Research Topics
Genomes and GenesSpecies | JOSEPH LEO WIEMELSSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Assessment of autoantibodies to meningioma in a population-based studyJoseph L Wiemels
Department of Epidemiology and Biostatistics, School of Medicine, Helen Diller Cancer Research Building, University of California, San Francisco, 1450 3rd Street, MC 0520, San Francisco, CA 94158, USA
Am J Epidemiol 177:75-83. 2013..1, 11 (P(trend) = 0.006)). These results indicate that men with meningioma commonly react with a serologic antimeningioma response; if supported by further research, this finding suggests a distinctive etiology for meningioma in men...- Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemiaMarcela Braga Mansur
Paediatric Haematology Oncology Program, Research Centre, Instituto Nacional de Cancer, Rio de Janeiro, RJ, Brazil
BMC Cancer 12:9. 2012..The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases... - Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controlsJoseph L Wiemels
Department of Neurosurgery and Epidemiology and Biostatistics, University of California at San Francisco School of Medicine, San Francisco, CA 94158, USA
Int J Cancer 129:1932-9. 2011..As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted... 
Perspectives on the causes of childhood leukemiaJoseph Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Center Research Building, 1450 3rd Street, HD274, San Francisco, CA 94158, United States
Chem Biol Interact 196:59-67. 2012....- FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemiaPatrick Chang
Department of Epidemiology and Biostatistics, UCSF, Helen Diller Cancer Research Building, San Francisco, CA 94158, USA
BMC Cancer 10:513. 2010..The causes and timing of the mutations are not currently known. We evaluated the prevalence and timing of origin of FLT3 mutations in a population series of childhood leukemia patients from Northern California... - Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributionsE Andres Houseman
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
BMC Bioinformatics 9:365. 2008..Model-based cluster analysis is often used to identify DNA methylation subgroups in data, but it is unclear how to cluster DNA methylation data from arrays in a scalable and reliable manner... - Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatallyJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 941143 0441, USA
Cancer Res 68:9935-44. 2008..These data are compatible with a two-stage natural history: TEL-AML1 occurs prenatally, and del(12p) occurs postnatally in more mature cells with a structure that suggests the involvement of retrotransposon instability... 
Allergy-related polymorphisms influence glioma status and serum IgE levelsJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 16:1229-35. 2007..Further exploration of immune susceptibility factors, including genetics, in glioma etiology is advisable...- Backtracking of leukemic clones to birthJoseph Wiemels
Laboratory for Molecular Epidemiology, University of California, 2331 Eunice St, Berkeley, San Francisco, CA 94708, USA
Methods Mol Biol 538:7-27. 2009..We here described methods for cloning translocations and other rearrangements for "backtracking" studies, and methods for sensitive detection of such rearrangements and a point mutation in ANB cards... - Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemiaJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and Helen Diller Comprehensive Cancer Center, University of California San Francisco, CA 94158, USA
Blood Cells Mol Dis 45:186-91. 2010..We posit a natural history for hyperdiploid leukemia in which prenatal mitotic catastrophe is followed by a postnatal RAS mutation to produce the leukemic cell phenotype... - Epidemiology and etiology of meningiomaJoseph Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Research Building, MC 0520, San Francisco, CA 94158, USA
J Neurooncol 99:307-14. 2010..In this review, we highlight current knowledge about meningioma epidemiology and etiology and suggest future research directions... - Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control studyJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
Cancer Epidemiol Biomarkers Prev 20:2377-83. 2011.... - IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide eraJoseph L Wiemels
Department of Neurosurgery and Epidemiology, UCSF, San Francisco, CA 94143 0441, USA
Int J Cancer 125:680-7. 2009..These results have implications for the study of immunologic factors in glioma as well as for immunotherapy protocols for treating glioma... - Allergies and childhood leukemiaJeffrey S Chang
Department of Epidemiology and Biostatistics, 44 Page Street, University of California San Francisco, San Francisco, CA 94143 1215, USA
Blood Cells Mol Dis 42:99-104. 2009..In addition, the utilities of genetic and molecular studies to disentangle the association between allergies and childhood leukemia and to elucidate the biological mechanisms are also discussed... - DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expressionShichun Zheng
Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
Neuro Oncol 13:280-9. 2011..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications... - SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization systemAlexander R Pico
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Nucleic Acids Res 37:D803-9. 2009..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data... - Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forestsJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California, San Francisco, 44 Page Street, Suite 503, San Francisco, CA 94143 1215, USA
Cancer Epidemiol Biomarkers Prev 17:1368-73. 2008..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma... - In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemiaJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
Blood 99:3801-5. 2002.... - Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemiaJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California, San Francisco 94143, USA
Proc Natl Acad Sci U S A 99:15101-6. 2002.... - Reduced immunoglobulin E and allergy among adults with glioma compared with controlsJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143 0560, USA
Cancer Res 64:8468-73. 2004..Furthermore, the results indicate a complex relationship between allergic disease and glioma risk that varies by allergen and allergic pathology... - Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathwaysAnil Sapru
Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
Intensive Care Med 32:1293-303. 2006.... - Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult gliomaMi Zhou
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
Cancer Res 70:7534-42. 2010..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis... - Maternal immunoglobulin E and childhood leukemiaJeffrey S Chang
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143 1215, USA
Cancer Epidemiol Biomarkers Prev 18:2221-7. 2009.... - Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemiaShichun Zheng
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
Cancer Res 64:2000-6. 2004..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL... - MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemiaKevin Y Urayama
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
Cancer Epidemiol Biomarkers Prev 16:1172-7. 2007.... - Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in CaliforniaMelinda C Aldrich
University of California Berkeley, 2150 Shattuck Avenue, Suite 500, Berkeley, CA 94720 7380, USA
Cancer Epidemiol Biomarkers Prev 15:578-81. 2006..The mechanistic basis for this 2-fold variation in frequency of TEL-AML1 may be due to ethnic-specific risk factors or genetics and should be explored further... - Molecular biomarkers for the study of childhood leukemiaMartyn T Smith
Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Toxicol Appl Pharmacol 206:237-45. 2005..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia... - History of allergies among adults with glioma and controlsJoseph L Wiemels
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94102, USA
Int J Cancer 98:609-15. 2002..Future work might reveal an important role for immunologic factors in gliomagenesis and potential preventative and/or therapeutic modalities... - Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sourcesRandi A Paynter
Division of Environmental Health Sciences, School of Public Health, University of California, 140 Earl Warren Hall 7360, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 15:2533-6. 2006..We conclude that highly multiplexed Illumina genotyping may be done on gDNA and wgaDNA obtained from whole blood, buccal samples, dried blood spots on Guthrie cards, and possibly even urine samples, with minimal misclassification... - Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemiaGhislaine Scelo
School of Public Health, University of California Berkeley, Berkeley, California 94704 7380, USA
Environ Health Perspect 117:133-9. 2009..Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia... - DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platformHelen M Hansen
Department of Neurological Surgery, University of California, Suite AC 34, 1 Irving Street, San Francisco, CA 94143 0441, USA
Cancer Epidemiol Biomarkers Prev 16:1686-90. 2007..14-118.32, 0.29-2.19, and 0.01-0.27 ng/microL, respectively). Human-specific quantitative PCR is a highly useful guide for determining the suitability of wgaDNA before high-throughput single-nucleotide polymorphism analysis... - NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysisNeela Guha
Division of Epidemiology, School of Public Health, University of California, Berkeley, California 94704, USA
Am J Epidemiol 168:1221-32. 2008..Therefore, further research is warranted on the role of NQO1 polymorphisms in the etiology of childhood leukemia, especially among MLL-positive leukemias... - Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in CaliforniaCliona M McHale
School of Public Health, University of California, Berkeley 94720-7360, USA
Genes Chromosomes Cancer 37:36-43. 2003..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X...
Research Grants
- BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIAJoseph Wiemels; Fiscal Year: 2006..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. ..
- Meningioma: Risk Factors and Quality of LifeJoseph Wiemels; Fiscal Year: 2006..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
- BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIAJoseph Wiemels; Fiscal Year: 2003..In summary, this project aims to elucidate the timing and structure of the genetic events that lead to childhood leukemia. ..
- Meningioma: Risk Factors and Quality of LifeJOSEPH LEO WIEMELS; Fiscal Year: 2010..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..