Clayton A Wiley

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
  2. pmc Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic dege
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 172:1603-16. 2008
  3. pmc Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurosci Lett 426:117-22. 2007
  4. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
  5. pmc Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis
    Stephanie J Bissel
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Virol 82:5031-42. 2008
  6. pmc PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neurobiol Aging 30:1217-26. 2009
  7. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Neurobiol Dis 29:232-41. 2008
  8. pmc Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, PA, USA
    Brain Pathol 22:530-46. 2012
  9. pmc In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    J Neuroinflammation 7:34. 2010
  10. ncbi request reprint A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 102:2118-31. 2007

Detail Information

Publications34

  1. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  2. pmc Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic dege
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 172:1603-16. 2008
    ..A combination of PET imaging and the assessment of these peripheral immune parameters may facilitate longitudinal assessment of lentiviral encephalitis in living patients as well as evaluation of therapeutic efficacies...
  3. pmc Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurosci Lett 426:117-22. 2007
    ....
  4. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
    ....
  5. pmc Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis
    Stephanie J Bissel
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Virol 82:5031-42. 2008
    ..These findings support the hypothesis that inherent differences in host systemic and CNS monocyte/macrophage viral production are associated with the development of encephalitis...
  6. pmc PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neurobiol Aging 30:1217-26. 2009
    ....
  7. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Neurobiol Dis 29:232-41. 2008
    ....
  8. pmc Astrocyte and macrophage regulation of YKL-40 expression and cellular response in neuroinflammation
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, PA, USA
    Brain Pathol 22:530-46. 2012
    ....
  9. pmc In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    J Neuroinflammation 7:34. 2010
    ..We have previously reported elevated CHI3L1 concentration in the cerebrospinal fluid (CSF) of human and non-human primates with lentiviral encephalitis and using immunohistochemistry showed that CHI3L1 was associated with astrocytes...
  10. ncbi request reprint A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 102:2118-31. 2007
    ....
  11. pmc Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis
    Stephanie J Bissel
    Department of Infectious Diseases and Microbiology, Graduate School of Public Health, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Pathol 168:1553-69. 2006
    ..These findings suggest that inherent differences in host monocyte viral production are related to development of encephalitis...
  12. pmc YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor
    Dafna Bonneh-Barkay
    Departments of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Pathol 173:130-43. 2008
    ....
  13. pmc YKL-40 expression in traumatic brain injury: an initial analysis
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:1215-23. 2010
    ....
  14. pmc The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, and Presbyterian University Hospital, Neuropathology Division, Pittsburgh, Pennsylvania 15213, USA
    J Neuropathol Exp Neurol 67:1001-10. 2008
    ....
  15. ncbi request reprint Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurovirol 12:262-71. 2006
    ....
  16. ncbi request reprint Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis
    Elizabeth M Chalovich
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Neuropathology 25:315-25. 2005
    ..These findings suggest that p107 and p130 are differentially expressed in CNS macrophage populations which may have multiple derivations and/or roles in lentiviral encephalitis...
  17. pmc Preventive immunization of aged and juvenile non-human primates to β-amyloid
    Julia Kofler
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neuroinflammation 9:84. 2012
    ....
  18. pmc Exacerbation of experimental autoimmune encephalomyelitis in the absence of breast regression protein 39/chitinase 3-like 1
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neuropathol Exp Neurol 71:948-58. 2012
    ..These findings support the role of BRP-39 expression in limiting immune cell infiltration into the CNS and offer a new target to modulate neuroinflammation...
  19. pmc The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Prog Neurobiol 80:308-22. 2006
    ..Current evidence suggests these findings might be applied to the development of clinical assessments of microglial activation in neurological disorders...
  20. pmc Acute murine H5N1 influenza A encephalitis
    Stephanie J Bissel
    Division of Neuropathology, Department of Pathology Graduate Program in Immunology Department of Microbiology and Molecular Genetics Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Pathol 22:150-8. 2012
    ....
  21. ncbi request reprint Destruction of extracellular matrix proteoglycans is pervasive in simian retroviral neuroinfection
    Rafael Medina-Flores
    Division of Neuropathology, Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Dis 16:604-16. 2004
    ..Matrix damage is pervasive during SIV neuroinfection, which suggests interventions to conserve brain matrix proteoglycans might avert or delay retroviral-induced neurodegeneration...
  22. pmc Antibody breadth and protective efficacy are increased by vaccination with computationally optimized hemagglutinin but not with polyvalent hemagglutinin-based H5N1 virus-like particle vaccines
    Brendan M Giles
    Center for Vaccine Research, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Vaccine Immunol 19:128-39. 2012
    ..The single COBRA HA antigen elicited a broader antibody response and reduced morbidity and viral titers more effectively than a polyvalent mixture of primary H5N1 HA antigens...
  23. pmc Elicitation of anti-1918 influenza virus immunity early in life prevents morbidity and lower levels of lung infection by 2009 pandemic H1N1 influenza virus in aged mice
    Brendan M Giles
    Center for Vaccine Research, a Graduate Program in Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Virol 86:1500-13. 2012
    ..These findings show that immunity acquired early in life can restrict the anatomical location of influenza viral replication, rather than preventing infection, in the aged...
  24. doi request reprint Comparison of telepathology systems in neuropathological intraoperative consultations
    Craig Horbinski
    Department of Pathology, Division of Neuropathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania15213, USA
    Neuropathology 29:655-63. 2009
    ..These results show that telepathology can be used to diagnose challenging tumors, and that differences in outcomes are as much a function of the different surgeries performed at different sites as is the diagnostic modality used...
  25. pmc YKL-40 is directly produced by tumor cells and is inversely linked to EGFR in glioblastomas
    Craig Horbinski
    Department of Pathology, Division of Neuropathology, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Int J Clin Exp Pathol 3:226-37. 2010
    ..3), but loss of heterozygosity in 10q23 correlated with increased YKL-40 expression (P = 0.03). These data suggest that YKL-40 is predominantly expressed by neoplastic glial cells and is related to certain key molecular alterations...
  26. doi request reprint Microglia: key innate immune cells of the brain
    Julia Kofler
    1Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Toxicol Pathol 39:103-14. 2011
    ..With our greater appreciation of microglial involvement in the innate immune response, we have entered a new era in which the modulation of microglia can be proposed as a means of modulating neurological disease...
  27. pmc Brain extracellular matrix in neurodegeneration
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Brain Pathol 19:573-85. 2009
    ..Descriptive studies of human neurodegenerative disorders and experimental studies of animal models of neurodegeneration have begun to define potential mechanisms of ECM disruption that can lead to synaptic and neuronal loss...
  28. ncbi request reprint Telepathology for intraoperative neuropathologic consultations at an academic medical center: a 5-year report
    Craig Horbinski
    Department of Pathology, Division of Neuropathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Neuropathol Exp Neurol 66:750-9. 2007
    ..However, the practice of providing these remote consultations requires a sophisticated and technologically advanced environment along with substantial planning, communication, and training of both pathologists and pathology assistants...
  29. pmc Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child
    Kathryn McFadden
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropathol Exp Neurol 64:545-52. 2005
    ..We suggest that juvenile NIID is a spinocerebellar brainstem ataxic disease possibly related to an abnormality in SUMOylation...
  30. doi request reprint Psychostimulant abuse and neuroinflammation: emerging evidence of their interconnection
    Kenneth H Clark
    Department of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neurotox Res 23:174-88. 2013
    ..Finally, we offer one hypothesis of a possible mechanism by which psychostimulants result in IIR activation and discuss the potential therapeutic implications of these findings for treatment of the recovering addict...
  31. ncbi request reprint October 2003: a 59-year-old woman with sudden onset of diplopia. Listerial rhombencephalitis
    Rafael Medina-Flores
    Department of Pathology Neuropathology, University of Pittsburgh School of Medicine, PA, USA
    Brain Pathol 14:225-6. 2004
  32. pmc An agent-based model of inflammation and fibrosis following particulate exposure in the lung
    Bryan N Brown
    Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Math Biosci 231:186-96. 2011
    ..This ABM may hold future utility in the setting of airway disease resulting from inflammation and fibrosis following particulate exposure...
  33. ncbi request reprint Systemic distribution of West Nile virus infection: postmortem immunohistochemical study of six cases
    Henry B Armah
    Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA 15213, USA
    Brain Pathol 17:354-62. 2007
    ..Comparison of our findings with previous reports suggests that patients with WNV encephalitis can have widespread systemic infection...
  34. pmc PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS
    Sriram Venneti
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Invest 113:981-9. 2004
    ....