Research Topics
Genomes and Genes
| John K WienckeSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Epigenetic biomarkers of T-cells in human gliomaJohn K Wiencke
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA USA
Epigenetics 7:1391-402. 2012....- Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributionsE Andres Houseman
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
BMC Bioinformatics 9:365. 2008..Model-based cluster analysis is often used to identify DNA methylation subgroups in data, but it is unclear how to cluster DNA methylation data from arrays in a scalable and reliable manner... - Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastomaJohn K Wiencke
Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 9:271-9. 2007.... 
Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cellsJ K Wiencke
Laboratory of Neuro and Molecular Epidemiology, Ambulatory Care AC 34, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
Oncogene 27:2412-21. 2008..Awareness of H3K9Me3 as a mark of gene activity, not repression, is especially important for the classification of human cancer using chromatin and histone profiles...- DNA methylation, isocitrate dehydrogenase mutation, and survival in gliomaBrock C Christensen
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
J Natl Cancer Inst 103:143-53. 2011.... - CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratificationMelinda C Aldrich
Department of Medicine and Division of Neuroepidemiology, University of California, San Francisco, California, USA
Cancer Res 69:2340-8. 2009..These results suggest that a variant occurring within the CYP1A2 region may be conferring an increased risk of lung cancer in Latinos... - Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African AmericansJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
Int J Cancer 123:2095-104. 2008..61; 95% CI: 0.42-0.88). Our study suggests different elements of the NER pathway may be important in the different ethnic groups resulting either from different linkage relationship, genetic backgrounds and/or exposure histories... - Allergy-related polymorphisms influence glioma status and serum IgE levelsJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 16:1229-35. 2007..Further exploration of immune susceptibility factors, including genetics, in glioma etiology is advisable... - Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-AmericansHelen M Hansen
Division of Neuroepidemiology, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Hum Mol Genet 19:3652-61. 2010..002). The identified regions contain SNPs predicted to affect gene regulation. There are multiple lung cancer risk loci in the 15q25.1 region in African-Americans... 
Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forestsJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, 44 Page Street, Suite 503, San Francisco, CA 94143 1215, USA
Cancer Epidemiol Biomarkers Prev 17:1368-73. 2008..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma...- Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survivalMargaret Wrensch
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94102, USA
Cancer Res 66:4531-41. 2006..3 region influence survival. We also suggest that tumor EGFR expression be incorporated into clinical evaluation of anaplastic astrocytoma patients... - Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-AmericansJeffrey S Chang
Department of Epidemiology and Biostatistics, Division of Neuroepidemiology, University of California San Francisco, San Francisco, CA 94143 1215, USA
Carcinogenesis 30:78-87. 2009..This study suggests that there are genetic differences in the association between BER pathway and lung cancer between Latinos and African-Americans... - ERCC1 and ERCC2 polymorphisms and adult gliomaMargaret Wrensch
Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
Neuro Oncol 7:495-507. 2005..3). Given the numbers of comparisons made, these findings could be due to chance. However, the results might warrant clarification in additional series in conjunction with the nearby putative glioma suppressor genes (GLTSCR1 and GLTSCR2)... - Comparison of statistical methods for estimating genetic admixture in a lung cancer study of African Americans and LatinosMelinda C Aldrich
University of California, San Francisco, Box 2911 Rock Hall, Mission Bay 582, 1550 4th Street, San Francisco, CA 94143 2911, USA
Am J Epidemiol 168:1035-46. 2008..Genetic admixture proportions provide a quantitative measure of ancestry differences among Latinos that can be used in analyses of genetic risk factors... - Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenicCraig Steinmaus
Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, California, USA
J Toxicol Environ Health A 70:159-70. 2007..Overall, this study provides evidence that MTHFR and GSTM1 are involved in arsenic metabolism in humans, and polymorphisms in the genes that encode these enzymes may play a role in susceptibility to arsenic-induced cancer... - Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemiaCatherine Metayer
School of Public Health, University of California, Berkeley, 1995 University Avenue, Suite 460, Berkeley, CA 94704 7392, USA
Cancer Causes Control 22:1243-58. 2011..We examined whether child's germline genetic variation in the folate pathway is associated with childhood acute lymphoblastic leukemia (ALL), and whether periconception maternal folate and alcohol intake modify the risk... - Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferaseJohn K Wiencke
Division of Neuroepidemiology, Department of Neurological Surgery, School of Medicine, University of California San Francisco, Box 0441, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 14:1774-83. 2005..MGMT expression may depend on the TP53 status of cells... - HLA-DP genetic variation, proxies for early life immune modulation and childhood acute lymphoblastic leukemia riskKevin Y Urayama
School of Public Health, University of California, Berkeley, CA 94704, USA
Blood 120:3039-47. 2012..These findings support an immune mechanism in the etiology of childhood ALL involving the HLA-DPB1 gene in the context of an insufficiently modulated immune system... - Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult gliomaMi Zhou
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
Cancer Res 70:7534-42. 2010..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis... - DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expressionShichun Zheng
Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
Neuro Oncol 13:280-9. 2011..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications... - SSBP2 variants are associated with survival in glioblastoma patientsYuanyuan Xiao
Department of Epidemiology and Biostatistics, University of California, San Francisco 185 Berry St, Suite 5700, San Francisco, CA 94107, USA
Clin Cancer Res 18:3154-62. 2012..Glioblastoma is a devastating, incurable disease with few known prognostic factors. Here, we present the first genome-wide survival and validation study for glioblastoma... - Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemiaJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
Cancer Epidemiol Biomarkers Prev 19:2152-63. 2010..The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk... - SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization systemAlexander R Pico
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Nucleic Acids Res 37:D803-9. 2009..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data... - IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide eraJoseph L Wiemels
Department of Neurosurgery and Epidemiology, UCSF, San Francisco, CA 94143 0441, USA
Int J Cancer 125:680-7. 2009..These results have implications for the study of immunologic factors in glioma as well as for immunotherapy protocols for treating glioma... - Molecular biomarkers for the study of childhood leukemiaMartyn T Smith
Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Toxicol Appl Pharmacol 206:237-45. 2005..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia... - Reduced immunoglobulin E and allergy among adults with glioma compared with controlsJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143 0560, USA
Cancer Res 64:8468-73. 2004..Furthermore, the results indicate a complex relationship between allergic disease and glioma risk that varies by allergen and allergic pathology... - CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African AmericansMargaret R Wrensch
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA
Int J Cancer 113:141-7. 2005.... - Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemiaAnand P Chokkalingam
School of Public Health, University of California Berkeley, Berkeley, CA, USA
Cancer Causes Control 23:1577-85. 2012..Additional studies are needed to confirm these findings and identify specific causal variants... - Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 Regions Identifies Functional and Histology-Specific Lung Cancer Susceptibility Loci in African-AmericansKyle M Walsh
Corresponding Author Kyle M Walsh, University of California San Francisco, 1450 3rd Street, Box 0520, HD 276, San Francisco, CA 94143 0520
Cancer Epidemiol Biomarkers Prev 22:251-60. 2013..1-p21.31, and 15q25.1. We investigated whether these regions contain lung cancer susceptibly loci in African-Americans and refined previous association signals by using the reduced linkage disequilibrium observed in African-Americans... - Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemiaAnand P Chokkalingam
Division of Epidemiology, School of Public Health, University of California Berkeley, 1995 University Avenue, Berkeley, CA 94704, USA
Cancer Causes Control 22:1721-30. 2011..These abnormalities may be influenced by altered DNA repair and cell cycle control processes... - Variation in xenobiotic transport and metabolism genes, household chemical exposures, and risk of childhood acute lymphoblastic leukemiaAnand P Chokkalingam
Division of Epidemiology, UC Berkeley School of Public Health, University of California Berkeley, 1995 University Ave, Berkeley, CA 94704, USA
Cancer Causes Control 23:1367-75. 2012..We sought to evaluate the role of genes involved in xenobiotic transport and metabolism in childhood ALL risk, both alone and in conjunction with household chemical exposures previously found to be associated with childhood ALL risk... - Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in ArgentinaLee E Moore
School of Public Health, Arsenic Health Effects Research Program, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Cancer Lett 211:199-207. 2004..Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer... - PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcomeSabine Mueller
Department of Pediatrics, University of California, San Francisco, CA, USA
Neuro Oncol 14:1146-52. 2012..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors... - A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor networkSeung Tae Lee
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
Nucleic Acids Res 40:11339-51. 2012.... - Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studiesKyle M Walsh
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Genet Epidemiol 37:222-8. 2013..These results highlight that the deficiencies of the candidate-gene approach lay in selecting both appropriate genes and relevant SNPs within these genes... - Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibilityMargaret Wrensch
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Nat Genet 41:905-8. 2009..85 x 10(-10). On 20q13.3, rs6010620 intronic to RTEL1 had discovery P = 1.5 x 10(-7), replication P = 0.00035 and combined P = 3.40 x 10(-9). For both SNPs, the direction of association was the same in discovery and replication phases... - Decreased NK cells in patients with head and neck cancer determined in archival DNAWilliam P Accomando
Department of Pathology and Laboratory Medicine, Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
Clin Cancer Res 18:6147-54. 2012..To examine NK cell levels in archived bloods from a study of human head and neck squamous cell carcinoma (HNSCC), a new DNA-based quantification method was developed... - Cigarette smoking associated with lung adenocarcinoma in situ in a large case-control study (SFBALCS)Paige M Bracci
Departmentsof Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California 94158, USA
J Thorac Oncol 7:1352-60. 2012..Compared with other lung cancer histologies, AIS patients are less likely to be smokers, yet associations with other lung cancer risk factors and differences by sex have not been determined... - Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemiaJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and Helen Diller Comprehensive Cancer Center, University of California San Francisco, CA 94158, USA
Blood Cells Mol Dis 45:186-91. 2010..We posit a natural history for hyperdiploid leukemia in which prenatal mitotic catastrophe is followed by a postnatal RAS mutation to produce the leukemic cell phenotype... - TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320aChristofer Diakos
Laboratory for Molecular Epidemiology, University of California, San Francisco, San Francisco, CA, USA
Blood 116:4885-93. 2010..In summary our data suggest that TEL-AML1 might exert its antiapoptotic action at least in part by suppressing miRNA-494 and miRNA-320a, lowering their expression causing enhanced survivin expression... - Chemokine polymorphisms and lymphoma: a pooled analysisPaige M Bracci
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118 1944, USA
Leuk Lymphoma 51:497-506. 2010..The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings... - Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypesLuoping Zhang
School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720-7360, USA
Mutat Res 558:63-74. 2004..Together, these studies suggest that low levels of occupational BD exposure do not pose a significant risk of genetic damage... - MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemiaKevin Y Urayama
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
Cancer Epidemiol Biomarkers Prev 16:1172-7. 2007.... - Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemiaShichun Zheng
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
Cancer Res 64:2000-6. 2004..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL... - DNA adduct burden and tobacco carcinogenesisJohn K Wiencke
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, CA 94143 0560, USA
Oncogene 21:7376-91. 2002..As these trends continue a variety of innovative study designs and approaches will become important in human populations... - Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibilityJohn K Wiencke
Department of Epidemiology and Biostatistics, University of California San Francisco, School of Medicine, San Francisco, California 94143 0560, USA
Environ Health Perspect 110:555-8. 2002..Targeted intervention in adolescent smoking may yield even greater reductions in lung cancer occurrence than otherwise anticipated... - RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemiaJ L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
Leukemia 19:415-9. 2005.... - Early age at smoking initiation and tobacco carcinogen DNA damage in the lungJ K Wiencke
Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 94143 0560, USA
J Natl Cancer Inst 91:614-9. 1999.... - Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control studyJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
Cancer Epidemiol Biomarkers Prev 20:2377-83. 2011.... - DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platformHelen M Hansen
Department of Neurological Surgery, University of California, Suite AC 34, 1 Irving Street, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 16:1686-90. 2007..14-118.32, 0.29-2.19, and 0.01-0.27 ng/microL, respectively). Human-specific quantitative PCR is a highly useful guide for determining the suitability of wgaDNA before high-throughput single-nucleotide polymorphism analysis... - Lack of association of rare alleles in the HRAS variable number of tandem repeats (VNTR) region with adult gliomaP Chen
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco 94143 0560, USA
Neuro Oncol 2:120-4. 2000..Our data do not suggest an excess of HRAS rare alleles among adult glioma cases... - Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-AmericansKyle M Walsh
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Oncotarget 3:1428-38. 2012..These findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans... - Glutathione-S-transferase variants and adult gliomaMargaret Wrensch
University of California, San Francisco, CA 94143, USA
Cancer Epidemiol Biomarkers Prev 13:461-7. 2004..Conflicting findings have been reported for associations of primary brain tumors and constitutive polymorphisms in glutathione-S-transferases (GSTs)... - History of allergies among adults with glioma and controlsJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94102, USA
Int J Cancer 98:609-15. 2002..Future work might reveal an important role for immunologic factors in gliomagenesis and potential preventative and/or therapeutic modalities... - Impact of race/ethnicity on molecular pathways in human cancerJohn K Wiencke
University of California San Francisco, Department of Epidemiology and Biostatistics, 500 Parnassus Avenue, San Francisco, California 94143, USA
Nat Rev Cancer 4:79-84. 2004 - Ethnicity delineates different genetic pathways in malignant gliomaP Chen
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, CA 94143, USA
Cancer Res 61:3949-54. 2001.... - A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma riskEric J Duell
Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA 02115, USA
J Natl Cancer Inst 94:297-306. 2002.... - Population- and community-based recruitment of African Americans and Latinos: the San Francisco Bay Area Lung Cancer StudyDaramöla N Cabral
Northern California Cancer Center, Union City, CA 94587, USA
Am J Epidemiol 158:272-9. 2003..05). Further assessment of strategies for successful recruitment of minority participants into epidemiologic studies is warranted... - A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinomaEric J Duell
Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 62:4630-6. 2002..Our findings, including stronger associations and interactions among women, require replication in additional study populations... - DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomasMartha J Felini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Neuroepidemiology 29:55-8. 2007..26; CI 0.90-1.75) and the MGMT Ile143Val polymorphism (Ile or Val/Val versus Ile/Ile: adjusted OR = 1.20; CI 0.85-1.71)... - Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survivalCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Building I, Room 607, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Genet Cytogenet 162:115-21. 2005.... - Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancerKim S Kraunz
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 118:1364-9. 2006.... - Ethnic difference in daycare attendance, early infections, and risk of childhood acute lymphoblastic leukemiaXiaomei Ma
Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, New Haven, CT 06520 8034, USA
Cancer Epidemiol Biomarkers Prev 14:1928-34. 2005..These results offer indirect yet strong support for the infectious disease hypothesis in the etiology of ALL in non-Hispanic White children and highlight an important ethnic difference... - DNA adducts in granulocytes of hospital workers exposed to ethylene oxideLee C Yong
Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio 45226, USA
Am J Ind Med 50:293-302. 2007..Occupational EtO exposure in many countries is regulated at 1 ppm (8-hr TWA), but levels of EtO-DNA adducts in humans with low occupational EtO exposures have not been reported... - Polyphenol associated-DNA adducts in lung and blood mononuclear cells from lung cancer patientsAndrea Varkonyi
Microbiology Research Group National Institute for Epidemiology, Budapest, Piheno u 1 H 1529, Hungary
Cancer Lett 236:24-31. 2006..46; P<0.01). To our knowledge these results are the only comparison of adducts in MNCs with lung tissue, and the only data set indicating that blood MNCs are a valid surrogate for lung adduct DNA burden... - The C3435T polymorphism of MDR1 and susceptibility to adult gliomaKatie L Miller
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Neuroepidemiology 25:85-90. 2005..We compare adult glioma cases and controls for the C3435T polymorphism that has been associated with reduced MDR1 expression... - The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-AmericansCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Carcinogenesis 26:1446-9. 2005..This study points to the need for further examination of this gene and its variant in lung cancer and other diseases... - Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancerCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 64:8702-7. 2004.... - Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescenceCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Int J Cancer 114:219-23. 2005..1-2.3]. These results indicate that starting smoking under age 18 is an independent risk for RASSF1A hypermethylation, thus identifying a molecular alteration related to the epidemiologic effect of teenage smoking as a lung cancer risk... - Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1Sergi Mas
Department of Pharmacology, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
Anticancer Res 27:1151-6. 2007.... - Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiformeJianming Tang
Department of Medicine, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
Cancer Epidemiol Biomarkers Prev 14:2040-4. 2005..B*07 and the B*07-Cw*07 haplotype are much more common in Caucasians than other ethnic groups in the U.S., which may partially explain the higher incidence of glioblastoma multiforme in Caucasians... - PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alterationCarmen J Marsit
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Hum Pathol 36:768-76. 2005..PTEN loss may also be a favorable prognostic marker, although further studies are needed to confirm this finding... - Decrease in specific micronutrient intake in colorectal cancer patients with tumors presenting Ki-ras mutationNuria Laso
Department of Pharmacologys, School of Medicine, IDIBAPS, University of Barcelona, Casanova 143, 08036 Barcelona, Spain
Anticancer Res 24:2011-20. 2004..CONCLUSION: These results support previous findings that certain micronutrients protect against colorectal neoplasia and emphasize the importance of considering the different molecular forms of CRC as etiologically distinct diseases... - On the use of biomarkers for environmental health researchLouise Ryan
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Stat Methods Med Res 13:207-25. 2004....
Research Grants
- Biomarkers of survival in glioma epidemiologyJohn K Wiencke; Fiscal Year: 2010....
- BIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIESJohn Wiencke; Fiscal Year: 2009..This will be only the second large genetic epidemiologic study of lung cancer in African-Americans; African-American men in California have an 11% lifetime risk of lung cancer. ..
- BIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIESJohn Wiencke; Fiscal Year: 2003..The further note that the DNA bank and comprehensive questionnaire data on smoking and other important risk factors also will prove invaluable for continuing studies of the genetic epidemiology of lung cancer. ..
- Biomarkers of survival in glioma epidemiologyJohn Wiencke; Fiscal Year: 2009....