Kevin W Williams

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
    Kevin W Williams
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Neurosci 15:1350-5. 2012
  2. ncbi The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:13147-56. 2011
  3. ncbi Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    Michael M Scott
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:2413-21. 2011
  4. ncbi Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:2472-9. 2010
  5. ncbi Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 71:488-97. 2011
  6. ncbi Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
  7. ncbi 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    Yong Xu
    Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 13:1457-9. 2010
  8. ncbi Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9077, USA
    Mol Neurobiol 45:225-33. 2012
  9. ncbi 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
    Yong Xu
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 60:582-9. 2008
  10. ncbi "AMPing up" our understanding of the hypothalamic control of energy balance
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 85390 9051, USA
    J Clin Invest 117:2089-92. 2007

Collaborators

Detail Information

Publications15

  1. ncbi From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
    Kevin W Williams
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Nat Neurosci 15:1350-5. 2012
    ..This Review highlights contributions to our understanding of peripheral and central factors regulating food intake and energy expenditure...
  2. ncbi The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:13147-56. 2011
    ....
  3. ncbi Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
    Michael M Scott
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:2413-21. 2011
    ..Together, these data support a physiologically important role of direct leptin action in the hindbrain...
  4. ncbi Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:2472-9. 2010
    ..Collectively, these data suggest that cross talk between leptin and insulin occurs within a network of cells rather than within individual POMC neurons...
  5. ncbi Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Neuron 71:488-97. 2011
    ..Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels. VIDEO ABSTRACT:..
  6. ncbi Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
    ....
  7. ncbi 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver
    Yong Xu
    Division of Hypothalamic Research and Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA
    Nat Neurosci 13:1457-9. 2010
    ..Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver...
  8. ncbi Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways
    Jong Woo Sohn
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9077, USA
    Mol Neurobiol 45:225-33. 2012
    ..This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis...
  9. ncbi 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis
    Yong Xu
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 60:582-9. 2008
    ..The findings also highlight the physiological relevance of the 5-HT2CR-melanocortin circuitry in the long-term regulation of energy balance...
  10. ncbi "AMPing up" our understanding of the hypothalamic control of energy balance
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 85390 9051, USA
    J Clin Invest 117:2089-92. 2007
    ..These findings maintain AMPK signaling as a common cellular mechanism in proopiomelanocortin and neuropeptide Y/agouti-related protein neurons and links hypothalamic AMPK to coordinated energy and glucose homeostasis...
  11. ncbi Brain SIRT1: anatomical distribution and regulation by energy availability
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Neurosci 28:9989-96. 2008
    ..Collectively, our findings establish the distribution of Sirt1 mRNA throughout the neuraxis and suggest a previously unrecognized role of brain SIRT1 in regulating energy homeostasis...
  12. ncbi Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Pharmacol 660:2-12. 2011
    ....
  13. ncbi Induction of leptin resistance by activation of cAMP-Epac signaling
    Makoto Fukuda
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 13:331-9. 2011
    ..Finally, central infusion of an Epac activator blunted the anorexigenic actions of leptin. Thus, activation of hypothalamic cAMP-Epac pathway is sufficient to induce multiple indices of leptin resistance...
  14. ncbi From observation to experimentation: leptin action in the mediobasal hypothalamus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 85390 905, USA
    Am J Clin Nutr 89:985S-990S. 2009
    ....
  15. ncbi Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area
    Huxing Cui
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9127, USA
    J Comp Neurol 520:4168-83. 2012
    ..Our findings provide new insights into MC4R signaling in the LHA and its potential implications in homeostatic regulation of body energy balance...