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Species | J A WilliamsSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Molecular components of the circadian system in DrosophilaJ A Williams
Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
Annu Rev Physiol 63:729-55. 2001..It has, however, become clear that in addition to the brain clock, autonomous or semi-autonomous clocks occur in peripheral tissues where they confer circadian regulation on specific functions...- Molecular analysis of sleep: wake cycles in DrosophilaA Sehgal
Howard Hughes Medical Institute, USA
Cold Spring Harb Symp Quant Biol 72:557-64. 2007..Thus, the Drosophila model allows the use of cellular and molecular approaches that should ultimately lead to a better understanding of sleep biology... - A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPKJ A Williams
Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Science 293:2251-6. 2001.... - A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasisJ C Hendricks
Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce St, Philadelphia, Pennsylvania, 19104 USA
Nat Neurosci 4:1108-15. 2001..In wild types, in vivo CREB activity increased after rest deprivation and remained elevated for a 72-hour recovery period. These data indicate that cAMP signaling has a non-circadian role in waking and rest homeostasis in Drosophila... - Rest in Drosophila is a sleep-like stateJ C Hendricks
Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
Neuron 25:129-38. 2000..Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep... - Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundaryJ A Williams
Howard Hughes Medical Institute, University of Wisconsin Madison 53706
Nature 368:299-305. 1994..The link between dorsal/ventral compartmentalization and wing formation distinguishes the development of this sheet-like appendage from that of legs and antennae... - Dynamic rearrangement of the spectrin membrane skeleton during the generation of epithelial polarity in DrosophilaG H Thomas
Department of Biology and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
J Cell Sci 112:2843-52. 1999.... - A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogasterN J Clegg
Department of Zoology, University of British Columbia, Canada
Genome 36:676-85. 1993..The phenotypes of our mutants are consistent with a role for Cdc2 in cell proliferation; however, we did not observe any perturbation of the endoreduplication cycle associated with the acquisition of polyteny... - Pattern formation and eyespot determination in butterfly wingsS B Carroll
Howard Hughes Medical Institute, Madison, WI
Science 265:109-14. 1994..These circular pattern elements appear to be generated by a process similar to, and perhaps evolved from, proximodistal pattern formation in insect appendages... - Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic aciniR D Duan
Department of Physiology, University of Michigan, Ann Arbor 48109, USA
Am J Physiol 268:G1060-5. 1995..In conclusion, the activation of MAP kinase by CCK can be explained by activation of MEK and may involve the activation of Ras by a protein kinase C-dependent mechanism... - A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphataseM J Wishart
Department of Physiology, University of Michigan, Ann Arbor 48109 0606, USA
J Biol Chem 270:26782-5. 1995..We believe this is the first example of a naturally occurring "dominant negative" phosphotyrosine/serine/threonine-binding protein which is structurally related to dsPTPases... 
Molecular organization of the vestigial region in Drosophila melanogasterJ A Williams
Department of Genetics, University of Alberta, Edmonton, Canada
EMBO J 7:1355-63. 1988..As well, a revertant of a 412 insertion mutant allele was shown to have resulted from a further insertion of a roo element into the 412 element...- Molecular analysis of hybrid dysgenesis-induced derivatives of a P-element allele at the vg locusJ A Williams
Department of Genetics, University of Alberta, Edmonton, Canada
Mol Cell Biol 8:1489-97. 1988..The effects of the alleles on vg expression were determined. The results are consistent with a model in which the insertions disrupt vg gene expression by transcriptional interference... - The functional organization of the vestigial locus in Drosophila melanogasterJ A Williams
Department of Genetics, University of Alberta, Edmonton, Canada
Mol Gen Genet 221:8-16. 1990..8 kb transcription unit, thus accounting for its ability to complement classical alleles. The results indicate that sequences within a vg intron are essential for normal wing and haltere development... - Genetic and molecular analysis of vgU and vgW: two dominant vg alleles associated with gene fusions in DrosophilaJ A Williams
Department of Genetics, University of Alberta, Edmonton, Canada
Genetics 125:833-44. 1990..The results are consistent with a model in which inappropriate expression of inv causes the dominant homeotic effects seen in vgW... - Control of Drosophila wing and haltere development by the nuclear vestigial gene productJ A Williams
Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin Madison 53706
Genes Dev 5:2481-95. 1991..These results suggest that vg is directly involved in determining which thoracic imaginal disc cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins... - A P element chimera containing captured genomic sequences was recovered at the vestigial locus in Drosophila following targeted transpositionT R Heslip
Department of Genetics, University of Alberta, Edmonton, Canada
Genetics 131:917-27. 1992....