John K Wiencke

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Early age at smoking initiation and tobacco carcinogen DNA damage in the lung
    J K Wiencke
    Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 94143 0560, USA
    J Natl Cancer Inst 91:614-9. 1999
  2. ncbi DNA adduct burden and tobacco carcinogenesis
    John K Wiencke
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, CA 94143 0560, USA
    Oncogene 21:7376-91. 2002
  3. ncbi Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility
    John K Wiencke
    Department of Epidemiology and Biostatistics, University of California San Francisco, School of Medicine, San Francisco, California 94143 0560, USA
    Environ Health Perspect 110:555-8. 2002
  4. ncbi Impact of race/ethnicity on molecular pathways in human cancer
    John K Wiencke
    University of California San Francisco, Department of Epidemiology and Biostatistics, 500 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Rev Cancer 4:79-84. 2004
  5. ncbi Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase
    John K Wiencke
    Division of Neuroepidemiology, Department of Neurological Surgery, School of Medicine, University of California San Francisco, Box 0441, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 14:1774-83. 2005
  6. ncbi CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification
    Melinda C Aldrich
    Department of Medicine and Division of Neuroepidemiology, University of California, San Francisco, California, USA
    Cancer Res 69:2340-8. 2009
  7. ncbi Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    Int J Cancer 123:2095-104. 2008
  8. ncbi Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans
    Helen M Hansen
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 19:3652-61. 2010
  9. ncbi Allergy-related polymorphisms influence glioma status and serum IgE levels
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 16:1229-35. 2007
  10. ncbi Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival
    Margaret Wrensch
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94102, USA
    Cancer Res 66:4531-41. 2006

Detail Information

Publications69

  1. ncbi Early age at smoking initiation and tobacco carcinogen DNA damage in the lung
    J K Wiencke
    Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 94143 0560, USA
    J Natl Cancer Inst 91:614-9. 1999
    ....
  2. ncbi DNA adduct burden and tobacco carcinogenesis
    John K Wiencke
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, CA 94143 0560, USA
    Oncogene 21:7376-91. 2002
    ..As these trends continue a variety of innovative study designs and approaches will become important in human populations...
  3. ncbi Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility
    John K Wiencke
    Department of Epidemiology and Biostatistics, University of California San Francisco, School of Medicine, San Francisco, California 94143 0560, USA
    Environ Health Perspect 110:555-8. 2002
    ..Targeted intervention in adolescent smoking may yield even greater reductions in lung cancer occurrence than otherwise anticipated...
  4. ncbi Impact of race/ethnicity on molecular pathways in human cancer
    John K Wiencke
    University of California San Francisco, Department of Epidemiology and Biostatistics, 500 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Rev Cancer 4:79-84. 2004
  5. ncbi Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase
    John K Wiencke
    Division of Neuroepidemiology, Department of Neurological Surgery, School of Medicine, University of California San Francisco, Box 0441, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 14:1774-83. 2005
    ..MGMT expression may depend on the TP53 status of cells...
  6. ncbi CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification
    Melinda C Aldrich
    Department of Medicine and Division of Neuroepidemiology, University of California, San Francisco, California, USA
    Cancer Res 69:2340-8. 2009
    ..These results suggest that a variant occurring within the CYP1A2 region may be conferring an increased risk of lung cancer in Latinos...
  7. ncbi Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
    Int J Cancer 123:2095-104. 2008
    ..61; 95% CI: 0.42-0.88). Our study suggests different elements of the NER pathway may be important in the different ethnic groups resulting either from different linkage relationship, genetic backgrounds and/or exposure histories...
  8. ncbi Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans
    Helen M Hansen
    Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 19:3652-61. 2010
    ..002). The identified regions contain SNPs predicted to affect gene regulation. There are multiple lung cancer risk loci in the 15q25.1 region in African-Americans...
  9. ncbi Allergy-related polymorphisms influence glioma status and serum IgE levels
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 16:1229-35. 2007
    ..Further exploration of immune susceptibility factors, including genetics, in glioma etiology is advisable...
  10. ncbi Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival
    Margaret Wrensch
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94102, USA
    Cancer Res 66:4531-41. 2006
    ..3 region influence survival. We also suggest that tumor EGFR expression be incorporated into clinical evaluation of anaplastic astrocytoma patients...
  11. ncbi Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 44 Page Street, Suite 503, San Francisco, CA 94143 1215, USA
    Cancer Epidemiol Biomarkers Prev 17:1368-73. 2008
    ..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma...
  12. ncbi Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and Latinos
    Melinda C Aldrich
    University of California, San Francisco, Box 2911 Rock Hall, Mission Bay 582, 1550 4th Street, San Francisco, CA 94143 2911, USA
    Am J Epidemiol 168:1035-46. 2008
    ..Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors...
  13. ncbi Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, Division of Neuroepidemiology, University of California San Francisco, San Francisco, CA 94143 1215, USA
    Carcinogenesis 30:78-87. 2009
    ..This study suggests that there are genetic differences in the association between BER pathway and lung cancer between Latinos and African-Americans...
  14. ncbi ERCC1 and ERCC2 polymorphisms and adult glioma
    Margaret Wrensch
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 7:495-507. 2005
    ..3). Given the numbers of comparisons made, these findings could be due to chance. However, the results might warrant clarification in additional series in conjunction with the nearby putative glioma suppressor genes (GLTSCR1 and GLTSCR2)...
  15. ncbi CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans
    Margaret R Wrensch
    Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA
    Int J Cancer 113:141-7. 2005
    ....
  16. ncbi Glutathione-S-transferase variants and adult glioma
    Margaret Wrensch
    University of California, San Francisco, CA 94143, USA
    Cancer Epidemiol Biomarkers Prev 13:461-7. 2004
    ..Conflicting findings have been reported for associations of primary brain tumors and constitutive polymorphisms in glutathione-S-transferases (GSTs)...
  17. ncbi Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma
    Mi Zhou
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:7534-42. 2010
    ..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis...
  18. ncbi SSBP2 variants are associated with survival in glioblastoma patients
    Yuanyuan Xiao
    Department of Epidemiology and Biostatistics, University of California, San Francisco 185 Berry St, Suite 5700, San Francisco, CA 94107, USA
    Clin Cancer Res 18:3154-62. 2012
    ..Glioblastoma is a devastating, incurable disease with few known prognostic factors. Here, we present the first genome-wide survival and validation study for glioblastoma...
  19. ncbi Reduced immunoglobulin E and allergy among adults with glioma compared with controls
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143 0560, USA
    Cancer Res 64:8468-73. 2004
    ..Furthermore, the results indicate a complex relationship between allergic disease and glioma risk that varies by allergen and allergic pathology...
  20. ncbi IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era
    Joseph L Wiemels
    Department of Neurosurgery and Epidemiology, UCSF, San Francisco, CA 94143 0441, USA
    Int J Cancer 125:680-7. 2009
    ..These results have implications for the study of immunologic factors in glioma as well as for immunotherapy protocols for treating glioma...
  21. ncbi SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system
    Alexander R Pico
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Nucleic Acids Res 37:D803-9. 2009
    ..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data...
  22. ncbi Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    Cancer Epidemiol Biomarkers Prev 19:2152-63. 2010
    ..The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk...
  23. ncbi Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 Regions Identifies Functional and Histology-Specific Lung Cancer Susceptibility Loci in African-Americans
    Kyle M Walsh
    Corresponding Author Kyle M Walsh, University of California San Francisco, 1450 3rd Street, Box 0520, HD 276, San Francisco, CA 94143 0520
    Cancer Epidemiol Biomarkers Prev 22:251-60. 2013
    ..1-p21.31, and 15q25.1. We investigated whether these regions contain lung cancer susceptibly loci in African-Americans and refined previous association signals by using the reduced linkage disequilibrium observed in African-Americans...
  24. ncbi DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression
    Shichun Zheng
    Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
    Neuro Oncol 13:280-9. 2011
    ..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications...
  25. ncbi Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
    John K Wiencke
    Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 9:271-9. 2007
    ....
  26. ncbi Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility
    Margaret Wrensch
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 41:905-8. 2009
    ..85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). For both SNPs, the direction of association was the same in discovery and replication phases...
  27. ncbi Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic
    Craig Steinmaus
    Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, California, USA
    J Toxicol Environ Health A 70:159-70. 2007
    ..Overall, this study provides evidence that MTHFR and GSTM1 are involved in arsenic metabolism in humans, and polymorphisms in the genes that encode these enzymes may play a role in susceptibility to arsenic-induced cancer...
  28. ncbi PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome
    Sabine Mueller
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Neuro Oncol 14:1146-52. 2012
    ..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors...
  29. ncbi Epigenetic biomarkers of T-cells in human glioma
    John K Wiencke
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA USA
    Epigenetics 7:1391-402. 2012
    ....
  30. ncbi Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies
    Kyle M Walsh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Genet Epidemiol 37:222-8. 2013
    ..These results highlight that the deficiencies of the candidate-gene approach lay in selecting both appropriate genes and relevant SNPs within these genes...
  31. ncbi A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network
    Seung Tae Lee
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:11339-51. 2012
    ....
  32. ncbi Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS)
    Paige M Bracci
    Departmentsof Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94158, USA
    J Thorac Oncol 7:1352-60. 2012
    ..Compared with other lung cancer histologies, AIS patients are less likely to be smokers, yet associations with other lung cancer risk factors and differences by sex have not been determined...
  33. ncbi TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a
    Christofer Diakos
    Laboratory for Molecular Epidemiology, University of California, San Francisco, San Francisco, CA, USA
    Blood 116:4885-93. 2010
    ..In summary our data suggest that TEL-AML1 might exert its antiapoptotic action at least in part by suppressing miRNA-494 and miRNA-320a, lowering their expression causing enhanced survivin expression...
  34. ncbi Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and Helen Diller Comprehensive Cancer Center, University of California San Francisco, CA 94158, USA
    Blood Cells Mol Dis 45:186-91. 2010
    ..We posit a natural history for hyperdiploid leukemia in which prenatal mitotic catastrophe is followed by a postnatal RAS mutation to produce the leukemic cell phenotype...
  35. ncbi Decreased NK cells in patients with head and neck cancer determined in archival DNA
    William P Accomando
    Department of Pathology and Laboratory Medicine, Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
    Clin Cancer Res 18:6147-54. 2012
    ..To examine NK cell levels in archived bloods from a study of human head and neck squamous cell carcinoma (HNSCC), a new DNA-based quantification method was developed...
  36. ncbi MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia
    Kevin Y Urayama
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
    Cancer Epidemiol Biomarkers Prev 16:1172-7. 2007
    ....
  37. ncbi Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells
    J K Wiencke
    Laboratory of Neuro and Molecular Epidemiology, Ambulatory Care AC 34, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    Oncogene 27:2412-21. 2008
    ..Awareness of H3K9Me3 as a mark of gene activity, not repression, is especially important for the classification of human cancer using chromatin and histone profiles...
  38. ncbi RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
    J L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Leukemia 19:415-9. 2005
    ....
  39. ncbi Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control study
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
    Cancer Epidemiol Biomarkers Prev 20:2377-83. 2011
    ....
  40. ncbi DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform
    Helen M Hansen
    Department of Neurological Surgery, University of California, Suite AC 34, 1 Irving Street, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 16:1686-90. 2007
    ..14-118.32, 0.29-2.19, and 0.01-0.27 ng/microL, respectively). Human-specific quantitative PCR is a highly useful guide for determining the suitability of wgaDNA before high-throughput single-nucleotide polymorphism analysis...
  41. ncbi Chemokine polymorphisms and lymphoma: a pooled analysis
    Paige M Bracci
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118 1944, USA
    Leuk Lymphoma 51:497-506. 2010
    ..The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings...
  42. ncbi Lack of association of rare alleles in the HRAS variable number of tandem repeats (VNTR) region with adult glioma
    P Chen
    Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco 94143 0560, USA
    Neuro Oncol 2:120-4. 2000
    ..Our data do not suggest an excess of HRAS rare alleles among adult glioma cases...
  43. ncbi Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans
    Kyle M Walsh
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Oncotarget 3:1428-38. 2012
    ..These findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans...
  44. ncbi History of allergies among adults with glioma and controls
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94102, USA
    Int J Cancer 98:609-15. 2002
    ..Future work might reveal an important role for immunologic factors in gliomagenesis and potential preventative and/or therapeutic modalities...
  45. ncbi Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia
    Shichun Zheng
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
    Cancer Res 64:2000-6. 2004
    ..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL...
  46. ncbi DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    J Natl Cancer Inst 103:143-53. 2011
    ....
  47. ncbi Daycare attendance and risk of childhood acute lymphoblastic leukaemia
    X Ma
    Division of Public Health Biology and Epidemiology, University of California Berkeley, California, CA 94720 7360, USA
    Br J Cancer 86:1419-24. 2002
    ....
  48. ncbi Ethnicity delineates different genetic pathways in malignant glioma
    P Chen
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA 94143, USA
    Cancer Res 61:3949-54. 2001
    ....
  49. ncbi Polyphenol associated-DNA adducts in lung and blood mononuclear cells from lung cancer patients
    Andrea Varkonyi
    Microbiology Research Group National Institute for Epidemiology, Budapest, Piheno u 1 H 1529, Hungary
    Cancer Lett 236:24-31. 2006
    ..46; P<0.01). To our knowledge these results are the only comparison of adducts in MNCs with lung tissue, and the only data set indicating that blood MNCs are a valid surrogate for lung adduct DNA burden...
  50. ncbi The C3435T polymorphism of MDR1 and susceptibility to adult glioma
    Katie L Miller
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Neuroepidemiology 25:85-90. 2005
    ..We compare adult glioma cases and controls for the C3435T polymorphism that has been associated with reduced MDR1 expression...
  51. ncbi Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancer
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 64:8702-7. 2004
    ....
  52. ncbi The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 26:1446-9. 2005
    ..This study points to the need for further examination of this gene and its variant in lung cancer and other diseases...
  53. ncbi Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer
    Kim S Kraunz
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 118:1364-9. 2006
    ....
  54. ncbi Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Int J Cancer 114:219-23. 2005
    ..1-2.3]. These results indicate that starting smoking under age 18 is an independent risk for RASSF1A hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk...
  55. ncbi DNA adducts in granulocytes of hospital workers exposed to ethylene oxide
    Lee C Yong
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio 45226, USA
    Am J Ind Med 50:293-302. 2007
    ..Occupational EtO exposure in many countries is regulated at 1 ppm (8-hr TWA), but levels of EtO-DNA adducts in humans with low occupational EtO exposures have not been reported...
  56. ncbi Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1
    Sergi Mas
    Department of Pharmacology, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
    Anticancer Res 27:1151-6. 2007
    ....
  57. ncbi DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas
    Martha J Felini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Neuroepidemiology 29:55-8. 2007
    ..26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71)...
  58. ncbi Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme
    Jianming Tang
    Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
    Cancer Epidemiol Biomarkers Prev 14:2040-4. 2005
    ..B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians...
  59. ncbi A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma
    Eric J Duell
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:4630-6. 2002
    ..Our findings, including stronger associations and interactions among women, require replication in additional study populations...
  60. ncbi Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemia
    Xiaomei Ma
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 14:1928-34. 2005
    ..These results offer indirect yet strong support for the infectious disease hypothesis in the etiology of ALL in non-Hispanic White children and highlight an important ethnic difference...
  61. ncbi A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk
    Eric J Duell
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 94:297-306. 2002
    ....
  62. ncbi Population- and community-based recruitment of African Americans and Latinos: the San Francisco Bay Area Lung Cancer Study
    Daramöla N Cabral
    Northern California Cancer Center, Union City, CA 94587, USA
    Am J Epidemiol 158:272-9. 2003
    ..05). Further assessment of strategies for successful recruitment of minority participants into epidemiologic studies is warranted...
  63. ncbi Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survival
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Building I, Room 607, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Genet Cytogenet 162:115-21. 2005
    ....
  64. ncbi Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
    Lee E Moore
    School of Public Health, Arsenic Health Effects Research Program, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Cancer Lett 211:199-207. 2004
    ..Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer...
  65. ncbi On the use of biomarkers for environmental health research
    Louise Ryan
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Stat Methods Med Res 13:207-25. 2004
    ....
  66. ncbi Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes
    Luoping Zhang
    School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720-7360, USA
    Mutat Res 558:63-74. 2004
    ..Together, these studies suggest that low levels of occupational BD exposure do not pose a significant risk of genetic damage...
  67. ncbi Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
    ..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia...
  68. ncbi Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutation
    Nuria Laso
    Department of Pharmacologys, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
    Anticancer Res 24:2011-20. 2004
    ..CONCLUSION: These results support previous findings that certain micronutrients protect against colorectal neoplasia and emphasize the importance of considering the different molecular forms of CRC as etiologically distinct diseases...
  69. ncbi PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
    Carmen J Marsit
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Pathol 36:768-76. 2005
    ..PTEN loss may also be a favorable prognostic marker, although further studies are needed to confirm this finding...