Carmen J Williams

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption
    Levent Tutuncu
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 270:246-60. 2004
  2. ncbi request reprint Transgenic RNAi: a tool to study testis-specific genes
    Carmen J Williams
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 247:1-3. 2006
  3. ncbi request reprint Signalling mechanisms of mammalian oocyte activation
    Carmen J Williams
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania, 19104 6142, USA
    Hum Reprod Update 8:313-21. 2002
  4. doi request reprint Extracellular adenosine 5'-triphosphate alters motility and improves the fertilizing capability of mouse sperm
    Esmeralda Rodriguez-Miranda
    Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 79:164-71. 2008
  5. ncbi request reprint Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations
    Jason G Knott
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 296:388-95. 2006
  6. pmc Alterations of PLCbeta1 in mouse eggs change calcium oscillatory behavior following fertilization
    Hideki Igarashi
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 312:321-30. 2007
  7. ncbi request reprint PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs
    Francesca E Duncan
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
    Dev Biol 280:38-47. 2005
  8. ncbi request reprint Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs
    Marcela A Michaut
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
    Dev Biol 280:26-37. 2005
  9. ncbi request reprint Transgenic RNA interference reveals role for mouse sperm phospholipase Czeta in triggering Ca2+ oscillations during fertilization
    Jason G Knott
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 72:992-6. 2005
  10. ncbi request reprint Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defects
    Francesca E Duncan
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Dev Dyn 235:2961-8. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption
    Levent Tutuncu
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 270:246-60. 2004
    ..These studies suggest a role for calreticulin as a lectin that may be involved in signal transduction events during or after sperm-egg interactions at fertilization...
  2. ncbi request reprint Transgenic RNAi: a tool to study testis-specific genes
    Carmen J Williams
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Endocrinol 247:1-3. 2006
  3. ncbi request reprint Signalling mechanisms of mammalian oocyte activation
    Carmen J Williams
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania, 19104 6142, USA
    Hum Reprod Update 8:313-21. 2002
    ..Finally, the mechanisms of physiological oocyte activation are compared with events of oocyte activation that occur after ICSI...
  4. doi request reprint Extracellular adenosine 5'-triphosphate alters motility and improves the fertilizing capability of mouse sperm
    Esmeralda Rodriguez-Miranda
    Department of Obstetrics and Gynecology, Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 79:164-71. 2008
    ....
  5. ncbi request reprint Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations
    Jason G Knott
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 296:388-95. 2006
    ..These results strongly suggest that CaMKII is a major integrator of the Ca(2+) changes that occur following fertilization...
  6. pmc Alterations of PLCbeta1 in mouse eggs change calcium oscillatory behavior following fertilization
    Hideki Igarashi
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 312:321-30. 2007
    ..These results provide the first evidence for a role of an egg-derived PLC acting in conjunction with a sperm-derived PLCzeta in egg activation...
  7. ncbi request reprint PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs
    Francesca E Duncan
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
    Dev Biol 280:38-47. 2005
    ..This cortical PAR-3 localization depends on intact microfilaments. These results suggest a role for PAR-3 in establishing asymmetry in the egg and in defining the future site of polar body emission...
  8. ncbi request reprint Phosphorylated MARCKS: a novel centrosome component that also defines a peripheral subdomain of the cortical actin cap in mouse eggs
    Marcela A Michaut
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, Philadelphia, PA 19104, USA
    Dev Biol 280:26-37. 2005
    ..These results show that p-MARCKS is a novel centrosome component and also defines a previously unrecognized subdomain of the actin cap overlying the spindle...
  9. ncbi request reprint Transgenic RNA interference reveals role for mouse sperm phospholipase Czeta in triggering Ca2+ oscillations during fertilization
    Jason G Knott
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 72:992-6. 2005
    ..These data strongly suggest that PLCzeta is the physiological trigger of Ca(2+) oscillations required for activation of development...
  10. ncbi request reprint Knockdown of the cAMP-dependent protein kinase (PKA) Type Ialpha regulatory subunit in mouse oocytes disrupts meiotic arrest and results in meiotic spindle defects
    Francesca E Duncan
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Dev Dyn 235:2961-8. 2006
    ..Furthermore, we implicate PKA as a modulator of spindle morphology and function during meiosis...
  11. ncbi request reprint Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity
    Manqi Deng
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104 6018, USA
    Dev Biol 278:358-66. 2005
    ..These results provide new insights into how cortical reorganization occurs independently of extracellular signals to generate egg polarity...
  12. pmc The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression
    Francesca E Duncan
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 91:1462-5. 2009
    ..However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching...
  13. ncbi request reprint Chromatin-mediated cortical granule redistribution is responsible for the formation of the cortical granule-free domain in mouse eggs
    Manqi Deng
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 257:166-76. 2003
    ..Results of these experiments suggest that CG redistribution is the dominant factor in formation of the CGFD...
  14. ncbi request reprint Effects of extracellular adenosine 5'-triphosphate on human sperm motility
    Scott E Edwards
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA
    Reprod Sci 14:655-66. 2007
    ..These results suggest that ATPe could constitute a new therapeutic modality in the treatment of male infertility...
  15. ncbi request reprint Maturation-associated increase in IP3 receptor type 1: role in conferring increased IP3 sensitivity and Ca2+ oscillatory behavior in mouse eggs
    Zhe Xu
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Dev Biol 254:163-71. 2003
    ....
  16. ncbi request reprint AKAP7gamma is a nuclear RI-binding AKAP
    Rebecca L Brown
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, University of Pennsylvania, Rm 1312 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104 6142, USA
    Biochem Biophys Res Commun 306:394-401. 2003
    ..This work identifies AKAP7gamma as the first nuclear AKAP to bind RI and suggests that AKAP7gamma may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes...
  17. ncbi request reprint Requirements for glucose beyond sperm capacitation during in vitro fertilization in the mouse
    Alexander J Travis
    Center for Research on Reproduction and Women s Health, Philadelphia, PA 19104, USA
    Biol Reprod 71:139-45. 2004
    ..Taken as a whole, the data suggest requirements for glucose during both capacitation and fertilization under normal physiologic conditions...
  18. pmc Long-term effects of culture of preimplantation mouse embryos on behavior
    David J Ecker
    Department of Biology, University of Pennsylvania, 415 South University Avenue, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:1595-600. 2004
    ....
  19. ncbi request reprint Differential RNA expression and polyribosome loading of alternative transcripts of the Akap4 gene in murine spermatids
    Rick W Nipper
    Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Mol Reprod Dev 70:397-405. 2005
    ..Antisense RNA transcripts complementary to both the Akap82 and Fsc1 mRNAs were present, suggesting that translatability may be regulated by these RNAs...
  20. ncbi request reprint Genomic imprinting and assisted reproductive technology: connections and potential risks
    Jennifer R Thompson
    Center for Research on Reproduction and Women s Health and Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Reprod Med 23:285-95. 2005
    ....
  21. ncbi request reprint A-kinase anchor proteins as potential regulators of protein kinase A function in oocytes
    Rebecca L Brown
    Center for Research on Reproduction and Women s Health and Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Reprod 67:981-7. 2002
    ..AKAP140 was shown to be a dual-specific AKAP, having the ability to bind both RI and RII. By compartmentalizing PKA, AKAP140 and/or other AKAPs could spatially regulate PKA activity during oocyte development...
  22. ncbi request reprint The science of ART
    Richard M Schultz
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    Science 296:2188-90. 2002
    ....
  23. ncbi request reprint Establishment of the mammalian membrane block to polyspermy: evidence for calcium-dependent and -independent regulation
    Allison J Gardner
    Division of Reproductive Biology, Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Room W3606, 615 N Wolfe St, Maryland, USA
    Reproduction 133:383-93. 2007
    ..The membrane block to polyspermy in mammalian eggs is likely to be the culmination of multiple post-fertilization events that together modify the egg membrane's receptivity to sperm...
  24. ncbi request reprint Involvement of calcium signaling and the actin cytoskeleton in the membrane block to polyspermy in mouse eggs
    Beth A McAvey
    Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Biol Reprod 67:1342-52. 2002
    ..Furthermore, egg activation-associated increased intracellular calcium levels are necessary but not sufficient to affect postfertilization membrane dynamics that contribute to a membrane block to polyspermy...
  25. ncbi request reprint Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse
    Madhuri Wadehra
    Molecular Biology Institute, Department of Pathology and Laboratory Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Dev Biol 292:430-41. 2006
    ..These studies indicate a previously unknown function of tetraspan proteins in implantation and could provide a molecular framework for the development of therapeutic modalities for both contraception and fertility...
  26. pmc The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization
    Kenneth C Hess
    Department of Pharmacology, Joan and Sanford Weill Medical College, Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Dev Cell 9:249-59. 2005
    ..This inhibitor revealed that capacitation is defined by separable events: induction of protein tyrosine phosphorylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC...