Howard W Wiener

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Comparison of measures of marker informativeness for ancestry and admixture mapping
    Lili Ding
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    BMC Genomics 12:622. 2011
  2. ncbi request reprint A polymorphism in SOD2 is associated with development of Alzheimer's disease
    H W Wiener
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Genes Brain Behav 6:770-5. 2007
  3. ncbi request reprint X-linked extension of the revised Haseman-Elston algorithm for linkage analysis in sib pairs
    Howard Wiener
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Ala 35294 0022, USA
    Hum Hered 55:97-107. 2003
  4. pmc Linkage analysis of schizophrenia in African-American families
    H W Wiener
    University of Alabama at Birmingham, School of Public Health, Dept of Epidemiology, 1665 University Blvd, RPHB, Birmingham, AL 35294 0022, USA
    Schizophr Res 109:70-9. 2009
  5. pmc COGA phenotypes and linkages on chromosome 2
    Howard W Wiener
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Genet 6:S125. 2005
  6. ncbi request reprint Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease
    Zuomin Chen
    Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 147:363-9. 2008
  7. pmc A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative
    M Ryan Dickson
    Department of Epidemiology and International Health, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0001, USA
    Am J Med Genet B Neuropsychiatr Genet 147:784-92. 2008
  8. doi request reprint FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response
    Robert Makowsky
    Department of Biostatistics, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pharmacogenet Genomics 23:455-62. 2013
  9. pmc Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed
    Michael I Falola
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e64813. 2013
  10. pmc Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer's disease in the NIMH sibling dataset
    Tesfaye M Baye
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dis Markers 24:293-309. 2008

Detail Information

Publications31

  1. pmc Comparison of measures of marker informativeness for ancestry and admixture mapping
    Lili Ding
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    BMC Genomics 12:622. 2011
    ....
  2. ncbi request reprint A polymorphism in SOD2 is associated with development of Alzheimer's disease
    H W Wiener
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Genes Brain Behav 6:770-5. 2007
    ..We discuss the importance of our findings and the relevance of SOD2 to AD risk...
  3. ncbi request reprint X-linked extension of the revised Haseman-Elston algorithm for linkage analysis in sib pairs
    Howard Wiener
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Ala 35294 0022, USA
    Hum Hered 55:97-107. 2003
    ..Simulation results are presented to describe the power of this technique for a theoretical best case scenario...
  4. pmc Linkage analysis of schizophrenia in African-American families
    H W Wiener
    University of Alabama at Birmingham, School of Public Health, Dept of Epidemiology, 1665 University Blvd, RPHB, Birmingham, AL 35294 0022, USA
    Schizophr Res 109:70-9. 2009
    ..3-p12 found in studies sampling largely families of European ancestry; and 11p11.2-q22.3 reported by a study of African-American families. These results should prove quite useful for uncovering loci affecting risk for schizophrenia...
  5. pmc COGA phenotypes and linkages on chromosome 2
    Howard W Wiener
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Genet 6:S125. 2005
    ..A region on chromosome 2 at 250 cM was found to be linked to both of these derived phenotypes. Further examination of the SNPs in this region identified several haplotypes strongly associated with these derived phenotypes...
  6. ncbi request reprint Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease
    Zuomin Chen
    Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 147:363-9. 2008
    ..These SNPs are located in areas of the gene containing sequences that could be involved in alternative splicing and/or regulation of NTRK2. Our results suggest that NTRK2 may be a genetic susceptibility gene contributing to AD pathology...
  7. pmc A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative
    M Ryan Dickson
    Department of Epidemiology and International Health, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0001, USA
    Am J Med Genet B Neuropsychiatr Genet 147:784-92. 2008
    ..Results replicate previous findings, but identify additional suggestive peaks indicating the genetics of AAO in AD is complex with many chromosomal regions potentially containing modifying genes...
  8. doi request reprint FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response
    Robert Makowsky
    Department of Biostatistics, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pharmacogenet Genomics 23:455-62. 2013
    ..However, it is not known whether the existing gene copy number (GCN) variability relates to KD treatment response, susceptibility, or associated sequelae...
  9. pmc Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed
    Michael I Falola
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e64813. 2013
    ..We have tested this hypothesis in two study populations from a clinical trial of anthrax vaccination...
  10. pmc Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer's disease in the NIMH sibling dataset
    Tesfaye M Baye
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dis Markers 24:293-309. 2008
    ..alzgene.org)...
  11. pmc Variants in interleukin family of cytokines genes influence clearance of high risk HPV in HIV-1 coinfected African-American adolescents
    Staci L Sudenga
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States
    Hum Immunol 74:1696-700. 2013
    ..These data suggest that the analyzed genetic variants in interleukin family of cytokines modulate HR-HPV clearance in HIV-1 seropositive African-Americans that warrants replication...
  12. pmc Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents
    Sadeep Shrestha
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e13384. 2010
    ....
  13. pmc A genome-wide association study of carotid atherosclerosis in HIV-infected men
    Sadeep Shrestha
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, AL 35294 0022, USA
    AIDS 24:583-92. 2010
    ..The role of host genetics in the development of subclinical atherosclerosis in the context of HIV-infected persons who are being treated with highly active antiretroviral therapy (HAART) is not well understood...
  14. ncbi request reprint Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort
    Rodney T Perry
    Department of Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Med Genet B Neuropsychiatr Genet 144:220-7. 2007
    ..In an effort to pinpoint this putative AD susceptibility gene, we have begun to analyze SNPs in other candidate genes in and around this narrowed region to test for additional associations to AD...
  15. pmc Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects
    Maria De Luca
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Exp Gerontol 46:60-4. 2011
    ..Future studies are warranted to replicate these findings in independent and larger populations and to investigate whether rs659822 is the causal variant responsible for the observed associations...
  16. ncbi request reprint Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses
    Rodney C P Go
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 139:28-32. 2005
    ..Our results suggest that NRG1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of LOAD families...
  17. ncbi request reprint Empirical bayes method for incorporating data from multiple genome scans
    T Mark Beasley
    Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
    Hum Hered 60:36-42. 2005
    ..This EB method for incorporating data from multiple studies into genome scan analyses seems promising...
  18. ncbi request reprint Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)
    Douglas T Johnston
    University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, AL 35294 3300, USA
    Clin Immunol 119:346-50. 2006
    ..0001). Inheritance of HLA-B44 may yield susceptibility to recurrent sinopulmonary infection even in the presence of normal serum immunoglobulin levels...
  19. pmc An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scans
    Kui Zhang
    Department of Biostatistics, Section of Statistical Genetics, University of Alabama, Birmingham 35294, USA
    Genetics 173:2283-96. 2006
    ..In the face of marked heterogeneity among studies, the empirical Bayes method outperforms the comparator...
  20. ncbi request reprint Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods
    Muktar H Aliyu
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, AL 35294 2041, and Duke University Medical Center John Umstead Hospital, Butner, NC, United States
    Schizophr Res 87:32-44. 2006
    ..This novel integration of diagnostic, neurocognitive and genetic data will also generate valuable information for future phenotypic and genetic studies of schizophrenia...
  21. pmc The utility of mitochondrial and y chromosome phylogenetic data to improve correction for population stratification
    Robert Makowsky
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham Birmingham, AL, USA
    Front Genet 3:301. 2012
    ....
  22. pmc Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men
    Marguerite Ryan Irvin
    Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 21:798-807. 2011
    ..Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)...
  23. doi request reprint Association test of multiallelic gene copy numbers in family trios
    Sadeep Shrestha
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Genet Epidemiol 34:2-6. 2010
    ..We present theoretical derivation of the statistics and results of simulation studies that show robustness of our approach and power under several genetic models...
  24. ncbi request reprint Effects of chronic stress and interleukin-10 gene polymorphisms on antibody response to tetanus vaccine in family caregivers of patients with Alzheimer's disease
    Jian Li
    Department of Epidemiology and International Health, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Psychosom Med 69:551-9. 2007
    ..To assess the effects of psychological stress on the antibody response to tetanus vaccine adjusting for cytokine gene polymorphisms and other nongenetic factors in caregivers of patients with Alzheimer's disease (AD)...
  25. pmc Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease
    Rodney T Perry
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
    Neurobiol Aging 29:185-93. 2008
    ..010) and >65 years (p=0.013), and families not homozygous for the APOE4 allele (p=0.041). We hypothesize that Hb F may be less toxic than adult Hb in its interaction with A beta and may protect against the development of AD...
  26. pmc Characteristics of Streptococcus mutans genotypes and dental caries in children
    Kyounga Cheon
    Department of Pediatric Dentistry, University of Alabama School of Dentistry, Birmingham, AL 35294, USA
    Eur J Oral Sci 121:148-55. 2013
    ..mutans genotypes...
  27. ncbi request reprint HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack of association with severity of iron overload
    James C Barton
    Southern Iron Disorders Center, Birmingham, AL 35209, USA
    Blood Cells Mol Dis 34:38-47. 2005
    ....
  28. ncbi request reprint Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  29. pmc Further evidence of a maternal parent-of-origin effect on chromosome 10 in late-onset Alzheimer's disease
    Susan Spear Bassett
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 141:537-40. 2006
    ....
  30. ncbi request reprint Salivary Actinomyces naeslundii genospecies 2 and Lactobacillus casei levels predict pregnancy outcomes
    Ananda P Dasanayake
    Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY 10010, USA
    J Periodontol 76:171-7. 2005
    ..Gravida's poor periodontal health is emerging as a modifiable independent risk factor for preterm delivery and low birth weight...
  31. ncbi request reprint Results of a high-resolution genome screen of 437 Alzheimer's disease families
    Deborah Blacker
    Massachusetts General Hospital, Charlestown, MA, USA
    Hum Mol Genet 12:23-32. 2003
    ..Although some of these will surely prove to be false positives, these linkage signals should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD...