Genomes and Genes
Affiliation: University of Colorado
- Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxideMarucia Chacur
Instituto Butantan, Sao Paolo, Brazil
Pain 108:180-91. 2004..As a variety of immune cells also produce and release sPLA2s during inflammatory states, the data may have general implications for the understanding of inflammatory pain...
- Immune-to-brain communication dynamically modulates pain: physiological and pathological consequencesJulie Wieseler-Frank
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Behav Immun 19:104-11. 2005....
- Central proinflammatory cytokines and pain enhancementJulie Wieseler-Frank
Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, CO 80309 0345, USA
Neurosignals 14:166-74. 2005..Gene therapy to augment the endogenous anti-inflammatory cytokine, interleukin-10, is one of the more promising therapies currently under study...
- Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10Erin D Milligan
Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
Mol Pain 1:9. 2005..Taken together, these data provide initial support that intrathecal gene therapy to drive the production of IL-10 may prove to be an efficacious treatment for neuropathic pain...
- Glial activation and pathological painJulie Wieseler-Frank
Department of Psychology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Neurochem Int 45:389-95. 2004..Moreover, the glial-neuronal interactions discussed here are likely not exclusive to pain, but rather are likely to play significant roles in other behavioral phenomena...
- A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphineIan N Johnston
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 24:7353-65. 2004..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates...
- A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulusJulie Wieseler-Frank
Department of Psychology, University of Colorado, Boulder, CO, USA
Brain Behav Immun 21:711-8. 2007..The ability of the meninges to release to proinflammatory signals suggests a potential role in the modulation of pain...
- Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10Erin D Milligan
Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309, USA
Eur J Neurosci 21:2136-48. 2005..These studies support that this gene therapy approach provides an alternative to neuronally focused drug and gene therapies for clinical pain control...
- Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioidsLinda R Watkins
Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Behav Immun 21:131-46. 2007....
- Spinal gap junctions: potential involvement in pain facilitationLeah E Spataro
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado 90309 0345, USA
J Pain 5:392-405. 2004..In addition, it decreased gp120-induced proinflammatory cytokines. This suggests gap junction activation might lead to proinflammatory cytokine release by distantly activated glia...
- HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS)Adelina Holguin
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309, USA
Pain 110:517-30. 2004..Furthermore, gp120 increases mRNA for IL1 converting enzyme and matrix metalloproteinase-9, enzymes responsible for activation and release of proinflammatory cytokines...
- Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediatorsMarucia Chacur
Laboratorio de Fisiopatologia, Instituto Butantan, Av Vital Brazil, 1500, 05503 900 Sao Paulo, SP, Brazil
Pain 111:65-76. 2004..Lastly, celecoxib, an inhibitor of cyclooxygenase-2, attenuated sPLA2 actions. These data provide the first evidence of spinal mediators involved in pain facilitation induced by subcutaneous venoms...