 neurons arises after pubertal development
    Roberta M Cravo
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e58698. 2013

Collaborators

Detail Information

Publications22

  1. pmc From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
    Kevin W Williams
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Neurosci 15:1350-5. 2012
    ..This Review highlights contributions to our understanding of peripheral and central factors regulating food intake and energy expenditure...
  2. pmc The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:13147-56. 2011
    ....
  3. pmc Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    Michael M Scott
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:2413-21. 2011
    ..Together, these data support a physiologically important role of direct leptin action in the hindbrain...
  4. pmc Estradiol modulates Kiss1 neuronal response to ghrelin
    Renata Frazao
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas
    Am J Physiol Endocrinol Metab 306:E606-14. 2014
    ..Our findings indicate that E₂ alters the responsiveness of kisspeptin neurons to metabolic signals, potentially acting as a critical player in the metabolic control of the reproductive physiology...
  5. pmc Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:2472-9. 2010
    ..Collectively, these data suggest that cross talk between leptin and insulin occurs within a network of cells rather than within individual POMC neurons...
  6. pmc Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons
    Jong Woo Sohn
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell 152:612-9. 2013
    ....
  7. pmc Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 71:488-97. 2011
    ..Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels...
  8. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
    ....
  9. pmc 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    Yong Xu
    Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 13:1457-9. 2010
    ..Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver...
  10. pmc Leptin signaling in Kiss1 neurons arises after pubertal development
    Roberta M Cravo
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e58698. 2013
    ..Our findings unequivocally demonstrate that kisspeptin neurons are not the direct target of leptin in the onset of puberty. Leptin signaling in kisspeptin neurons arises only after completion of sexual maturation...
  11. pmc Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area
    Huxing Cui
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9127, USA
    J Comp Neurol 520:4168-83. 2012
    ..Our findings provide new insights into MC4R signaling in the LHA and its potential implications in homeostatic regulation of body energy balance...
  12. pmc 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
    Yong Xu
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 60:582-9. 2008
    ..The findings also highlight the physiological relevance of the 5-HT2CR-melanocortin circuitry in the long-term regulation of energy balance...
  13. pmc Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9077, USA
    Mol Neurobiol 45:225-33. 2012
    ..This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis...
  14. pmc Neuronal circuits that regulate feeding behavior and metabolism
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Trends Neurosci 36:504-12. 2013
    ..This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glucose homeostasis by metabolic signals. ..
  15. pmc Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia
    Eric D Berglund
    1 Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA 2
    Nat Neurosci 17:911-3. 2014
    ..Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis. ..
  16. pmc Shift in Kiss1 cell activity requires estrogen receptor α
    Renata Frazao
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 33:2807-20. 2013
    ..Collectively, our findings indicate that changes in cellular activity may underlie Kiss1 action in pubertal initiation and female reproduction...
  17. pmc "AMPing up" our understanding of the hypothalamic control of energy balance
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 85390 9051, USA
    J Clin Invest 117:2089-92. 2007
    ..These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis...
  18. pmc Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Pharmacol 660:2-12. 2011
    ....
  19. pmc Brain SIRT1: anatomical distribution and regulation by energy availability
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:9989-96. 2008
    ..Collectively, our findings establish the distribution of Sirt1 mRNA throughout the neuraxis and suggest a previously unrecognized role of brain SIRT1 in regulating energy homeostasis...
  20. pmc Induction of leptin resistance by activation of cAMP-Epac signaling
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 13:331-9. 2011
    ..Finally, central infusion of an Epac activator blunted the anorexigenic actions of leptin. Thus, activation of hypothalamic cAMP-Epac pathway is sufficient to induce multiple indices of leptin resistance...
  21. pmc Mrap2: an accessory protein linked to obesity
    Tiemin Liu
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Cell Metab 18:309-11. 2013
    ..2013; Sebag et al., 2013) establish a role for melanocortin receptor accessory protein 2 (Mrap2) in regulating melanocortin receptor activity and in the development of obesity in zebrafish, rodents, and humans...
  22. pmc From observation to experimentation: leptin action in the mediobasal hypothalamus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 85390 905, USA
    Am J Clin Nutr 89:985S-990S. 2009
    ....