Kathryn A Wikenheiser-Brokamp

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Rb family proteins differentially regulate distinct cell lineages during epithelial development
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 131:4299-310. 2004
  2. ncbi request reprint Retinoblastoma family proteins: insights gained through genetic manipulation of mice
    K A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Ohio, 45267 0529, USA
    Cell Mol Life Sci 63:767-80. 2006
  3. ncbi request reprint Retinoblastoma regulatory pathway in lung cancer
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Curr Mol Med 6:783-93. 2006
  4. pmc Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis
    David S Simpson
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 69:8733-41. 2009
  5. pmc Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo
    Trisha M Wise-Draper
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 69:1792-9. 2009
  6. pmc Retinoblastoma function is essential for establishing lung epithelial quiescence after injury
    Nicole A Mason-Richie
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 68:4068-76. 2008
  7. pmc The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer
    Lisa M Privette Vinnedge
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e46985. 2012
  8. pmc The fanconi anemia pathway limits human papillomavirus replication
    Elizabeth E Hoskins
    Division of Oncology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Virol 86:8131-8. 2012
  9. pmc DEK proto-oncogene expression interferes with the normal epithelial differentiation program
    Trisha M Wise-Draper
    Division of Pediatric Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Pathol 174:71-81. 2009
  10. pmc Future directions and treatment strategies for head and neck squamous cell carcinomas
    Trisha M Wise-Draper
    Division of Hematology and Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Transl Res 160:167-77. 2012

Collaborators

  • Parinda Mehta
  • Kasiani C Myers
  • Lisa R Young
  • Nishant Gupta
  • Shuk Mei Ho
  • Darron R Brown
  • Susanne I Wells
  • Trisha M Wise-Draper
  • Elizabeth E Hoskins
  • David S Simpson
  • Nicole A Mason-Richie
  • Timothy M Chlon
  • Stella M Davies
  • Lisa M Privette Vinnedge
  • Riffat Meraj
  • Paul F Lambert
  • Richard J Morreale
  • David P Witte
  • D Ashley Hill
  • Teresa A Morris
  • E E Hoskins
  • Rachael A Mintz-Cole
  • Caitlin A Gettler
  • James M Wells
  • Christopher N Mayhew
  • Sue Byrnes
  • Alfredo A Molinolo
  • Maura L Gillison
  • Gerard J Nuovo
  • Laimonis A Laimins
  • Jennifer M Higginbotham
  • Mi Ok Kim
  • David J Draper
  • Francis X McCormack
  • J Silvio Gutkind
  • Melinda Butsch Kovacic
  • Stephen P Werner
  • Timothy P Cripe
  • David Desruisseau
  • Christina A Gurnett
  • Gerard C Grosveld
  • P Kelly
  • E Cha
  • Yoav Messinger
  • Brian K Suarez
  • Jennifer Ivanovich
  • Dawn Bracamontes
  • John R Priest
  • Jason A Jarzembowski
  • S Duensing
  • N Spardy
  • J M Higginbotham
  • Mark A Currier
  • Louis P Dehner
  • Nader Husseinzadeh
  • D A Williams
  • T A Morris
  • Gretchen Williams
  • Paul J Goodfellow
  • Scott J Balsitis
  • Alison J Whelan
  • S I Wells
  • Asmaa Elayyadi
  • Meenakshi J Mistry

Detail Information

Publications15

  1. ncbi request reprint Rb family proteins differentially regulate distinct cell lineages during epithelial development
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 131:4299-310. 2004
    ....
  2. ncbi request reprint Retinoblastoma family proteins: insights gained through genetic manipulation of mice
    K A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Ohio, 45267 0529, USA
    Cell Mol Life Sci 63:767-80. 2006
    ..This review summarizes the phenotypic consequences of Rb family ablation in mice, and discusses how these findings contribute to the increasingly complex picture of Rb family function in development and tumor suppression...
  3. ncbi request reprint Retinoblastoma regulatory pathway in lung cancer
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Curr Mol Med 6:783-93. 2006
    ....
  4. pmc Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis
    David S Simpson
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 69:8733-41. 2009
    ..Taken together, these studies identify distinct Rb family functions critical in controlling epithelial cell growth, and provide direct evidence that p107 cooperates with Rb to protect against a common adult cancer...
  5. pmc Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo
    Trisha M Wise-Draper
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 69:1792-9. 2009
    ..Taken together, our data uncover oncogenic DEK activities as postulated from its frequent up-regulation in human malignancies, and suggest that the targeted suppression of DEK may become a strategic approach to the treatment of cancer...
  6. pmc Retinoblastoma function is essential for establishing lung epithelial quiescence after injury
    Nicole A Mason-Richie
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 68:4068-76. 2008
    ..Because human cancers are associated with chronic cellular damage, these findings have important new implications for RB-mediated tumor suppression...
  7. pmc The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer
    Lisa M Privette Vinnedge
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e46985. 2012
    ..Together, our data suggest that DEK promotes the pathogenesis of ER+ breast cancer and that the targeted inhibition of DEK may enhance the efficacy of conventional hormone therapies...
  8. pmc The fanconi anemia pathway limits human papillomavirus replication
    Elizabeth E Hoskins
    Division of Oncology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Virol 86:8131-8. 2012
    ....
  9. pmc DEK proto-oncogene expression interferes with the normal epithelial differentiation program
    Trisha M Wise-Draper
    Division of Pediatric Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Pathol 174:71-81. 2009
    ..We suggest that DEK up-regulation may contribute to carcinoma development at least in part through increased proliferation and retardation of differentiation...
  10. pmc Future directions and treatment strategies for head and neck squamous cell carcinomas
    Trisha M Wise-Draper
    Division of Hematology and Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Transl Res 160:167-77. 2012
    ..Targeting molecules such as DEK in combination with new and/or conventional therapies, holds promise for novel future therapeutics for head and neck cancer...
  11. pmc High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells
    Timothy M Chlon
    Cincinnati Children s Hospital Medical Center, Cancer and Blood Diseases Institute, Cincinnati, Ohio, USA
    J Virol 88:11315-26. 2014
    ..Thus, we conclude that the FA pathway is required for the growth of iPSC beyond reprogramming and that p53-independent mechanisms are involved...
  12. doi request reprint Occam's razor or Hickam's dictum?
    Nishant Gupta
    Department of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, OH, USA
    J Bronchology Interv Pulmonol 19:216-9. 2012
    ..The similar clinical and radiographic manifestations of sarcoidosis and histoplasmosis and a possible role of histoplasmosis as an etiologic agent for sarcoidosis are discussed...
  13. doi request reprint Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis
    Riffat Meraj
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45529, USA
    Front Med 6:395-405. 2012
    ..We conclude that transbronchial biopsy may be a safe and effective method for establishing the diagnosis of LAM, obviating the need for surgical lung biopsy in more than half of LAM patients...
  14. pmc DICER1 mutations in familial pleuropulmonary blastoma
    D Ashley Hill
    Washington University Medical Center, St Louis, MO 63110, USA
    Science 325:965. 2009
    ..We hypothesize that loss of DICER1 in the epithelium of the developing lung alters the regulation of diffusible factors that promote mesenchymal proliferation...
  15. pmc Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture
    E E Hoskins
    Division of Hematology Oncology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Oncogene 28:674-85. 2009
    ..Our findings support a new role for FA pathways in the maintenance of differentiation-dependent cell cycle exit, with the implication that FA deficiencies may contribute to the high risk of FA patients for developing HPV-associated SCC...