JOSEPH LEO WIEMELS

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein
    Christofer Diakos
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America Department of Pediatrics, St Anna Children s Hospital, Medical University of Vienna, Vienna, Austria
    PLoS ONE 9:e87602. 2014
  2. pmc A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network
    Seung Tae Lee
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:11339-51. 2012
  3. pmc Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls
    G M Vasconcelos
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143 0441, USA
    Br J Cancer 99:1668-72. 2008
  4. pmc Assessment of autoantibodies to meningioma in a population-based study
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, School of Medicine, Helen Diller Cancer Research Building, University of California, San Francisco, 1450 3rd Street, MC 0520, San Francisco, CA 94158, USA
    Am J Epidemiol 177:75-83. 2013
  5. pmc Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
    Marcela Braga Mansur
    Paediatric Haematology Oncology Program, Research Centre, Instituto Nacional de Cancer, Rio de Janeiro, RJ, Brazil
    BMC Cancer 12:9. 2012
  6. pmc Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls
    Joseph L Wiemels
    Department of Neurosurgery and Epidemiology and Biostatistics, University of California at San Francisco School of Medicine, San Francisco, CA 94158, USA
    Int J Cancer 129:1932-9. 2011
  7. pmc Perspectives on the causes of childhood leukemia
    Joseph Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Center Research Building, 1450 3rd Street, HD274, San Francisco, CA 94158, United States
    Chem Biol Interact 196:59-67. 2012
  8. pmc FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia
    Patrick Chang
    Department of Epidemiology and Biostatistics, UCSF, Helen Diller Cancer Research Building, San Francisco, CA 94158, USA
    BMC Cancer 10:513. 2010
  9. pmc Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions
    E Andres Houseman
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
    BMC Bioinformatics 9:365. 2008
  10. pmc Epidemiology and etiology of meningioma
    Joseph Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Research Building, MC 0520, San Francisco, CA 94158, USA
    J Neurooncol 99:307-14. 2010

Research Grants

  1. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2001
  2. Meningioma: Risk Factors and Quality of Life
    Joseph Wiemels; Fiscal Year: 2009
  3. Meningioma: Risk Factors and Quality of Life
    Joseph Wiemels; Fiscal Year: 2007
  4. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
  5. Meningioma: Risk Factors and Quality of Life
    Joseph Wiemels; Fiscal Year: 2006
  6. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2005
  7. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2004
  8. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2003
  9. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2002
  10. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. doi request reprint Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein
    Christofer Diakos
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America Department of Pediatrics, St Anna Children s Hospital, Medical University of Vienna, Vienna, Austria
    PLoS ONE 9:e87602. 2014
    ..These findings may also provide evidence of potentially attractive therapeutic targets. ..
  2. pmc A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network
    Seung Tae Lee
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:11339-51. 2012
    ....
  3. pmc Adenovirus detection in Guthrie cards from paediatric leukaemia cases and controls
    G M Vasconcelos
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143 0441, USA
    Br J Cancer 99:1668-72. 2008
    ..In contrast to a previous report, AdV DNA was not detected at a higher frequency among neonates who later developed leukaemia, when compared with controls...
  4. pmc Assessment of autoantibodies to meningioma in a population-based study
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, School of Medicine, Helen Diller Cancer Research Building, University of California, San Francisco, 1450 3rd Street, MC 0520, San Francisco, CA 94158, USA
    Am J Epidemiol 177:75-83. 2013
    ..1, 11 (P(trend) = 0.006)). These results indicate that men with meningioma commonly react with a serologic antimeningioma response; if supported by further research, this finding suggests a distinctive etiology for meningioma in men...
  5. pmc Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia
    Marcela Braga Mansur
    Paediatric Haematology Oncology Program, Research Centre, Instituto Nacional de Cancer, Rio de Janeiro, RJ, Brazil
    BMC Cancer 12:9. 2012
    ..The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases...
  6. pmc Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls
    Joseph L Wiemels
    Department of Neurosurgery and Epidemiology and Biostatistics, University of California at San Francisco School of Medicine, San Francisco, CA 94158, USA
    Int J Cancer 129:1932-9. 2011
    ..As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted...
  7. pmc Perspectives on the causes of childhood leukemia
    Joseph Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Center Research Building, 1450 3rd Street, HD274, San Francisco, CA 94158, United States
    Chem Biol Interact 196:59-67. 2012
    ....
  8. pmc FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia
    Patrick Chang
    Department of Epidemiology and Biostatistics, UCSF, Helen Diller Cancer Research Building, San Francisco, CA 94158, USA
    BMC Cancer 10:513. 2010
    ..The causes and timing of the mutations are not currently known. We evaluated the prevalence and timing of origin of FLT3 mutations in a population series of childhood leukemia patients from Northern California...
  9. pmc Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions
    E Andres Houseman
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
    BMC Bioinformatics 9:365. 2008
    ..Model-based cluster analysis is often used to identify DNA methylation subgroups in data, but it is unclear how to cluster DNA methylation data from arrays in a scalable and reliable manner...
  10. pmc Epidemiology and etiology of meningioma
    Joseph Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, Helen Diller Cancer Research Building, MC 0520, San Francisco, CA 94158, USA
    J Neurooncol 99:307-14. 2010
    ..In this review, we highlight current knowledge about meningioma epidemiology and etiology and suggest future research directions...
  11. pmc Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and Helen Diller Comprehensive Cancer Center, University of California San Francisco, CA 94158, USA
    Blood Cells Mol Dis 45:186-91. 2010
    ..We posit a natural history for hyperdiploid leukemia in which prenatal mitotic catastrophe is followed by a postnatal RAS mutation to produce the leukemic cell phenotype...
  12. doi request reprint Backtracking of leukemic clones to birth
    Joseph Wiemels
    Laboratory for Molecular Epidemiology, University of California, 2331 Eunice St, Berkeley, San Francisco, CA 94708, USA
    Methods Mol Biol 538:7-27. 2009
    ..We here described methods for cloning translocations and other rearrangements for "backtracking" studies, and methods for sensitive detection of such rearrangements and a point mutation in ANB cards...
  13. pmc Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 941143 0441, USA
    Cancer Res 68:9935-44. 2008
    ..These data are compatible with a two-stage natural history: TEL-AML1 occurs prenatally, and del(12p) occurs postnatally in more mature cells with a structure that suggests the involvement of retrotransposon instability...
  14. pmc Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control study
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA
    Cancer Epidemiol Biomarkers Prev 20:2377-83. 2011
    ....
  15. ncbi request reprint Allergy-related polymorphisms influence glioma status and serum IgE levels
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 16:1229-35. 2007
    ..Further exploration of immune susceptibility factors, including genetics, in glioma etiology is advisable...
  16. pmc IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era
    Joseph L Wiemels
    Department of Neurosurgery and Epidemiology, UCSF, San Francisco, CA 94143 0441, USA
    Int J Cancer 125:680-7. 2009
    ..These results have implications for the study of immunologic factors in glioma as well as for immunotherapy protocols for treating glioma...
  17. doi request reprint Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 44 Page Street, Suite 503, San Francisco, CA 94143 1215, USA
    Cancer Epidemiol Biomarkers Prev 17:1368-73. 2008
    ..Despite less than complete inclusion of genes and SNPs relevant to glioma and a small sample size, RF analysis identified one important biological pathway and several SNPs potentially associated with the development of glioblastoma...
  18. pmc DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression
    Shichun Zheng
    Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA
    Neuro Oncol 13:280-9. 2011
    ..DNA methylation markers are useful in characterizing distinct glioma subtypes and may hold promise for clinical applications...
  19. ncbi request reprint Reduced immunoglobulin E and allergy among adults with glioma compared with controls
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143 0560, USA
    Cancer Res 64:8468-73. 2004
    ..Furthermore, the results indicate a complex relationship between allergic disease and glioma risk that varies by allergen and allergic pathology...
  20. ncbi request reprint Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways
    Anil Sapru
    Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
    Intensive Care Med 32:1293-303. 2006
    ....
  21. doi request reprint Allergies and childhood leukemia
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, 44 Page Street, University of California San Francisco, San Francisco, CA 94143 1215, USA
    Blood Cells Mol Dis 42:99-104. 2009
    ..In addition, the utilities of genetic and molecular studies to disentangle the association between allergies and childhood leukemia and to elucidate the biological mechanisms are also discussed...
  22. pmc Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143, USA
    Proc Natl Acad Sci U S A 99:15101-6. 2002
    ....
  23. pmc SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system
    Alexander R Pico
    Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
    Nucleic Acids Res 37:D803-9. 2009
    ..We have found integration of SNP annotation in the context of pathway information and functional prediction scores to be a powerful approach to the analysis and interpretation of SNP-disease association data...
  24. ncbi request reprint In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
    Blood 99:3801-5. 2002
    ....
  25. ncbi request reprint Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California
    Melinda C Aldrich
    University of California Berkeley, 2150 Shattuck Avenue, Suite 500, Berkeley, CA 94720 7380, USA
    Cancer Epidemiol Biomarkers Prev 15:578-81. 2006
    ..The mechanistic basis for this 2-fold variation in frequency of TEL-AML1 may be due to ethnic-specific risk factors or genetics and should be explored further...
  26. ncbi request reprint Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia
    Shichun Zheng
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
    Cancer Res 64:2000-6. 2004
    ..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL...
  27. pmc Circulating levels of the innate and humoral immune regulators CD14 and CD23 are associated with adult glioma
    Mi Zhou
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:7534-42. 2010
    ..These results augment the long-observed association between allergies and glioma and support a role for the innate and adaptive humoral functions of the immune system, in particular immunoregulatory proteins, in gliomagenesis...
  28. doi request reprint Maternal immunoglobulin E and childhood leukemia
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143 1215, USA
    Cancer Epidemiol Biomarkers Prev 18:2221-7. 2009
    ....
  29. ncbi request reprint MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia
    Kevin Y Urayama
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
    Cancer Epidemiol Biomarkers Prev 16:1172-7. 2007
    ....
  30. ncbi request reprint History of allergies among adults with glioma and controls
    Joseph L Wiemels
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94102, USA
    Int J Cancer 98:609-15. 2002
    ..Future work might reveal an important role for immunologic factors in gliomagenesis and potential preventative and/or therapeutic modalities...
  31. ncbi request reprint Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
    ..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia...
  32. ncbi request reprint Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sources
    Randi A Paynter
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Earl Warren Hall 7360, Berkeley, CA 94720 7360, USA
    Cancer Epidemiol Biomarkers Prev 15:2533-6. 2006
    ..We conclude that highly multiplexed Illumina genotyping may be done on gDNA and wgaDNA obtained from whole blood, buccal samples, dried blood spots on Guthrie cards, and possibly even urine samples, with minimal misclassification...
  33. ncbi request reprint DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform
    Helen M Hansen
    Department of Neurological Surgery, University of California, Suite AC 34, 1 Irving Street, San Francisco, CA 94143 0441, USA
    Cancer Epidemiol Biomarkers Prev 16:1686-90. 2007
    ..14-118.32, 0.29-2.19, and 0.01-0.27 ng/microL, respectively). Human-specific quantitative PCR is a highly useful guide for determining the suitability of wgaDNA before high-throughput single-nucleotide polymorphism analysis...
  34. pmc NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis
    Neela Guha
    Division of Epidemiology, School of Public Health, University of California, Berkeley, California 94704, USA
    Am J Epidemiol 168:1221-32. 2008
    ..Therefore, further research is warranted on the role of NQO1 polymorphisms in the etiology of childhood leukemia, especially among MLL-positive leukemias...
  35. pmc Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia
    Ghislaine Scelo
    School of Public Health, University of California Berkeley, Berkeley, California 94704 7380, USA
    Environ Health Perspect 117:133-9. 2009
    ..Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia...
  36. ncbi request reprint Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
    Cliona M McHale
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Genes Chromosomes Cancer 37:36-43. 2003
    ..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X...

Research Grants11

  1. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2001
    ..In summary, this project aims to elucidate the timing and structure of the genetic events that lead to childhood leukemia. ..
  2. Meningioma: Risk Factors and Quality of Life
    Joseph Wiemels; Fiscal Year: 2009
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  3. Meningioma: Risk Factors and Quality of Life
    Joseph Wiemels; Fiscal Year: 2007
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  4. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. ..
  5. Meningioma: Risk Factors and Quality of Life
    Joseph Wiemels; Fiscal Year: 2006
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  6. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2005
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. ..
  7. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2004
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. ..
  8. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2003
    ..In summary, this project aims to elucidate the timing and structure of the genetic events that lead to childhood leukemia. ..
  9. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2002
    ..In summary, this project aims to elucidate the timing and structure of the genetic events that lead to childhood leukemia. ..
  10. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..