Sharon Wigal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 17:593-604. 2007
  2. doi request reprint Exercise: applications to childhood ADHD
    Sharon B Wigal
    University of California, Irvine, USA
    J Atten Disord 17:279-90. 2013
  3. doi request reprint An update on lisdexamfetamine dimesylate for the treatment of attention deficit hyperactivity disorder
    Sharon B Wigal
    University of California, Child Development Center, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
    Expert Opin Pharmacother 14:137-45. 2013
  4. doi request reprint The novel use of objective laboratory school tasks to measure stress responses in children with ADHD
    Sharon B Wigal
    Child Development Center, Department of Pediatrics, University of California, Irvine, Irvine, CA 92612, USA
    Postgrad Med 124:49-57. 2012
  5. doi request reprint Adverse events in medication treatment-naïve children with attention-deficit/hyperactivity disorder: results from a small, controlled trial of lisdexamfetamine dimesylate
    Sharon B Wigal
    Child Development Center, Department of Pediatrics, University of California, Irvine, Irvine, California 92612, USA
    J Child Adolesc Psychopharmacol 22:149-56. 2012
  6. doi request reprint Metabolic, toxicological, and safety considerations for drugs used to treat ADHD
    Sophie Duong
    University of California, Child Development Center, Irvine, Department of Pediatrics, Irvine, CA 92612, USA
    Expert Opin Drug Metab Toxicol 8:543-52. 2012
  7. doi request reprint Reading performance as a function of treatment with lisdexamfetamine dimesylate in elementary school children diagnosed with ADHD
    Sharon B Wigal
    University of California, Child Development Center, Irvine, CA, USA
    J Atten Disord 16:23-33. 2012
  8. doi request reprint Does prior exposure to stimulants in children with ADHD impact cardiovascular parameters from lisdexamfetamine dimesylate?
    Sharon B Wigal
    Child Development Center, Department of Pediatrics, University of California, Irvine, Irvine, CA, USA
    Postgrad Med 122:27-34. 2010
  9. ncbi request reprint Pharmacokinetics of methylphenidate in preschoolers with attention-deficit/hyperactivity disorder
    Sharon B Wigal
    Child Development Center, University of California, Irvine, California 92612, USA
    J Child Adolesc Psychopharmacol 17:153-64. 2007
  10. ncbi request reprint The laboratory school protocol: its origin, use, and new applications
    Sharon B Wigal
    University of California, Irvine, Child Development Center, CA 92612, USA
    J Atten Disord 10:92-111. 2006

Research Grants

  1. Evaluation of Stimulant Drugs
    Sharon Wigal; Fiscal Year: 2006

Detail Information

Publications39

  1. ncbi request reprint Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 17:593-604. 2007
    ..The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS)...
  2. doi request reprint Exercise: applications to childhood ADHD
    Sharon B Wigal
    University of California, Irvine, USA
    J Atten Disord 17:279-90. 2013
    ..The hypothesis that exercise training alters the underlying physiology present in ADHD and other medical conditions as well as conceptual issues behind its potential clinical utility is reviewed...
  3. doi request reprint An update on lisdexamfetamine dimesylate for the treatment of attention deficit hyperactivity disorder
    Sharon B Wigal
    University of California, Child Development Center, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
    Expert Opin Pharmacother 14:137-45. 2013
    ..The focus of this paper is the prodrug amphetamine stimulant, lisdexamfetamine (LDX) , which is an example of such an agent with a novel delivery system...
  4. doi request reprint The novel use of objective laboratory school tasks to measure stress responses in children with ADHD
    Sharon B Wigal
    Child Development Center, Department of Pediatrics, University of California, Irvine, Irvine, CA 92612, USA
    Postgrad Med 124:49-57. 2012
    ....
  5. doi request reprint Adverse events in medication treatment-naïve children with attention-deficit/hyperactivity disorder: results from a small, controlled trial of lisdexamfetamine dimesylate
    Sharon B Wigal
    Child Development Center, Department of Pediatrics, University of California, Irvine, Irvine, California 92612, USA
    J Child Adolesc Psychopharmacol 22:149-56. 2012
    ....
  6. doi request reprint Metabolic, toxicological, and safety considerations for drugs used to treat ADHD
    Sophie Duong
    University of California, Child Development Center, Irvine, Department of Pediatrics, Irvine, CA 92612, USA
    Expert Opin Drug Metab Toxicol 8:543-52. 2012
    ..Metabolic, toxicological, and safety information are critical for an informed evaluation of the risk/benefit considerations in prescribing practices...
  7. doi request reprint Reading performance as a function of treatment with lisdexamfetamine dimesylate in elementary school children diagnosed with ADHD
    Sharon B Wigal
    University of California, Child Development Center, Irvine, CA, USA
    J Atten Disord 16:23-33. 2012
    ..The current study characterizes the effects of lisdexamfetamine dimesylate (LDX; Vyvanse(®), Shire US Inc.), at peak efficacy, on reading performance in children with ADHD...
  8. doi request reprint Does prior exposure to stimulants in children with ADHD impact cardiovascular parameters from lisdexamfetamine dimesylate?
    Sharon B Wigal
    Child Development Center, Department of Pediatrics, University of California, Irvine, Irvine, CA, USA
    Postgrad Med 122:27-34. 2010
    ....
  9. ncbi request reprint Pharmacokinetics of methylphenidate in preschoolers with attention-deficit/hyperactivity disorder
    Sharon B Wigal
    Child Development Center, University of California, Irvine, California 92612, USA
    J Child Adolesc Psychopharmacol 17:153-64. 2007
    ..The aim of this study was to compare the pharmacokinetics of immediate-release methylphenidate (MPH) in preschool and school-aged children with attention-deficit/hyperactivity disorder (ADHD)...
  10. ncbi request reprint The laboratory school protocol: its origin, use, and new applications
    Sharon B Wigal
    University of California, Irvine, Child Development Center, CA 92612, USA
    J Atten Disord 10:92-111. 2006
    ..To investigate such impairments in a school-like setting, the laboratory school protocol (LSP) was developed at the University of California, Irvine...
  11. pmc Efficacy and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: sex and age effects and effect size across the day
    Sharon B Wigal
    University of California, Irvine, Child Development Center, Irvine, California, USA
    Child Adolesc Psychiatry Ment Health 4:32. 2010
    ..abstract:..
  12. doi request reprint Advances in the treatment of attention-deficit/hyperactivity disorder: a guide for pediatric neurologists
    Sharon B Wigal
    Department of Pediatrics, Child Development Center, University of California, Irvine, CA 92612, USA
    Semin Pediatr Neurol 17:230-6. 2010
    ....
  13. ncbi request reprint A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder
    Sharon B Wigal
    Child Development Center, University of California, Irvine, CA 92612, USA
    J Atten Disord 9:275-89. 2005
    ..001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD...
  14. doi request reprint Pharmacokinetic evaluation of eltoprazine
    Sharon B Wigal
    University of California, Irvine, Child Development Center, Department of Pediatrics, Irvine, CA 92612, USA
    Expert Opin Drug Metab Toxicol 7:775-81. 2011
    ..Eltoprazine hydrochloride, a serotonergic agent currently under development, is the focus of the current paper...
  15. ncbi request reprint A double-blind, placebo-controlled trial of dexmethylphenidate hydrochloride and d,l-threo-methylphenidate hydrochloride in children with attention-deficit/hyperactivity disorder
    Sharon Wigal
    Irvine Child Development Center, University of California, Irvine, CA 92612, USA
    J Am Acad Child Adolesc Psychiatry 43:1406-14. 2004
    ....
  16. ncbi request reprint Hematologic and blood biochemistry monitoring during methylphenidate treatment in children with attention-deficit/hyperactivity disorder: 2-year, open-label study results
    Sharon B Wigal
    Department of Pediatrics, University of California, Irvine, CA 92612, USA
    Pediatrics 120:e120-8. 2007
    ..The objective of this study was to evaluate the long-term effects of methylphenidate treatment on blood biochemistry and hematologic values...
  17. ncbi request reprint Development of a new once-a-day formulation of methylphenidate for the treatment of attention-deficit/hyperactivity disorder: proof-of-concept and proof-of-product studies
    James Swanson
    University of California, Irvine, Department of Pediatrics, Child Development Center, CA, USA
    Arch Gen Psychiatry 60:204-11. 2003
    ..Tachyphylaxis was hypothesized to account for the reduced effects, and an ascending drug delivery pattern was proposed to overcome this acute tolerance...
  18. ncbi request reprint Safety and tolerability of methylphenidate in preschool children with ADHD
    Tim Wigal
    University of California, Irvine, USA
    J Am Acad Child Adolesc Psychiatry 45:1294-303. 2006
    ..To report on the safety and tolerability of methylphenidate (MPH) 3- to 5-year-old children with attention-deficit/hyperactivity disorder (ADHD) during 1 year of treatment...
  19. ncbi request reprint Efficacy of a new pattern of delivery of methylphenidate for the treatment of ADHD: effects on activity level in the classroom and on the playground
    James M Swanson
    Child Development Center, University of California, Irvine, CA, USA
    J Am Acad Child Adolesc Psychiatry 41:1306-14. 2002
    ....
  20. ncbi request reprint Stimulant-related reductions of growth rates in the PATS
    James Swanson
    Child Development Center, University of California, Irvine 92612, USA
    J Am Acad Child Adolesc Psychiatry 45:1304-13. 2006
    ..2 mg/day) administered three times daily, 7 days/week for asymptotically equal to1 year...
  21. ncbi request reprint A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD
    James J McGough
    University of California, Los Angeles, Semel Institute for Neuroscience and Human Behavior, 90095, USA
    J Atten Disord 9:476-85. 2006
    ..This study evaluates the efficacy, duration of action, and tolerability of methylphenidate transdermal system (MTS) in children with ADHD...
  22. ncbi request reprint Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    James M Swanson
    Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
    J Child Adolesc Psychopharmacol 17:635-46. 2007
    ....
  23. ncbi request reprint A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (the Comacs Study)
    James M Swanson
    University of California at Irvine Child Development Center, Irvine, California 92612, USA
    Pediatrics 113:e206-16. 2004
    ..According to this PK/PD model, clinical superiority is expected at any point in time for the formulation with the highest MPH plasma concentration...
  24. ncbi request reprint Long-term tolerability and effectiveness of once-daily mixed amphetamine salts (Adderall XR) in children with ADHD
    James J McGough
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA, USA
    J Am Acad Child Adolesc Psychiatry 44:530-8. 2005
    ..To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR; Adderall XR) in children with attention-deficit/hyperactivity disorder (ADHD)...
  25. doi request reprint Efficacy and safety limitations of attention-deficit hyperactivity disorder pharmacotherapy in children and adults
    Sharon B Wigal
    Child Development Center, University of California Irvine, Irvine, California 92162, USA
    CNS Drugs 23:21-31. 2009
    ..Future research may provide an improved understanding of polypharmacy and better characterization of the factors that influence the diagnosis and successful treatment of patients with ADHD...
  26. ncbi request reprint Catecholamine response to exercise in children with attention deficit hyperactivity disorder
    Sharon B Wigal
    Child Development Center, University of California, Irvine 92612, USA
    Pediatr Res 53:756-61. 2003
    ..005). Our data suggest that CA excretion after exercise challenges in children with ADHD is deficient. This deficiency can be detected using a minimally invasive, nonpharmacologic challenge...
  27. ncbi request reprint Special considerations in diagnosing and treating attention-deficit/hyperactivity disorder
    Sharon B Wigal
    Department of Pediatrics, University of California Irvine, Irvine, CA, USA
    CNS Spectr 12:1-14; quiz 15-6. 2007
    ....
  28. ncbi request reprint A double-blind, placebo-controlled withdrawal trial of dexmethylphenidate hydrochloride in children with attention deficit hyperactivity disorder
    L Eugene Arnold
    Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 14:542-54. 2004
    ..This study complements that report by studying the effect of placebo-controlled discontinuation and retesting the duration of action...
  29. ncbi request reprint A post hoc subgroup analysis of an 18-day randomized controlled trial comparing the tolerability and efficacy of mixed amphetamine salts extended release and atomoxetine in school-age girls with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Ther 28:280-93. 2006
    ....
  30. ncbi request reprint A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:727-35. 2006
    ....
  31. ncbi request reprint Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, flexible-dose study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatrics 116:e777-84. 2005
    ..This study evaluated a new formulation of modafinil (modafinil film-coated tablets) in children and adolescents with ADHD...
  32. ncbi request reprint Forecasting three-month outcomes in a laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children With ADHD
    Stephen V Faraone
    State University of New York Upstate Medical University, NY, USA
    J Atten Disord 11:74-82. 2007
    ..Compare observed and forecasted efficacy of mixed amphetamine salts extended release (MAS-XR; Adderall) with atomoxetine (Strattera) in ADHD children...
  33. doi request reprint Pharmacokinetics of methylphenidate transdermal system (MTS): results from a laboratory classroom study
    David Pierce
    Shire Pharmaceutical Development Ltd, Basingstoke, United Kingdom
    J Child Adolesc Psychopharmacol 18:355-64. 2008
    ..To evaluate the pharmacokinetic properties of the methylphenidate transdermal system (MTS) in pediatric patients diagnosed with ADHD (attention-deficit/hyperactivity disorder) in a laboratory school setting...
  34. doi request reprint Varying the wear time of the methylphenidate transdermal system in children with attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:700-8. 2008
    ..The objectives of this study were to determine the efficacy, duration of action, and safety of methylphenidate transdermal system worn for variable times by children (ages 6-12) diagnosed with ADHD...
  35. ncbi request reprint Parent versus teacher ratings of attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Desiree W Murray
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Child Adolesc Psychopharmacol 17:605-20. 2007
    ..To assess parent-teacher concordance on ratings of DSM-IV symptoms of attention-deficit/hyperactivity disorder (ADHD) in a sample of preschool children referred for an ADHD treatment study...
  36. ncbi request reprint Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Howard B Abikoff
    New York University Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
    J Child Adolesc Psychopharmacol 17:581-92. 2007
    ....
  37. ncbi request reprint Comorbidity moderates response to methylphenidate in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Jaswinder K Ghuman
    University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Child Adolesc Psychopharmacol 17:563-80. 2007
    ..The aim of this study was to examine whether demographic or pretreatment clinical and social characteristics influenced the response to methylphenidate (MPH) in the Preschoolers with ADHD Treatment Study (PATS)...
  38. ncbi request reprint Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Kelly Posner
    New York State Psychiatric Institute Columbia University, 1041 Riverside Drive, New York, NY 10032, USA
    J Child Adolesc Psychopharmacol 17:547-62. 2007
    ..The diagnosis and evaluation process will also be described...
  39. ncbi request reprint Factor structure of parent- and teacher-rated attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Kristina K Hardy
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Child Adolesc Psychopharmacol 17:621-34. 2007
    ....

Research Grants1

  1. Evaluation of Stimulant Drugs
    Sharon Wigal; Fiscal Year: 2006
    ..Within-subject PK variability in time-course of serum concentration for each medication will be analyzed, and the time-response characteristics also will be estimated based on PD measures for methylphenidate. ..