Margaret E Wierman
Affiliation: University of Colorado Denver
Kiseljak Vassiliades K, Zhang Y, Bagby S, Kar A, Pozdeyev N, Xu M, et al
. Development of new preclinical models to advance adrenocortical carcinoma research. Endocr Relat Cancer. 2018;25:437-451 pubmed publisher
..These new preclinical models of ACC significantly advance the field by allowing investigation of underlying molecular mechanisms of ACC and the ability to test patient-specific therapeutic targets. ..
Xiong W, Matheson C, Xu M, Backos D, Mills T, Salian Mehta S, et al
. Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors. Mol Cancer Ther. 2016;15:412-20 pubmed publisher
..Together, these data identify hesperadin as the first potent, selective inhibitor of the MST4 kinase with the capacity to block pituitary tumor cell growth in a hypoxic microenvironment. ..
Salian Mehta S, Xu M, Pierce A, Bliesner B, Tobet S, Wierman M. Loss of Growth arrest specific gene 6 (Gas6) results in altered GnRH neuron migration, delayed vaginal opening and sexual maturation in mice. Mol Cell Endocrinol. 2014;393:164-70 pubmed publisher
..The phenotype of Gas6 KO mice suggests that TAMs function in a ligand-dependent and independent manner to control GnRH neuron development to modulate normal reproductive function. ..
Salian Mehta S, Xu M, McKinsey T, Tobet S, Wierman M. Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement. J Biol Chem. 2015;290:14045-56 pubmed publisher
..Together, these studies identify a novel interaction of Class IIa HDAC9 with Class IIb HDAC6 to modulate cell movement and survival in GnRH neurons. ..