Research Topics
Genomes and Genes | Carmen J WilliamsSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumptionLevent Tutuncu
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 270:246-60. 2004..These studies suggest a role for calreticulin as a lectin that may be involved in signal transduction events during or after sperm-egg interactions at fertilization...- Transgenic RNAi: a tool to study testis-specific genesCarmen J Williams
Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Cell Endocrinol 247:1-3. 2006 - Signalling mechanisms of mammalian oocyte activationCarmen J Williams
Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania, 19104 6142, USA
Hum Reprod Update 8:313-21. 2002..Finally, the mechanisms of physiological oocyte activation are compared with events of oocyte activation that occur after ICSI... 
Extracellular adenosine 5'-triphosphate alters motility and improves the fertilizing capability of mouse spermEsmeralda Rodriguez-Miranda
Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Reprod 79:164-71. 2008....- Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillationsJason G Knott
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 296:388-95. 2006..These results strongly suggest that CaMKII is a major integrator of the Ca(2+) changes that occur following fertilization... 
Alterations of PLCbeta1 in mouse eggs change calcium oscillatory behavior following fertilizationHideki Igarashi
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 312:321-30. 2007..These results provide the first evidence for a role of an egg-derived PLC acting in conjunction with a sperm-derived PLCzeta in egg activation...- PAR-3 defines a central subdomain of the cortical actin cap in mouse eggsFrancesca E Duncan
Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
Dev Biol 280:38-47. 2005..This cortical PAR-3 localization depends on intact microfilaments. These results suggest a role for PAR-3 in establishing asymmetry in the egg and in defining the future site of polar body emission... - Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggsMarcela A Michaut
Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
Dev Biol 280:26-37. 2005..These results show that p-MARCKS is a novel centrosome component and also defines a previously unrecognized subdomain of the actin cap overlying the spindle... - Transgenic RNA interference reveals role for mouse sperm phospholipase Czeta in triggering Ca2+ oscillations during fertilizationJason G Knott
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Reprod 72:992-6. 2005..These data strongly suggest that PLCzeta is the physiological trigger of Ca(2+) oscillations required for activation of development... - Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defectsFrancesca E Duncan
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Dev Dyn 235:2961-8. 2006..Furthermore, we implicate PKA as a modulator of spindle morphology and function during meiosis... - Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarityManqi Deng
Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104 6018, USA
Dev Biol 278:358-66. 2005..These results provide new insights into how cortical reorganization occurs independently of extracellular signals to generate egg polarity... - The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expressionFrancesca E Duncan
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 91:1462-5. 2009..However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching... - Chromatin-mediated cortical granule redistribution is responsible for the formation of the cortical granule-free domain in mouse eggsManqi Deng
Center for Research on Reproduction and Women's Health and Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
Dev Biol 257:166-76. 2003..Results of these experiments suggest that CG redistribution is the dominant factor in formation of the CGFD... - Effects of extracellular adenosine 5'-triphosphate on human sperm motilityScott E Edwards
Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA
Reprod Sci 14:655-66. 2007..These results suggest that ATPe could constitute a new therapeutic modality in the treatment of male infertility... - Maturation-associated increase in IP3 receptor type 1: role in conferring increased IP3 sensitivity and Ca2+ oscillatory behavior in mouse eggsZhe Xu
Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA 19104-6018, USA
Dev Biol 254:163-71. 2003.... - AKAP7gamma is a nuclear RI-binding AKAPRebecca L Brown
Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Rm 1312 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104 6142, USA
Biochem Biophys Res Commun 306:394-401. 2003..This work identifies AKAP7gamma as the first nuclear AKAP to bind RI and suggests that AKAP7gamma may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes... - Requirements for glucose beyond sperm capacitation during in vitro fertilization in the mouseAlexander J Travis
Center for Research on Reproduction and Women's Health, Philadelphia, PA 19104, USA
Biol Reprod 71:139-45. 2004..Taken as a whole, the data suggest requirements for glucose during both capacitation and fertilization under normal physiologic conditions... - Long-term effects of culture of preimplantation mouse embryos on behaviorDavid J Ecker
Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:1595-600. 2004.... - Differential RNA expression and polyribosome loading of alternative transcripts of the Akap4 gene in murine spermatidsRick W Nipper
Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
Mol Reprod Dev 70:397-405. 2005..Antisense RNA transcripts complementary to both the Akap82 and Fsc1 mRNAs were present, suggesting that translatability may be regulated by these RNAs... - Genomic imprinting and assisted reproductive technology: connections and potential risksJennifer R Thompson
Center for Research on Reproduction and Women's Health and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Semin Reprod Med 23:285-95. 2005.... - A-kinase anchor proteins as potential regulators of protein kinase A function in oocytesRebecca L Brown
Center for Research on Reproduction and Women's Health and Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Reprod 67:981-7. 2002..AKAP140 was shown to be a dual-specific AKAP, having the ability to bind both RI and RII. By compartmentalizing PKA, AKAP140 and/or other AKAPs could spatially regulate PKA activity during oocyte development... - The science of ARTRichard M Schultz
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
Science 296:2188-90. 2002.... - Establishment of the mammalian membrane block to polyspermy: evidence for calcium-dependent and -independent regulationAllison J Gardner
Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Room W3606, 615 N Wolfe St, Maryland, USA
Reproduction 133:383-93. 2007..The membrane block to polyspermy in mammalian eggs is likely to be the culmination of multiple post-fertilization events that together modify the egg membrane's receptivity to sperm... - Involvement of calcium signaling and the actin cytoskeleton in the membrane block to polyspermy in mouse eggsBeth A McAvey
Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Biol Reprod 67:1342-52. 2002..Furthermore, egg activation-associated increased intracellular calcium levels are necessary but not sufficient to affect postfertilization membrane dynamics that contribute to a membrane block to polyspermy... - Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouseMadhuri Wadehra
Molecular Biology Institute, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Dev Biol 292:430-41. 2006..These studies indicate a previously unknown function of tetraspan proteins in implantation and could provide a molecular framework for the development of therapeutic modalities for both contraception and fertility... - The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilizationKenneth C Hess
Department of Pharmacology, Joan and Sanford Weill Medical College, Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
Dev Cell 9:249-59. 2005..This inhibitor revealed that capacitation is defined by separable events: induction of protein tyrosine phosphorylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC...