J A Williams

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Molecular components of the circadian system in Drosophila
    J A Williams
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 63:729-55. 2001
  2. ncbi request reprint Molecular analysis of sleep: wake cycles in Drosophila
    A Sehgal
    Howard Hughes Medical Institute, USA
    Cold Spring Harb Symp Quant Biol 72:557-64. 2007
  3. ncbi request reprint A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK
    J A Williams
    Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 293:2251-6. 2001
  4. ncbi request reprint A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce St, Philadelphia, Pennsylvania, 19104 USA
    Nat Neurosci 4:1108-15. 2001
  5. ncbi request reprint Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
  6. ncbi request reprint Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary
    J A Williams
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Nature 368:299-305. 1994
  7. ncbi request reprint Dynamic rearrangement of the spectrin membrane skeleton during the generation of epithelial polarity in Drosophila
    G H Thomas
    Department of Biology and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    J Cell Sci 112:2843-52. 1999
  8. ncbi request reprint A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
    N J Clegg
    Department of Zoology, University of British Columbia, Canada
    Genome 36:676-85. 1993
  9. ncbi request reprint Pattern formation and eyespot determination in butterfly wings
    S B Carroll
    Howard Hughes Medical Institute, Madison, WI
    Science 265:109-14. 1994
  10. ncbi request reprint Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini
    R D Duan
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 268:G1060-5. 1995

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Molecular components of the circadian system in Drosophila
    J A Williams
    Howard Hughes Medical Institute, Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Physiol 63:729-55. 2001
    ..It has, however, become clear that in addition to the brain clock, autonomous or semi-autonomous clocks occur in peripheral tissues where they confer circadian regulation on specific functions...
  2. ncbi request reprint Molecular analysis of sleep: wake cycles in Drosophila
    A Sehgal
    Howard Hughes Medical Institute, USA
    Cold Spring Harb Symp Quant Biol 72:557-64. 2007
    ..Thus, the Drosophila model allows the use of cellular and molecular approaches that should ultimately lead to a better understanding of sleep biology...
  3. ncbi request reprint A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK
    J A Williams
    Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 293:2251-6. 2001
    ....
  4. ncbi request reprint A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 991 Maloney Building, 3600 Spruce St, Philadelphia, Pennsylvania, 19104 USA
    Nat Neurosci 4:1108-15. 2001
    ..In wild types, in vivo CREB activity increased after rest deprivation and remained elevated for a 72-hour recovery period. These data indicate that cAMP signaling has a non-circadian role in waking and rest homeostasis in Drosophila...
  5. ncbi request reprint Rest in Drosophila is a sleep-like state
    J C Hendricks
    Center for Sleep and Respiratory Neurobiology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Neuron 25:129-38. 2000
    ..Finally, normal homeostatic regulation depends on the timeless but not the period central clock gene. Understanding the molecular features of Drosophila rest should shed new light on the mechanisms and function of sleep...
  6. ncbi request reprint Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary
    J A Williams
    Howard Hughes Medical Institute, University of Wisconsin Madison 53706
    Nature 368:299-305. 1994
    ..The link between dorsal/ventral compartmentalization and wing formation distinguishes the development of this sheet-like appendage from that of legs and antennae...
  7. ncbi request reprint Dynamic rearrangement of the spectrin membrane skeleton during the generation of epithelial polarity in Drosophila
    G H Thomas
    Department of Biology and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    J Cell Sci 112:2843-52. 1999
    ....
  8. ncbi request reprint A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
    N J Clegg
    Department of Zoology, University of British Columbia, Canada
    Genome 36:676-85. 1993
    ..The phenotypes of our mutants are consistent with a role for Cdc2 in cell proliferation; however, we did not observe any perturbation of the endoreduplication cycle associated with the acquisition of polyteny...
  9. ncbi request reprint Pattern formation and eyespot determination in butterfly wings
    S B Carroll
    Howard Hughes Medical Institute, Madison, WI
    Science 265:109-14. 1994
    ..These circular pattern elements appear to be generated by a process similar to, and perhaps evolved from, proximodistal pattern formation in insect appendages...
  10. ncbi request reprint Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini
    R D Duan
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 268:G1060-5. 1995
    ..In conclusion, the activation of MAP kinase by CCK can be explained by activation of MEK and may involve the activation of Ras by a protein kinase C-dependent mechanism...
  11. ncbi request reprint A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase
    M J Wishart
    Department of Physiology, University of Michigan, Ann Arbor 48109 0606, USA
    J Biol Chem 270:26782-5. 1995
    ..We believe this is the first example of a naturally occurring "dominant negative" phosphotyrosine/serine/threonine-binding protein which is structurally related to dsPTPases...
  12. pmc Molecular organization of the vestigial region in Drosophila melanogaster
    J A Williams
    Department of Genetics, University of Alberta, Edmonton, Canada
    EMBO J 7:1355-63. 1988
    ..As well, a revertant of a 412 insertion mutant allele was shown to have resulted from a further insertion of a roo element into the 412 element...
  13. pmc Molecular analysis of hybrid dysgenesis-induced derivatives of a P-element allele at the vg locus
    J A Williams
    Department of Genetics, University of Alberta, Edmonton, Canada
    Mol Cell Biol 8:1489-97. 1988
    ..The effects of the alleles on vg expression were determined. The results are consistent with a model in which the insertions disrupt vg gene expression by transcriptional interference...
  14. ncbi request reprint The functional organization of the vestigial locus in Drosophila melanogaster
    J A Williams
    Department of Genetics, University of Alberta, Edmonton, Canada
    Mol Gen Genet 221:8-16. 1990
    ..8 kb transcription unit, thus accounting for its ability to complement classical alleles. The results indicate that sequences within a vg intron are essential for normal wing and haltere development...
  15. pmc Genetic and molecular analysis of vgU and vgW: two dominant vg alleles associated with gene fusions in Drosophila
    J A Williams
    Department of Genetics, University of Alberta, Edmonton, Canada
    Genetics 125:833-44. 1990
    ..The results are consistent with a model in which inappropriate expression of inv causes the dominant homeotic effects seen in vgW...
  16. ncbi request reprint Control of Drosophila wing and haltere development by the nuclear vestigial gene product
    J A Williams
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin Madison 53706
    Genes Dev 5:2481-95. 1991
    ..These results suggest that vg is directly involved in determining which thoracic imaginal disc cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins...
  17. pmc A P element chimera containing captured genomic sequences was recovered at the vestigial locus in Drosophila following targeted transposition
    T R Heslip
    Department of Genetics, University of Alberta, Edmonton, Canada
    Genetics 131:917-27. 1992
    ....