Kathryn A Wikenheiser-Brokamp

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Rb family proteins differentially regulate distinct cell lineages during epithelial development
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 131:4299-310. 2004
  2. ncbi Retinoblastoma family proteins: insights gained through genetic manipulation of mice
    K A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Ohio, 45267 0529, USA
    Cell Mol Life Sci 63:767-80. 2006
  3. ncbi Retinoblastoma regulatory pathway in lung cancer
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Curr Mol Med 6:783-93. 2006
  4. ncbi Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis
    David S Simpson
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 69:8733-41. 2009
  5. ncbi Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo
    Trisha M Wise-Draper
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 69:1792-9. 2009
  6. ncbi Retinoblastoma function is essential for establishing lung epithelial quiescence after injury
    Nicole A Mason-Richie
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 68:4068-76. 2008
  7. ncbi The fanconi anemia pathway limits human papillomavirus replication
    Elizabeth E Hoskins
    Division of Oncology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Virol 86:8131-8. 2012
  8. ncbi DEK proto-oncogene expression interferes with the normal epithelial differentiation program
    Trisha M Wise-Draper
    Division of Pediatric Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Pathol 174:71-81. 2009
  9. ncbi Future directions and treatment strategies for head and neck squamous cell carcinomas
    Trisha M Wise-Draper
    Division of Hematology and Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Transl Res 160:167-77. 2012
  10. ncbi The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer
    Lisa M Privette Vinnedge
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e46985. 2012

Collaborators

  • Shuk Mei Ho
  • Darron R Brown
  • Trisha M Wise-Draper
  • Susanne I Wells
  • Elizabeth E Hoskins
  • David S Simpson
  • Nicole A Mason-Richie
  • Lisa M Privette Vinnedge
  • David P Witte
  • Paul F Lambert
  • Richard J Morreale
  • Rachael A Mintz-Cole
  • D Ashley Hill
  • Teresa A Morris
  • E E Hoskins
  • Caitlin A Gettler
  • Jennifer M Higginbotham
  • Gerard J Nuovo
  • David J Draper
  • Stephen P Werner
  • Alfredo A Molinolo
  • Mi Ok Kim
  • J Silvio Gutkind
  • Laimonis A Laimins
  • Maura L Gillison
  • Parinda A Mehta
  • Stella M Davies
  • Melinda Butsch Kovacic
  • P Kelly
  • Yoav Messinger
  • Jason A Jarzembowski
  • Timothy P Cripe
  • David Desruisseau
  • Gerard C Grosveld
  • Brian K Suarez
  • Christina A Gurnett
  • S I Wells
  • Scott J Balsitis
  • N Spardy
  • Gretchen Williams
  • Paul J Goodfellow
  • Dawn Bracamontes
  • Louis P Dehner
  • D A Williams
  • T A Morris
  • Alison J Whelan
  • John R Priest
  • Nader Husseinzadeh
  • E Cha
  • S Duensing
  • Jennifer Ivanovich
  • J M Higginbotham
  • Mark A Currier
  • Asmaa Elayyadi
  • Meenakshi J Mistry

Detail Information

Publications12

  1. ncbi Rb family proteins differentially regulate distinct cell lineages during epithelial development
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 131:4299-310. 2004
    ....
  2. ncbi Retinoblastoma family proteins: insights gained through genetic manipulation of mice
    K A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Ohio, 45267 0529, USA
    Cell Mol Life Sci 63:767-80. 2006
    ..This review summarizes the phenotypic consequences of Rb family ablation in mice, and discusses how these findings contribute to the increasingly complex picture of Rb family function in development and tumor suppression...
  3. ncbi Retinoblastoma regulatory pathway in lung cancer
    Kathryn A Wikenheiser-Brokamp
    Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
    Curr Mol Med 6:783-93. 2006
    ....
  4. ncbi Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis
    David S Simpson
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 69:8733-41. 2009
    ..Taken together, these studies identify distinct Rb family functions critical in controlling epithelial cell growth, and provide direct evidence that p107 cooperates with Rb to protect against a common adult cancer...
  5. ncbi Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo
    Trisha M Wise-Draper
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 69:1792-9. 2009
    ..Taken together, our data uncover oncogenic DEK activities as postulated from its frequent up-regulation in human malignancies, and suggest that the targeted suppression of DEK may become a strategic approach to the treatment of cancer...
  6. ncbi Retinoblastoma function is essential for establishing lung epithelial quiescence after injury
    Nicole A Mason-Richie
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 68:4068-76. 2008
    ..Because human cancers are associated with chronic cellular damage, these findings have important new implications for RB-mediated tumor suppression...
  7. ncbi The fanconi anemia pathway limits human papillomavirus replication
    Elizabeth E Hoskins
    Division of Oncology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Virol 86:8131-8. 2012
    ....
  8. ncbi DEK proto-oncogene expression interferes with the normal epithelial differentiation program
    Trisha M Wise-Draper
    Division of Pediatric Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Pathol 174:71-81. 2009
    ..We suggest that DEK up-regulation may contribute to carcinoma development at least in part through increased proliferation and retardation of differentiation...
  9. ncbi Future directions and treatment strategies for head and neck squamous cell carcinomas
    Trisha M Wise-Draper
    Division of Hematology and Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Transl Res 160:167-77. 2012
    ..Targeting molecules such as DEK in combination with new and/or conventional therapies, holds promise for novel future therapeutics for head and neck cancer...
  10. ncbi The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer
    Lisa M Privette Vinnedge
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e46985. 2012
    ..Together, our data suggest that DEK promotes the pathogenesis of ER+ breast cancer and that the targeted inhibition of DEK may enhance the efficacy of conventional hormone therapies...
  11. ncbi DICER1 mutations in familial pleuropulmonary blastoma
    D Ashley Hill
    Washington University Medical Center, St Louis, MO 63110, USA
    Science 325:965. 2009
    ..We hypothesize that loss of DICER1 in the epithelium of the developing lung alters the regulation of diffusible factors that promote mesenchymal proliferation...
  12. ncbi Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture
    E E Hoskins
    Division of Hematology Oncology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Oncogene 28:674-85. 2009
    ..Our findings support a new role for FA pathways in the maintenance of differentiation-dependent cell cycle exit, with the implication that FA deficiencies may contribute to the high risk of FA patients for developing HPV-associated SCC...