Diana L Williams

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation
    Diana L Williams
    University of Washington, Harborview Medical Center, 325 9th Ave, Box 359675, Seattle, WA 98104, USA
    Diabetes 55:3387-93. 2006
  2. ncbi request reprint Overfeeding-induced weight gain suppresses plasma ghrelin levels in rats
    D L Williams
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    J Endocrinol Invest 29:863-8. 2006
  3. ncbi request reprint Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat
    D L Williams
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    Endocrinology 144:4692-7. 2003
  4. ncbi request reprint Vagotomy dissociates short- and long-term controls of circulating ghrelin
    Diana L Williams
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Mail Stop 111 ENDO, Seattle, Washington 98108, USA
    Endocrinology 144:5184-7. 2003
  5. pmc Immunocytochemistry and laser capture microdissection for real-time quantitative PCR identify hindbrain neurons activated by interaction between leptin and cholecystokinin
    Diana L Williams
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA
    J Histochem Cytochem 56:285-93. 2008
  6. ncbi request reprint Food deprivation after treatment blocks the multiple-day hyperphagic response to SHU9119 administration
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Brain Res 996:180-6. 2004
  7. ncbi request reprint Regulation of ghrelin in physiologic and pathophysiologic states
    Diana L Williams
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104, USA
    J Nutr 135:1320-5. 2005
  8. pmc Leptin action in the forebrain regulates the hindbrain response to satiety signals
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 115:703-10. 2005
  9. doi request reprint Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
    James E Blevins
    VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009
  10. pmc Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis
    David A Sarruf
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA
    Endocrinology 150:707-12. 2009

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation
    Diana L Williams
    University of Washington, Harborview Medical Center, 325 9th Ave, Box 359675, Seattle, WA 98104, USA
    Diabetes 55:3387-93. 2006
    ....
  2. ncbi request reprint Overfeeding-induced weight gain suppresses plasma ghrelin levels in rats
    D L Williams
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    J Endocrinol Invest 29:863-8. 2006
    ..Having discounted diet composition and differences in gastric contents at the time of blood sampling, the decrease in ghrelin levels with overfeeding can be unambiguously attributed to physiological correlates of weight gain...
  3. ncbi request reprint Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat
    D L Williams
    Department of Psychology, University of Pennsylvania, Philadelphia, USA
    Endocrinology 144:4692-7. 2003
    ....
  4. ncbi request reprint Vagotomy dissociates short- and long-term controls of circulating ghrelin
    Diana L Williams
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Mail Stop 111 ENDO, Seattle, Washington 98108, USA
    Endocrinology 144:5184-7. 2003
    ..The dissociation between nutrient load- and deprivation-related ghrelin responses indicates that the regulation of circulating ghrelin levels involves separate mechanisms operating through anatomically distinct pathways...
  5. pmc Immunocytochemistry and laser capture microdissection for real-time quantitative PCR identify hindbrain neurons activated by interaction between leptin and cholecystokinin
    Diana L Williams
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA
    J Histochem Cytochem 56:285-93. 2008
    ..These histochemical findings identify hindbrain catecholamine cells as potential mediators of the interaction between leptin and CCK...
  6. ncbi request reprint Food deprivation after treatment blocks the multiple-day hyperphagic response to SHU9119 administration
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Brain Res 996:180-6. 2004
    ..The results indicate an interaction between melanocortin receptor activity and the metabolic state of the animal, and constrain our thinking about the peripheral signals and central mechanisms that underlie this interaction...
  7. ncbi request reprint Regulation of ghrelin in physiologic and pathophysiologic states
    Diana L Williams
    Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA 98104, USA
    J Nutr 135:1320-5. 2005
    ..We also consider potential hormonal and neural mediators of the effects of nutrients and weight change on ghrelin levels...
  8. pmc Leptin action in the forebrain regulates the hindbrain response to satiety signals
    Gregory J Morton
    Department of Medicine, Harborview Medical Center and University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 115:703-10. 2005
    ..These findings demonstrate that forebrain signaling by leptin, a long-term regulator of body adiposity, limits food intake on a meal-to-meal basis by regulating the hindbrain response to short-acting satiety signals...
  9. doi request reprint Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
    James E Blevins
    VA Puget Sound Health Care System, Mail stop S 151, 1660 South Columbian Way, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 296:R476-84. 2009
    ....
  10. pmc Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis
    David A Sarruf
    Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA 98195, USA
    Endocrinology 150:707-12. 2009
    ....
  11. pmc Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    Diana L Williams
    Department of Psychology, Florida State University, Tallahassee, Florida 32306 4301, USA
    Endocrinology 150:1680-7. 2009
    ..We conclude that GLP-1 released from the intestine in response to ingested nutrients is a physiologically active satiety signal...
  12. pmc Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance
    Brent E Wisse
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98108, USA
    Brain Res 1144:101-6. 2007
    ....
  13. ncbi request reprint Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R
    Harvey J Grill
    Graduate Groups of Psychology and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1190-3. 2004
    ..Exendin-(9-39) delivery thus limited to forebrain did not attenuate the anorexic response to LPS. These data suggest that LPS anorexia is mediated, in part, by release of the native peptide acting on GLP-1-R within the caudal brain stem...
  14. ncbi request reprint Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis
    Aaron W Pardini
    Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA
    Brain Res 1112:169-78. 2006
    ..An improved understanding of mechanisms underlying normal and abnormal energy homeostasis may be gained by analysis of the role played by signaling through IRS-2 in these brain areas...
  15. ncbi request reprint Meal-related ghrelin suppression requires postgastric feedback
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA
    Endocrinology 144:2765-7. 2003
    ..We conclude that the meal-related suppression of plasma ghrelin requires postgastric (pre- or postabsorptive) stimulation...
  16. ncbi request reprint Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat
    Diana L Williams
    Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia 19104, USA
    Psychopharmacology (Berl) 161:47-53. 2002
    ..Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated...
  17. pmc Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis
    Diana L Williams
    Department of Psychology, 1107 West Call Street, Florida State University, Tallahassee, Florida 32306 4301, USA
    Endocrinology 150:2997-3001. 2009
    ..This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites...
  18. ncbi request reprint Out of synch: Clock mutation causes obesity in mice
    Diana L Williams
    Department of Medicine, Harborview Medical Center, and University of Washington, Seattle, Washington 98104, USA
    Cell Metab 1:355-6. 2005
    ..New evidence that Clock mutant mice are hyperphagic and obese suggests a previously unrecognized link between molecular controls of circadian rhythm and energy homeostasis...
  19. ncbi request reprint The melanocortin system as a central integrator of direct and indirect controls of food intake
    Diana L Williams
    Am J Physiol Regul Integr Comp Physiol 289:R2-3. 2005
  20. pmc Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection
    Annemieke Geluk
    Department of Immunohematology and Blood Transfusion, LUMC PO Box 9600, 2300 RC Leiden, The Netherlands
    Infect Immun 73:5636-44. 2005
    ..leprae-exposed individuals. These proteins may provide new tools to develop tests for specific diagnosis of M. leprae infection and may enhance our understanding of leprosy and its transmission...
  21. ncbi request reprint Disseminated mycobacteriosis in a bald eagle (Haliaeetus leucocephalus)
    J Jill Heatley
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4474, USA
    J Avian Med Surg 21:201-9. 2007
    ..Results of culture, a polymerase chain reaction testing, and direct deoxyribonucleic acid (DNA) sequencing for mycobacterial 16S ribosomal ribonucleic acid DNA determined this organism most likely to be Mycobacterium avium...
  22. ncbi request reprint Molecular detection of drug resistance in Mycobacterium leprae
    Diana L Williams
    Molecular Biology Research Department, Laboratory Research Branch, Division of the National Hansen s Disease Programs, Baton Rouge, LA, USA
    Lepr Rev 75:118-30. 2004
  23. pmc Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru
    Holger Mayta
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Clin Microbiol 41:5774-7. 2003
    ....
  24. ncbi request reprint A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions
    Deanna A Hagge
    Biological Sciences Department, Louisiana State University, Baton Rouge, Louisana 70803, USA
    J Infect Dis 186:1283-96. 2002
    ..leprae retained 53% viability. This article describes a new model for studying the effects of M. leprae on Schwann cells...

Research Grants3

  1. Hindbrain integration of adiposity and satiety signals
    Diana Williams; Fiscal Year: 2007
    ....
  2. Brain integration of adiposity and satiety signals in the control of food intake
    Diana Williams; Fiscal Year: 2007
    ..Our studies will improve our understanding of the neural circuitry that regulates food intake and body weight, and will help identify biological factors that contribute to the development and maintenance of obesity. ..