Jacqueline P Williams

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model
    Jacqueline P Williams
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Radiat Res 161:560-7. 2004
  2. ncbi request reprint Effectiveness of fractionated external beam radiation in the inhibition of vascular restenosis
    J P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, New York, USA
    Cardiovasc Radiat Med 1:257-64. 1999
  3. pmc After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS)
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center Rochester, NY 14642, USA
    Int J Radiat Biol 87:851-68. 2011
  4. pmc Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Curr Drug Targets 11:1386-94. 2010
  5. pmc Animal models for medical countermeasures to radiation exposure
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Radiat Res 173:557-78. 2010
  6. pmc Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein
    Casey M Manning
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Radiat Res 179:617-29. 2013
  7. pmc Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure
    Casey M Manning
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Int J Radiat Oncol Biol Phys 86:128-35. 2013
  8. pmc Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure
    Carl J Johnston
    Departments of Pediatrics and Neonatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 173:522-35. 2010
  9. doi request reprint Normal tissue development, homeostasis, senescence, and the sensitivity to radiation injury across the age spectrum
    Arnold C Paulino
    Department of Radiation Oncology, The Methodist Hospital, Houston, TX, USA
    Semin Radiat Oncol 20:12-20. 2010
  10. ncbi request reprint Regulation of prostaglandin E2 synthesis after brain irradiation
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:267-72. 2005

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model
    Jacqueline P Williams
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    Radiat Res 161:560-7. 2004
    ..Additional experiments are needed to assess whether statins offer a potential treatment for the amelioration of late effects in breast and lung cancer patients undergoing radiation therapy...
  2. ncbi request reprint Effectiveness of fractionated external beam radiation in the inhibition of vascular restenosis
    J P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, New York, USA
    Cardiovasc Radiat Med 1:257-64. 1999
    ..Thus, we undertook a pilot study in a rodent model, using a single dose of 15 Gy compared with fractionation schedules of 5 or 10 daily applications of 3 Gy...
  3. pmc After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS)
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center Rochester, NY 14642, USA
    Int J Radiat Biol 87:851-68. 2011
    ....
  4. pmc Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Curr Drug Targets 11:1386-94. 2010
    ..Nonetheless, current technology allows us to propose likely targets that are either currently being researched or should be considered in future studies...
  5. pmc Animal models for medical countermeasures to radiation exposure
    Jacqueline P Williams
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 647, Rochester, NY 14642, USA
    Radiat Res 173:557-78. 2010
    ..Discussions covered the most appropriate species and strains available as well as other factors that may affect differential findings between groups and institutions. This report provides the workshop findings...
  6. pmc Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein
    Casey M Manning
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Radiat Res 179:617-29. 2013
    ..This novel finding may have considerable therapeutic implications with respect to both thoracic tumor patients and recipients of bone marrow transplants...
  7. pmc Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure
    Casey M Manning
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Int J Radiat Oncol Biol Phys 86:128-35. 2013
    ..To address whether irradiation-induced changes in the lung environment alter responses to a viral challenge delivered late after exposure but before the appearance of late lung radiation injury...
  8. pmc Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure
    Carl J Johnston
    Departments of Pediatrics and Neonatology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 173:522-35. 2010
    ..They may be candidates for use in marker-based biodosimetry. However, the lack of cytokine induction in early life suggests that different end points (and mitigating treatments) may be required for children...
  9. doi request reprint Normal tissue development, homeostasis, senescence, and the sensitivity to radiation injury across the age spectrum
    Arnold C Paulino
    Department of Radiation Oncology, The Methodist Hospital, Houston, TX, USA
    Semin Radiat Oncol 20:12-20. 2010
    ....
  10. ncbi request reprint Regulation of prostaglandin E2 synthesis after brain irradiation
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:267-72. 2005
    ..Previous work suggested that cyclooxygenase (COX)-2 activity was important for changes in gene expression associated with neuroinflammation as well as increased prostaglandin E2 (PGE2) levels seen after radiation treatment...
  11. pmc Effect of total body irradiation on late lung effects: hidden dangers
    Carl J Johnston
    Departments of Pediatrics and Neonatology, University of Rochester Medical Center, Rochester, New York, USA
    Int J Radiat Biol 87:902-13. 2011
    ....
  12. doi request reprint The impact of Smad3 loss of function on TGF-β signaling and radiation-induced capsular contracture
    Evan B Katzel
    Division of Plastic and Reconstructive Surgery, Department of General Surgery, The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Plast Reconstr Surg 127:2263-9. 2011
    ..To test this hypothesis, capsular contracture formation in wild-type and Smad3 knockout mice was compared using micro-computed tomographic and histologic examination...
  13. pmc Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Support Care Cancer 20:831-9. 2012
    ....
  14. ncbi request reprint Inflammatory cell recruitment following thoracic irradiation
    Carl J Johnston
    Department of Environmental Medicine, University of Rochester, New York 14642, USA
    Exp Lung Res 30:369-82. 2004
    ....
  15. ncbi request reprint Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation
    Heather F Lakatos
    Department of Environmental Medicine and Lung Biology and Disease Program, University of Rochester, Rochester, New York 14642, USA
    Exp Lung Res 32:181-99. 2006
    ..Oropharyngeal aspiration should be considered as an alternative to intratracheal instillation of silica and other particulates in studies of respiratory toxicity and lung disease...
  16. pmc Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients
    Julie L Ryan
    Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA
    Radiat Res 180:34-43. 2013
    ..In conclusion, oral curcumin, 6.0 g daily during radiotherapy, reduced the severity of radiation dermatitis in breast cancer patients. ..
  17. pmc Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain
    Michael J Moravan
    Department of Neurobiology and Anatomy and, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Radiat Res 176:459-73. 2011
    ..Our results indicate that cranial irradiation leads to persistent neuroinflammatory changes in the C57BL/6 mouse brain that includes unique immunomodulatory cell populations...
  18. pmc Neonatal irradiation sensitizes mice to delayed pulmonary challenge
    Carl J Johnston
    Department of a Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Radiat Res 179:475-84. 2013
    ..This finding may have implications for the development of countermeasures in the context of systemic radiation exposure...
  19. ncbi request reprint Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain
    Amy H Moore
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Radiat Res 161:153-60. 2004
    ....
  20. ncbi request reprint Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 62:273-8. 2005
    ..The purpose of the present study was to measure mRNA levels of inflammatory cytokines in abdominally irradiated mouse bowel...
  21. ncbi request reprint Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor
    Li Liang
    Department of Radiation Oncology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Clin Oncol 26:S114-21. 2003
    ..The differential effects of celecoxib on inflammation help to explain the selective protection by celecoxib of irradiated cutaneous tissues without a concurrent protection of MCa-35 tumors...
  22. ncbi request reprint Animal models and medical countermeasures development for radiation-induced lung damage: report from an NIAID Workshop
    Jacqueline P Williams
    University of Rochester Medical Center, Rochester, New York, USA
    Radiat Res 177:e0025-39. 2012
    ..This report reviews the data presented, as well as key points from the ensuing discussion...
  23. ncbi request reprint Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families
    Carl J Johnston
    University of Rochester, Department of Pediatrics, Environmental Medicine, and Radiation Oncology, Rochester, New York 14642, USA
    Radiat Res 157:256-65. 2002
    ..These studies suggest that monocyte/macrophage and lymphocyte recruitment and activation are key components of radiation-induced fibrosis...
  24. pmc Antioxidants reduce consequences of radiation exposure
    Paul Okunieff
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Adv Exp Med Biol 614:165-78. 2008
    ..In this review we discuss what is known about the radioprotective properties of antioxidants, and what those properties tell us about the DNA and other cellular targets of radiation...
  25. pmc Galactic cosmic radiation leads to cognitive impairment and increased aβ plaque accumulation in a mouse model of Alzheimer's disease
    Jonathan D Cherry
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 7:e53275. 2012
    ..Overall, our results show for the first time that HZE particle radiation can increase Aβ plaque pathology in an APP/PS1 mouse model of AD...
  26. doi request reprint Radiation effects on human leptomeningeal cell response to cerebrospinal fluid and PDGF-BB
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, Rochester, NY, USA
    Int J Radiat Biol 88:547-55. 2012
    ..We therefore evaluated whether radiation stimulates human leptomeningeal cell proliferation and activates growth regulatory pathways...
  27. pmc Testicular cancer survivorship: research strategies and recommendations
    Lois B Travis
    Department of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Natl Cancer Inst 102:1114-30. 2010
    ..Just as testicular cancer once served as the paradigm of a curable malignancy, comprehensive follow-up studies of testicular cancer survivors can pioneer new methodologies in survivorship research for all adult-onset cancer...
  28. ncbi request reprint The effects of brain-irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J mice
    Russell J Ferland
    Graduate Program in Neuroscience, Strong Epilepsy Center, Department of Neurology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Neurol 179:71-82. 2003
    ....
  29. pmc Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, New York, NY 14642, USA
    Clin Breast Cancer 11:161-70. 2011
    ..Despite knowing the beneficial effects of conventional exercise interventions on these mediators, little is known about the physiologic effects of TCC on these pathways in breast cancer survivors...
  30. doi request reprint Cancer genesis across the age spectrum: associations with tissue development, maintenance, and senescence
    Philip Rubin
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Semin Radiat Oncol 20:3-11. 2010
    ..Additional basic science investigations and epidemiologic studies will assist in our understanding of the mechanisms that underlie the notable difference in site-specific cancer incidence according to age...
  31. ncbi request reprint Is there a favorable subset of patients with prostate cancer who develop oligometastases?
    Deepinder Singh
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642 8647, USA
    Int J Radiat Oncol Biol Phys 58:3-10. 2004
    ....
  32. ncbi request reprint Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury
    Stephanos Kyrkanides
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Res Mol Brain Res 104:159-69. 2002
    ..These results indicate that COX-2 modulates the inflammatory response in brain following radiation injury, and suggest the use of COX-2 selective inhibitors for the management of CNS inflammation...
  33. pmc Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)
    Rhonda J Staversky
    Department of Pediatrics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Am J Pathol 161:1383-93. 2002
    ..This observation has important implications for therapeutic strategies designed to attenuate long-term chronic lung disease after oxidant injury...
  34. doi request reprint A novel animal model for studying silicone gel-related capsular contracture
    Evan B Katzel
    Division of Plastic and Reconstructive Surgery, Department of General Surgery, The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Plast Reconstr Surg 126:1483-91. 2010
    ..This study evaluates a new murine model with which to facilitate research into the cellular and molecular pathways underlying capsular contracture and provides a surrogate for evaluating potential therapies...
  35. ncbi request reprint Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study
    Arvind B Soni
    Department of Radiation Oncology, University of Rochester Medical Center, 601 ElmwoodAvenue, Rochester, NY 14642, USA
    Int J Radiat Oncol Biol Phys 54:1174-9. 2002
    ..To perform a Phase I study to determine the safety and feasibility of using external beam radiotherapy to prevent neointimal hyperplasia in patients after surgical bypass of occluded infrainguinal arteries...
  36. ncbi request reprint Factors affecting hospital-based nurses' willingness to respond to a radiation emergency
    Tener Goodwin Veenema
    Disaster Nursing and Strategic Initiatives, Center for Disaster Medicine and Emergency Preparedness, University of Rochester, USA
    Disaster Med Public Health Prep 2:224-9. 2008
    ....
  37. pmc Sublethal radiation injury uncovers a functional transition during erythroid maturation
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 39:434-45. 2011
    ..To better understand this phenomenon, we investigated the kinetics and apoptotic response of the erythron to sublethal radiation injury...