Kevin Wilhelmsen

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation
    Kevin Wilhelmsen
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Signal 8:ra86. 2015
  2. pmc ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes
    Kevin Wilhelmsen
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:26478-94. 2012
  3. pmc Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice
    Arun Prakash
    Department of Anesthesia and Perioperative Care, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Anesthesiology 117:822-35. 2012
  4. pmc Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response
    Kevin Wilhelmsen
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Innate Immun 18:602-16. 2012
  5. doi Vascular endothelial cell Toll-like receptor pathways in sepsis
    Samira Khakpour
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA Biomedical Sciences and Immunology Programs, University of California, San Francisco, CA, USA
    Innate Immun 21:827-46. 2015

Collaborators

Detail Information

Publications5

  1. doi Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation
    Kevin Wilhelmsen
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Signal 8:ra86. 2015
    ..Together, our studies support a proinflammatory role for ERK5 in primary human endothelial cells and monocytes, and suggest that ERK5 is a potential therapeutic target in diverse disorders that cause inflammatory critical illness. ..
  2. pmc ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes
    Kevin Wilhelmsen
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    J Biol Chem 287:26478-94. 2012
    ..This study newly identifies ERK5 as a key regulator of TLR2 signaling in EC and monocytes and indicates that there are fundamental differences in TLR signaling pathways between EC and monocytes...
  3. pmc Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice
    Arun Prakash
    Department of Anesthesia and Perioperative Care, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Anesthesiology 117:822-35. 2012
    ..Recently, evidence has emerged that receptors and pathways of the innate immune system are involved in recognizing sterile inflammation and overlap considerably with those involved in the recognition of and response to pathogens...
  4. pmc Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response
    Kevin Wilhelmsen
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Innate Immun 18:602-16. 2012
    ..This study suggests that endothelial TLR2 may be an important regulator of neutrophil trafficking to sites of infection in general, and that direct activation of lung endothelial TLR2 may contribute to acute lung injury during sepsis...
  5. doi Vascular endothelial cell Toll-like receptor pathways in sepsis
    Samira Khakpour
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA Biomedical Sciences and Immunology Programs, University of California, San Francisco, CA, USA
    Innate Immun 21:827-46. 2015
    ....