Research Topics
Genomes and Genes | Jesse C WileySummaryAffiliation: University of Washington Country: USA Publications
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Publications
Comparative Mouse Genomics Centers Consortium: the Mouse Genotype DatabaseJesse C Wiley
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
Mutat Res 595:137-44. 2006..niehs.nih.gov/genotype/), which maintains both a consortium specific and public access display of the available and developing mouse models...
Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cellsJesse C Wiley
Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e9135. 2010....
Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragmentJesse C Wiley
Department of Physiology and Biophysics, University of Washginton, Seattle, Washington 98195, USA
J Neurochem 94:1189-201. 2005....
Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic miceJesse C Wiley
Department of Comparative Medicine, University of Washington School of Medicine, Seattle, USA
Aging Cell 10:418-28. 2011..The data suggest that PBA ameliorates the cognitive and pathological features of AD and supports the investigation of PBA as a therapeutic for AD...
Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domainJesse C Wiley
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 282:33313-25. 2007....
Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capabilityKevin C Kanning
Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
J Neurosci 23:5425-36. 2003....
Determining true HER2 gene status in breast cancers with polysomy by using alternative chromosome 17 reference genes: implications for anti-HER2 targeted therapyChun Hing Tse
PhenoPath Laboratories, 551 N 34th St, Seattle, WA 98103, USA
J Clin Oncol 29:4168-74. 2011..However, pangenomic studies have demonstrated that polysomy 17 is rare. This study tests the hypothesis that the use of alternative chromosome 17 reference genes might more accurately assess true HER2 gene status...
