Holger Wille

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein
    Holger Wille
    Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:3740-5. 2009
  2. pmc Natural and synthetic prion structure from X-ray fiber diffraction
    Holger Wille
    Institute for Neurodegenerative Diseases, Departments of Neurology and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16990-5. 2009
  3. pmc Protease-resistant prions selectively decrease Shadoo protein
    Joel C Watts
    Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 7:e1002382. 2011
  4. pmc Design and construction of diverse mammalian prion strains
    David W Colby
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:20417-22. 2009
  5. pmc Electron crystallography of the scrapie prion protein complexed with heavy metals
    Holger Wille
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA Department of Neurology, University of California, San Francisco, CA 94143, USA
    Arch Biochem Biophys 467:239-48. 2007
  6. pmc Spontaneous generation of anchorless prions in transgenic mice
    Jan Stöhr
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:21223-8. 2011
  7. pmc Evidence for assembly of prions with left-handed beta-helices into trimers
    Cedric Govaerts
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:8342-7. 2004
  8. pmc Molecular modeling of the misfolded insulin subunit and amyloid fibril
    Jay H Choi
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
    Biophys J 97:3187-95. 2009
  9. pmc Conformational diversity of wild-type Tau fibrils specified by templated conformation change
    Bess Frost
    Department of Neurology, University of California, San Francisco, California 94158, USA
    J Biol Chem 284:3546-51. 2009
  10. pmc Colloid formation by drugs in simulated intestinal fluid
    Allison K Doak
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158 2550, USA
    J Med Chem 53:4259-65. 2010

Collaborators

Detail Information

Publications14

  1. pmc Surface charge of polyoxometalates modulates polymerization of the scrapie prion protein
    Holger Wille
    Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:3740-5. 2009
    ..The mechanism by which POMs function in competing prion polymerization pathways--one favoring 2D crystals and the other, amyloid fibrils--remains to be established...
  2. pmc Natural and synthetic prion structure from X-ray fiber diffraction
    Holger Wille
    Institute for Neurodegenerative Diseases, Departments of Neurology and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:16990-5. 2009
    ....
  3. pmc Protease-resistant prions selectively decrease Shadoo protein
    Joel C Watts
    Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 7:e1002382. 2011
    ..Additional studies using this paradigm may provide insight into the cellular pathways and systems subverted by PrP(Sc) during prion disease...
  4. pmc Design and construction of diverse mammalian prion strains
    David W Colby
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:20417-22. 2009
    ....
  5. pmc Electron crystallography of the scrapie prion protein complexed with heavy metals
    Holger Wille
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA Department of Neurology, University of California, San Francisco, CA 94143, USA
    Arch Biochem Biophys 467:239-48. 2007
    ..Differential staining also confirmed the location of the internal deletion of PrP(Sc)106 at or near these densities...
  6. pmc Spontaneous generation of anchorless prions in transgenic mice
    Jan Stöhr
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:21223-8. 2011
    ..Remarkably, disease from ill Tg(PrP,ΔGPI) mice transmitted to mice expressing wild-type PrP(C), indicating the spontaneous generation of prions...
  7. pmc Evidence for assembly of prions with left-handed beta-helices into trimers
    Cedric Govaerts
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 101:8342-7. 2004
    ..Moreover, the parallel left-handed beta-helical model for PrP(Sc) may provide important clues to the structure of filaments found in some other neurodegenerative diseases...
  8. pmc Molecular modeling of the misfolded insulin subunit and amyloid fibril
    Jay H Choi
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
    Biophys J 97:3187-95. 2009
    ....
  9. pmc Conformational diversity of wild-type Tau fibrils specified by templated conformation change
    Bess Frost
    Department of Neurology, University of California, San Francisco, California 94158, USA
    J Biol Chem 284:3546-51. 2009
    ..WT Tau is thus capable of conformational diversity that arises via templated conformation change, as has been described for amyloid beta, beta2-microglobulin, and prion proteins...
  10. pmc Colloid formation by drugs in simulated intestinal fluid
    Allison K Doak
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158 2550, USA
    J Med Chem 53:4259-65. 2010
    ..Six formed colloids at concentrations equal to or lower than the concentrations reached in the gut, suggesting that aggregation may have an effect on the absorption and distribution of these drugs, and potentially others, in vivo...
  11. pmc Small-molecule aggregates inhibit amyloid polymerization
    Brian Y Feng
    Department of Pharmaceutical Chemistry and Graduate Group in Chemistry and Chemical Biology, University of California San Francisco, 1700 4th Street, San Francisco, California 94158 2330, USA
    Nat Chem Biol 4:197-9. 2008
    ..They also blocked infection of yeast cells with Sup35 prions, which suggests that colloidal inhibition may be relevant in more biological milieus...
  12. pmc Human prions and plasma lipoproteins
    Jiri G Safar
    Institute for Neurodegenerative Diseases, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:11312-7. 2006
    ..Whether detection of PrP(Sc) in VLDL and LDL particles can be adapted into an antemortem diagnostic test for prions in the blood of humans, livestock, and free-ranging cervids remains to be determined...
  13. pmc Structural studies of the scrapie prion protein by electron crystallography
    Holger Wille
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:3563-8. 2002
    ..These low-resolution projection maps and models have implications for understanding prion propagation and the pathogenesis of neurodegeneration...
  14. pmc Genes contributing to prion pathogenesis
    GULTEKIN TAMGUNEY
    Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA
    J Gen Virol 89:1777-88. 2008
    ....