Research Topics
| Brian A WilliamsSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Diplopia: a complication of dural punctureIsuta Nishio
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
Anesthesiology 100:158-64. 2004
Diabetes mellitus and subclinical neuropathy: a call for new paths in peripheral nerve block researchBrian A Williams
Anesthesiology 109:361-2. 2008- Seeds, trees, and shade-personal experience in research career developmentBrian A Williams
Reg Anesth Pain Med 32:545-6. 2007 - Electrical stimulation: an important force behind the growth of regional anesthesiaBrian A Williams
Can J Anaesth 54:585-6; author reply 586-7. 2007 - Skin reactions at the femoral perineural catheter insertion site: retrospective summary of a randomized clinical trialBrian A Williams
Anesth Analg 104:1309-10. 2007 - Forecast for perineural analgesia procedures for ambulatory surgery of the knee, foot, and ankle: applying patient-centered paradigm shiftsBrian A Williams
University of Pittsburgh, Pennsylvania 15261, USA
Int Anesthesiol Clin 50:126-42. 2012..Ongoing research in this direction seems to represent the next major advancement in the subspecialty, being distinguished from refinement research involving strictly techniques and technology... - Process analysis in outpatient knee surgery: effects of regional and general anesthesia on anesthesia-controlled timeB A Williams
Same Day Surgical Services, University of Pittsburgh Medical Center, PA 15213 2582, USA
Anesthesiology 93:529-38. 2000..The authors hypothesized that, using the anesthesia care team model, RA would be associated with reduced anesthesia-controlled time compared with general anesthesia (GA) alone or combined general-regional anesthesia (GA-RA)... - Routine multimodal antiemesis including low-dose perphenazine in an ambulatory surgery unit of a university hospital: a 10-year history. Supplement to: Eliminating postoperative nausea and vomiting in outpatient surgery with multimodal strategies includinBrian A Williams
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
ScientificWorldJournal 7:978-86. 2007..e., increase PACU bypass), reduce the need for any nursing interventions for postoperative nausea and/or vomiting (PONV), and influence the extent to which any variable costs of postoperative nursing care are reduced... - General health and knee function outcomes from 7 days to 12 weeks after spinal anesthesia and multimodal analgesia for anterior cruciate ligament reconstructionBrian A Williams
Department of Anesthesiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Anesth Analg 108:1296-302. 2009..We now report the prospectively collected general health and knee function outcomes in the 7 days to 12 wk after surgery in these same patients... - Nausea and vomiting after outpatient ACL reconstruction with regional anesthesia: are lumbar plexus blocks a risk factor?Brian A Williams
Same Day Surgical Services, University of Pittsburgh Medical Center, Pittsburgh, PA 15203, USA
J Clin Anesth 16:276-81. 2004.... - Economics of nerve block pain management after anterior cruciate ligament reconstruction: potential hospital cost savings via associated postanesthesia care unit bypass and same-day dischargeBrian A Williams
Same Day Surgical Services, University of Pittsburgh Medical Center, Pennsylvania 15203, USA
Anesthesiology 100:697-706. 2004..In this study, the authors examine the associations of nerve block analgesia for these patients and its associated reductions in PACU use, hospital admission, and hospital costs... - Neurotoxicity of adjuvants used in perineural anesthesia and analgesia in comparison with ropivacaineBrian A Williams
University of Pittsburgh School of Medicine, Department of Anesthesiology, Pittsburgh, PA, USA
Reg Anesth Pain Med 36:225-30. 2011..Therefore, the impact of these adjuvants on ropivacaine (R)-induced death of isolated sensory neurons was assessed... - Reduction of verbal pain scores after anterior cruciate ligament reconstruction with 2-day continuous femoral nerve block: a randomized clinical trialBrian A Williams
Department of Anesthesiology, University of Pittsburgh Medical Center, 2000 Mary Street, Pittsburgh, PA 15203, USA
Anesthesiology 104:315-27. 2006..In the current study, the authors prospectively determined the effect of continuous femoral nerve block on a numeric rating scale (NRS) of pain intensity with movement for 7 postoperative days... - PACU bypass after outpatient knee surgery is associated with fewer unplanned hospital admissions but more phase II nursing interventionsBrian A Williams
Anesthesiology, Department of Same Day Surgical Services, University of Pittsburgh Medical Center, Pennsylvania 15261, USA
Anesthesiology 97:981-8. 2002..We report PACU bypass rates using these criteria, and the extent to which PACU bypass was associated with (1) required nursing interventions in the step-down recovery unit, and (2) successful same-day discharge... - Femoral-sciatic nerve blocks for complex outpatient knee surgery are associated with less postoperative pain before same-day discharge: a review of 1,200 consecutive cases from the period 1996-1999Brian A Williams
University of Pittsburgh, A 1305 Scaife Hall, Pittsburgh, Pennsylvania, 15261, USA
Anesthesiology 98:1206-13. 2003..The aim of this report is to demonstrate differences in pain and unplanned hospital admission associated with surgical complexity and nerve blocks used... - Nausea, vomiting, sleep, and restfulness upon discharge home after outpatient anterior cruciate ligament reconstruction with regional anesthesia and multimodal analgesia/antiemesisBrian A Williams
Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
Reg Anesth Pain Med 32:193-202. 2007..The outcomes specifically addressed in this report are nausea, vomiting, and retching (NVR) and quality of sleep/difficulty falling asleep/daytime restfulness... - Health-related quality of life after tricompartment knee arthroplasty with and without an extended-duration continuous femoral nerve block: a prospective, 1-year follow-up of a randomized, triple-masked, placebo-controlled studyBrian M Ilfeld
Department of Anesthesiology, UCSD Center for Pain Medicine, 9300 Campus Point Dr MC 7651, La Jolla, CA 92037 7651, USA
Anesth Analg 108:1320-5. 2009..However, it remains unknown if the extended infusion improves subsequent health-related quality of life between 7 days and 12 mo... - Rebound pain scores as a function of femoral nerve block duration after anterior cruciate ligament reconstruction: retrospective analysis of a prospective, randomized clinical trialBrian A Williams
Department of Anesthesiology, UPMC South Side, University of Pittsburgh, Pittsburgh, PA, USA
Reg Anesth Pain Med 32:186-92. 2007..In the current study, we determined rebound pain scores in autograft ACLR outpatients after nerve block analgesia resolved... - Eliminating postoperative nausea and vomiting in outpatient surgery with multimodal strategies including low doses of nonsedating, off-patent antiemetics: is "zero tolerance" achievable?Susan J Skledar
University of Pittsburgh School of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
ScientificWorldJournal 7:959-77. 2007..If available, a consultation for therapeutic acupuncture procedure is ordered. Our approach toward "zero tolerance" of PONV emphasizes liberal identification of and prophylaxis against common risks... - Anesthesia and postoperative analgesia: outcomes following orthopedic surgeryJacques E Chelly
Department of Anesthesiology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Orthopedics 26:s865-71. 2003..Regional techniques are usually part of a multimodal strategy that includes both pharmacological and nonpharmacological approaches to pain management... - Antiemetics in outpatient regional anesthesia for invasive orthopedic surgeryMichael L Kentor
Department of Anesthesiology, University of Pittsburgh, PA 15203, USA
Int Anesthesiol Clin 43:205-13. 2005 
Future considerations for pharmacologic adjuvants in single-injection peripheral nerve blocks for patients with diabetes mellitusBrian A Williams
Department of Anesthesiology, University of Pittsburgh Medical Center South Side, University of Pittsburgh, Pittsburgh, PA 15203, USA
Reg Anesth Pain Med 34:445-57. 2009....- The 8-item Short-Form Health Survey and the physical comfort composite score of the quality of recovery 40-item scale provide the most responsive assessments of pain, physical function, and mental function during the first 4 days after ambulatory knee surJames E Bost
Center for Research on Health Care, and Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Anesth Analg 105:1693-700, table of contents. 2007..The objective was to provide a robust psychometric basis for outcome survey selection for surgical outpatients undergoing regional anesthesia without general anesthesia... - Regional anesthesia procedures for ambulatory knee surgery: effects on in-hospital outcomesBrian A Williams
Department of Anesthesiology, University of Pittsburgh, Pennsylvania 15203, USA
Int Anesthesiol Clin 43:153-60. 2005 - Aprepitant plus ondansetron compared with ondansetron alone in reducing postoperative nausea and vomiting in ambulatory patients undergoing plastic surgeryManuel C Vallejo
Department of Anesthesiology, Magee Womens Hospital of the University of Pittsburgh Medical Center, 300 Halket Street, Pittsburgh, PA 15213, USA
Plast Reconstr Surg 129:519-26. 2012..This study evaluated the efficacy of a neurokinin-1 receptor antagonist (aprepitant) in reducing postoperative symptoms for up to 48 hours in patients undergoing outpatient plastic surgery... - Aprepitant in a multimodal approach for prevention of postoperative nausea and vomiting in high-risk patients: is there such a thing as "too many modalities"?John J Hache
University of Pittsburgh Department of Anesthesiology, Liliane S Kaufmann Building, 3471 Fifth Avenue, Suite 910, Pittsburgh, PA 15213, USA
ScientificWorldJournal 9:291-9. 2009..However, there may be the potential that too many unique antiemetic mechanisms combined with preoperative aprepitant may actually increase the incidence of perioperative nausea... - Diabetes mellitus, independent of body mass index, is associated with a "higher success" rate for supraclavicular brachial plexus blocksRalf E Gebhard
Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL 15203, USA
Reg Anesth Pain Med 34:404-7. 2009..The authors retrospectively evaluated the influence of diabetes, body mass index (BMI), age, and sex on the success of supraclavicular block (SCB) placed with a landmark-based paresthesia technique... - For outpatient rotator cuff surgery, nerve block anesthesia provides superior same-day recovery over general anesthesiaAdmir Hadzic
Department of Anesthesiology, St Luke s Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York 10025, USA
Anesthesiology 102:1001-7. 2005..The authors' goal was to compare nerve block with general anesthesia with respect to recovery profile and patient satisfaction after rotator cuff surgery... - Hospitalization costs of total knee arthroplasty with a continuous femoral nerve block provided only in the hospital versus on an ambulatory basis: a retrospective, case-control, cost-minimization analysisBrian M Ilfeld
Department of Anesthesiology, University of California San Diego, San Diego, CA, USA
Reg Anesth Pain Med 32:46-54. 2007..This study quantified the hospitalization costs for 10 TKA patients receiving ambulatory CFNB versus a matched cohort of 10 patients who received CFNB only during hospitalization... - Adverse outcomes associated with stimulator-based peripheral nerve blocks with versus without ultrasound visualizationSteven L Orebaugh
University of Pittsburgh Medical Center South Side, PA 15203, USA
Reg Anesth Pain Med 34:251-5. 2009.... - Effect of adjuvant drugs on the action of local anesthetics in isolated rat sciatic nervesEser Yilmaz-Rastoder
Department of Anesthesiology and Center for Pain Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Reg Anesth Pain Med 37:403-9. 2012.... - Regional anesthesia group practice in the university hospital setting and ambulatory/regional anesthesia clinical pathway formulationBrian A Williams
Department of Anesthesiology, University of Pittsburgh, Pennsylvania 15203, USA
Int Anesthesiol Clin 43:3-13. 2005 - Loss of extension following anterior cruciate ligament reconstruction: analysis of incidence and etiology using IKDC criteriaCraig S Mauro
Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Arthroscopy 24:146-53. 2008.... - Hospital facilities and resource management: economic impact of a high-volume regional anesthesia program for outpatientsBrian A Williams
Department of Anesthesiology, University of Pittsburgh, Pennsylvania 15203, USA
Int Anesthesiol Clin 43:43-51. 2005 - Ultrasound guidance with nerve stimulation reduces the time necessary for resident peripheral nerve blockadeSteven L Orebaugh
Department of Anesthesiology, UPMC Southside, University of Pittsburgh School of Medicine, Pittsburgh, PA 15203, USA
Reg Anesth Pain Med 32:448-54. 2007..Ultrasound guidance may affect the efficiency and effectiveness of nerve block. We examined the impact of ultrasound guidance on resident performance of peripheral nerve block in a regional anesthesia rotation... - Brachial plexus anatomy: normal and variantSteven L Orebaugh
University of Pittsburgh, UPMC South Side, 2000 Mary Street, Pittsburgh, PA 15203, USA
ScientificWorldJournal 9:300-12. 2009..The ability to explore anatomy at the bedside, with real-time ultrasonography, has improved our appreciation of brachial plexus anatomy as well... - Transient heat hyperalgesia during resolution of ropivacaine sciatic nerve block in the ratLavinia M Kolarczyk
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Reg Anesth Pain Med 36:220-4. 2011..5% leads to transient heat hyperalgesia in rats independent of mechanical nociception. We also evaluated functional toxicity (eg, long-term hyperalgesia and/or tactile allodynia 2 weeks after injection)... - Regional anesthesia procedures for outpatient shoulder surgeryReginald E Julien
Department of Anesthesiology, Health Science Center of Brooklyn, State University of New York, 11203, USA
Int Anesthesiol Clin 43:167-75. 2005 - Making an ambulatory surgery centre suitable for regional anaesthesiaBrian A Williams
University of Pittsburgh Medical Center, Department of Anesthesiology, UPMC South Side, Pittsburgh, USA
Best Pract Res Clin Anaesthesiol 16:175-94. 2002..The remainder of the care process relies on teamwork among all healthcare providers and meaningful administrative support... - Retrospective evaluation of unanticipated admissions and readmissions after same day surgery and associated costsKim C Coley
Center for Pharmacoinformatics and Outcomes Research, University of Pittsburgh School of Pharmacy, 921 Salk Hall, Pittsburgh, PA 15261, USA
J Clin Anesth 14:349-53. 2002..Pain accounted for more than one third of return visits, incurring significant costs. Efforts to manage pain should focus not only on pain in the hospital but also anticipation of pain-related issues on discharge... - Adverse outcomes associated with nerve stimulator-guided and ultrasound-guided peripheral nerve blocks by supervised trainees: update of a single-site databaseSteven L Orebaugh
From the Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA
Reg Anesth Pain Med 37:577-82. 2012.... - Economics and practice management issues associated with acute pain managementDennis P Phillips
Department of Anesthesiology, University of Pittsburgh Medical Center, Liliane S Kaufmann Building, 3471 Fifth Avenue Suite 910, Pittsburgh, PA 15213, USA
Anesthesiol Clin 29:213-32. 2011..Additional review and commentary address surgical site infections, cancer recurrence, blood transfusions, and chronic postsurgical pain... - Development of a standardized peripheral nerve block procedure note formJ C Gerancher
Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1009, USA
Reg Anesth Pain Med 30:67-71. 2005..Our objective was to create a peripheral nerve block form based on key elements of literature evidence and on our own group consensus... - For outpatients, does regional anesthesia truly shorten the hospital stay, and how should we define postanesthesia care unit bypass eligibility?Brian A Williams
Anesthesiology 101:3-6. 2004 - The incidence of falls at home in patients with perineural femoral catheters: a retrospective summary of a randomized clinical trialBrian A Williams
Anesth Analg 104:1002. 2007 - Fast-track ambulatory anesthesia: impact on nursing workload when analgesia and antiemetic prophylaxis are near-optimalBrian A Williams
Can J Anaesth 54:243-4. 2007 - Potential economic benefits of regional anesthesia for acute pain management: the need to study both inputs and outcomesBrian A Williams
Reg Anesth Pain Med 31:95-9. 2006 - Continuous perineural infusions at home: narrowing the focusJacques E Chelly
Reg Anesth Pain Med 29:1-3. 2004 - A post hoc analysis of research study staffing: budgetary effects of the Health Insurance Portability and Accountability Act on research staff work hours during a prospective, randomized clinical trialBrian A Williams
Anesthesiology 107:860-1. 2007 - Billing for outpatient regional anesthesia services in the United StatesJennifer Greger
Greater Houston Anesthesia, TX 77057-4817, USA
Int Anesthesiol Clin 43:33-41. 2005
Research Grants
- Outcomes After ACL Reconstruction: Femoral Nerve BlockBrian Williams; Fiscal Year: 2005..The methods learned and the model developed herein will be the basis of future studies funded through the R01 mechanism. ..