Genomes and Genes
Howard W Wiener
Affiliation: University of Alabama at Birmingham
- Comparison of measures of marker informativeness for ancestry and admixture mappingLili Ding
Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
BMC Genomics 12:622. 2011....
- A polymorphism in SOD2 is associated with development of Alzheimer's diseaseH W Wiener
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Genes Brain Behav 6:770-5. 2007..We discuss the importance of our findings and the relevance of SOD2 to AD risk...
- X-linked extension of the revised Haseman-Elston algorithm for linkage analysis in sib pairsHoward Wiener
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Ala 35294 0022, USA
Hum Hered 55:97-107. 2003..Simulation results are presented to describe the power of this technique for a theoretical best case scenario...
- Linkage analysis of schizophrenia in African-American familiesH W Wiener
University of Alabama at Birmingham, School of Public Health, Dept of Epidemiology, 1665 University Blvd, RPHB, Birmingham, AL 35294 0022, USA
Schizophr Res 109:70-9. 2009..3-p12 found in studies sampling largely families of European ancestry; and 11p11.2-q22.3 reported by a study of African-American families. These results should prove quite useful for uncovering loci affecting risk for schizophrenia...
- COGA phenotypes and linkages on chromosome 2Howard W Wiener
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
BMC Genet 6:S125. 2005..A region on chromosome 2 at 250 cM was found to be linked to both of these derived phenotypes. Further examination of the SNPs in this region identified several haplotypes strongly associated with these derived phenotypes...
- Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's diseaseZuomin Chen
Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama 35294, USA
Am J Med Genet B Neuropsychiatr Genet 147:363-9. 2008..These SNPs are located in areas of the gene containing sequences that could be involved in alternative splicing and/or regulation of NTRK2. Our results suggest that NTRK2 may be a genetic susceptibility gene contributing to AD pathology...
- A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic InitiativeM Ryan Dickson
Department of Epidemiology and International Health, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0001, USA
Am J Med Genet B Neuropsychiatr Genet 147:784-92. 2008..Results replicate previous findings, but identify additional suggestive peaks indicating the genetics of AAO in AD is complex with many chromosomal regions potentially containing modifying genes...
- Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer's disease in the NIMH sibling datasetTesfaye M Baye
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Dis Markers 24:293-309. 2008..alzgene.org)...
- FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment responseRobert Makowsky
Departments of aBiostatistics bEpidemiology cMedicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama dDepartment of Pediatrics, Seattle Children s Research Institute, University of Washington, Seattle, Washington, USA
Pharmacogenet Genomics 23:455-62. 2013..However, it is not known whether the existing gene copy number (GCN) variability relates to KD treatment response, susceptibility, or associated sequelae...
- Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescentsSadeep Shrestha
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 5:e13384. 2010....
- A genome-wide association study of carotid atherosclerosis in HIV-infected menSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, AL 35294 0022, USA
AIDS 24:583-92. 2010..The role of host genetics in the development of subclinical atherosclerosis in the context of HIV-infected persons who are being treated with highly active antiretroviral therapy (HAART) is not well understood...
- Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohortRodney T Perry
Department of Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Am J Med Genet B Neuropsychiatr Genet 144:220-7. 2007..In an effort to pinpoint this putative AD susceptibility gene, we have begun to analyze SNPs in other candidate genes in and around this narrowed region to test for additional associations to AD...
- Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychosesRodney C P Go
University of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Med Genet B Neuropsychiatr Genet 139:28-32. 2005..Our results suggest that NRG1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of LOAD families...
- Empirical bayes method for incorporating data from multiple genome scansT Mark Beasley
Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
Hum Hered 60:36-42. 2005..This EB method for incorporating data from multiple studies into genome scan analyses seems promising...
- Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjectsMaria De Luca
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Exp Gerontol 46:60-4. 2011..Future studies are warranted to replicate these findings in independent and larger populations and to investigate whether rs659822 is the causal variant responsible for the observed associations...
- Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)Douglas T Johnston
University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 3300, USA
Clin Immunol 119:346-50. 2006..0001). Inheritance of HLA-B44 may yield susceptibility to recurrent sinopulmonary infection even in the presence of normal serum immunoglobulin levels...
- An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scansKui Zhang
Department of Biostatistics, Section of Statistical Genetics, University of Alabama, Birmingham 35294, USA
Genetics 173:2283-96. 2006..In the face of marked heterogeneity among studies, the empirical Bayes method outperforms the comparator...
- Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methodsMuktar H Aliyu
Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294 2041, and Duke University Medical Center John Umstead Hospital, Butner, NC, United States
Schizophr Res 87:32-44. 2006..This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia...
- Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbedMichael I Falola
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 8:e64813. 2013..We have tested this hypothesis in two study populations from a clinical trial of anthrax vaccination...
- The utility of mitochondrial and y chromosome phylogenetic data to improve correction for population stratificationRobert Makowsky
Department of Biostatistics, School of Public Health, University of Alabama at Birmingham Birmingham, AL, USA
Front Genet 3:301. 2012....
- Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected menMarguerite Ryan Irvin
Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA
Pharmacogenet Genomics 21:798-807. 2011..Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)...
- Association test of multiallelic gene copy numbers in family triosSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Genet Epidemiol 34:2-6. 2010..We present theoretical derivation of the statistics and results of simulation studies that show robustness of our approach and power under several genetic models...
- Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's diseaseJian Li
Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Psychosom Med 69:551-9. 2007..To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD)...
- Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's diseaseRodney T Perry
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Neurobiol Aging 29:185-93. 2008..010) and >65 years (p=0.013), and families not homozygous for the APOE4 allele (p=0.041). We hypothesize that Hb F may be less toxic than adult Hb in its interaction with A beta and may protect against the development of AD...
- HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overloadJames C Barton
Southern Iron Disorders Center, Birmingham, AL 35209, USA
Blood Cells Mol Dis 34:38-47. 2005....
- Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's diseaseMarian L Hamshere
Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Hum Mol Genet 16:2703-12. 2007..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
- Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's diseaseSusan Spear Bassett
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 141:537-40. 2006....
- Salivary Actinomyces naeslundii genospecies 2 and Lactobacillus casei levels predict pregnancy outcomesAnanda P Dasanayake
Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY 10010, USA
J Periodontol 76:171-7. 2005..Gravida's poor periodontal health is emerging as a modifiable independent risk factor for preterm delivery and low birth weight...
- Results of a high-resolution genome screen of 437 Alzheimer's disease familiesDeborah Blacker
Massachusetts General Hospital, Charlestown, MA, USA
Hum Mol Genet 12:23-32. 2003..Although some of these will surely prove to be false positives, these linkage signals should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD...