Research Topics
| Robert L WilenskySummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
Angiotensin-receptor blockers: revival of the systemic prevention of restenosis?Robert L Wilensky
Hospital of the University of Pennsylvania, 3400 Spruce St, 9 Gates, Philadelphia, PA 19104, USA
Cardiovasc Drugs Ther 17:63-73. 2003....- The molecular basis of vulnerable plaque: potential therapeutic role for immunomodulationRobert L Wilensky
University of Pennsylvania, Philadelphia, Pennsylvania, USA
Curr Opin Cardiol 22:545-51. 2007..Through recent studies the role of the immune system on development of atherosclerosis and approaches to modulate this response are being elucidated... - Relation of percutaneous coronary intervention of complex lesions to clinical outcomes (from the NHLBI Dynamic Registry)Robert L Wilensky
Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
Am J Cardiol 90:216-21. 2002..An increased in-hospital adverse clinical event rate was independently noted for thrombotic, bifurcation, and calcified lesions, and bifurcation lesions had worse long-term event rates... 
Lipoprotein-associated phospholipase A(2) and atherosclerosisRobert L Wilensky
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Curr Opin Lipidol 20:415-20. 2009..However, only recently have data emerged demonstrating a role of Lp-PLA2 in development of advanced coronary artery disease. Indeed, Lp-PLA2 may be an important link between lipid homeostasis and the vascular inflammatory response...- Role of magnetic resonance and intravascular magnetic resonance in the detection of vulnerable plaquesRobert L Wilensky
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 47:C48-56. 2006..The self-contained intravascular MRI probe appears to hold promise in the identification of high-risk coronary atherosclerotic lesions with increased superficial lipid content... 
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque developmentRobert L Wilensky
Hospital of the University of Pennsylvania, 3400 Spruce Street, 9 Gates, Philadelphia, Pennsylvania 19104, USA
Nat Med 14:1059-66. 2008....- Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculatureEmile R Mohler
University of Pennsylvania, Philadelphia, PA 19104, USA
Arterioscler Thromb Vasc Biol 28:850-5. 2008..We hypothesized that genes in the vasculature related to cholesterol metabolism, inflammation, and insulin signaling pathways are differentially regulated in a site-specific and time-dependent manner... - Diabetes reduces bone marrow and circulating porcine endothelial progenitor cells, an effect ameliorated by atorvastatin and independent of cholesterolEmile R Mohler
Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cytometry A 75:75-82. 2009..These data suggest a model wherein accelerated atherosclerosis seen with DM may, in part, result from reduction in EPCs which may be ameliorated by treatment with a statin... - Vascular responses to drug-eluting and bare metal stents in diabetic/hypercholesterolemic and nonatherosclerotic porcine coronary arteriesRaul Llano
Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Circ Cardiovasc Interv 4:438-46. 2011.... - Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responsesYi Shi
Department of Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
Atherosclerosis 191:54-62. 2007..To explore the biologic role of Lp-PLA2 in atherosclerosis, we examined its expression and contribution to leukocyte activation under proatherogenic conditions... - Subsequent development of fibroatheromas with inflamed fibrous caps can be predicted by intracoronary near infrared spectroscopyDHAVALKUMAR PATEL
Cardiovascular Division, Hospital of the University of Pennsylvania and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Arterioscler Thromb Vasc Biol 33:347-53. 2013..To prospectively evaluate whether the development of fibroatheromas exhibiting features of potential instability can be detected and predicted by serial invasive imaging... - Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery diseaseDamir Hamamdzic
Cardiovascular Division, Hospital of University of Pennsylvania and Cardiovascular Institute, University of Pennsylvania 19104, USA
Am J Physiol Heart Circ Physiol 299:H699-706. 2010..Our results revealed a synergistic effect of DM and HC in triggering abnormal Akt signaling, resulting in advanced atherosclerosis... - Clinical progression of incidental, asymptomatic lesions discovered during culprit vessel coronary interventionRuchira Glaser
University of Pennsylvania, Philadelphia, PA 19104, USA
Circulation 111:143-9. 2005..CONCLUSIONS: Approximately 6% of PCI patients will have clinical plaque progression requiring nontarget lesion PCI by 1 year. Greater coronary artery disease burden confers a significantly higher risk for clinical plaque progression... - Hypercholesterolemia suppresses Kir channels in porcine bone marrow progenitor cells in vivoEmile R Mohler
Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Biochem Biophys Res Commun 358:317-24. 2007..We further asses the hypercholesterolemia sensitivity of Kir channels in BM-SP cells, which may play a key role in hypercholesterolemia-mediated regulation of EPCs... - Effect of gender on prognosis following percutaneous coronary intervention for stable angina pectoris and acute coronary syndromesRuchira Glaser
University of Pennsylvania, Philadelphia, USA
Am J Cardiol 98:1446-50. 2006..05, p = 0.5). In conclusion, women undergoing PCI for NSTACS have a higher risk of major adverse cardiac events than men or women undergoing PCI for stable angina... - Intracoronary delivery of mesenchymal stem cells at high flow rates after myocardial infarction improves distal coronary blood flow and decreases mortality in pigsRaul Llano
Cardiovascular Division, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Catheter Cardiovasc Interv 73:251-7. 2009..Evaluate the effects of pressure and duration of intracoronary (IC) infusion of mesenchymal stem cells (MSCs) on delivery efficiency and safety after myocardial infarction (MI)... - Bisphosphonate-mediated gene vector delivery from the metal surfaces of stentsIlia Fishbein
Division of Cardiology, The Children's Hospital of Philadelphia, Department of Chemical, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:159-64. 2006..68 +/- 0.27 and 3.4 +/- 0.35; Ad-iNOS vs. control, P < 0.01). It is concluded that effective gene vector delivery from metallic stent surfaces can be achieved by using this approach... - A placebo controlled, dose-ranging, safety study of allogenic mesenchymal stem cells injected by endomyocardial delivery after an acute myocardial infarctionSeyed M Hashemi
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Eur Heart J 29:251-9. 2008..Although mesenchymal stem cells (MSCs) show promising signs in reducing myocardial infarct (MI) size, the safety of endomyocardial delivery and the most efficacious dose is unknown... - Usefulness of noncoronary vascular disease in predicting adverse events in the year following percutaneous coronary interventionSrihari S Naidu
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Cardiol 95:575-80. 2005..Because PCI is often performed before vascular surgery, these data may lend insight to the risk/benefit ratio of such an approach... - Beta-cyclodextrin tetradecasulfate, a novel cyclic oligosaccharide, inhibits thrombus and neointimal formation after coronary vascular injuryNicolas F Meneveau
Department of Medicine, University of Pennsylvania, USA
Coron Artery Dis 13:189-97. 2002..We postulate that beta-CDT was effective by the combination of increasing endothelial coverage, reducing mural thrombus formation, inhibiting factor Xa activity and reducing cellular proliferation... - Comparison of bare-metal and drug-eluting stents in patients with chronic kidney disease (from the NHLBI Dynamic Registry)Sandy M Green
Heart and Vascular Institute, University of Pittsburgh Medical Center, Pennsylvania, USA
Am J Cardiol 108:1658-64. 2011..In conclusion, presence of CKD predicted poor outcomes after PCI with high rates of mortality regardless of stent type. The effect of DES in decreasing repeat revascularization appeared to be attenuated in these patients... - Comparison of invasive and noninvasive assessment of aortic stenosis severity in the elderlyZachary M Gertz
Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Circ Cardiovasc Interv 5:406-14. 2012..Accurate assessment of AVA is crucial to determine which patients are appropriate candidates for aortic valve replacement... - FilterWire distal embolic protection device for vein graft stenting: initial single-center experienceDaniel M Kolansky
Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Cardiol 28:556-60. 2005..The FilterWire distal embolic protection device has recently been approved as an adjunct to SVG intervention. We report here our initial experience in a single center in 30 consecutive patients using this device in SVG stenting... - One-year clinical outcomes of protected and unprotected left main coronary artery stentingMichael P Kelley
Hospital of the University of Pennsylvania, University Health System, 9 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Eur Heart J 24:1554-9. 2003..Stenting for unprotected LMCA disease in a high-risk population should only be considered in the absence of other revascularization options. Further studies are needed to evaluate the role of stenting for unprotected LMCA disease... - Local drug delivery for treatment of coronary and peripheral artery diseaseZachary M Gertz
Cardiovascular Division, Hospital of the University of Pennsylvania, and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA
Cardiovasc Ther 29:e54-66. 2011..In this review, we discuss the development, the clinical use, and the effects of LDD from balloon and stent-based platforms in the treatment of restenosis and thrombus... - Renal insufficiency is an independent predictor of mortality after percutaneous coronary interventionSrihari S Naidu
Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Cardiol 92:1160-4. 2003.... - Effect of atorvastatin on postcardiac transplant increase in low-density lipoprotein cholesterol reduces development of intimal hyperplasia and progression of endothelial dysfunctionVincent Y See
Cardiovascular Division, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4024, USA
Am J Cardiol 92:11-5. 2003.... - Site specific gene delivery in the cardiovascular systemIlia Fishbein
Cardiology Research Laboratories, Children's Hospital of Philadelphia, Abramson Research Center, PA 19104, USA
J Control Release 109:37-48. 2005..Our group has successfully investigated in animal studies localized gene therapy using an ion channel mutation to treat atrial arrhythmias... - Gene delivery to pig coronary arteries from stents carrying antibody-tethered adenovirusBruce D Klugherz
The Division of Cardiology, Children's Hospital of Philadelphia, University of Pennsylvania Health System and Philadelphia Veterans Administration Medical Center, Philadelphia, PA 19104, USA
Hum Gene Ther 13:443-54. 2002..Gene delivery using stent-based anti-viral antibody tethering of vectors should be suitable for a wide array of single or multiple therapeutic gene strategies... - Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivoYun Fang
Institute for Medicine and Engineering, Department of Pathology and Laboratory Medicine, University of Pennsylvania, USA
Circ Res 98:1064-71. 2006..Therefore, we suggest that suppression of Kir current is one of the important factors in hypercholesterolemia-induced endothelial dysfunction... - Recent developments with lipoprotein-associated phospholipase A2 inhibitorsRyan J Chauffe
Pennsylvania Hospital, 1 Pine West, 800 Spruce Street, Philadelphia, PA 19107, USA
Curr Atheroscler Rep 12:43-7. 2010..This article reviews the most recent developments with Lp-PLA(2) inhibitors... - A novel ultrasound method for evaluation of collateral development in limb ischemiaEmile R Mohler
Department of Medicine, Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Vasc Med 7:169-75. 2002..This non-invasive method is useful to quantify blood flow, visualize angiogenesis and determine areas of persistent lower limb ischemia, and may have an important role in evaluating new approaches to modulate angiogenesis... - Duration of clopidogrel therapy after placement of drug-eluting intracoronary stentSarah A Spinler
Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104, USA
Am J Health Syst Pharm 64:1432-4. 2007 - DarapladibQuang T Bui
University of Pennsylvania, Hospital of the University of Pennsylvania, Cardiovascular Institute, Cardiovascular Division, Philadelphia, PA 19104, USA
Expert Opin Investig Drugs 19:161-8. 2010..Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) seems to play a major role in the development of such high-risk lesions, in both the coronary and carotid arteries. Darapladib is a selective inhibitor of Lp-PLA(2)... - Twenty-eight-day efficacy and phamacokinetics of the sirolimus-eluting stentBruce D Klugherz
Laboratory for Experimental Cardiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Coron Artery Dis 13:183-8. 2002.... - Intravascular magnetic resonance imagingVictor A Ferrari
University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Top Magn Reson Imaging 18:401-8. 2007.... - The anti-oxidative capacity of high-density lipoprotein is reduced in acute coronary syndrome but not in stable coronary artery diseaseParin J Patel
Division of Cardiovascular Medicine, Department of Medicine, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 58:2068-75. 2011..This study examined an anti-inflammatory property of high-density lipoprotein (HDL) in subjects with acute coronary syndrome (ACS) and stable coronary artery disease (CAD) compared with control subjects... - Patient satisfaction is comparable to early discharge versus overnight observation after elective percutaneous coronary interventionRuchira Glaser
Cardiology Consultants, Pennsylvania, Division of Cardiovascular Medicine, Christiana Hospital, Newark, Delaware, USA
J Invasive Cardiol 21:464-7. 2009..S. cohorts. We sought to assess patient satisfaction, safety and cost of a strategy of selective early discharge in U.S. patients undergoing PCI via a femoral approach with contemporary adjunctive pharmacologic and hemostasis agents... - Electron-beam computerized tomography correlates with coronary angiogram in chronic kidney disease patientsJanelle Robinson
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Nephrol 27:247-52. 2007..The aim of this study was to determine the correlation in CKD patients between CAC measured by EBCT and 50% stenosis determined by coronary angiography (CA), the gold standard to identify atherosclerotic lesions... - Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humansWen Liang Song
Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 122:1459-68. 2012..Thus, PGD₂, like PGI₂, may function as a homeostatic response to thrombogenic and hypertensive stimuli and may have particular relevance as a constraint on platelets during niacin therapy... - Minimally invasive resection of papillary fibroelastoma in a high-risk patientRichard W Kim
Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, PA 19104, USA
J Cardiovasc Med (Hagerstown) 8:639-41. 2007.... - Comparison of degree of platelet inhibition by abciximab versus tirofiban in patients with unstable angina pectoris and non-Q-wave myocardial infarction undergoing percutaneous coronary interventionHoward C Herrmann
University of Pennsylvania Medical Center, Philadelphia 19104, USA
Am J Cardiol 89:1293-7. 2002 - Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosisAmit V Khera
Cardiovascular Institute, University of Pennsylvania, Philadelphia, USA
N Engl J Med 364:127-35. 2011..We hypothesized that the capacity of HDL to accept cholesterol from macrophages would serve as a predictor of atherosclerotic burden... - Atherosclerotic plaque developmentQuang T Bui
Cardiovascular Division, Hospital of the University of Pennsylvania, 9 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Int J Biochem Cell Biol 41:2109-13. 2009..The interplay of macrophages, T lymphocytes and mast cells play a central role in both the development but more importantly in the progression of coronary and carotid artery disease to high-risk phenotypes... - Intracoronary delivery of bone-marrow-derived stem cellsQuang T Bui
Cardiovascular Division, Hospital of the University of Pennsylvania and Cardiovascular Institute, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Stem Cell Res Ther 1:29. 2010..The aim of this review will be to discuss the potential therapeutic effects of myocardial stem cell and progenitor cell therapy delivered by an intracoronary route with special reference to treatment of infarcted myocardium... - Comparison of the efficacy of direct coronary stenting with sirolimus-eluting stents versus stenting with predilation by intravascular ultrasound imaging (from the DIRECT trial)Atsushi Hirohata
Center for Research in Cardiovascular Intervention, Stanford University, Stanford, California, USA
Am J Cardiol 98:1464-7. 2006..This strategy appears to be associated with less neointimal hyperplasia near the distal stent edge... - Reduced vascular complications after percutaneous coronary interventions with a nonmechanical suture device: results from the randomized RACE studyTimothy A Sanborn
Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
Catheter Cardiovasc Interv 61:327-32. 2004..The incidence of major complications after PCI was reduced with the device... - Preclinical evaluation of drug-eluting stents for peripheral applications: recommendations from an expert consensus groupRobert S Schwartz
Minneapolis Heart Institute Foundation, Minnesota Cardiovascular Research Institute, 920 E 28th St, Minneapolis, MN 55407, USA
Circulation 110:2498-505. 2004 - Separate and combined effects of local and continuous intravenous administration of beta-cyclodextrin tetradecasulfate on intimal hyperplasia after angioplasty in porcine coronary arteriesNicolas F Meneveau
Department of Medicine (Cardiovascular Division) of the University of Pennsylvania, 19104, USA
J Cardiovasc Pharmacol Ther 8:53-60. 2003.... - Diagnosis of thin-cap fibroatheromas by a self-contained intravascular magnetic resonance imaging probe in ex vivo human aortas and in situ coronary arteriesJacob Schneiderman
Department of Vascular Surgery and Gottesdiener Vascular Biology Laboratory, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Am Coll Cardiol 45:1961-9. 2005.... - A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarctionToby Freyman
Boston Scientific Corporation, Natick, MA, USA
Eur Heart J 27:1114-22. 2006..EC delivery into acutely infarcted myocardial tissue was safe and well tolerated and was associated with decreased remote organ engraftment with compared with IC and IV deliveries... - Rash with both clopidogrel and ticlopidine in two patients following percutaneous coronary intervention with drug-eluting stentsKathy Makkar
Mercy Suburban Hospital, Norristown, PA, USA
Ann Pharmacother 40:1204-7. 2006.... - Unrestricted use of drug-eluting stents compared with bare-metal stents in routine clinical practice: findings from the National Heart, Lung, and Blood Institute Dynamic RegistryJ Dawn Abbott
Department of Cardiology, Rhode Island Hospital, Providence, Rhode Island, USA
J Am Coll Cardiol 50:2029-36. 2007..We investigated the effectiveness and safety of drug-eluting stents (DES) as used in routine clinical practice... - Drug-eluting stents in preclinical studies: recommended evaluation from a consensus groupRobert S Schwartz
Minnesota Cardiovascular Research Institute and Minneapolis Heart Institute Foundation Minneapolis, 55407, USA
Circulation 106:1867-73. 2002 - Safety of sirolimus-eluting stenting and its effect on restenosis in patients with unstable angina pectoris (a SIRIUS substudy)Giora Weisz
Columbia University Medical Center, and Cardiovascular Research Foundation, New York, New York, USA
Am J Cardiol 99:1044-50. 2007..Patients with unstable angina undergoing percutaneous coronary intervention who meet the entry criteria of the SIRIUS study should be preferentially treated with SESs... - A comparison of bare-metal and drug-eluting stents for off-label indicationsOscar C Marroquin
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, USA
N Engl J Med 358:342-52. 2008..Recent reports suggest that off-label use of drug-eluting stents is associated with an increased incidence of adverse events. Whether the use of bare-metal stents would yield different results is unknown... - Role of cardiac troponin T in the long-term risk stratification of patients undergoing percutaneous coronary interventionJorge R Kizer
Division of Cardiology, Department of Medicine and Public Health, Weill Medical College of Cornell University, New York, NY, USA
Eur Heart J 24:1314-22. 2003..Whether the prognostic significance of smaller post-procedural TnT elevations extends beyond the intermediate-term awaits further investigation... - Drug-eluting stents are here--now what? Implications for clinical practice and health care costsJohn W Hirshfeld
Cleve Clin J Med 71:825-8. 2004 - Volume-to-creatinine clearance ratio: a pharmacokinetically based risk factor for prediction of early creatinine increase after percutaneous coronary interventionWarren K Laskey
Division of Cardiology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
J Am Coll Cardiol 50:584-90. 2007..This study sought to validate a pharmacokinetically derived measure of the risk of an early increase in serum creatinine after percutaneous coronary intervention (PCI)... - Completeness of revascularization for multivessel coronary artery disease and its effect on one-year outcome: a report from the NHLBI Dynamic RegistryVankeepuram S Srinivas
Division of Cardiology, Montefiore Medical Center, New York, NY 10461, USA
J Interv Cardiol 20:373-80. 2007..In conclusion, despite the presence of more unfavorable characteristics, patients undergoing TR demonstrate 1-year outcomes equivalent to those having CR, supporting its continued use in selected patients... - Importance of the postdischarge interval in assessing major adverse clinical event rates following percutaneous coronary interventionWarren K Laskey
Division of Cardiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
Am J Cardiol 95:1135-9. 2005..Most postdischarge events derive from pathology related to the controlled vessel. A 30-day MACE rate may serve as a more comprehensive measurement of procedural outcome... - Adenovirus-catheter compatibility increases gene expression after delivery to porcine myocardiumWendy A Naimark
Boston Scientific Corporation, Natick, MA 01760, USA
Hum Gene Ther 14:161-6. 2003..In conclusion, this study highlights the importance of adenovirus-material compatibility in gene delivery to the myocardium. Efficiency was greater when using the catheter designed to enhance biocompatibility... - Outcome of percutaneous coronary intervention in unstable angina pectoris versus stable angina pectoris in two different time periodsSrihari S Naidu
The Cardiovascular Division, Weill Cornell Medical Center, New York, New York, USA
Am J Cardiol 98:447-52. 2006.... - Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trialGregg W Stone
Department of Cardiology, Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute, New York, NY 10022, USA
JAMA 290:2284-91. 2003.... - Ethnic differences in the presentation, treatment strategy, and outcomes of percutaneous coronary intervention (a report from the National Heart, Lung, and Blood Institute Dynamic Registry)James Slater
New York University Medical Center, New York, New York 1016 649, USA
Am J Cardiol 92:773-8. 2003....