- ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytesKevin Wilhelmsen
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
J Biol Chem 287:26478-94. 2012..This study newly identifies ERK5 as a key regulator of TLR2 signaling in EC and monocytes and indicates that there are fundamental differences in TLR signaling pathways between EC and monocytes...
- Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in miceArun Prakash
Department of Anesthesia and Perioperative Care, San Francisco General Hospital, University of California, San Francisco, CA, USA
Anesthesiology 117:822-35. 2012..Recently, evidence has emerged that receptors and pathways of the innate immune system are involved in recognizing sterile inflammation and overlap considerably with those involved in the recognition of and response to pathogens...
- Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil responseKevin Wilhelmsen
Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
Innate Immun 18:602-16. 2012..This study suggests that endothelial TLR2 may be an important regulator of neutrophil trafficking to sites of infection in general, and that direct activation of lung endothelial TLR2 may contribute to acute lung injury during sepsis...