Jocelyn Wiggins

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Geriatric assessment for the nephrologist
    Jocelyn Wiggins
    Department of Internal Medicine, Division of Geriatrics, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Semin Dial 25:623-7. 2012
  2. ncbi Aging in the glomerulus
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Geriatrics, Department of Internal Medicine, 1560 MSRBII, Box 5676, Ann Arbor, MI 48109 5676, USA
    J Gerontol A Biol Sci Med Sci 67:1358-64. 2012
  3. ncbi Geriatrics
    Jocelyn Wiggins
    Internal Medicine, Division of Geriatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Kidney Dis 46:147-58. 2005
  4. ncbi NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus
    Jocelyn E Wiggins
    Divisions of Geriatrics, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 21:587-97. 2010
  5. ncbi Podocytes and glomerular function with aging
    Jocelyn Wiggins
    Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5676, USA
    Semin Nephrol 29:587-93. 2009
  6. ncbi Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 17:1382-7. 2006
  7. ncbi Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109-0676, USA
    J Am Soc Nephrol 16:2953-66. 2005
  8. ncbi GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury
    Yeong Hoon Kim
    Nephrology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Nephron 90:471-6. 2002
  9. ncbi Why do our kidneys get old?
    Jocelyn Wiggins
    Division of Geriatrics, Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA wiggi umich edu
    Nephron Exp Nephrol 119:e1-5. 2011
  10. ncbi Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker
    Silja K Sanden
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    J Am Soc Nephrol 14:2484-93. 2003

Research Grants

  1. The Aging Glomerulus
    Jocelyn Wiggins; Fiscal Year: 2007

Collaborators

  • ROGER CHARLES WIGGINS
  • M Kretzler
  • Sang Koo Lee
  • L B Holzman
  • Meera Goyal
  • Bryan L Wharram
  • Silja K Sanden
  • Yuji Sato
  • Yeong Hoon Kim
  • Madhusudan Venkatareddy
  • Larysa Wickman
  • Chrysta Lienczewski
  • Jai Won Chang
  • Wanda E Filipiak
  • Thomas L Saunders
  • Kenji Kohno
  • Sabiha Hussain
  • Robert C Dysko
  • Lisa K Riggs
  • David Kershaw
  • Bryan Wharram

Detail Information

Publications12

  1. ncbi Geriatric assessment for the nephrologist
    Jocelyn Wiggins
    Department of Internal Medicine, Division of Geriatrics, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Semin Dial 25:623-7. 2012
    ..This article reviews the role of Comprehensive Geriatric Assessment in these patients and discusses how each of its elements interacts with routine dialysis care...
  2. ncbi Aging in the glomerulus
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Geriatrics, Department of Internal Medicine, 1560 MSRBII, Box 5676, Ann Arbor, MI 48109 5676, USA
    J Gerontol A Biol Sci Med Sci 67:1358-64. 2012
    ..The relationship between pathways involved in aging and the decline in kidney function is reviewed. There is speculation on the significance of these changes in relation to normal and pathological aging...
  3. ncbi Geriatrics
    Jocelyn Wiggins
    Internal Medicine, Division of Geriatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Kidney Dis 46:147-58. 2005
  4. ncbi NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus
    Jocelyn E Wiggins
    Divisions of Geriatrics, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 21:587-97. 2010
    ..Furthermore, these results provide a potential mechanistic explanation for the close relationship between ESRD and atherosclerotic organ failure as two parallel arms of age-associated NFkappaB-driven processes...
  5. ncbi Podocytes and glomerular function with aging
    Jocelyn Wiggins
    Division of Geriatrics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5676, USA
    Semin Nephrol 29:587-93. 2009
    ..Newer data on changes in gene expression and possible changes in biology in the glomerulus are discussed. There is speculation on the implications of this change in biology for human disease and progression...
  6. ncbi Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 17:1382-7. 2006
    ....
  7. ncbi Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction
    Jocelyn E Wiggins
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109-0676, USA
    J Am Soc Nephrol 16:2953-66. 2005
    ..Hypertrophy above a certain threshold was associated with podocyte stress and then failure, culminating in reduced podocyte numbers in sclerotic glomeruli. This process could be prevented by calorie restriction...
  8. ncbi GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury
    Yeong Hoon Kim
    Nephrology Division, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Nephron 90:471-6. 2002
    ..We conclude that GLEPP1 expression, unlike podocalyxin, reflects podocyte injury induced by PAN. GLEPP1 expression may be a useful marker of podocyte injury...
  9. ncbi Why do our kidneys get old?
    Jocelyn Wiggins
    Division of Geriatrics, Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA wiggi umich edu
    Nephron Exp Nephrol 119:e1-5. 2011
    ..This is a very brief review of aging biology and how it might impact on renal aging...
  10. ncbi Evaluation of a thick and thin section method for estimation of podocyte number, glomerular volume, and glomerular volume per podocyte in rat kidney with Wilms' tumor-1 protein used as a podocyte nuclear marker
    Silja K Sanden
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    J Am Soc Nephrol 14:2484-93. 2003
    ..A rat model of aging has been used to track changes in glomerular podocyte number, glomerular volume per podocyte, and glomerular volume. Implications for clinical use of these variables are discussed...
  11. ncbi Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene
    Bryan L Wharram
    University of Michigan Health System, Division of Nephrology, Department of Internal Medicine, 1570 MSRBII, Box 0676, Ann Arbor, MI 48109-0676, USA
    J Am Soc Nephrol 16:2941-52. 2005
    ..This model system provides strong support for the concept that podocyte depletion could be a major mechanism driving glomerulosclerosis and progressive loss of renal function in human glomerular diseases...
  12. ncbi Urine podocyte mRNAs mark progression of renal disease
    Yuji Sato
    University of Michigan Health System, Division of Nephrology, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 20:1041-52. 2009
    ..Podocyte mRNAs in urine may be a useful clinical tool for the diagnosis and monitoring of glomerular diseases...

Research Grants2

  1. The Aging Glomerulus
    Jocelyn Wiggins; Fiscal Year: 2007
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